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| Not yet recruiting | 4 | 150 | | Metoprolol Tartrate tablet 50mg/d ;Flunarizine Hydrochloride capsule 5mg/d ;Metoprolol Tartrate tablet 50mg/d combined Flunarizine Hydrochloride capsule 5mg/d | Aerospace Central Hospital; None, Research Foundation of Aerospace Central Hospital | migraine | | | | |
NCT02123056: Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects |
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| Active, not recruiting | 4 | 52 | Canada | Metoprolol, Lopressor, Toprol-XL, Mteprolol Succinate ER, Matching Placebo | University of Calgary, Vanderbilt University | Vasovagal Syncope | 03/21 | 12/25 | | |
NCT04767061: Impact of Beta-blockers on Physical Function in HFpEF |
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| Completed | 4 | 9 | US | Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate | Weill Medical College of Cornell University, The New York Community Trust | Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease | 04/22 | 04/23 | | |
NCT05261464: Heart Rate Controller in Computed Tomography Coronary Angiography |
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| Recruiting | 4 | 246 | RoW | Metoprolol tartrate, Ivabradine, Diltiazem | Mahidol University | Heart Rate, Coronary Computed Tomography Angiography | 06/22 | 06/22 | | |
NCT04661709: Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris |
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| Not yet recruiting | 4 | 502 | NA | Wen Xin granule, WXG, Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet, Atorvastatin Calcium, Isosorbide Mononitrate Tab 20 MG, Metoprolol Tartrate Tab 25 MG, Aspirin Enteric-coated Tablets, WXG placebo, Trimetazidine Dihydrochloride Tablets, glyceryl trinitrate | Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Special Project of National Traditional Chinese Medicine Clinical Research Base of State Administration of Traditional Chinese Medicine, National Natural Science Foundation of China | Coronary Heart Disease, Unstable Angina, Chinese Herbal Medicine | 03/23 | 06/23 | | |
NCT04757584: Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF |
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| Completed | 4 | 9 | US | Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate | Weill Medical College of Cornell University, National Institute on Aging (NIA) | Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease | 04/23 | 04/23 | | |
2015-000284-14: Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects |
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| Ongoing | 3 | 248 | Europe | Metoprolol tartrate, placebo, Tablet, Metoprolol | University of Calgary, University of Calgary, Mawdsley & Brooks | Vasovagal Syncope, Vasovagal syncope is one of the most common causes of fainting., Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2022-002494-28: Clinical trial to assess the efficacy of intravenous metoprolol in patients with Acute Respiratory Distress Syndrome (ARDS). Ensayo clínico para evaluar la eficacia de metoprolol intravenoso en pacientes con Síndrome de Distrés Respiratorio Agudo (SDRA). |
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| Ongoing | 3 | 350 | Europe | Metoprolol tartrate, Solution for infusion, Beloken | Consorcio Centro de Investigacion Biomedica en Red, (CIBER), Instituto de Salud Carlos IIII | Intensive Care Unit patients with Acute Respiratory Distress Syndrome (ARDS) Pacientes ingresados en la Unidad de Cuidados Intensivos con Síndrome de Distrés Respiratorio Agudo (SDRA), Intensive Care Unit patients with Acute Respiratory Distress Syndrome (ARDS) Pacientes ingresados en la Unidad de Cuidados Intensivos con Síndrome de Distrés Respiratorio Agudo (SDRA), Diseases [C] - Respiratory Tract Diseases [C08] | | | | |
| Active, not recruiting | 2 | 100 | RoW | Intravenous metoprolol tartrate, Standard Care (in control arm) | Alexandria University | Septic Shock, Ventilator Acquired Pneumonia | 12/23 | 10/24 | | |
2020-000229-24: An Open-label Drug-Drug Interaction Study to Assess the Effects ofNemolizumab on Cytochrome P450 Substrates in Subjects with Moderate-to-Serve Atopic Dermatitis |
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| Not yet recruiting | 2 | 25 | Europe | Nemolizumab, CD14152, Powder and solution for solution for injection, Solution for injection, Tablet, Midazolam Injection, USP, MsKesson Omeprazole Delayed Release Tablets 20 mg, WARFARIN SODIUM – warfarin sodium tablet, JET-ALERT Regular Strength, Metoprolol Tartrate Tablets, USP | Galderma S.A., Galderma S.A. | Moderate-to-severe atopic dermatitis, Atopic dermatitis, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
| Recruiting | 1 | 20 | | Phase 1: Metoprolol Tab made by Synco (H.K.) Limited, Hong Kong; Phase 2: Metoprolol Tab 100 mg (Astrazeneca Hong Kong Ltd.) ;Phase 1: Metoprolol Tab 100 mg (Astrazeneca Hong Kong Ltd.); Phase 2: Metoprolol Tab made by Synco (H.K.) Limited, Hong Kong | Institute of Clinical Pharmacy, Central South University; None, Synco (H.K.) Limited,Hong Kong | Pharmacokinetics and Bioequivalence Study in human | | | | |
NCT05745337: Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Monitor |
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| Recruiting | 1 | 20 | US | As needed pharmacological rate control with beta-blocker (metoprolol tartrate, metoprolol succinate) or calcium channel blocker (diltiazem, verapamil) | University of Vermont | Atrial Fibrillation, Diastolic Dysfunction, HFpEF - Heart Failure With Preserved Ejection Fraction | 12/23 | 12/25 | | |
NCT05891119: Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis |
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| Active, not recruiting | 1 | 21 | US | Caffeine, Caffeine Citrate, Metoprolol, Metoprolol Tartrate, Midazolam, Midazolam Hydrochloride, Warfarin, Warfarin Sodium, Vitamin K, Omeprazole, Omeprazole magnesium, Rocatinlimab, AMG 451 | Amgen | Atopic Dermatitis | 08/24 | 12/24 | | |
NCT06582680: Aging, Beta Blockers, and Thermoregulatory Responses |
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| Not yet recruiting | 1 | 22 | NA | Placebo, Propranolol, Inderal, Metoprolol, Lopressor | University of Texas Southwestern Medical Center | Heat Stress, Aging | 09/26 | 09/26 | | |
ChiCTR1800017658: Study for characteristics of symptoms of Chinese medicine of premature ventricular beats and determining the effectiveness of Yang-Yin Ding-Ji granules in the treatment of Yin deficiency of PVB. |
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| Recruiting | N/A | 90 | | High dose Yangying Dingji granules and Metoprolol tartrate ;Small dose Yangying Dingji granules and Metoprolol tartrate ;Metoprolol tartrate | Guang'anmen Hospital, China Academy of Chinese Medical Sciences; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Capital Health Development Research Project | premature ventricular beats | | | | |
ChiCTR1900024979: Study for the assessment of efficacy, safety and benefit-risk of Xinsuning capsule on the treatment for premature ventricular beats |
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| Not yet recruiting | N/A | 800 | | Xinsuning capsule, placebo of metoprolol tartrate ;Metoprolol tartrate, placebo of Xinsuning capsule ;Xinsuning capsule, Metoprolol tartrate ;placebo of Xinsuning capsule, placebo of Metoprolol tartrate | Tianjin University of Traditional Chinese Medicine; Tianjin University of Traditional Chinese Medicine, National key research and development program | premature ventricular beats | | | | |
ChiCTR1900025446: Study for the safety and effectiveness of Wen-Yang Zhen-Shuai granule in treatment of chronic heart failure (Yang deficiency and water flooding syndrome) |
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| Not yet recruiting | N/A | 300 | | hydrochlorothiazide, enalaprilat, Metoprolol tartrate, Isosorbide mononitrate tablets ;Wen-Yang Zhen-Shuai granules + hydrochlorothiazide, enalaprilat, Metoprolol tartrate, Isosorbide mononitrate tablets | The First Affiliated Hospital of Hu'nan University of Traditional Chinese Medicine; The First Affiliated Hospital of Hu'nan University of Traditional Chinese Medicine, State administration of traditional Chinese medicine | the chronic heart failure | | | | |
ChiCTR2100051308: Compatibility rule mining of traditional Chinese medicine based on Beiji Qianjin Yaofang and Qianjin Yifang on Palpitation treatment, and its clinical research on intervention of ventricular premature complexes |
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| Not yet recruiting | N/A | 90 | | Qianjin Fumai Granules ;Qianjin Fumai Granules Placebo ;Metoprolol tartrate | Guang'anmen Hospital of China Academy of Chinese Medical Sciences; Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Sun Simiao Graduate School of Beijing University of Chinese Medicine(SSMYJY-1-2020-03) | Ventricular Premature Complexes | | | | |
NCT01608893: Carvedilol for Prevention of Paroxysmal Atrial Fibrillation |
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| Active, not recruiting | N/A | 300 | Canada | Carvedilol, Coreg, Metoprolol, Lopressor | University of Calgary, Heart and Stroke Foundation of Canada, Libin Cardiovascular Institute of Alberta | Atrial Fibrillation | 06/25 | 06/25 | | |
NCT03519906: Bariatric Surgery and Pharmacokinetics of Metoprolol |
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| Recruiting | N/A | 12 | Europe | Metoprolol, Betaloc, Lopressor, Spesicor, Toprol | Norwegian University of Science and Technology, St. Olavs Hospital, Volvat Medisinsk Senter Stokkan, Namsos Hospital, Alesund Hospital | Obesity, Morbid | 10/26 | 10/26 | | |
