- |||||||||| BRASH SYNDROME (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_1106;
- |||||||||| lisinopril / Generic mfg.
ACE Inhibitor-Associated Isolated Small Bowel Angioedema: A Rare Cause of Abdominal Pain (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4646;
We present a very rare case of Lisinopril associated isolated small bowel angioedema Case Description/ A 47-year-old female presented with severe upper abdominal pain associated with nausea and vomiting...It is often missed as a cause of abdominal pain which leads to unnecessary work-up and sometimes, high-risk surgical interventions. Though self- limiting, if ACE-I induced isolated angioedema is not diagnosed and managed early, continued use may lead to significant morbidity in affected patients Figure: Mild bowel wall thickening and mucosal enhancement of the jejunum and ileum and small amount of ascites
- |||||||||| lisinopril / Generic mfg.
A Rare Case of Visceral Angioedema Secondary to Angiotensin-Converting Enzyme Inhibitor (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4636;
It was presumed that the edema was likely medication-induced and she was asked to stop taking Lisinopril...It would avoid unnecessary invasive procedures such as exploratory laparotomy, intestinal biopsy, and resection. Figure: CT Abdomen with mural thickening of the proximal small bowel loops in the left upper quadrant with the bowel wall measuring up to 1 cm.
- |||||||||| Lamprene (clofazimine) / Novartis
Unexpected Finding: Pseudomelanosis Duodeni on Surveillance Endoscopy in a Patient With Hemosiderosis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3894;
The patient's pertinent outpatient medications include iron carbonyl hydralazine, furosemide, and lisinopril...Differentiating between PD, iron pill-induced mucositis, clofazimine related pigmentation, diffuse malignant melanoma, brown bowel syndrome and eosinophilic enteritis is crucial, as the management and prognosis vary significantly...(B) Histopathology showed brown-black pigment deposition in lamina propria macrophages of duodenum on H&E 40x stain. (C)The tissue stained positive for Iron on Iron Stain 20x.
- |||||||||| lisinopril / Generic mfg.
It (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3148;
He had been taking lisinopril 40 mg daily for 7 years prior to presentation...Recurrent abdominal pain with bowel wall edema should include consideration of ACEi-induced intestinal angioedema to avoid unnecessary testing and to decrease patient morbidity. Figure: Figure: CT abdomen and pelvis demonstrating thickening of (A) the cecum and (B) the small bowel loops with associated mesenteric edema.
- |||||||||| Protein-Losing Enteropathy: An Isolated Presentation of Lupus Nephritis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3131;
She had 1 prior hospital admission with a similar complaint and was diagnosed with a UTI, colitis, anemia, and unspecified fever, and was treated with a course of cefuroxime...Patient was started on high dose steroid taper, hydroxychloroquine, azathioprine, and lisinopril with subsequent improvement...Endoscopic biopsies aid in excluding other disease processes, but may not may not define the etiopathogenesis of protein-loss enteropathy, and in many cases, they are normal or show nonspecific findings. Early and aggressive steroid and immunosuppressant therapy is necessary to improve prognosis.
- |||||||||| chlorthalidone / Generic mfg., diltiazem / Generic mfg., lisinopril / Generic mfg.
Iatrogenic GERD With Extraesophageal Manifestations Proven by Impedance Testing (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_937;
Afterwards, to maximize medical management prior to surgical evaluation, she was asked to discontinue her diltiazem and lisinopril and switch to chlorthalidone for hypertension management. Patient
- |||||||||| hydrochlorothiazide / Generic mfg., lisinopril / Generic mfg.
An Interesting Case of Microscopic Colitis Flare Induced by Diuretics and ACE-I (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_759;
This could lead to some mucosal injury and cause an acute flare of the MC. Upon literature review there are currently no case reports that indicate a similar presentation to this patient, however, there are very few reported cases of ACE-I-induced MC flare.
- |||||||||| Ozempic (semaglutide SC once-weekly) / Novo Nordisk
Acute Pancreatitis Due to Semaglutide: Another Medication to Worry About! (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_522;
Current medications were metformin 500 mg daily, zolpidem 50 mg daily, lisinopril 10 mg daily, atorvastatin 500 mg twice daily by mouth along with 0.5 mg subcutaneous semaglutide once weekly (started two months prior to presentation)...Figure: FIG-1A: Computed tomography (CT) scan of the abdomen and pelvis with contrast showed no pancreatic pathology. Figure 1B: Magnetic resonance cholangiopancreatography (MRCP) showing a normal caliber common bile duct, pancreatic duct, and a remnant cystic duct status post cholecystectomy.
- |||||||||| ACEi-ing It! Discovering a Rare Case of LisinoprilInduced Pancreatitis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_518;
Figure: MRI-cholangiopancreatography image showing acute necrotic pancreatitis (less than 30%) in the body of the pancreas which has irregular extensions into the peripancreatic fat stranding and appears to be in communication with the main pancreatic duct. The large cystic lesion measuring 8 x 6.6 x 6 cm represents walled-off necrosis.
- |||||||||| Considerations And Optimal Management Strategies For Vertebral Compression Fractures (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_3148;
Resting supine and not moving is the only alleviating factor.PMHx: CAD, an MI 5 years ago with DES of the LAD, moderate COPD, osteopenia, hypothyroidism, HTN, DM2, fibromyalgia.PSHx:Cholecystectomy 1990, bilateral TKA 2001MEDS:Acetaminophen 1000mg BID PRN, lisinopril 20mg qd, HCTZ 25mg qd, metoprolol XL 25mg qd, simvastatin 20mg qHS, ASA 325mg, omeprazole 40mg qd, metformin 1000mg BIDPHYS BP 130/85, HR 63, RR 14, T 99.0, and SpO2 93% RA...At what point would you consider this intervention?a.How would you manage her aspirin prescription perioperatively?7.Is retropulsion of the vertebral body into the canal automatically a contraindication to performing a vertebral augmentation procedure?...Given there is 20% retropulsion and resultant moderate central canal stenosis, would you perform intraoperative neuromonitoring?8.When performing vertebral augmentation on a patient on a patient with suspicion of a pathologic fracture, besides the usual steps of gaining access into the vertebral body, inflating the balloon (in the case of balloon kyphoplasty) and injecting cement, what else should you do?9.What are the risks of performing vertebral augmentation? Divide into perioperative and postoperative.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Anesthetic Considerations In The Perioperative Period For Guideline-directed Medical Therapy In Heart Failure With Reduced Ejection Fraction (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_2904;
Divide into perioperative and postoperative. His prior to admission medications include carvedilol, lisinopril, furosemide, and empagliflozin.Key Question 1:Are there any contraindications to proceeding with this case today?Key Question 2:Would you measure a B-type natriuretic peptide (BNP) or N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) preoperatively?...Toward the end of the case, the central venous pressure is 20 mm Hg from a baseline of 14 mm Hg, the patient is on a low-dose epinephrine infusion, and oxygenation on the arterial blood gas is acceptable, but has declined throughout surgery.Key Question 9:What effect does this patient
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Anesthetic Considerations In The Perioperative Period For Guideline-directed Medical Therapy In Heart Failure With Reduced Ejection Fraction (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_2495;
His prior to admission medications include carvedilol, lisinopril, furosemide, and empagliflozin.Key Question 1:Are there any contraindications to proceeding with this case today?Key Question 2:Would you measure a B-type natriuretic peptide (BNP) or N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) preoperatively?...Toward the end of the case, the central venous pressure is 20 mm Hg from a baseline of 14 mm Hg, the patient is on a low-dose epinephrine infusion, and oxygenation on the arterial blood gas is acceptable, but has declined throughout surgery.Key Question 9:What effect does this patient His prior to admission medications include carvedilol, lisinopril, furosemide, and empagliflozin.Key Question 1:Are there any contraindications to proceeding with this case today?Key Question 2:Would you measure a B-type natriuretic peptide (BNP) or N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) preoperatively?...Toward the end of the case, the central venous pressure is 20 mm Hg from a baseline of 14 mm Hg, the patient is on a low-dose epinephrine infusion, and oxygenation on the arterial blood gas is acceptable, but has declined throughout surgery.Key Question 9:What effect does this patient
- |||||||||| Neuroanesthesia Myths And Dogmas (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1840;
His prior to admission medications include carvedilol, lisinopril, furosemide, and empagliflozin.Key Question 1:Are there any contraindications to proceeding with this case today?Key Question 2:Would you measure a B-type natriuretic peptide (BNP) or N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) preoperatively?...Toward the end of the case, the central venous pressure is 20 mm Hg from a baseline of 14 mm Hg, the patient is on a low-dose epinephrine infusion, and oxygenation on the arterial blood gas is acceptable, but has declined throughout surgery.Key Question 9:What effect does this patient The patient
- |||||||||| Considerations And Optimal Management Strategies For Vertebral Compression Fractures (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1542;
Resting supine and not moving is the only alleviating factor.PMHx: CAD, an MI 5 years ago with DES of the LAD, moderate COPD, osteopenia, hypothyroidism, HTN, DM2, fibromyalgia.PSHx:Cholecystectomy 1990, bilateral TKA 2001MEDS:Acetaminophen 1000mg BID PRN, lisinopril 20mg qd, HCTZ 25mg qd, metoprolol XL 25mg qd, simvastatin 20mg qHS, ASA 325mg, omeprazole 40mg qd, metformin 1000mg BIDPHYS BP 130/85, HR 63, RR 14, T 99.0, and SpO2 93% RA...At what point would you consider this intervention?a.How would you manage her aspirin prescription perioperatively?7.Is retropulsion of the vertebral body into the canal automatically a contraindication to performing a vertebral augmentation procedure?...Given there is 20% retropulsion and resultant moderate central canal stenosis, would you perform intraoperative neuromonitoring?8.When performing vertebral augmentation on a patient on a patient with suspicion of a pathologic fracture, besides the usual steps of gaining access into the vertebral body, inflating the balloon (in the case of balloon kyphoplasty) and injecting cement, what else should you do?9.What are the risks of performing vertebral augmentation? Divide into perioperative and postoperative.
- |||||||||| Here We Go Again: Acromegalic Patient For Repeat Pituitary Tumor Resection (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1530;
Current medications include metformin, insulin, lisinopril, metoprolol and PRN lorazepam for anxiety, which he admits to using for sleep on occasion.1...Should the patient receive perioperative dexamethasone for PONV prophylaxis?The surgeon begins topicalization of the nasal mucosa using injected lidocaine 1% with epinephrine...What additional labs would you request to determine the diagnosis?15. How would you treat this condition?
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Hocus Pocus - Evaluating Shock Through The Magic Of Ultrasound. (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1346;
She also has HTN for which she takes furosemide 20 mg and lisinopril 10 mg daily, DM type I (HgbA1c 8.6) on glargine 29 U every morning as well as aspartate 6 mg before meals, hypothyroidism on 0.025 mcg levothyroxine, hyperlipidemia on simvastatin 20 mg daily, history of Charcot arthropathy and recent hardware removal...100 mg hydrocortisone bolus is given, and a cortisol level is sent...Why is dobutamine added?...Alteplase (TPA) 100 mg is infused over 2 hours...She becomes net neg of 1.5 liters for the day over the next 4 hours and bumetanide is further decreased to 0.05 mg/hr...She is given fluids of 300 cc over the next 4 hours. After 15 days in the ICU, she is transferred to the floor and after 1 month she has her left BKA and by the 7th week she is transferred to rehab.
- |||||||||| Here We Go Again: Acromegalic Patient For Repeat Pituitary Tumor Resection (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1182;
Current medications include metformin, insulin, lisinopril, metoprolol and PRN lorazepam for anxiety, which he admits to using for sleep on occasion.1...Should the patient receive perioperative dexamethasone for PONV prophylaxis?The surgeon begins topicalization of the nasal mucosa using injected lidocaine 1% with epinephrine...What additional labs would you request to determine the diagnosis?15. How would you treat this condition?
- |||||||||| Clotinab (abciximab) / ISU Abxis, Integrilin (eptifibatide) / Takeda, NovoLog (insulin aspart) / Novo Nordisk
Keeping Coronary Stents Patent In Patients (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_356;
His past medical history was significant for coronary artery disease, myocardial infarction 10 years ago followed by a coronary artery bypass surgery, ESRD on dialysis three times a week via an arterio-venous fistula, diabetes mellitus, obstructive sleep apnea and a history of deep vein thrombosis (was on warfarin until 2 years ago).Medications: Novolog, glipizide, metoprolol, carvedilol, lisinopril, lasix, aspirin (ASA), nitroglycerin (NTG) patch.Dialyzed: 1 day agoECG- inferolateral ischemiaMeds taken: metoprolol, carvedilol, NTG patch.Recent stress test at outside hospital (copy requested)Cardiac catheterization...What is the implication of Dabigatran (Pradaxa) as compared to clopidogrel (Plavix) or ASA?10...(ASA, Clopidogrel (Plavix), Eptifibatide (Integrelin), Abciximab (Reopro)Intra operatively, the patient develops hypotension, ST elevation and T wave inversion on EKG.16. What are the therapeutic options available in this scenario?
- |||||||||| Neuroanesthesia Myths And Dogmas (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_54;
What are the therapeutic options available in this scenario? The patient
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Hocus Pocus - Evaluating Shock Through The Magic Of Ultrasound. (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_50;
She also has HTN for which she takes furosemide 20 mg and lisinopril 10 mg daily, DM type I (HgbA1c 8.6) on glargine 29 U every morning as well as aspartate 6 mg before meals, hypothyroidism on 0.025 mcg levothyroxine, hyperlipidemia on simvastatin 20 mg daily, history of Charcot arthropathy and recent hardware removal...100 mg hydrocortisone bolus is given, and a cortisol level is sent...Why is dobutamine added?...Alteplase (TPA) 100 mg is infused over 2 hours...She becomes net neg of 1.5 liters for the day over the next 4 hours and bumetanide is further decreased to 0.05 mg/hr...She is given fluids of 300 cc over the next 4 hours. After 15 days in the ICU, she is transferred to the floor and after 1 month she has her left BKA and by the 7th week she is transferred to rehab.
- |||||||||| lisinopril / Generic mfg.
Preclinical, Journal: Optimization and evaluation of Lisinopril mucoadhesive sustained release matrix pellets: In-vitro and ex-vivo studies. (Pubmed Central) - Jul 17, 2023
Additionally, ex-vivo permeation determination of LIS from the optimized LIS-SR formulation was found to be significantly higher (1.7-folds) as compared to free LIS. In LIS-SR matrix pellets, prepared with an extrusion/spheronization have desirable excellent characteristics in-vitro and ex-vivo sustained-release pellet formulation of LIS-SR was able to sustain the release of LIS for up to 8
- |||||||||| triamcinolone acetonide / Generic mfg., lisinopril / Generic mfg.
Dermal facial fillers and COVID-19 vaccination: About a case () - Jul 3, 2023 - Abstract #WCD2023WCD_5176;
Delayed inflammatory reactions cases related to HA dermal fillers are likely to become prevalent due to the ongoing popularity of HA dermal fillers and as the rate of SARS COV2 infections and vaccination is increasing around the world. Therefore, Aesthetic medicine practitioners should be aware of the risk of DIR and patients who wish to receive a HA soft tissue filler should be informed of the risk of COVID-19 and infection-related adverse reactions prior to treatment.
- |||||||||| Journal: Multiclass determination of drug residues in water and fish for bioaccumulation potential assessment. (Pubmed Central) - Jun 19, 2023
The developed method was used to determine drug concentrations in river water and in feral freshwater fish, including whole fish and muscle tissue, from the Sava River (Croatia), in order to estimate their corresponding bioaccumulation potential. With respect to bioaccumulation potential in whole fish and fish muscle, the most relevant drugs were lisinopril, sertraline, terbinafine, torsemide, diazepam, desloratadine, and loratadine with estimated bioaccumulation factors ranging from 20 to 838 and from 1 to 431, respectively.
- |||||||||| lisinopril / Generic mfg.
Journal: Identification and Characterization of Novel ACE Inhibitory and Antioxidant Peptides from Sardina pilchardus Hydrolysate. (Pubmed Central) - Jun 10, 2023
Molecular docking was used to screen for peptides with ACE inhibitory activity, resulting in the identification of 11 peptides with higher -CDOCKER ENERGY and -CDOCKER INTERACTION ENERGY scores than lisinopril...After experimental verification, it was found that all six of these peptides have antioxidant activities, and we also found that the SPH and ultrafiltration fractions of SPH had antioxidant activities. These findings suggest that Sardina pilchardus may be a potential source of natural antioxidants and ACE inhibitors for the development of functional foods, and using LC-MS/MS in combination with an online database and molecular docking represents a promising, effective, and accurate approach for the discovery of novel ACE inhibitory peptides.
- |||||||||| Journal: Comparison of hospitalization costs for the same adverse reaction associated with different medications. (Pubmed Central) - Jun 8, 2023
Although we found few differences in the cost of hospitalization when comparing drugs with similar indications and the same adverse reaction, there were specific drug-ADR pairs that merit attention and consideration of interventions to improve safe and appropriate medication use. Evaluation of the effect of those interventions on the incidence of ADRs is an area for future study.
- |||||||||| Journal: Drugs for migraine. (Pubmed Central) - Jun 6, 2023
No abstract available No abstract available
- |||||||||| sirolimus / Generic mfg.
The impact of early sirolimus treatment on the tuberous sclerosis complex clinical outcome - a case report (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_868;
Despite of the factors predictive for severe clinical manifestations of TSC (TSC2 mutation, polycystic kidney changes), the successful control of cardiological and neurological TSC-manifestations was obtained in the reported case. Initiation of sirolimus therapy in infancy might have positive impact on the clinical outcome, thus additional studies are needed to establish the optimal treatment of newborns with TSC.
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