lisinopril Trials - LARVOL Sigma

Trial + Data / Events

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Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

lisinopril / Generic mfg.

2005-004469-40: Multicenter, pilot, open, randomized, parallel group study to evaluate the association of Neoral with ACE-inhibitors as compared to ACE-inhibitors alone in the treatment of de novo nephrotic syndrome due to idiopathic membranous glomerulopathy

Ongoing

Europe

Neoral, zestril, Capsule*, Tablet, Neoral, zestril

Hopital Erasme

Membranous Nephropathy

2005-004460-22: Multicenter, pilot, open, randomized, parallel group study to evaluate the association of Neoral with ACE-inhibitors as compared to corticosteroids with ACE-inhibitors in the treatment of de novo nephrotic syndrome due to focal segmental glomerulosclerosis.

Ongoing

Europe

Neoral, Medrol, zestril, Capsule*, Tablet, Neoral, Medrol, zestril

Hopital Erasme

focal and segmental glomerulosclerosis

2008-002610-21: Mechanisms of albuminuria in diabetes; reversal of injury to the glycocalyx by the ACE inhibitor lisinopril

Ongoing

Europe

lisinopril, 26330, Lisinopril, Lisinopril

Academic Medical Centre

Diabetes mellitus

2004-001862-42: A multicenter, double-blind, randomized 2x2 factorial design study to compare the efficacy of early (<6 hours) versus late (24-48 hours) ACE-inhibition and to compare the efficacy of Zofenopril and Lisinopril on oxidative reperfusion injury after a first acute anterior myocardial infarction: the ZAAMIS (Zofenopril After Acute Myocardial Infarction Study).

Ongoing

Europe

Zofenil, Zestril, PA0865, PA0970, Zofil (zofenopril), Zofil (zofenopril)

Clinical Research Facilities

Study population: Subjects undergoing a primary percutaneous coronary intervention (PCI) to be performed within 6 hours after the onset of symptoms of a first acute anterior myocardial infarction (MI). According to current standards of care, all subjects will have the PCI started less than 6 hours after the onset of the symptoms of AMI.

2005-005295-32: Trial in rheumatoid arthritis of lisinopril (TRALIS)

Ongoing

200

Europe

Lisinopril, N/A, Lisinopril, Lisinopril

Research and Development Department, Addenbrookes NHS Foundation Trust

Rheumatoid arthritis

2007-007482-21: Multi-center, Open-label Study of the Safety and Efficacy of Control of Proteinuria with ACE Inhibitors and ARBS in Patients with Fabry Diseaswe Who Are receiving Farazyme : Tha Farazyme + Arbs + ACE inhibitors Treatments (FAACET) Study: The FAACET Study

Ongoing

Europe

perdix, ZESTORIC, innozide, lisinopril, zestril, coversyl, coversyl PLUS, Accupro, Accuretic, lopace, triapin& triapin Mite, rampril, tritace, gopten, carace, Staril, acepril, CAPOZIDE, AMIAS, TEVETON, aprovel, 0lmetec, micardis, Co Diovan, perdix, Zestoretic 10,20, INNOZIDE, lisinopril, zestril, coversyl, coversyl PLUS, Accupro, Accuretic, lopace, triapin, RAMPRIL, TRITACE, GOPTEN, carace, Staril, Acepril, CAPOZIDE, CAPOTEN, AMIAS, TEVETEN, aprovel, olmetec, micardis, Co Diovan, perdix, Zestoretic 10,20, INNOZIDE, lisinopril, zestril, coversyl, coversyl PLUS, Accupro, Accuretic, lopace, triapin, RAMPRIL, TRITACE, GOPTEN, carace, Staril, Acepril, CAPOZIDE, CAPOTEN, AMIAS, TEVETEN, aprovel, olmetec, micardis, Co Diovan

Salford Royal NHS Foundation Trust

Fabry disease with proteinuria.

2004-002470-31: N/A

Ongoing

180

Europe

Lisinopril / Irbesartán, A: Lisinopril / B: Irbesartán, Lisinopril, Lisinopril

Hospital Universitario Gregorio Marañón, FIS, Sociedad Española de Nefrología

Diabetes Mellitus tipo II. Nefropatía Diabética.

PROERCAN01, NCT03195023: Effect of RAS Blockers on CKD Progression in Elderly Patients With Non Proteinuric Nephropathies

Recruiting

106

Europe

Lisinopril, Angiotensin converting enzyme inhibitors, Amlodipine, Lercanidipine, Furosemide, Thiazides

Hospital General Universitario Gregorio Marañon

Renal Insufficiency, Chronic, Proteinuria

12/19

12/22

ACE, NCT05049616: Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension

Active, not recruiting

ACE Inhibitors and Diuretics, NIFEdipine ER

The University of Texas Health Science Center, Houston

Hypertension in Pregnancy, Postpartum Preeclampsia

06/22

10/23

MRA-ACE, NCT03502031: Safety and Efficacy of Two Year of RAAS Alone or in Combination With Spironolactone Therapy

Recruiting

Renin-Angiotensin (RAAS) alone, Lispril, Enalapril, Perindopril, Losarta, Valsar etc.,, Renin-Angiotensin (RAAS) blockers in combination with Spironolactone, Lisinopril, Enalapril, Perindopril, Losartan, Valsartan, or Spironolactone

James A. Tumlin, MD, Nelson Kopyt, MD

Renal Insufficiency, Chronic, Diabetic Nephropathy Type 2

10/22

10/24

NCT05644769: Chymase Angiotensin-(1-12) Axis In Hypertensive Disease

Recruiting

Determine the presence of Human sequence Ang-(1-12) on no medication, Human sequence Ang-(1-12) on Lisinopril 40mg every day

Trinity Hypertension & Metabolic Research Institute, Wake Forest University Health Sciences

Hypertension

03/23

WARRIOR, NCT03417388: Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Active, not recruiting

2476

High dose potent statin, atorvastatin or rosuvastatin, ACE-I (lisinopril) or ARB (losartan), ACE-I or ARB, Aspirin, Lifestyle Counseling, PACE Lifestyle Intervention, Quality of Life Questionnaires, QOL

University of Florida, United States Department of Defense

Coronary Artery Disease

02/25

09/25

CLIgAN, NCT04662723 / 2021-006854-29: Multicentre Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy.

Recruiting

878

Europe

Corticosteroid, Methylprednisolone succinate, prednisolone, Renin-angiotensin sytem blockers, Ramipril, lisinopril, losartan, Sodium-glucose cotransporter 2 inhibitor, dapagliflozin, canagliflozin, empagliflozin

Fondazione Schena, University of Bari

Glomerulonephritis, Immunoglobulin A Nephropathy

06/24

12/26

NCT02817360: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Recruiting

2400

Europe, RoW

RAS-antagonist and beta-blocker up-to maximal dosages, Enalapril 40mg/d, Ramipril 10mg/d, Lisinopril 40mg/d, Cilazapril 5mg/d, Perindopril 8mg/d, Captopril 150mg/d, Spirapril 24mg/d, Quinapril 40mg/d, Trandolapril 4mg/d, Zofenopril 60mg/d, Fosinopril 40mg/d, Candesartan 32mg/d, Valsartan 320mg/d, Irbesartan 300mg/d, Losartan 150mg/d, Eprosartan 800mg/d, Bisoprolol 10mg/d, Metoprololsuccinat 200mg/d, Carvedilol 50mg/d (100mg/d if weight is > 85kg), Nebivolol 10mg/d, RAS-antagonist and beta-blocker none or at stable dose

Martin Huelsmann

Heart Diseases, Diabetes Mellitus, Type 2

12/25

12/26

2015-000239-34: A clinical study to investigate the use of commonly used heart failure medicines in the prevention of heart related illnesses in patients with diabetes mellitus but without heart disease.

Ongoing

3/4

2400

Europe, RoW

Enalapril maleate, Ramipril, Lisinopril dihydrate, Perindopril arginine, Perindopril erbumine, Perindopril tert-butylamine, Captopril, Quinapril hydrochloride, Trandolapril, Fosinopril sodium, Candesartan cilextil, Valsartan, Irbesartan, Losartan potassium, Eprosartan mesilate, Bisoprolol fumerate, Carvedilol, Nebivilol hydrochloride, Not applicable, Tablet, , Capsule

Medizinische Universität Wien, Medical University of Vienna, Medizinische Universität Wien,

Type 2 diabetes mellitus, Type 2 diabetes, Diseases [C] - Hormonal diseases [C19]

ACTRN12618001124224: FAN Trial: A randomised-controlled trial assessing the effect of lisinopril on Fontan-Associated Nephropathy

Not yet recruiting

Murdoch Children's Research Institute, Heart Foundation

Congenital heart defect, Nephropathy

STABILIZE-CKD, NCT05056727 / 2021-001911-96: A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of Hyperkalaemia

Terminated

716

Europe, Canada, Japan, US, RoW

Sodium Zirconium Cyclosilicate (SZC), Lokelma TM, Placebo, Lisinopril, Valsartan, Irbesartan

AstraZeneca

Renal Insufficiency, Chronic, Hyperkalemia

02/24

REMAP-CAP, NCT02735707 / 2015-002340-14: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruiting

20000

Europe, Canada, Japan, US, RoW

Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir

UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore

Community-acquired Pneumonia, Influenza, COVID-19

02/26

02/28

2012-002877-71: cGMP Enhancing Therapeutic Strategy for HFpEF: The cGETS Study An interventional, single blind, multicentre study. cGMP verhogende strategieën bij HFpEF: De cGETS Studie. Een interventionele, enkelblinde, multicentre studie.

Ongoing

Europe

Tritace, Tablet, Film-coated tablet, Capsule, Januvia, Cialis, Lipitor, Zestril, Crestor, Zocor, Coversyl, Tritace, Atacand, Nebilet

European Commission FP7 Health 2010, European Commission FP7 Health 2010

HFpEF patients over 18 years old and concomitant arterial hypertension, overweight or obesity and pulmonary hypertension. Patiënten met HFpEF die ouder zijn dan 18 jaar en tevens lijden aan arteriële hypertensie, overgewicht of obesitas en pulmonale hypertensie., Heart Failure with preserved Ejection Fraction in combination with a high blood pressure, high pulmonary blood pressure and overweight or obesity. Hartfalen met een bewaarde ejectiefractie met daarnaast een hoge bloeddruk, hoge longbloeddruk en overgewicht of zwaarlijvigheid., Diseases [C] - Cardiovascular Diseases [C14]

NCT03422705: A Pilot Study: Preventing Adverse Remodelling Following Pacemaker Implantation

Not yet recruiting

Optimised programming, Lisinopril, Standard care

University of Leeds

Pacemakers, Heart Failure

12/22

NCT04190433: Autophagy Activation for the Alleviation of Cardiomyopathy Symptoms After Anthracycline Treatment, ATACAR Trial

Withdrawn

Carvedilol, Coreg, Lisinopril, N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline, Dihydrate, Prinivil, Zestril, Pravastatin, [1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid, Spironolactone, 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate, Aldactone, SC 9420, SPL

Mayo Clinic, National Cancer Institute (NCI)

Breast Carcinoma, Hematopoietic and Lymphoid Cell Neoplasm, Lymphoma, Sarcoma

04/23

NCT04550481: Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study

Recruiting

Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Lisinopril, N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline, Dihydrate, Prinivil, Zestril, Liver Ultrasonographic Elastography, Fibroscan, TE, Transient Elastography, VCTE, Vibration-Controlled Transient Elastrography, Magnetic Resonance Elastography, MRE, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Proton Density Fat Fraction, Fat Fraction by Proton Density, PDFF, Questionnaire Administration

National Cancer Institute (NCI)

Hepatocellular Carcinoma, Nonalcoholic Steatohepatitis

03/25

09/25

NCT04486118: Centrally Acting ACE Inhibition in SLE

Active, not recruiting

Lisinopril Pills, Benazepril Pill

Northwell Health, Lupus Research Alliance

Systemic Lupus Erythematosus

06/25

11/25

NCT03201939: Optimal Management of HIV Infected Adults At Risk for Kidney Complications in Nigeria

Suspended

280

RoW

Lisinopril, Intervention arm, Placebo Oral Tablet, Control arm

Vanderbilt University Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Aminu Kano Teaching Hospital, SAIC-Frederick, Inc., Brigham and Women's Hospital

HIV/AIDS, Albuminuria, Kidney Diseases, Genetic Predisposition

02/25

MK-0616-026, NCT06772779: A Study of Enlicitide Decanoate (MK-0616), Warfarin, and Lisinopril in Healthy Adult Participants

Completed

Warfarin, Jantoven, Enlicitide Decanoate, MK-0616, Lisinopril, Zestril

Merck Sharp & Dohme LLC

Healthy

06/24

NCT05530655: A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer

Recruiting

Lisinopril Tablets

University of Rochester, Medical College of Wisconsin

Prostate Cancer, Radiation Toxicity, Urinary Complication

01/26

NCT06187493: Treatment of Patients With Diabetic Kidney Disease

Not yet recruiting

N/A

lisinopril, enalapril, dapagliflozin, empagliflozin

Assiut University

Diabetic Kidney Disease

01/25

12/25

OptiZest, NCT06372470: Personalised Dose Optimisation of Zestril Supported by the Digital Blood Pressure Diary in a Primary Care Environment in England: Pragmatic Observational Pilot Study for Remote Hypertension Treatment

Completed

N/A

Europe

Zestril

Closed Loop Medicine, Pharmanovia

Uncomplicated Hypertension

10/24

11/24

CLM-HTN-006, NCT06745726: OptiZ: Real World Evidence Study

Not yet recruiting

N/A

113

Europe

Zestril

Closed Loop Medicine

Hypertension

08/26

10/26



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