- |||||||||| prednisone / Generic mfg., cyclophosphamide / Generic mfg., lisinopril / Generic mfg.
Unveiling IgA Nephropathy with Crescents: A Prognostic and Therapeutic Dilemma (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_4380;
Our case indicates potential benefits of steroid-immunosuppression therapy, as demonstrated by partial renal function recovery within a short follow-up period. We propose that evaluating crescents alongside other MEST scores, clinical data, and novel biomarkers can facilitate a personalized therapeutic approach for patients with IgAN.
- |||||||||| prednisone / Generic mfg., mycophenolate mofetil / Generic mfg., lisinopril / Generic mfg.
C3 Glomerulonephritis in a Child with Elevated Anti-streptolysin O (ASO) Titer (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_4301;
As therapies of APIGN and C3GN differ, establishing correct diagnosis promptly is critical. In this case, timely performance of kidney biopsy established correct diagnosis, enabled to initiate in-depth evaluation of alternative complement pathway (ACP) and targeted therapy.
- |||||||||| amiloride hydrochloride / Generic mfg., lisinopril / Generic mfg.
Liddle Syndrome in a Family Presenting with Early-Onset Hypertension, Sudden Death, and Bilateral Kidney Cysts (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_4077;
LS is a tubulopathy typically characterized by hypokalemic HTN and metabolic alkalosis...Additionally, association of LS with sudden cardiac death was suspected due to hypertensive cardiomyopathy, potassium loss, and likely arrhythmia. Increased genetic testing in nephrology may contribute to phenotypic expansion of Mendelian diseases, enable earlier molecular diagnoses, and support inclusion of relevant genes in phenotype-driven panels.
- |||||||||| lisinopril / Generic mfg.
Cystinuria Screening Reveals Uncontrolled Hypertension and Subnephrotic-Range Proteinuria in a 20-Year-Old Patient: A Case Report (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3873;
Preliminary diagnosis was masked hypertension with hypertensive kidney disease, lisinopril was started and stimulant was discontinued...It is unclear in this patient whether the cystinuria and hypertension are linked. It also emphasizes the importance of screening of close family members for Cystinuria, which in this patient has led to early discovery of his hypertension and prevented severe end-organ damage.
- |||||||||| hydrochlorothiazide / Generic mfg., lisinopril / Generic mfg.
More Than an Accessory: Renal Artery Stenosis in a Second Renal Artery Driving Uncontrolled Hypertension (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3871;
The severely high renin activity levels was the main clue that prompted further evaluation of this ultrasound finding ultimately leading to stenting which proved impactful on his hypertension management. In investigating renovascular hypertension, one should utilize renin levels and consider unusual anatomy when a stenosed accessory renal artery is described.
- |||||||||| A Case of Reninoma in a 42-Year-Old Patient with Recurrent Strokes (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3870;
He was discharged on Hydralazine 75 mg twice a day, Quinapril 20 mg twice a day, and Labetalol 300 mg nightly.Repeat testing 3 months later in clinic showed an AM renin level of 46 ng/mL/h, AM aldosterone level of 71.2 ng/dL, serum creatinine of 0.87 mg/dL, sodium of 139, and potassium of 3.4...His blood pressure remained uncontrolled averaging 150s systolic over 90s diastolic during his office visits and his regimen was uptitrated to Lisinopril 40 mg daily, Spironolactone 75 mg daily, Hydralazine 75 mg thrice daily, and Carvedilol 12.5 mg twice a day...The mean age at diagnosis was 27 years with a mean duration of HTN of 47 months. Our case highlights the importance of keeping reninoma on the differential of causes of secondary HTN.
- |||||||||| Bilateral Nephrectomy as a Salvage Therapy for Resistant Hypertension in ESKD (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3868;
Post-surgery, Lisinopril was stopped, labetalol was discontinued after one month, and the doses of other antihypertensive medications were gradually reduced. The prevalence of bilateral nephrectomy as a treatment option ranges from 0 to 7% in various countries.[1] Bilateral nephrectomy leads to reduction in the levels of renin, angiotensin and aldosterone, which subsequently lowers the BP in resistant hypertension.[2][1]doi: 10.1016/j.ijscr.2022.107566[2]doi: 10.7759/cureus.9031
- |||||||||| lisinopril / Generic mfg.
When Hyponatremia Meets Hypertension: The Impact of Renal Artery Stenosis (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3866;
Hyponatremic hypertensive syndrome (HHS), particularly in the presence of RAS, requires comprehensive clinical evaluation and diagnostic imaging...Renal artery stenting improves perfusion and sodium levels, while ACE inhibitors reduce intraglomerular pressure and renal injury progression.In summary, managing HHS in the context of RAS requires understanding the pathophysiology, careful diagnostic workup, and a combination of interventional and pharmacologic treatments to improve outcomes. Pre stent vs post stent in left renal artery
- |||||||||| lisinopril / Generic mfg.
Lisinopril-Induced Rhinorrhea: A Case Report (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3861;
Most clinicians are aware of ACE-I-induced cough but less frequently recognize rhinorrhea as a side effect. Not everyone using an ACE-I will experience rhinorrhea, and some studies suggest a genetic predisposition.With the increasing prevalence of hypertension notwithstanding the benefits of ACE-I use, we favor the use of ARBs over ACE-Is when indicated in the management of hypertension and renal disease, more so in patients who are intolerant to ACE inhibitors, especially since ARBs are reasonably comparable in effectiveness and tolerability.
- |||||||||| Henletor (torsemide) / Orchid
A Curious Case of Salt-Sensitive Hypertension (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3858;
After years of ineffective anti-HTN therapy missing the mechanism of SS-HTN, serial PAC/PRA measurements with 24H, prompted an unconventional diuretic combination to achieve HTN control and reduce pill burden. This case highlights: 1) the utility of serial PAC/PRA with 24H to diagnose SS-HTN; 2) the efficacy of non-thiazide distal diuretics to treat SS-HTN; and 3) an evolving role for genetic testing to further our understanding of SS-HTN.
- |||||||||| prednisone / Generic mfg., lisinopril / Generic mfg.
A Child with Exostosin 2-Associated Membranous Nephropathy (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1737;
This case highlights that through identifying specific podocyte antigens, we can tailor individuals' care. Knowledge of the association of EXT2 with lupus nephritis allows for better anticipatory guidance to families.
- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
All in the Genes: Chronic Benign Proteinuria Due to CUBN Mutations (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1571;
This case shows the benefit of early genetic testing in cases with isolated, non-nephrotic range proteinuria with normal kidney function through early diagnosis and avoidance of unnecessary treatments or invasive tests such as biopsies. While unlikely, these patients should be followed routinely to screen for worsening renal function.
- |||||||||| lisinopril / Generic mfg.
Role of Family History and Genetic Testing in Diagnosing Rare Diseases (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1543;
FN is diagnosed with KB...Patient (1, 2) and mother KB (3, 4) shows large amounts of subendothelial and mesangial electron-dense deposits with vague fibrillary structure under high-power magnification. The mother's KB was post-transplant with recurrent disease.
- |||||||||| Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly
Journal: Concomitant Use of Oral Anticoagulants with Oral Dipeptidyl Peptidase-4 Inhibitors and Serious Bleeding Events. (Pubmed Central) - Sep 12, 2024
The adjusted RORs ranged from 0.01 (0.00-0.20) for rivaroxaban/lisinopril + saxagliptin to 2.99 (0.74-12.11) for apixaban/lisinopril + linagliptin. While we could not confirm previously identified signals because of statistical imprecision, several numerically elevated estimates still warrant caution in concomitant use and further examination.
- |||||||||| Januvia (sitagliptin) / Merck (MSD)
ANAPHYLACTIC SHOCK SECONDARY TO DPP-4 AND ACE-I USE (Convention Center Exhibit Hall: Rapid Fire Area 1A) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6696;
With the increasing use of DPP-4, careful consideration of life-threatening adverse reactions should be considered. Hemodynamic support and prompt diagnosis of angioedema with stabilization of the airway are necessary to achieve a good outcome.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD), Lenvima (lenvatinib) / Eisai, Merck (MSD)
MYOPATHY LEADING TO RHABDOMYOLYSIS AS A RARE SIDE EFFECT OF LENVATINIB AND PEMBROLUZIMAB THERAPY (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_5900;
Myositis and rhabdomyolysis have also been reported in the literature as a rare side effect in anti-PDL-1 drugs, such as pembrolizumab, and anti-CTLA-4 drugs, such as ipilimumab.[3,4] One proposed mechanism to this process is new autoimmune hypothyroidism leading to rhabdomyolysis.[5] In patients who are on both TKI's and ICI's, it may be difficult to discern the instigating agent as illustrated in this case report...Prior to admission, she was taking amlodipine, diazepam, glipizide, Lantus, levothyroxine, lisinopril-hydrochlorothiazide, metformin, rosuvastatin, pembrolizumab, and lenvatinib for several months... Serial CK levels can be useful in patients presenting to the clinic with muscle pain or weakness.7 Routine screening for musculoskeletal symptoms in patients on TKI's and ICI's should be a part of regular follow up.
- |||||||||| lisinopril / Generic mfg.
Targeting the renin-angiotensin system for the treatment of cerebral amyloid angiopathy (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_3022;
Ongoing analyses and postmortem experiments are being completed to investigate the potential benefits of telmisartan and lisinopril to mitigate neuropathological and cognitive impairments in Tg-SwDI mice. If the findings support our hypothesis, these widely available RAS-targeting drugs could be repurposed to prevent and/or treat CAA, reducing the burden of neurodegenerative diseases that currently lack effective treatments.
- |||||||||| furosemide / Generic mfg., lisinopril / Generic mfg.
Journal: Nephrotic Syndrome in a Child With NPHS2 Mutation. (Pubmed Central) - Aug 21, 2024
Immunosuppresive therapy was stopped, Lizinopril dose was increased and weekly infusions of Albumin/furosemide were initiated to manage edema. This case demonstrates that early genetic testing in children with SRNS avoids prolonged potentially harmful immunosuppressive therapy, allows for timely genetic family counseling, and allows earlier consideration for future living related donor kidney transplantation.
- |||||||||| A Rare Drug Induced Liver Injury leading to Liver Transplantation (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5302;
She was switched from Lisinopril to Losartan four weeks before presentation...She was treated with prednisone with minimal improvement in LFTs but worsening TB peaking at 53 mg/dl and albumin down to 1.8 mg/dL...1 Recent data suggests lower grade encephalopathy with bilirubin levels generally >15 mg/dL. 2 Liver function tests shows predominantly hepatocellular pattern of liver injury with modest alkaline phosphatase elevations
- |||||||||| lisinopril / Generic mfg., fenofibrate / Generic mfg., azathioprine / Generic mfg.
An Atypical Case of Autoimmune Hepatitis With Peripheral Eosinophilia Masquerading as Malignancy (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3599;
His medications are fenofibrate and lisinopril; he denies supplements, over-the-counter medications, or significant alcohol consumption...Azathioprine (AZA) was started with normalization of peripheral eosinophilia and transaminases 3 months later...Figure: Figure 1: MRI demonstrating scattered signal abnormalities with low-grade enhancement of the liver as highlighted by the yellow arrow. Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
- |||||||||| Undercover Ulcers: The Misleading Presentation of Duodenal Bulb Perforation as Pancreatitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2075;
Her home medications included aspirin, lisinopril, meloxicam, and donepezil...Intravenous fluids, morphine, bowel rest, and pantoprazole were started considering it as a case of AP...Figure: Figure A: Chest Xray demonstrating air under diaphragm (yellow arrow). Figure B: CT scan of abdomen with contrast showing large amount of free intraperitoneal air and moderately large amount of ascites adjacent to the liver (red star).
- |||||||||| Humira (adalimumab) / AbbVie
Small Bowel Angioedema Secondary to ACE Inhibitor (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2035;
Prompt diagnosis and discontinuation of this medication can save patients significant time, cost, and harmful exposures to unnecessary treatment and testing, including anesthesia, hospitalizations, and radiation. Figure: Figure 1: CT scan of the abdomen showing angioedema of the small bowel (white arrows).
- |||||||||| Hepatic Sarcoidosis: A Rare Symptomatic Case of Isolated Hepatic Sarcoidosis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1859;
She takes Glipizide, Levothyroxine, Lisinopril, Metformin, Risedronate, and Rosuvastatin...The patient had been diagnosed with hepatic sarcoidosis 22 years prior and was treated with Azathioprine and Ursodiol...Given the patient's progression and symptoms, she was initiated on prednisone 40mg daily...CT image showing a 1.3 cm focal calcification in the right hepatic dome (A). Histopathology showing a core of liver with a non-necrotizing granuloma (arrow) and giant cells in the lobule (B: x10; C: X20 H&E stain).
- |||||||||| Chantix (varenicline) / Pfizer
Review, Journal: Analytical Methodologies to Detect N-Nitrosamine Impurities in Active Pharmaceutical Ingredients, Drug Products and Other Matrices. (Pubmed Central) - Aug 19, 2024
Consequently, this review aims to concentrate on products recently reported to contain N-nitrosamine impurities. These products include rifampicin, champix, famotidine, nizatidine, atorvastatin, bumetanide, itraconazole, diovan, enalapril, propranolol, lisinopril, duloxetine, rivaroxaban, pioglitazones, glifizones, cilostazol, and sunitinib.
- |||||||||| Review, Journal, Adverse events: Mitigating Cardiotoxicity Associated with Anticancer Drugs: An Updated Systematic Review. (Pubmed Central) - Aug 19, 2024
Pharmacological interventions, including candesartan and carvedilol, have shown potential in reducing early DOX-induced subclinical cardiotoxicity (DISC)...Combination therapy with lisinopril and bisoprolol effectively preserved the LVEF...This systematic review underscores the promise of exercise and pharmacological interventions for preserving cardiac function in cancer patients receiving chemotherapy. These findings have significant implications for enhancing the quality of care for cancer patients.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
Could it be ACE-I Induced Angioedema in the Perioperative Period? (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4687;
Benadryl and Decadron were administered with improvement in swelling and patient subsequently discharged from PACU. Our case report reviews management strategies of ACE-I induced angioedema in the perioperative and post-operative patient.
- |||||||||| FONTAN PHYSIOLOGY AND AMBULATORY ANESTHESIA (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_3552;
She was on tadalafil, lisinopril and aspirin...She received 1 liter crystalloid, NO at 20 ppm through HFNC, ketamine 75 mg, fentanyl, midazolam and paracervical block...At extubation, she had transitory desaturation that returned to baseline with reapplication of HFNC. She was discharged home later that day.
- |||||||||| Spikevax (elasomeran) / Moderna
facial lesions after hyaluronic acid fillers and Covid-19 vaccine: case report (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2847;
There is no established clear line of treatment, but options include oral or intralesional corticosteroids, alone or combined with 5-Fluorouracil, macrolides, tetracyclines, and hyaluronidase...We aim to present a case of delayed inflammatory reaction to hyaluronic acid fillers following the first dose of the Moderna Covid-19 vaccine, which was refractory to several treatments, but showed a rapid and sustained response to doxycycline... We present a case of delayed inflammatory reaction to hyaluronic acid dermal fillers following Covid-19 vaccination, resistant to treatment with oral corticosteroids and lisinopril, with an excellent response maintained with oral doxycycline.
- |||||||||| verapamil modified release / Generic mfg., lisinopril / Generic mfg., epinephrine / Generic mfg.
DON'T BE BRASH: A FATAL CASE OF VERAPAMIL OVERDOSE (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5216;
Calcium channel overdose and BRASH syndrome both carry a high mortality rate. Early recognition and management are crucial to improve patient survival.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
AN UNUSUAL CASE OF LUNG ADENOCARCINOMA CAMOUFLAGED BY PULMONARY FIBROSIS IN A HUMAN IMMUNODEFICIENT VIRUS PATIENT (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2880;
Cough did not respond to trials of PPI, antihistamines, albuterol inhalers or discontinuing lisinopril...Empirically started on steroids and Bactrim for pneumocystis jiroveci prophylaxis...However, he developed pneumonitis after first round of chemotherapy and immunotherapy (Keytruda) was discontinued... We aim to highlight the increase of lung cancers in PLHIV and bring attention to an uncommon presentation of adenocarcinoma that precluded early detection.
- |||||||||| dexamethasone / Generic mfg., lisinopril / Generic mfg.
A PARADOX UNVEILED: CEREBRAL INFARCTIONS IN SEVERE THROMBOCYTOPENIA: A CASE REPORT (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1448;
Our case suggests that thromboembolism can occur even in the presence of severe thrombocytopenia, which could manifest as an initial presentation of ITP. Hence, physicians must remain vigilant in promptly and accurately diagnosing thrombotic events in ITP to ensure appropriate treatment, including antiplatelet and anticoagulant therapy, alongside ITP-specific interventions to improve outcomes.
- |||||||||| A STRANGE CASE OF VIBRIO VULNIFICUS (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1325;
Exposure through open wounds and water contact is not always required. Swift identification and detailed history are crucial for effectively managing Vibrio vulnificus infections.
- |||||||||| verapamil / Generic mfg., lisinopril / Generic mfg.
DON'T BE RASH, THINK ABOUT BRASH (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1282;
Given the high prevalence of these medications, physicians should remain cognizant of potential drug interactions, especially when evaluating patients with polypharmacy. In the outpatient setting, we should also remain mindful of rare but life-threatening complications when prescribing AVNBs to patients with underlying renal dysfunction.
- |||||||||| lisinopril / Generic mfg.
Journal: Proteomic Analysis of Human Macrophages Overexpressing Angiotensin-Converting Enzyme. (Pubmed Central) - Jul 13, 2024
Additionally, proteomic changes and cellular uptake following treatment with an ACE C-domain selective inhibitor, lisinopril-tryptophan, were also assessed...A novel, functionally enriched immune pathway that appeared both with ACE overexpression and inhibitor treatment was neutrophil degranulation. ACE overexpression within human macrophages showed similarities with ACE 10/10 murine macrophages, paving the way for mechanistic studies aimed at understanding the altered immune function.
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