leucovorin calcium / Generic mfg. 
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 424 Diseases   807 Trials   807 Trials   14372 News 


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  • ||||||||||  dilpacimab (ABT-165) / AbbVie
    Enrollment open, Metastases:  A Study of ABT-165 in Subjects With Solid Tumors (clinicaltrials.gov) -  Nov 21, 2018   
    P1,  N=95, Recruiting, 
    Trial completion date: Mar 2023 --> Mar 2022 Active, not recruiting --> Recruiting
  • ||||||||||  Vectibix (panitumumab) / Amgen
    Trial completion date, Trial primary completion date:  PARADIGM: Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC (clinicaltrials.gov) -  Nov 14, 2018   
    P3,  N=823, Active, not recruiting, 
    Trial completion date: May 2022 --> Aug 2022 | Initiation date: Oct 2018 --> Jan 2019 | Trial primary completion date: May 2022 --> Aug 2022 Trial completion date: May 2020 --> Mar 2020 | Trial primary completion date: May 2020 --> Mar 2020
  • ||||||||||  Farydak (panobinostat) / Secura Bio
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date, Combination therapy:  Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome (clinicaltrials.gov) -  Nov 14, 2018   
    P1,  N=19, Terminated, 
    Trial completion date: May 2020 --> Mar 2020 | Trial primary completion date: May 2020 --> Mar 2020 N=36 --> 19 | Trial completion date: Aug 2020 --> Apr 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2020 --> Apr 2018; Slow accrual
  • ||||||||||  monalizumab (IPH2201) / AstraZeneca, Innate, Imfinzi (durvalumab) / AstraZeneca
    Phase classification, Enrollment change, Trial primary completion date, IO biomarker, Metastases:  A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors (clinicaltrials.gov) -  Nov 13, 2018   
    P1/2,  N=501, Recruiting, 
    Not yet recruiting --> Recruiting Phase classification: P1 --> P1/2 | N=262 --> 501 | Trial primary completion date: Feb 2020 --> Oct 2021
  • ||||||||||  Avastin (bevacizumab) / Roche, Erbitux (cetuximab) / Eli Lilly
    Trial completion:  ITACa: Sequential Treatment Strategy for Metastatic Colorectal Cancer (clinicaltrials.gov) -  Nov 9, 2018   
    P3,  N=350, Completed, 
    Not yet recruiting --> Recruiting Active, not recruiting --> Completed
  • ||||||||||  Trial completion date, Trial initiation date, Trial primary completion date:  PROMENADE: Proactive Management of Endoperitoneal Spread in Colonic Cancer (clinicaltrials.gov) -  Nov 9, 2018   
    P3,  N=140, Not yet recruiting, 
    Active, not recruiting --> Completed Trial completion date: Mar 2025 --> Sep 2025 | Initiation date: Sep 2018 --> Mar 2019 | Trial primary completion date: Mar 2023 --> Sep 2023
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., irinotecan / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date, Metastases:  High-dose FOLFIRI in Advanced Colorectal Cancer Patients With Wild-type UGT1A1*6 and *28 (clinicaltrials.gov) -  Nov 9, 2018   
    P2,  N=90, Recruiting, 
    Trial completion date: Mar 2025 --> Sep 2025 | Initiation date: Sep 2018 --> Mar 2019 | Trial primary completion date: Mar 2023 --> Sep 2023 Trial completion date: Nov 2020 --> Nov 2021 | Initiation date: Nov 2017 --> Nov 2018 | Trial primary completion date: Jun 2018 --> Nov 2018
  • ||||||||||  conatumumab (AMG 655) / Amgen
    Trial completion date, Trial primary completion date:  Open Label Extension Study of Conatumumab and Ganitumab (AMG 479) (clinicaltrials.gov) -  Nov 6, 2018   
    P2,  N=12, Active, not recruiting, 
    Trial completion date: Aug 2018 --> Mar 2019 | Trial primary completion date: Aug 2018 --> Mar 2019 Trial completion date: Jan 2019 --> Nov 2019 | Trial primary completion date: Jan 2019 --> Sep 2019
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  Chemoradiation or Brachytherapy for Rectal Cancer (clinicaltrials.gov) -  Nov 6, 2018   
    P2,  N=138, Active, not recruiting, 
    Trial completion date: Jan 2019 --> Nov 2019 | Trial primary completion date: Jan 2019 --> Sep 2019 Trial completion date: Oct 2018 --> Oct 2021 | Trial primary completion date: Oct 2018 --> Oct 2020
  • ||||||||||  5-fluorouracil / Generic mfg.
    Trial completion date, Trial primary completion date, Metastases:  Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer (clinicaltrials.gov) -  Oct 25, 2018   
    P1,  N=14, Active, not recruiting, 
    Active, not recruiting --> Completed | Trial completion date: Jan 2018 --> Aug 2018 Trial completion date: Aug 2022 --> May 2023 | Trial primary completion date: Aug 2017 --> May 2018
  • ||||||||||  oxaliplatin / Generic mfg., leucovorin calcium / Generic mfg., palonosetron intravenous / Generic mfg.
    Clinical, Journal:  A patient with oxaliplatin immune-induced syndrome (OIIS) who also developed leucovorin and palonosetron-associated thrombocytopenia. (Pubmed Central) -  Oct 21, 2018   
    To our knowledge, these two drugs have never been described in the literature as a cause of DDPA. We suggest that OIIS in addition to oxaliplatin-induced thrombocytopenia may be associated with the development of DDPAs to other drugs causing clinically significant thrombocytopenia which is important to recognize and manage with discontinuation of provoking agents.
  • ||||||||||  veliparib (ABT-888) / AbbVie
    Trial completion date, Trial primary completion date, Combination therapy, Metastases:  ABT-888 With Modified FOLFOX6 in Patients With Metastatic Pancreatic Cancer (clinicaltrials.gov) -  Oct 19, 2018   
    P1/2,  N=79, Recruiting, 
    We suggest that OIIS in addition to oxaliplatin-induced thrombocytopenia may be associated with the development of DDPAs to other drugs causing clinically significant thrombocytopenia which is important to recognize and manage with discontinuation of provoking agents. Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019
  • ||||||||||  Enrollment open, Metastases:  Short-course Radiotherapy (5 (clinicaltrials.gov) -  Oct 17, 2018   
    P1,  N=9, Recruiting, 
    Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting