- |||||||||| atenolol / Generic mfg.
Clinical, Journal: Effects of Antihypertensive Class on Falls, Syncope, and Orthostatic Hypotension in Older Adults. (Pubmed Central) - Nov 27, 2019
P3
We also determined the adjusted association of self-reported atenolol use (ascertained at the 1-month visit for indications other than hypertension) on outcomes in Cox models adjusted for age, sex, and race...However, amlodipine increased risk of falls during the first year of follow-up compared with chlorthalidone (hazard ratio [95% CI]: 2.24 [1.06-4.74]; P=0.03) or lisinopril (hazard ratio [95% CI]: 2.61 [1.03-6.72]; P=0.04)...Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00000542.
- |||||||||| Lopressor (metoprolol tartrate) / Novartis, Tenormin (atenolol) / AstraZeneca
Clinical, Journal: Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals. (Pubmed Central) - Nov 24, 2019
A relatively small number of gene variants related to loci associated with drug-signaling pathways (KCNK3, SULT1C3, AMH, PDE3A, PLCE1, PRKAG2) with large effect size (-3.5 to +3.5 mm Hg difference in response per allele) and differing allele frequencies in black versus white individuals explained a large proportion of the difference in response to candesartan and hydrochlorothiazide between these groups. These findings suggest that a genomic precision medicine approach can be used to individualize antihypertensive treatment within and across populations without recourse to surrogates of genetic structure such as self-defined ethnicity.
- |||||||||| lisinopril / generics
Review, Journal: An Evidence-Based Systematic Review of the Off-Label Uses of Lisinopril. (Pubmed Central) - Nov 19, 2019
The identified studies showed that lisinopril was highly effective for proteinuric kidney disease- with a minor but inconsiderable decrease in GFR. Positive effects of lisinopril were demonstrated in seven other off-label uses; however, lisinopril cannot be recommended as the first choice for them until further clinical trials confirm these positive effects.
- |||||||||| lisinopril / generics
Journal: Lizinopril in the Treatment of Arterial Hypertension. (Pubmed Central) - Nov 18, 2019
Among large number of representatives of this class lisinopril deserves special attention as one of best known and well-studied ACEIs. Wide spectrum of activity and proven organoprotective qualities of lisinopril allow to use it a variety of situations.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, Allergan
Review, Journal: Pharmacologic Prevention of Migraine: A Narrative Review of the State of the Art in 2018. (Pubmed Central) - Nov 11, 2019
The spectrum of response to preventive therapy varies; in general, complete cessation of headaches is uncommon, although there are "super-responders" to every therapy, as illustrated by patient reports of dramatic responses to treatment. Preventive treatment should be started at a low dose and doses increased slowly until therapeutic benefit is achieved or side effects preclude continued use.
- |||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Migraine Headache Prophylaxis. (Pubmed Central) - Nov 10, 2019
Acebutolol, oxcarbazepine, lamotrigine, and telmisartan are ineffective...The complementary treatments petasites, feverfew, magnesium, and riboflavin are probably effective. Nonpharmacologic therapies such as relaxation training, thermal biofeedback combined with relaxation training, electromyographic feedback, and cognitive behavior therapy also have good evidence to support their use in migraine prevention.
- |||||||||| lisinopril / generics
Clinical, Journal: Treating Hypertension in Children With n-of-1 Trials. (Pubmed Central) - Nov 10, 2019
No single medication was preferred for more than half of hypertensive children. n of-1 trials with repeated ABPM may promote better informed and individualized decisions in pediatric hypertension management.
- |||||||||| lisinopril / generics
HYPOGAMMAGLOBULINEMIA IN THE SETTING OF IGA VASCULITIS, THE CHICKEN OR THE EGG? (Monitor 4) - Nov 9, 2019 - Abstract #ACAAI2019ACAAI_769;
Patient received steroids, lisinopril and IVIG (600 mg/kg)x1 with mild IgG improvement...Decision to use immunoglobulin replacement in this clinical situation is dictated by the evidence or risk of infections. However, patients may do well with low IgG concentrations if they can response to vaccinations.
- |||||||||| Berinert (C1 esterase inhibitor (human) IV) / CSL Behring
ANGIOTENSIN-CONVERTING ENZYME INHIBITOR (ACE-I) ANGIOEDEMA: DID C1 ESTERASE INHIBITOR (BERINERT) HELP OR HARM THE DIAGNOSIS? (Monitor 3) - Nov 9, 2019 - Abstract #ACAAI2019ACAAI_717;
Lisinopril was stopped.Three days later, he developed oropharyngeal angioedema, again unresponsive to epinephrine...Only medication was hydralazine...The mechanism of action for Berinert in ACE-I angioedema is suppression of bradykinin production. As the half-life of Berinert is 36 hours, this patient’s recurrent angioedema may have actually been transient improvements due to bradykinin suppression rather than discrete episodes.
- |||||||||| Firazyr (icatibant) / Takeda
REFRACTORY TONGUE ANGIOEDEMA INDUCED BY TISSUE PLASMINOGEN ACTIVATOR (Monitor 3) - Nov 9, 2019 - Abstract #ACAAI2019ACAAI_716;
Several case reports have described successful use of icatibant or c1 esterase inhibitor replacement for severe cases refractory to initial treatments for allergic reactions. Physical maneuvers such as bite blocks and compression wrappings also have a role in OA resolution by promoting lymphatic and venous resorption.
- |||||||||| lisinopril / generics
ACROMEGALY MISTAKEN FOR ANGIOEDEMA (Monitor 3) - Nov 9, 2019 - Abstract #ACAAI2019ACAAI_695;
It was initially thought that Lisinopril, a medication he was on for management of his blood pressure was the culprit...Our patient was diagnosed within 2 years after development of symptoms. The most important lesson in this case would be to take a good history and physical.
- |||||||||| ANGIOTENSIN CONVERTING ENZYME INHIBITOR-INDUCED ISOLATED ABDOMINAL ANGIOEDEMA (Monitor 1) - Nov 9, 2019 - Abstract #ACAAI2019ACAAI_628;
A comprehensive allergic evaluation helped determining onset of symptoms at two to three days after starting an ACEi for the underlying hypertension.The patient was instructed to discontinue lisinopril and avoid all ACEi, leading to complete resolution of her symptoms...The less frequent abdominal presentation of ACEi-induced angioedema should be considered and addressed in an attempt to reduce delay in diagnosis and treatment. A) Lower endoscopy with lumen reduction secondary to wall thickening; B) MRI (coronal) showing wall thickening of descending colon; C) MRI (sagittal) showing wall thickening of (bottom-to-top and left to right) ascending colon, transverse colon and descending colon
- |||||||||| lisinopril / generics
Fibrillary Glomerulonephritis Presenting as Hematuria () - Oct 23, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_5804;
Patient continues to have hematuria after 1 year of follow up but renal function remained stable with lisinopril 20mg daily...Currently there are no optimal treatments for idiopathic FGN and high as 40-50% of patients develop ESRD. DNAJB9 immunohistochemistry
- |||||||||| Rituxan (rituximab) / Roche, Biogen
Immunotactoid Glomerulopathy in a Patient with Monoclonal B-Cell Lymphocytosis: A Rare Finding () - Oct 23, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_5783;
Case Description A 54-year-old male with history of well-controlled hypertension on lisinopril was evaluated for significant bilateral leg swelling...The patient was started on bendamustine and rituximab (BR)...Our case in a patient with MBL highlights the importance of evaluation for an underlying lymphoproliferative disorder with appropriate imaging studies, peripheral flow cytometry and bone marrow biopsy even in the absence of a peripheral paraproteinemia. An early target-directed therapy towards B-cell or plasma-cell clone may result in preservation of renal function.
- |||||||||| ibuprofen / generics
Overlapping Features of Membranous Glomerulonephritis and Focal Segmental Glomerulosclerosis in a Patient with Nephrotic Syndrome () - Oct 23, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_5759;
Case Description A 37-year old Caucasian male with chronic daily headaches on ibuprofen daily presented for elevated creatinine (2.4 mg/dL, compared to 0.8 mg/dL 3 years prior)...He was advised to stop all NSAID use and was started on amlodipine, carvedilol, lisinopril, and spironolactone...Discussion The coexistence of MGN and FSGS is a rare phenomenon, but may occur in patients who share risk factors like chronic NSAID use, uncontrolled hypertension, and obesity. Although the pathogenesis is unclear, MGN injury may contribute to FSGS since subepithelial deposits may hinder podocyte adhesion, and FSGS-mediated podocyte damage may lead to local antigen exposure and subepithelial immune complex formation.
- |||||||||| lisinopril / generics
Toxic RBC Casts as the Culprit of Irreversible AKI in IgA Nephropathy () - Oct 23, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_5679;
Immunosuppression use was deferred in the absence of glomerular involvement and history of spontaneous bacterial peritonitis .Low dose lisinopril was initiated.After 3 months Cr had declined to 2.3...Intra tubular obstruction by RBCs, direct tubular toxicity by hemoglobin(Hb) byproducts and intra renal vasoconstriction play a role. Data on specific therapy is scarce and the role of renal heme oxygenase and Hb scavenging by CD163 receptors on tissue macrophages may provide a potential avenue for future therapeutic ventures.
- |||||||||| Pradaxa (dabigatran etexilate) / Boehringer Ingelheim, warfarin / Generic Mfg., Eliquis (apixaban) / BMS
A Woman with Anticoagulant-Related Nephropathy (ARN): Recently Recognized AKI Syndrome () - Oct 23, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_5669;
The recent retrospective analysis of RE-LY shed light on it as well. The higher prescription volume of anticoagulants, with lack of data on treatment for ARN, calls for large prospective trials.
- |||||||||| Januvia (sitagliptin) / Merck (MSD)
FEELING BLUE: A CASE OF RASBURICASE-INDUCED METHEMOGLOBINEMIA (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Oct 23, 2019 - Abstract #CHEST2019CHEST_4803;
Patient had completed 1st cycle of gemcitabine/oxaliplatin 2 weeks prior to his admission.His medications include: sitagliptin, glipizide, mesalamine, amlodipine, hydrochlorothiazide, lisinopril, atorvastatin, aspirin, carvedilol, gabapentin, and esomeprazole.The patient had hyperuricemia, gout- like joint pain, hyperkalemia, and suspected TLS. Recognition of methemoglobinemia as a cause of SOB, cyanosis and hypoxemia requires a high index of suspicion as it can be cause by a vast number of medications, including rasburicase as demonstrated in this case.
- |||||||||| tacrolimus / Generic Mfg., Rituxan (rituximab) / Roche, Biogen
Pioglitazone (Pio) in Pediatric Nephrotic Syndrome (NS) (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_4627;
Despite ongoing treatment with prednisone (Pred), lisinopril, tacrolimus, mycophenolate (MMF), losartan, rituximab (Ritux), and Acthar he required twice weekly admissions for diuresis...She was treated with Pred 40 mg, valsartan 80 mg, simvastatin 20 mg, and Pio 15 mg daily...Discussion In pediatric NS, the addition of Pioglitazone may improve proteinuria and allow reduction in corticosteroid and other immunosuppressant medications. In this case series, no hypoglycemia or other adverse events occurred.
- |||||||||| hydralazine hydrochloride / Generic Mfg., Alverix (amiloride hydrochloride) / Remedica
Late-Onset Presentation of Severe Hypokalemic Hypertension Resistant to Mineralocorticoid Antagonism (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_4462;
Home medications were spironolactone 50 mg once daily, potassium chloride 20 mEq four times daily, clonidine 0.2 mg three times daily, lisinopril 20 mg once daily, amlodipine 10 mg, hydralazine 100 mg three times daily...Stopped spironolactone and started amiloride 5 mg daily...Subsequently patient was advised to check blood pressure twice per day and closely followed Discussion Epithelial sodium channel blockade improved blood pressure and electrolyte abnormalities significantly suggesting either Liddle syndrome (autosomal dominant) or apparent mineralocorticoid excess (autosomal recessive) which typically present in childhood. Our case illustrates a rare cause of hypertension having at this age which is associated with hypokalemia and metabolic alkalosis that is not amenable to mineralocorticoid blockade
- |||||||||| metformin / generics
Lactate Rising: The "Unconventional" Use of Continuous Renal Replacement Therapy in Metformin-Associated Lactic Acidosis (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_4429;
Although iHD has been the preferred modality for treatment of MALA, this case demonstrates that not only is CVVH an acceptable alternative, but may be the safest modality given the diagnostic uncertainty initially present. More studies evaluating the utility of CVVH in MALA may be beneficial to determine the optimal modality of extracorporeal therapy in patients with this rare but fatal condition.
- |||||||||| Alverix (amiloride hydrochloride) / Remedica
Ectopic Adrenocorticotropic Hormone Tumor Can Present as a Chloride-Depleted Metabolic Alkalosis (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_4130;
But contrary to expected, urine Cl was low in our case which makes it an unusual presentation of hypercortisolism. Treatment strategies in these patients should focus on eliminating the primary cause if possible (decreasing tumor burden) & using medications which inhibit MR (Spironolactone) or ENaC (Amiloride).
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
Tubulointerstitial Nephritis and Uveitis Unmasked by Decreasing Anti-TNF Alpha (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_4105;
Case Description 55-year-old Caucasian male with history of hypertension on lisinopril and psoriatic arthritis on adalimumab admitted for acute renal failure...He was also initiated on prednisone for concerns of acute interstitial nephritis...Discussion In patient with TINU, uveitis can present as vision loss without apparent inflammation, and it often presents separately from interstitial nephritis. This patient has atypical posterior uveitis and biopsy-proven AIN consistent with TINU, likely unmasked by tapering of adalimumab.
- |||||||||| Hytrin (terazosin) / Generic Mfg., hydralazine hydrochloride / Generic Mfg.
Management of Resistant Hypertension due to Renal Artery Stenosis (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_3243;
His Bp were ~ 130/70 mmHg one year later on lisinopril 10mg daily. Discussion The management of resistent hypertension due to renal artery stenosis needs to be individualized.
- |||||||||| sertraline / Generic Mfg., celecoxib oral / Generic Mfg.
A Horse in the Land of Zebras: A Case of Minimal Change Disease After Celecoxib Exposure (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_1763;
On presentation, her serum Cr was 0.8 mg/dl and her proteinuria (PU) measured 8 g. It did not improve with celecoxib discontinuation and lisinopril addition...Her PU resolved after a 2-month prednisone course, but she relapsed soon after steroids discontinuation...Subsequent addition of mycophenolic acid led to partial PU remission...While IgA deposits were deemed incidental and benign, sertraline-induced phospholipidosis could weaken the podocyte ability to maintain its structural integrity possibly exacerbating PU. Zebra bodies
- |||||||||| prednisone / generics, lisinopril / generics
IgA Nephropathy Associated with Intravesical Bacillus Calmette-Guerin: A Case Report (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_1736;
Prednisone 50 mg daily was started, and a kidney biopsy was arranged...He was continued on a prolonged steroid taper and lisinopril was started...Treatment is challenging given the need to balance immune suppression with antitubercular treatment. BCGosis is a rare but serious complication of BCG therapy and has been associated with other renal pathology including granulomatous interstitial nephritis, Henoch Schönlein purpura and membranous nephropathy.
- |||||||||| lisinopril / generics
A Case of Childhood Bilateral Renal Artery Stenosis Not Seen on Angiography (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_1521;
She is currently managed on clonidine, HCTZ, and lisinopril...Our patient underwent angiography by a skilled radiologist and bilateral RAS was not detected, thus we highlight the value of specialized vascular surgery centers for cases with a high index of suspicion. Angiography showing pt's bilateral RAS.
- |||||||||| tacrolimus / Generic Mfg., Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
Membranous Glomerulonephritis as an Immune-Related Adverse Effect of Checkpoint Blockade Therapy (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_1505;
The patient was discharged home on lisinopril, rosuvastatin, and bumetanide...Although HCC may also cause MGN, the rapid improvement of MGN with cessation of therapy more strongly suggests that this was an irAE. Given the increased use of checkpoint inhibitors, nephrologists should be mindful of this complication.
- |||||||||| lisinopril / generics
Sodium Thiosulfate Improves Renal Function and Oxygenation in L-NNA Induced Hypertensive Rats (Exhibit Hall, Walter E. Washington Convention Center) - Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_1311;
In a parallel study, rats were divided in 2 groups, 1) L-NNA with lisinopril (1mg/kg/day) mixed in the food and 2) L-NNA with both lisinopril and STS...Conclusion Our results suggest that supplementing H2S has therapeutic potential in hypertensive renal disease and might be of additive value in already existing antihypertensive regimens despite the increase in sodium load. Funding Private Foundation Support
- |||||||||| metformin / generics
Journal: Glucose Monitoring Dermopathy. (Pubmed Central) - Oct 12, 2019
The clinical differential diagnosis was more likely to be lichen simplex chronicus than pigmented Bowen's disease. A skin biopsy demonstrated an acanthotic epidermis with coarse collagen bundles in a thickened papillary dermis with extravasated erythrocytes, consistent with a dermal reparative reaction (Figure 2).
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