- |||||||||| dilpacimab (ABT-165) / AbbVie
Enrollment open, Metastases: A Study of ABT-165 in Subjects With Solid Tumors (clinicaltrials.gov) - Nov 21, 2018 P1, N=95, Recruiting, Trial completion date: Mar 2023 --> Mar 2022 Active, not recruiting --> Recruiting
- |||||||||| Vectibix (panitumumab) / Amgen
Trial completion date, Trial primary completion date: PARADIGM: Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC (clinicaltrials.gov) - Nov 14, 2018 P3, N=823, Active, not recruiting, Trial completion date: May 2022 --> Aug 2022 | Initiation date: Oct 2018 --> Jan 2019 | Trial primary completion date: May 2022 --> Aug 2022 Trial completion date: May 2020 --> Mar 2020 | Trial primary completion date: May 2020 --> Mar 2020
- |||||||||| monalizumab (IPH2201) / AstraZeneca, Innate, Imfinzi (durvalumab) / AstraZeneca
Phase classification, Enrollment change, Trial primary completion date, IO biomarker, Metastases: A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors (clinicaltrials.gov) - Nov 13, 2018 P1/2, N=501, Recruiting, Not yet recruiting --> Recruiting Phase classification: P1 --> P1/2 | N=262 --> 501 | Trial primary completion date: Feb 2020 --> Oct 2021
- |||||||||| Trial completion date, Trial initiation date, Trial primary completion date: PROMENADE: Proactive Management of Endoperitoneal Spread in Colonic Cancer (clinicaltrials.gov) - Nov 9, 2018
P3, N=140, Not yet recruiting, Active, not recruiting --> Completed Trial completion date: Mar 2025 --> Sep 2025 | Initiation date: Sep 2018 --> Mar 2019 | Trial primary completion date: Mar 2023 --> Sep 2023
- |||||||||| 5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., irinotecan / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date, Metastases: High-dose FOLFIRI in Advanced Colorectal Cancer Patients With Wild-type UGT1A1*6 and *28 (clinicaltrials.gov) - Nov 9, 2018 P2, N=90, Recruiting, Trial completion date: Mar 2025 --> Sep 2025 | Initiation date: Sep 2018 --> Mar 2019 | Trial primary completion date: Mar 2023 --> Sep 2023 Trial completion date: Nov 2020 --> Nov 2021 | Initiation date: Nov 2017 --> Nov 2018 | Trial primary completion date: Jun 2018 --> Nov 2018
- |||||||||| Onivyde (nanoliposomal irinotecan) / Servier, Ipsen, Takeda
New P2 trial, Metastases: NCI-2018-02122: Liposomal Irinotecan, Fluorouracil and Leucovorin in Treating Patients With Refractory Advanced High Grade Neuroendocrine Cancer of Gastrointestinal, Unknown, or Pancreatic Origin (clinicaltrials.gov) - Nov 9, 2018 P2, N=37, Not yet recruiting,
- |||||||||| Odomzo (sonidegib) / Sun Pharma
Trial completion date, Trial primary completion date, Combination therapy, Metastases: LDE225 With Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan for Untreated Advanced Pancreatic Cancer (clinicaltrials.gov) - Nov 8, 2018 P1b, N=39, Active, not recruiting, Not yet recruiting --> Recruiting Trial completion date: Aug 2018 --> Mar 2019 | Trial primary completion date: Aug 2018 --> Mar 2019
- |||||||||| conatumumab (AMG 655) / Amgen
Trial completion date, Trial primary completion date: Open Label Extension Study of Conatumumab and Ganitumab (AMG 479) (clinicaltrials.gov) - Nov 6, 2018 P2, N=12, Active, not recruiting, Trial completion date: Aug 2018 --> Mar 2019 | Trial primary completion date: Aug 2018 --> Mar 2019 Trial completion date: Jan 2019 --> Nov 2019 | Trial primary completion date: Jan 2019 --> Sep 2019
- |||||||||| NN1213 / Novo Nordisk
Trial completion date, Trial primary completion date: Chemoradiation or Brachytherapy for Rectal Cancer (clinicaltrials.gov) - Nov 6, 2018 P2, N=138, Active, not recruiting, Trial completion date: Jan 2019 --> Nov 2019 | Trial primary completion date: Jan 2019 --> Sep 2019 Trial completion date: Oct 2018 --> Oct 2021 | Trial primary completion date: Oct 2018 --> Oct 2020
- |||||||||| epacadostat (INCB024360) / Incyte
Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date, Metastases: A Study of Epacadostat in Combination With Pembrolizumab and Chemotherapy in Participants With Advanced or Metastatic Solid Tumors (ECHO-207/KEYNOTE-723) (clinicaltrials.gov) - Nov 6, 2018 P1/2, N=70, Active, not recruiting, Trial completion date: Oct 2021 --> Oct 2022 | Trial primary completion date: Mar 2020 --> Mar 2021 Recruiting --> Active, not recruiting | N=421 --> 70 | Trial completion date: Oct 2022 --> Jan 2020 | Trial primary completion date: Apr 2021 --> Oct 2019
- |||||||||| AZD0156 / AstraZeneca
Trial completion date, Trial primary completion date, Combination therapy, Monotherapy, PARP Biomarker, Metastases: AToM: Study to Assess the Safety and Preliminary Efficacy of AZD0156 at Increasing Doses Alone or in Combination With Other Anti-cancer Treatment in Patients With Advanced Cancer (clinicaltrials.gov) - Nov 5, 2018 P1, N=225, Recruiting, Recruiting --> Active, not recruiting Trial completion date: Oct 2020 --> Aug 2019 | Trial primary completion date: Oct 2020 --> Aug 2019
- |||||||||| 5-fluorouracil / Generic mfg., cisplatin / Generic mfg., docetaxel / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Study of Modified Docetaxel, Cisplatin, and Fluorouracil (mDCF) in Unresectable or Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma (clinicaltrials.gov) - Oct 30, 2018 P2, N=111, Completed, Trial completion date: Jan 2020 --> Mar 2020 | Trial primary completion date: Jan 2019 --> Mar 2020 Active, not recruiting --> Completed | Trial completion date: Oct 2019 --> Oct 2018 | Trial primary completion date: Oct 2019 --> Oct 2018
- |||||||||| 5-fluorouracil / Generic mfg.
Trial completion date, Trial primary completion date, Metastases: Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer (clinicaltrials.gov) - Oct 25, 2018 P1, N=14, Active, not recruiting, Active, not recruiting --> Completed | Trial completion date: Jan 2018 --> Aug 2018 Trial completion date: Aug 2022 --> May 2023 | Trial primary completion date: Aug 2017 --> May 2018
- |||||||||| GVAX Pancreas (allogeneic GM-CSF-secreting tumor cells) / Novartis
Trial completion date, Trial primary completion date, Tumor cell: Pancreatic Tumor Cell Vaccine (GVAX), Cyclophosphamide, SBRT, and FOLFIRINOX in Patients With Resected Adenocarcinoma of the Pancreas (clinicaltrials.gov) - Oct 23, 2018 P=N/A, N=19, Active, not recruiting, Recruiting --> Active, not recruiting Trial completion date: Jun 2019 --> Jun 2020 | Trial primary completion date: Aug 2018 --> Aug 2019
- |||||||||| veliparib (ABT-888) / AbbVie
Trial completion date, Trial primary completion date, Combination therapy, Metastases: ABT-888 With Modified FOLFOX6 in Patients With Metastatic Pancreatic Cancer (clinicaltrials.gov) - Oct 19, 2018 P1/2, N=79, Recruiting, We suggest that OIIS in addition to oxaliplatin-induced thrombocytopenia may be associated with the development of DDPAs to other drugs causing clinically significant thrombocytopenia which is important to recognize and manage with discontinuation of provoking agents. Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019
- |||||||||| Enrollment open, Metastases: Short-course Radiotherapy (5 (clinicaltrials.gov) - Oct 17, 2018
P1, N=9, Recruiting, Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
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