- |||||||||| donepezil / Generic mfg.
Donepezil Induced Nightmares in a Patient With Mild Cognitive Impairment: A Case Report (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_746;
The ascending pathway regulates REM sleep through serotonergic and noradrenergic systems. In contrast, the descending pathway, which runs through the reticular spinal descending axons, helps release muscle tension often present in REM sleep.
- |||||||||| lisinopril / Generic mfg.
Journal: Impact of (Pubmed Central) - May 13, 2023
Cardiometabolic effects of lisinopril correlated with testosterone, FAI and changes in insulin sensitivity. The obtained results suggest that cardiometabolic effects of lisinopril may be slightly less pronounced in sisters of women with PCOS than in women without a family history of this disorder.
- |||||||||| ketoconazole / Generic mfg.
Medical Management of Cushing's Syndrome Caused by Primary Bilateral Macronodular Adrenal Hyperplasia (PBMA) with Low Dose of Ketoconazole (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1991;
Due to the patient's hesitancy for surgery, she was initiated on fluconazole which initially normalized urine cortisol levels (24H cortisol 20 mcg/24hr), though a rise to 70 mcg/24hr was noted after 6 months of treatment...The amount of cortisol secretion is often sufficient to produce mild or overt Cushing's syndrome. Although surgical treatment was considered, our patient was successfully treated with low-dose ketoconazole and thus, this may be an option in patients with mild PBMA-related Cushing's syndrome.
- |||||||||| Henletor (torsemide) / Orchid
A Case of Nephrotic Syndrome Presenting With Hyperlipidemia. (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1897;
The abnormalities of serum lipids seen in nephrotic syndrome are largely due to the impaired clearance rather than biosynthesis and can lead to multiple complications. Making the diagnosis of nephrotic syndrome is very important as it is associated with significant cardiovascular and renal disease.
- |||||||||| A Case of Pheochromocytoma Initially Presenting as Takotsubo-like Cardiomyopathy (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_823;
Background: Takotsubo-like cardiomyopathy (TCM) is a known but rarely seen clinical complication associated with pheochromocytoma that is important to recognize.Case Presentation: A 68 year old woman with a history of hypertension on verapamil, lisinopril-hydrochlorothiazide, clonidine, hyperlipidemia, asthma, and chronic kidney disease presents for nausea and vomiting associated with pressure like chest pain...She was discharged home on beta blocker and losartan therapy...Alpha blocker tamsulosin was initiated and beta blocker therapy was discontinued...Earlier recognition of a potential pheochromocytoma would also have discouraged the use of a beta blocker initially until pheochromocytoma was ruled out. An individualized, multidisciplinary approach helps lead to a timely diagnosis and appropriate treatment decisions for these rare tumors.
- |||||||||| lisinopril / Generic mfg., allopurinol / Generic mfg.
Management of Hypoglycemia in Von Gierke's Disease (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_702;
Due to the deficiency of G6P, treatment with a specialized hypoglycemic regimen is warranted. A D10
- |||||||||| lisinopril / Generic mfg.
Syndrome of Apparent Mineralocorticoid Excess (AME) from Licorice Tea (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_507;
Lisinopril-HCTZ was changed to amlodipine 5 mg...Patients will present with hypokalemia hypertension, metabolic alkalosis, low plasma renin activity and low plasma aldosterone levels. Urinary free cortisone and cortisol levels can assist with diagnosis but as in this case review of history was enough to diagnose and treat the patient.
- |||||||||| Bredinin (mizoribine) / Asahi Kasei
Management of IgAN and IgAV (Room 5) - Apr 15, 2023 - Abstract #KSN2023KSN_92;
Based on the results of clinical trials, a 2-year combination therapy including prednisolone, mizoribine, and lisinopril for patients with severe childhood IgAN showing diffuse mesangial proliferation (WHO), and 2-year lisinopril for mild cases are recommended in the treatment guidelines 2020 for childhood IgAN by the Japanese society for pediatric nephrology. Severe IgAVN cases are defined as ISKDC classification grade IIIb
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca, lisinopril / Generic mfg.
63 yr-old M w HTN, PAD (ABI 0.50), RCA Stent, EF 45-50%, 20+ pack-yr (still smoking), GFR ~ 70, being followed by Cardiology, yet I started him on Dapagliflozin and Entresto (DC'd his Lisinopril and told him to wait 36 hrs before starting Entresto) today. Pt is on Metoprolol 1/ (Twitter) - Apr 12, 2023
- |||||||||| Isturisa (osilodrostat) / Novartis, Recordati
Ectopic ACTH syndrome secondary to metastatic liver cancer () - Apr 6, 2023 - Abstract #AFMRSER2023AFMR_SER_81;
Following K supplementation, he was treated with furosemide, lisinopril, and spironolactone.Workup for an aldosteronism-type syndrome was sent including renin, aldosterone, cortisol (prior to MRA)...High dose dexamethasone (8 mg) had no effect in suppressing cortisol (203.9 mcg/dl), supporting ectopic ACTH secretion over pituitary ACTH hypersecretion...The cortisol synthesis inhibitor osilodrostat is being considered pending biopsy results.Overall, our patient had ectopic ACTH syndrome, likely of paraneoplastic origin, resulting in pseudohyperaldosteronism...Primary liver NET (if confirmed) would be very rare, accounting for only 0.3% of primary NET. To our knowledge, there are only 3 reported cases within the literature of a paraneoplastic ATCH syndrome secondary to hepatic NET.
- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca, Basaglar (insulin glargine biosimilar) / Boehringer Ingelheim, Eli Lilly
A Case Report of the Medication Behind Euglycemic Diabetic Ketoacidosis (Walter E. Washington Convention Center, Area K, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8055;
It is important to recognize euglycemic DKA induced by an SGLT2 inhibitor. With its increasing use, clinicians must have it on their differentials for any diabetic patient presenting with hypoglycemia/euglycemia but has blood work suggestive of DKA.
- |||||||||| metformin / Generic mfg.
An Ophtha-MALA-gic Anomaly: Metformin Associated Lactic Acidosis Causing Transient Blindness (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6600;
Home medications included metformin, lisinopril, hydrochlorothiazide, amlodipine, and as-needed ibuprofen and naproxen for pain...He then developed profound shock necessitating initiation of norepinephrine, vasopressin, and stress-dosed hydrocortisone...Return of vision after bicarbonate administration but before hemodialysis in our case would seemingly point towards acidemia playing a key role in precipitating the blindness. Our case highlights the importance of prompt recognition of this clinical syndrome in allowing for correction of acidemia, improvement in hemodynamics and resolution of visual symptoms.
- |||||||||| carvedilol / Generic mfg., lisinopril / Generic mfg.
Platypnea Orthodeoxia Syndrome: Is It Really Rare or Just an Easily Overlooked Conundrum? (Walter E. Washington Convention Center, Area F, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6421;
Thorough pulmonary history and physical examination, in combination with multi-pronged approaches such as medication, oxygen therapy, and smoking cessation, is paramount in the proper diagnosis and optimization of treatment plans.We are reporting a rare case of POS secondary to AVM, despite a prolonged delay in diagnosis, that was eventually provided with appropriate referral for proper treatment plan. A high index of suspicion for POS in hypoxemic patients, in conjunction with appropriate physical examination maneuvers, will lead to an early and accurate diagnosis.
- |||||||||| What Is Next? - The Role of Fresh Frozen Plasma in Refractory Angioedema (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6099;
She had just initiated lisinopril therapy for her new-onset hypertension in the outpatient setting...Due to the concern for life-threatening angioedema, intramuscular (IM) epinephrine 0.3 mg, intravenous (IV) methylprednisolone 125mg , IV ondansetron, and tranexamic acid was administered without improvement of her symptoms...Guideline directed therapy for angioedema involves the use of steroids, antihistamines, and epinephrine as first line agents. However, there have been studies suggesting that FFP can improve outcomes in refractory angioedema and therefore should be considered.
- |||||||||| An Unusual Case of Hymenoptera Venom-induced Angioedema (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6098;
Current home medications include losartan (initiated 3 months prior), aspirin, amlodipine, and rosuvastatin...He was administered IV Solu-Medrol 125mg, IV Benadryl 25mg, and IV Pepcid with improvement in symptoms...His hospital course remained uneventful, and he was discharged home with prednisone, Benadryl, EpiPens, and an allergy/immunology follow-up for further allergen testing...PMID:6721263.2. Chapsa M, Roensch H, Langner M, Beissert S, Bauer A. UpToDate.
- |||||||||| A Rare Case of Neuroendocrine Breast Carcinoma With Lung Metastasis (Walter E. Washington Convention Center, Area L, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5798;
The patient is an 83-year-old female with a past medical history of stage IIA infiltrating ductal carcinoma of the left breast diagnosed 4 years prior who underwent mastectomy, adjuvant breast irradiation, and then initiation of anastrozole...She returned one week later for worsening symptoms, and her lisinopril was changed to losartan...There has been one case report of NEBC with lung metastases who experienced a partial response after epirubicin chemotherapy. Another case series suggested using platinum / etoposide regiments for those with poorly differentiated NEBC.
- |||||||||| Takotsubo Cardiomyopathy Following Viral Gastroenteritis: A Case Report (Walter E. Washington Convention Center, Area C, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5098;
The patient was started empirically on vancomycin and cefepime...She was started on carvedilol, Lisinopril, aspirin and statin for heart failure...This theory is further reinforced by recent findings of COVID-19-related Takotsubo cardiomyopathy. More research is needed to find the mechanisms with which Takotsubo cardiomyopathy can occur in the context of viral illnesses, to identify specific inflammatory markers implicated, and to predict its risk of occurrence in the context of various viral infections.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Pulmonary Renal Syndrome: A Rare Life-threatening Disease (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4573;
Home medications include lisinopril, hydrochlorothiazide and ezetimibe...She was discharged with long term steroids and rituximab...Treatment consists of a combination of steroids and immunosuppressive agents. The addition of plasmapheresis might bring benefits in severe cases.
- |||||||||| enalapril / Generic mfg., captopril / Generic mfg., lisinopril / Generic mfg.
Soluble Epoxide Hydrolase Inhibitors and ACE Inhibitors Ameliorate Phosgene Inhalation Injuries (Marriott Marquis Washington, Marquis Ballroom, Salons 3-4 (Level M2)) - Mar 25, 2023 - Abstract #ATS2023ATS_1954;
Treatment with sEHi or ACEi significantly improved Kaplan-Meier survival curves, decreased BALF protein, and decreased BALF total leucocytes. Additional studies are warranted to test long-term therapeutic effects in improving survival rates and mitigating inflammation.
- |||||||||| NN1213 / Novo Nordisk, Bystolic (nebivolol) / Menarini, AbbVie
Enrollment open, Trial completion date, Trial primary completion date: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients (clinicaltrials.gov) - Mar 14, 2023
P4, N=2400, Recruiting,
Additional studies are warranted to test long-term therapeutic effects in improving survival rates and mitigating inflammation. Unknown status --> Recruiting | Trial completion date: Feb 2021 --> Dec 2026 | Trial primary completion date: Feb 2019 --> Dec 2025
- |||||||||| ramipril / Generic mfg., lisinopril / Generic mfg.
Quantifying the effect of gut microbiota on ACE inhibitor metabolism by LC-MS/MS (Hall F-H (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_3279;
We found that C. comes harbored esterase activity, as it catabolized the esters quinapril and ramipril in vitro, but not the non-ester lisinopril. This finding provides evidence for the ability of gut microbiota to reduce drug efficacy via microbiome induced drug metabolism prior to drug absorption.
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