- |||||||||| Bredinin (mizoribine) / Asahi Kasei, Lee's Pharm
Journal: Pediatric IgA-Dominant Infection-Related Glomerulonephritis. (Pubmed Central) - Jun 30, 2024
The patient was successfully treated using a combination of prednisolone, mizoribine (an immunosuppressive drug), and lisinopril (an angiotensin-converting enzyme inhibitor) and three courses of methylprednisolone pulse therapy. No abstract available
- |||||||||| Bystolic (nebivolol) / Menarini, AbbVie
Biomarker, Journal: (NDMA) METFORMIN AND (NTTP) SITAGLIPTIN INDUCED CUTANEOUS MELANOMAS: LINKS TO NITROSOGENESIS, NITROSO-PHOTOCARCINOGENESIS, ONCOPHARMACOGENESIS AND THE METABOLIC REPROGRAMMING. (Pubmed Central) - May 29, 2024
Similarly to cutaneous melanomas occurring (and published in the scientific literature) after combined intake (or monomedication) of/ between ranitidine, valsartan, olmesartan, candesartan, telmisartan, irbesartan, losartan, enalapril, lisinopril, perindopril, hydrochlorothiazide, nifedipine, amlodipine, propafenone, bisoprolol, nebivolol, melitracen and a number of others, we inform about another rare but not unexpected clinical observation: occurrence of cutaneous melanomas after taking another class of drugs- oral antidiabetic ones...The data shared in patients one and two in the presented scientific work are confirmatory in relation to the potential pathogenetic action of nitrosamine contaminated drugs such as 1) bisoprolol/ nebivolol/ candesartan/ hydrochlorothiazide and amlodipine, as well as 2) furosemide in the direction of cutaneous melanoma...Apart from the "cancer-generating benefit", of course, which is already widely known. And let us not forget that: "A lie stops being a lie and becomes a truth the moment it is officially refuted".
- |||||||||| ribitol (BBP-418) / BridgeBio, Chantix (varenicline) / Pfizer
Journal, Adverse events: Repurposing of drugs against bacterial infections: A pharmacovigilance-based data mining approach. (Pubmed Central) - May 29, 2024
And let us not forget that: "A lie stops being a lie and becomes a truth the moment it is officially refuted". The molecular docking results have shown energetically favored binding conformation of lisinopril against 3-deoxy-manno-octulosonate cytidylyltransferase, UDP-2,3-diacylglucosamine hydrolase, and penicillin-binding protein 3 (PBP3) of Pseudomonas aeruginosa; olmesartan, atorvastatin against lipoteichoic acids flippase LtaA and rosiglitazone and varenicline against
- |||||||||| Review, Journal: Drugs for hypertension. (Pubmed Central) - May 21, 2024
The molecular docking results have shown energetically favored binding conformation of lisinopril against 3-deoxy-manno-octulosonate cytidylyltransferase, UDP-2,3-diacylglucosamine hydrolase, and penicillin-binding protein 3 (PBP3) of Pseudomonas aeruginosa; olmesartan, atorvastatin against lipoteichoic acids flippase LtaA and rosiglitazone and varenicline against No abstract available
- |||||||||| lisinopril / Generic mfg.
Renal Cell Type (W207) - May 20, 2024 - Abstract #ADA2024ADA_1172;
Semaglutide improves disease hallmarks in the db/db ReninAAV-UNx mouse model of advanced DKD associated with modulation of several renal cell types. Therapeutic outcomes and renal transcriptome signatures were further improved by combined antihypertensive standard-of-care.
- |||||||||| lisinopril / Generic mfg.
Enrollment change, Trial withdrawal: Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy. (clinicaltrials.gov) - May 19, 2024
P4, N=0, Withdrawn,
Therapeutic outcomes and renal transcriptome signatures were further improved by combined antihypertensive standard-of-care. N=200 --> 0 | Unknown status --> Withdrawn
- |||||||||| cisplatin / Generic mfg., valsartan / Generic mfg., lisinopril / Generic mfg.
Clinical, Preclinical, Journal: The Salutary Effects of Diminazene, Lisinopril or Valsartan on Cisplatin - Induced Acute Kidney Injury in Rats: A Comparative Study. (Pubmed Central) - May 6, 2024
The salutary effect of the three drugs used is, at least partially, due to their anti-inflammatory and antioxidant effects. Keywords: Cisplatin, Diminazene, ACE2 activator, Lisinopril, Valsartan, Acute kidney injury.
- |||||||||| lisinopril / Generic mfg.
Trial completion date, Trial primary completion date: Optimal Management of HIV Infected Adults at Risk for Kidney Complications in Nigeria (clinicaltrials.gov) - Apr 16, 2024
P2, N=280, Suspended,
Keywords: Cisplatin, Diminazene, ACE2 activator, Lisinopril, Valsartan, Acute kidney injury. Trial completion date: Feb 2024 --> Feb 2025 | Trial primary completion date: Feb 2024 --> Feb 2025
- |||||||||| Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date: WARRIOR: Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD (clinicaltrials.gov) - Apr 11, 2024
P4, N=2476, Active, not recruiting,
Trial completion date: Feb 2024 --> Feb 2025 | Trial primary completion date: Feb 2024 --> Feb 2025 Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Sep 2023 --> Sep 2024 | Recruiting --> Active, not recruiting | N=4422 --> 2476
- |||||||||| cardiotoxin (CB-6) / Celtic Biotech, MK-3795 / Merck (MSD)
Journal: Chronic hypoxia impairs skeletal muscle repair via HIF-2? stabilization. (Pubmed Central) - Apr 8, 2024
Administration of HIF-2? or ACE inhibitors may prove beneficial to ameliorate chronic hypoxia-associated muscle atrophy and weakness by improving muscle regeneration under chronic hypoxia.
- |||||||||| enalapril / Generic mfg., ramipril / Generic mfg., lisinopril / Generic mfg.
Review, Journal: Five-Membered Nitrogen Heterocycles Angiotensin-Converting Enzyme (ACE) Inhibitors Induced Angioedema: An Underdiagnosed Condition. (Pubmed Central) - Mar 28, 2024
The exploration of alternative drug options such as angiotensin II receptor blockers, the potential association of coadministration of DPP-4 inhibitors with ACE inhibitors, the presentation of angioedema and the significant clinical importance of this condition are also discussed. By focusing on the chemical structure of ACE inhibitors, specifically their nitrogen-based heterocycles-an attribute shared by over 880 drugs approved by the FDA within the pharmaceutical industry-this review emphasizes the pivotal role of nitrogen scaffolds in drug design and underscores their relevance in ACE inhibitor pharmacology.
- |||||||||| Filspari (sparsentan) / Travere Therap
Navigating Uncharted Waters: Management of IgA Nephropathy with combined Budesonide and Sparsentan () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_648;
The rationale of using both therapies is to maximize inhibition of the renin-angiotensin system and endothelin-1 blockade while reducing galactose-deficient IgA1 production in the Peyer's patches of the gut, an essential link in the 4-hit hypothesis of IgAN. Clinically, we observed an additive effect on proteinuria with minimal side effects.
- |||||||||| Soliris (eculizumab) / AstraZeneca
Use of Eculizumab During Pregnancy in a Patient with C3GN () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_615;
Prior data supports the use of eculizumab in pregnant patients with complement disorders such as paroxysmal nocturnal hemoglobinuria and thrombotic microangiopathy. Eculizumab appears to be relatively safe and should be considered in pregnant patients with C3GN.
- |||||||||| metformin / Generic mfg., lisinopril / Generic mfg.
Review, Journal: Factors associated with early-onset androgenetic alopecia: A scoping review. (Pubmed Central) - Mar 11, 2024
Active, not recruiting --> Terminated; The study started enrollment in Sep 2021 and despite huge efforts the rate of patient enrollment continued to be below target such that the completion of the study within a reasonable timeframe was deemed very unlikely. Early-onset AGA is a complex condition with various risk factors and etiology, associated comorbidities, and potential implications for treatment response and psychological health.
- |||||||||| Filspari (sparsentan) / Travere Therap
Improved Proteinuria Reduction with the use of Sparsentan and Targeted Release Budesonide in advanced IgAN (TUE-075; Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_952;
This serves as a surrogate marker for improved kidney function and outcomes in IgAN patients. Systemic glucocorticoids, though associated with significant proteinuria reduction, are usually rapidly tapered and discontinued to avoid significant systemic toxicity and the patients are eventually continued on traditional RAAS inhibition as well as Cellcept for maintenance in some cases.
- |||||||||| Ouch My Chest Hurts! Paraganglioma Induced Hypertensive Crisis and Stroke (San Diego Convention Center, Room 1A-B (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_7682;
Under close monitoring in the ICU, blood pressures slowly decreased and she was eventually switched to oral lisinopril 10 mg, nifedipine 60 mg, and carvedilol 12...This case highlights the importance for considering rare causes of secondary hypertension in the setting of hypertensive emergency in patients with a known history of treatment resistance. Imaging:
- |||||||||| Radical Therapy: Resolution of Refractory Cough After Nephrectomy for Renal Epithelioid Angiomyolipoma (San Diego Convention Center, Area G (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6190;
Her medications included high dose fluticasone/salmeterol, loratadine, and lisinopril...She was treated unsuccessfully for possible flares of both asthma and bronchiectasis with a course of prednisone and azithromycin...In this case, stepwise evaluation and treatment of common etiologies including asthma or bronchiectasis exacerbation, lisinopril therapy, and vocal cord dysfunction was unsuccessful. Clinicians should maintain a broad differential for cough that includes paraneoplastic syndrome, especially when more common causes are ruled out.
- |||||||||| lithium carbonate ER / Generic mfg.
Hemodialysis Reversed Bradyarrhythmia and Sinus Nodal Dysfunction From Acute Lithium Toxicity (San Diego Convention Center, Area K (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6002;
Regular medications included levothyroxine, lisinopril, lithium carbonate, and furosemide...Renal function recovered and lithium was switched to cariprazine per psychiatry consultation...The most common manifestations include sinus nodal abnormalities and profound bradycardia. The available literature described the reversibility of bradyarrhythmia and restoration of nodal function with lithium levels normalization post-dialysis, as demonstrated in our case, although temporary (and rarely permanent) cardiac pacing was warranted in some patients.
- |||||||||| azithromycin / Generic mfg.
From Tongue Swelling to Skin Sloughing: Azithromycin-induced SJS/TEN (San Diego Convention Center, Area K (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5995;
While there is no established standard of care with systemic therapy, as well as conflicting evidence in multiple studies, corticosteroids, IVIG, anti-TNF agents and plasmapheresis have been utilized depending on the severity of symptoms. Early suspicion and diagnosis remain vital for the prompt initiation of appropriate treatment.
- |||||||||| sodium valproate / Generic mfg., lisinopril / Generic mfg.
Another Case of the Blues, Methylene Blue as Adjunctive Therapy in Calcium-channel Blocker Induced Vasoplegia (San Diego Convention Center, Area K (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5991;
We demonstrate how early utilization of methylene blued led to faster liberation of pressor requirements and can be used in conjunction with hyperinsulinemia/euglycemia protocols in the face of multiple drug ingestions. The resultant vasopressor sparing effect greatly benefits certain patient populations where prolonged ICU hospitalization is not ideal.
- |||||||||| indomethacin / Generic mfg.
Indomethacin-induced Angioedema: A Rare and Challenging Case (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_981;
After decannulation, he was discharged with a prednisone taper...He received diphenhydramine, epinephrine, famotidine, methylprednisolone, and tranexamic acid...Reviewing his history revealed sporadic NSAID use, mainly Naproxen, without prior allergic reactions...In this case, the use of ACE inhibitors initially led to a biased hypothesis, as the association between angioedema and ACE inhibitors is well-documented in the literature. A comprehensive review of medications and other potential causes should always be considered.
- |||||||||| Trial completion date, Trial primary completion date: Centrally Acting ACE Inhibition in SLE (clinicaltrials.gov) - Feb 15, 2024
P2, N=36, Recruiting,
A comprehensive review of medications and other potential causes should always be considered. Trial completion date: Nov 2024 --> Nov 2025 | Trial primary completion date: Jan 2024 --> Jun 2025
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