leucovorin calcium / Generic mfg. 
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 424 Diseases   809 Trials   809 Trials   14393 News 


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  • ||||||||||  leucovorin calcium / Generic mfg., fluorouracil topical / Generic mfg., irinotecan / Generic mfg.
    Clinical, Journal:  Systemic therapy without radiation may be appropriate as neoadjuvant therapy for localized pancreas cancer. (Pubmed Central) -  Jun 9, 2020   
    Chemotherapy regimens included gemcitabine (n=17), gemcitabine/nab-paclitaxel (n=8), or 5-FU/leucovorin/irinotecan/oxaliplatin (FOLFIRINOX) (n=11)...A short course of neoadjuvant chemotherapy without chemoradiation may improve patient selection prior to surgical resection for pancreas cancer. Further, local disease progression did not limit surgical resection in this small series.
  • ||||||||||  leucovorin calcium / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  PK/PD Investigation of Calciumfolinat in Blood, Tumor and Adjacent Mucosa in Patient With Colon Cancer (clinicaltrials.gov) -  Jun 9, 2020   
    P=N/A,  N=48, Active, not recruiting, 
    Further, local disease progression did not limit surgical resection in this small series. Recruiting --> Active, not recruiting | Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2019 --> Dec 2020
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
    Trial completion, Surgery, Metastases:  Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal Cancer (clinicaltrials.gov) -  Jun 5, 2020   
    P2,  N=23, Completed, 
    These findings highlight the possible clinical utility of CMSs and suggests that refinement of the CMS classification may provide a path toward identifying patients with metastatic CRC who are most likely to benefit from specific targeted therapy as part of the initial treatment. Active, not recruiting --> Completed
  • ||||||||||  carfilzomib / Generic mfg.
    Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date:  Carfilzomib and Hyper-CVAD in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoma (clinicaltrials.gov) -  May 27, 2020   
    P1,  N=10, Active, not recruiting, 
    Our pre-planned, prospective analysis suggests that circulating FGF-2 levels' early increase could be used as a marker to identify patients who are more likely to gain benefit from FOLFIRI/bevacizumab first-line therapy. Recruiting --> Active, not recruiting | N=21 --> 10 | Trial completion date: Dec 2018 --> Mar 2021 | Trial primary completion date: Dec 2018 --> Nov 2020
  • ||||||||||  Vectibix (panitumumab) / Amgen
    Trial completion date, Trial primary completion date:  PARADIGM: Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC (clinicaltrials.gov) -  May 27, 2020   
    P3,  N=823, Active, not recruiting, 
    It also appears to result in durable local control when combined with chemotherapy, albeit with a small number of patients and limited follow-up. Trial completion date: Jun 2020 --> Aug 2021 | Trial primary completion date: Jun 2020 --> Aug 2021
  • ||||||||||  leucovorin calcium / Generic mfg., fluorouracil topical / Generic mfg., irinotecan / Generic mfg.
    Clinical, Clinical guideline, Journal:  Potentially Curable Pancreatic Adenocarcinoma: ASCO Clinical Practice Guideline Update. (Pubmed Central) -  May 23, 2020   
    The modified combination regimen of 5-fluorouracil, oxaliplatin, and irinotecan (mFOLFIRINOX; oxaliplatin 85 mg/m, leucovorin 400 mg/m, irinotecan 150 mg/m D1, and 5-fluorouracil 2.4 g/m over 46 hours every 14 days for 12 cycles) is now preferred in the absence of concerns for toxicity or tolerance; alternatively, doublet therapy with gemcitabine and capecitabine or monotherapy with gemcitabine alone or fluorouracil plus folinic acid alone can be offered. Additional information can be found at www.asco.org/gastrointestinal-cancer-guidelines .
  • ||||||||||  leucovorin calcium / Generic mfg.
    Trial completion date, Trial primary completion date:  Leucovorin for the Treatment of Language Impairment in Children With Autism Spectrum Disorder (clinicaltrials.gov) -  May 22, 2020   
    P2,  N=162, Not yet recruiting, 
    Routine use of adjuvant HIPEC is not advocated on the basis of this trial. Trial completion date: Jan 2023 --> Jun 2023 | Trial primary completion date: Jan 2022 --> Jun 2022
  • ||||||||||  oxaliplatin / Generic mfg., leucovorin calcium / Generic mfg.
    TRAILing chemoresistance: Oxaliplatin resistance sensitizes colorectal cancer to TRAIL via death receptor localization (Virtual Meeting II: E-Posters) -  May 16, 2020 - Abstract #AACRII2020AACR-II_3853;    
    Additionally, treating whole blood samples from patients with TRAIL-conjugated nanoparticles decreased the number of viable CTCs in circulation 4-fold compared to oxaliplatin monotherapy.These results demonstrate the utility of TRAIL based therapeutics to treat chemoresistant and metastatic CRC. Additionally, this mechanism of apoptosis signal propagation via lipid raft-death receptor complexes can be explored further to probe possible drug targets to augment receptor localization.
  • ||||||||||  oleclumab (MEDI9447) / AstraZeneca, monalizumab (IPH2201) / AstraZeneca, Innate, Imfinzi (durvalumab) / AstraZeneca
    Trial initiation date, Combination therapy:  Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC (clinicaltrials.gov) -  May 15, 2020   
    P2,  N=160, Not yet recruiting, 
    Studies to better understand optimal dose, quantity and timing of HD MTX are required to achieve optimal CNS prophylaxis. Initiation date: Apr 2020 --> Oct 2020
  • ||||||||||  leucovorin calcium / Generic mfg., fluorouracil / Generic mfg.
    Clinical, Journal:  Adjuvant chemotherapy in rectal cancer: state of the art and future perspectives. (Pubmed Central) -  May 14, 2020   
    Adjuvant chemotherapy after rectal cancer surgery reduces recurrence risks but the benefit is limited and for most patients not clinically relevant. Neoadjuvant therapy can be more effective but results from randomized trials are not yet available.