leucovorin calcium / Generic mfg. 
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  • ||||||||||  irinotecan / Generic mfg.
    Review, Journal:  Management of Large Cell Neuroendocrine Carcinoma. (Pubmed Central) -  Sep 14, 2021   
    Further effective and safe treatment options are desperately needed. Recently, new advances including a new understanding of the genetic subcategories of LCNEC and immunotherapy agents may guide further treatments.
  • ||||||||||  irinotecan / Generic mfg.
    Retrospective data, Journal:  Tumor Vascular Microenvironment of Colorectal Hepatic Metastasis and Chemotherapy Response. (Pubmed Central) -  Sep 12, 2021   
    The current data supports an oncological benefit for tumour downstaging and increased in R0 resection rate. Peripheral RE of metastatic hepatic tumor on CT was associated with angiogenesis in the tumor microenvironment and higher chemotherapy response.
  • ||||||||||  5-fluorouracil / Generic mfg., oxaliplatin / Generic mfg., leucovorin calcium / Generic mfg.
    Clinical, Journal:  Introducing Longitudinal Cumulative Dose to Describe Chemotherapy Patterns Over Time: Case Study of a Colon Cancer Trial. (Pubmed Central) -  Sep 9, 2021   
    We obtained data from the 2246 participants in the MOSAIC trial randomized to FOLFOX (all three agents) or 5-FU/LV (only 5-fluorouracil and leucovorin)...Median LCD for oxaliplatin in the FOLFOX arm at 24 weeks was 77%...Visualizing LCD highlighted the timing of deviations from standard administration in a way RDI could not, with major differences in 5-fluorouracil LCD across treatment arms beginning after the 6 dose. Further evaluation of longitudinal cumulative dose and its impacts on clinical outcomes may clarify mechanisms for heterogeneous patient outcomes.
  • ||||||||||  Enrollment open, Surgery:  PANCREAS: Pancreatic Adenocarcinoma Neoadjuvant Chemotherapy Before Surgery (clinicaltrials.gov) -  Sep 9, 2021   
    P2,  N=30, Recruiting, 
    Further evaluation of longitudinal cumulative dose and its impacts on clinical outcomes may clarify mechanisms for heterogeneous patient outcomes. Not yet recruiting --> Recruiting
  • ||||||||||  methotrexate IV / Generic mfg., methotrexate / Generic mfg.
    Journal:  Charcoal Hemoperfusion for Methotrexate Toxicity: A Safe and Effective Life-Rescue Alternative When Glucarpidase Is Not Available. (Pubmed Central) -  Sep 8, 2021   
    Charcoal hemoperfusion was performed with positive results and no complications as bridging until glucarpidase was available in two cases and in one case where two doses of glucarpidase led to insufficient reduction of MTX levels. CHP can be considered as a rescue treatment option in MTX intoxication, since it is an effective and safe extracorporeal method for removing MTX, in cases where rescue with leucovorin is insufficient and glucarpidase is not available or while waiting for delivery.
  • ||||||||||  Zelboraf (vemurafenib) / Roche
    Targeted BRAF Inhibitor Therapy Induces Remission of Unresectable Ampullary Adenocarcinoma (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_2837;    
    He was placed on Vemurafenib, a selective inhibitor of BRAF and V 600 mutations...These mutations are the predominant type in metastatic melanoma for which this drug is used as monotherapy. This case demonstrates the successful treatment of unresectable ampullary adenocarcinoma with targeted chemotherapyFigure: Figure A
  • ||||||||||  Lynparza (olaparib) / Merck (MSD), AstraZeneca
    Pancreatic Adenocarcinoma Presenting as Rectal Bleeding: A Case of a Deceitful Cancer During Deceitful Times (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_2301;    
    He was switched to Olaparib and has tolerated therapy well...Several cases reports have presented colonic metastases after pancreatic surgery. Even though synchronous metastatic disease to the colon is rare furthermore metastatic disease to the rectum, it must be kept in mind.Figure: Pancreatic Metastasis to the Rectum
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
    A Rare Presentation of Colon Cancer in a Young Female With Colonic Perforation (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_2211;    
    In this patient population, prompt recognition and thorough evaluation of rectal bleeding with modalities such as flexible sigmoidoscopy is crucial. These measures enhance prognosis, as a delay in surgical evaluation and intervention could worsen outcomes.
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
    A Rare Case of Esophageal Adenocarcinoma Arising in an Inlet Patch (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_2179;    
    Because of the rarity of the association between inlet patches and esophageal adenocarcinoma, there is no clear consensus concerning the need for surveillance. This case serves to stress the importance of performing a detailed endoscopic evaluation of the upper esophagus with close inspection of any heterotopic gastric mucosa with biopsies of abnormal areas noted.
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
    Never Where You Want It: A Rare Variant of Signet Ring Cell Carcinoma Synchronously in Stomach and Pancreas (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_1934;    
    SRCC has a poor prognosis, and early diagnosis is crucial.Figure: A-B, Signet ring cells featured in pancreas, large intra-cytoplasmic mucin vacuoles that expand in the malignant cells. The nucleus of the cell subsequently is pushed to periphery, creating a ‘signet ring’ configuration.
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
    Longitudinal Immunoprofiling of Pancreatic Cancer Patients to Identify Mediators of Therapy Resistance (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_1439;    
    Mass cytometry revealed distinct alterations in the myeloid population, with a shift toward CXCR2hiPD-L1hi granulocytes with FOLFIRINOX treatment over time (Fig1A). Analysis of PBMCs at the single cell level shows a distinct myeloid signature with FOLFIRINOX and in particular highlights interleukin-8, a chemokine involved in myeloid cell chemotaxis that is associated with poor prognosis in pancreatic cancer (Fig1B).
  • ||||||||||  Avastin (bevacizumab) / Roche
    Deadly Abdominal Pain: A Curious Case of Black Esophagus (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_1278;    
    doi:10.1007/s10620-014-3382-1 Forys, Olivia C. MD; Ferguson, Dawn D. MD Black Esophagus Associated with Malignancy and Use of FOLFOX/Avastin, American Journal of Gastroenterology: September 2007 - Volume 102 - Issue - p S125 Figure: Figure 1. Endoscopic images showing diffuse black esophagus
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., apixaban / Generic mfg.
    Metastatic Gastric Signet Ring Cell Carcinoma in a Colonic Anastomotic Site : A Case Report (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_1017;    
    Case Description/ An 87-year-old female, with history of atrial fibrillation on apixaban and stage IIIB colon cancer status post resection in 2016, presented to the hospital after an episode of near syncope with associated melena...Recognition of an anastomotic tumor as a second primary and not a recurrence is important for optimal management as locoregional recurrences are often amenable to surgical resection.Figure: Figure 1 (A. High power view of poorly differentiated carcinoma with signet ring cells in gastric rugal folds (H and E, 200x); B. High power view of metastatic poorly differentiated carcinoma with signet ring cells in colonic anastomotic site (H and E, 200x); C. High power view of CK7 stain highlighting the neoplastic cells (200x); D. CT imaging showing irregular nodular wall thickening just distal to the ileocolonic anastomosis; E. PET CT showing segmental abnormal FDG uptake is seen at the ileocolic anastomosis in the right superior abdomen, corresponding to an ill-defined lobulated soft tissue; F. Endoscopic view of irregular nodularity at the ileocolonic anastomosis.)
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
    Somatic Mutation Leading to Diffuse Gastric Cancer (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_891;    
    Patient had poor tolerance of FOLFOX therapy, ultimately receiving 5-Fluorouracil only...Pathol Res Pract. 2020;216(5):152941.Figure: Picture taken during EGD and biopsy demonstrating thickened folds, inflammation, and appearance of diffuse wall infiltration.
  • ||||||||||  Avastin (bevacizumab) / Roche
    Recurrent Metastatic Appendiceal Adenocarcinoma Presenting as Non-Specific Colitis – A Case Report (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_534;    
    After ruling out infectious etiologies, he was started on a prednisone taper with significant improvement in his symptoms...He was given FOLFOX and bevacizumab for chemotherapy for metastatic disease as he was not a surgical candidate...This a unique case in which patient had a nonspecific inflammatory colitis which responded well to corticosteroid treatment and imaging identified recurrence of appendicular mucinous adenocarcinoma. If infectious etiologies for non-specific colitis have been excluded, thorough evaluation needs to be performed to rule out metastatic disease in patients with appendicular adenocarcinoma and/or carcinoid as treatment options can vary.
  • ||||||||||  Avastin (bevacizumab) / Roche
    Triple Synchronous Primary Neoplasm of Colon, Urinary Bladder and Prostate: A Rare Entity (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_142;    
    He was subsequently started on FOLFOX and Bevacizumab for metastatic colon cancer as prognosis for MPNs depend on the most aggressive neoplasm, in this case, colon cancer...(C) PET scan shows FDG avid lesion in liver and adjacent to splenic flexure corresponding to lesions seen in figure A. (D) H&E; stain of colon mass biopsy shows dysplastic glands invading into the submucosa, consistent with moderately differentiated invasive adenocarcinoma. (E) H&E; stain of bladder biopsy shows papillary structures with fibrovascular core and thick urothelial lining, consistent with low grade papillary urothelial carcinoma without invasion (F) H&E; stain of prostate biopsy shows atypical glands which are predominantly discrete well-formed glands with some back-to-back/fused glands, consistent with adenocarcinoma.
  • ||||||||||  Elitek (rasburicase) / Sanofi
    Tumor Lysis Syndrome in a Patient With Metastatic Cholangiocarcinoma (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_20;    
    The patient was started on chemotherapy with folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX) while arranging for further diagnostic testing...He was diagnosed with TLS and treatment with intravenous rasburicase was started with minimal improvement in his electrolyte abnormalities...Gastroenterologists and hepatologists who may commonly treat patients with solid colon and liver malignancies should not forget that TLS is a medical emergency that can still occur in our patient population. Prompt diagnosis and treatment is vital for successful treatment of this syndrome.Figure: Figure 1: Computed tomography scan showing extensive and bulky metastatic disease involving the liver.
  • ||||||||||  methotrexate / Generic mfg.
    Clinical, Journal:  Severe oral stomatitis due to reactivation of herpes simplex virus type 1 in a methotrexate-treated patient with dermatomyositis. (Pubmed Central) -  Sep 8, 2021   
    Therefore, the drug was discontinued, and leucovorin was administered...Therefore, HSV-1 reactivation-induced oral stomatitis was diagnosed, and acyclovir treatment was started, which promptly improved oral stomatitis...Our case illustrates that HSV-1 reactivation induces severe stomatitis in patients treated with low-dose MTX for autoimmune diseases, not just in those with severe immunosuppressive conditions. Of note, HSV-1 reactivation-induced stomatitis is a diagnostic challenge, especially during MTX treatment.
  • ||||||||||  pegilodecakin (LY3500518) / Eli Lilly
    Trial completion date:  A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors (clinicaltrials.gov) -  Sep 5, 2021   
    P1,  N=350, Active, not recruiting, 
    These results encourage the use of this approach more frequently, as it decreases hospitalization and thus reduces cost, increases patient satisfaction, and helps to solve the issue of bed crisis. Trial completion date: Nov 2021 --> Nov 2022