- |||||||||| lisinopril / Generic mfg.
Journal: Key-Protease Inhibition Regimens Promote Tumor Targeting of Neurotensin Radioligands. (Pubmed Central) - Jun 13, 2020
Their profiles were investigated in NTS1R-positive colon adenocarcinoma WiDr cells and mice treated or not with the neprilysin (NEP)-inhibitor phosphoramidon (PA) and/or the angiotensin converting enzyme (ACE)-inhibitor lisinopril (Lis)...Coinjection of PA and/or Lis significantly stabilized all three analogs, leading to a remarkable enhancement of tumor uptake for Tc-DT1 and Tc-DT5, but was less effective in the case of poorly internalizing Tc-DT6. In conclusion, NEP and/or ACE inhibition represents a powerful tool to improve tumor targeting and the overall pharmacokinetics of NT-based radioligands, and warrants further validation in the field of NTS1R-targeted tumor imaging and therapy.
- |||||||||| lisinopril / Generic mfg.
Clinical, Journal: Predicting response to lisinopril in treating hypertension: a pilot study. (Pubmed Central) - Jun 4, 2020
In conclusion, NEP and/or ACE inhibition represents a powerful tool to improve tumor targeting and the overall pharmacokinetics of NT-based radioligands, and warrants further validation in the field of NTS1R-targeted tumor imaging and therapy. Further validation cohorts are needed to confirm the predictive values of these clinical and metabolic markers.
- |||||||||| simvastatin / Generic mfg.
Journal, HEOR: Cost-effectiveness of a fixed-dose combination pill for secondary prevention of cardiovascular disease in China, India, Mexico, Nigeria, and South Africa: a modelling study. (Pubmed Central) - May 26, 2020
The polypill is projected to be cost-effective compared with current care for secondary prevention of atherosclerotic cardiovascular disease in China, India, Mexico, Nigeria, and South Africa, particularly if it is made available at public-sector pricing. However, achieving meaningful improvements in cardiovascular health will require simultaneous investments in health infrastructure to increase the uptake of the polypill among patients with established atherosclerotic cardiovascular disease.
- |||||||||| lisinopril / Generic mfg., eplerenone / Generic mfg.
[VIRTUAL] Influence of aerobic loads on the clinical state of patients with chronic heart failure () - May 19, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_402;
The first group (I) consisted of 41 patients with I FC (10), II FC (21) and III FC CHF (10 patients) were taken with standard therapy - lisinopril; the second group (II) –61 patients with I FC (15), II FC (32) and III FC CHF (14 patients) who took losartan for 6 months on the background of standard therapy (the average dose of lisinopril was 7.8 ± 2.6 losartan - 76.3 ± 25.6 mg per day)...Against the background of 6 months of treatment with the inclusion of spiranolactone and eplerenone in the standard of treatment, the clinical condition of patients of both subgroups in which physical aerobic training was performed was noted...Conclusion. The complex of aerobic loads significantly improves the indicators of the clinical condition of patients and in the dynamics of treatment in both subgroups has similar indicators.
- |||||||||| metformin / Generic mfg., bupropion / Generic mfg.
CHRONIC SYSTEMIC INFECTION CONFUSED FOR IRRITABLE BOWEL SYNDROME () - May 4, 2020 - Abstract #DDW2020DDW_3789;
On review of laboratory values, he had a recent normal complete blood count and metabolic panel other than an MCV of 76 and peripheral eosinophilia (WBC 9,000/mL, 12% eosinophils). His stool was sent for ova and parasitology, which was negative for organisms.
- |||||||||| Trial completion date: REMAP-CAP: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (clinicaltrials.gov) - Apr 15, 2020
P4, N=7100, Recruiting,
His medications included amlodipine, hydrochlorothiazide, lisinopril, omeprazole, and nicotine replacement therapy. Trial completion date: Jun 2022 --> Dec 2023
- |||||||||| Golimumab Induced Thyroiditis (ENDOExpo) - Apr 1, 2020 - Abstract #ENDO2020ENDO_3721;
We report the first subacute thyroiditis associated with golimumab use. We suggest that drug-induced subacute thyroiditis should be one of the differential diagnoses of thyroid dysfunction in patients treated with golimumab.
- |||||||||| Coverex/Covercard (perindopril) / Egis, valsartan / Generic mfg.
Clinical, Review, Journal: Efficacy of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Preventative Treatment of Episodic Migraine in Adults. (Pubmed Central) - Mar 31, 2020
Angiotensin receptor blockers, ARB, angiotensin II receptor antagonists: candesartan cilexetil, irbesartan, olmesartan, valsartan, losartan, azilsartan medoxomil, telmisartan, and eprosartan...However, in populations with co-morbidities such as hypertension, they may be useful as first- or second-line prophylactics. Additional trials following the International Headache Society's guidelines on RCT are warranted.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, lisinopril / Generic mfg.
De Novo FSGS in a Renal Allograft Associated with CMV Infection () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_452;
CMV infection may be an underrecognized etiology of post-transplant de novo FSGS. Treatment may consist of antiviral therapy, reduction of immunosuppression, and possibly plasmapheresis and IVIG.
- |||||||||| Herceptin (trastuzumab) / Roche
What Is The Cause Of This Patient’s Hypertension? () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_405;
Health care providers and the public need to be aware of the potential adverse effects of excessive licorice intake. We report this case because detailed history taking is very important in arriving at the correct diagnosis.
- |||||||||| apixaban / Generic mfg.
Management of arterial thrombosis secondary to nephrotic syndrome in a patient on chronic apixaban () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_367;
He was treated with prednisone, furosemide and lisinopril, while apixaban was continued...Apixaban is non-inferior to warfarin for the treatment of thromboembolism in the general population. There is a need for further studies of direct oral anticoagulants to fully assess their effectiveness for prophylaxis against and treatment of thrombosis in patients with nephrotic syndrome.
- |||||||||| torasemide / Generic mfg., methamphetamine / Generic mfg., lisinopril / Generic mfg.
Unique case for C4 dense deposit disease () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_359;
The described cases of the disease so far have normal C3 and normal to slightly low C4 levels. Our patient had infact a low C3 level with a renal biopsy characteristic for C4 DDD.
- |||||||||| lisinopril / Generic mfg.
Perihilar Focal Segmental Glomerulosclerosis Secondary to Fabry Disease () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_352;
Supplementing previous observations, we submit that Fabry disease should be added to the list of conditions linked to secondary adaptive perihilar FSGS. We also highlight the importance of specimen adequacy in PKB and the value of EM for complete histopathological examination with a perihilar FSGS pattern of injury.
- |||||||||| Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
Fibrillary glomerulonephritis in the setting of well-controlled HIV Infection () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_178;
Immune complex glomerular disease is now the most common biopsy finding in HIV positive individuals, representing a heterogeneous spectrum of glomerular diseases. These diseases often present years after HIV diagnosis in individuals who are on ART, underscoring the importance of early recognition and kidney biopsy for more favorable outcomes.
- |||||||||| lisinopril / Generic mfg.
Focal glomerulopathy with mesangial fibrillary deposits associated with strongyloidiasis () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_125;
While the nephrotic range proteinuria was likely driven by the minimal change podocytopathy, the unusual mesangial fibrillary deposits constitute a novel observation that may be linked to Strongyloidiasis and play a role in the pathogenesis. This case highlights the importance of occupational history in the evaluation of nephrotic syndrome.
- |||||||||| Lopressor (metoprolol tartrate) / Novartis, Alverix (amiloride hydrochloride) / Remedica, lisinopril / Generic mfg.
Liddle's syndrome in middle aged African American female () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_106;
Vitals were significant for a blood pressure of 150/87 mmHg despite being on metoprolol, amlodipine and lisinopril...Patient was diagnosed with Liddle’s syndrome and treated with amiloride with subsequent improvement of hypokalemia and hypertension... Liddle's syndrome should be considered in the differential diagnosis of middle aged AA patients with a history of hypertension and presenting with hypokalemic metabolic alkalosis.
- |||||||||| lisinopril / Generic mfg.
Unveiling the Masked IgG Kappa Deposits () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_83;
The presence of extensive deposits on EM should prompt further evaluation with Paraffin IF, which unmasks IGs. Without this awareness, many patients with MGMID may be misdiagnosed with C3 GN.
- |||||||||| metformin / Generic mfg., Onglyza (saxagliptin) / AstraZeneca, Kombiglyze XR (saxagliptin + metformin XR) / AstraZeneca
Journal: A 37-Year-Old Man With Pleuritic Chest Pain. (Pubmed Central) - Mar 24, 2020
His parents were from Guam, although he was born and raised in San Diego, CA. He was employed as a social worker and denied any history of cigarette smoking, alcohol, or drug use.
- |||||||||| lisinopril / Generic mfg.
Clinical, Journal: Automated safety event monitoring using electronic medical records in a clinical trial setting: Validation study using the VA NEPHRON-D trial. (Pubmed Central) - Mar 20, 2020
The VA NEPHRON-D study was a multicenter, double-blind, randomized clinical trial designed to compare the effect of combination therapy (losartan plus lisinopril) versus monotherapy (losartan) on the progression of kidney disease in individuals with diabetes and proteinuria...This limits the effectiveness of the automated central database search for purposes of safety monitoring. Hence, this data captured approach should be carefully considered when implementing endpoint data collection in future pragmatic trials.
- |||||||||| methylprednisolone oral / Generic mfg., lisinopril / Generic mfg.
What We Don't Know Can Hurt Us (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area A) - Mar 15, 2020 - Abstract #ATS2020ATS_9711;
The patient was in her usual state of health until she took her lisinopril and developed rapid lip and tongue swelling...The patient was transferred to MICU after intubation and was started on IV methylprednisolone 125 mg, IV diphenhydramine 25 mg, IV ranitidine 20 mg, and was deeply sedated to prevent endotracheal tube dislodgement...Should we be comfortable with our understanding of this condition? Literature in the basic science of this area is scarce, and this patient pleads the case that we should be reaching for a better understanding.
- |||||||||| simvastatin / Generic mfg.
Spontaneous Non-Traumatic Subdural Intra-Spinal Thoracolumbar Hematoma Secondary to Standard Apixiban Dose for Atrial Fibrillation, Resulting in Acute Bilateral Lower Extremity Flaccid Paralysis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area A) - Mar 15, 2020 - Abstract #ATS2020ATS_9694;
We present a case involving a non-traumatic spontaneous subdural intra-spinal thoracolumbar hematoma in a patient on standard atrial fibrillation dosing of apixiban, who developed progressive bilateral lower extremity flaccid paralysis, requiring Andexanet alfa and laminectomy nerve decompression.Case Presentation:An 84 year-old Caucasian male with known past medical history of nonvalvular atrial fibrillation, hypertension, CABG, and diverticulitis presented to the ED with global weakness and tremors, hematemesis, abdominal pain, and general weakness...Medications were notable for aspirin, apixiban at 5 mg twice daily, lisinopril, and simvastatin...Anticoagulation was held post-operatively and the patient was continued on lisinopril, metoprolol, and atorvastatin in the ICU for further evaluation and monitoring...This uncommon case signifies the importance of anticoagulation evaluation, and the monitoring of standard apixiban dosing for atrial fibrillation, even without trauma or procedural provocation. Furthermore, diagnosis is challenging and requires a high level of clinical suspicion due to possible irreversible neurological impairment.
- |||||||||| cyclophosphamide intravenous / Generic mfg.
Isolated Pauci-Immune Pulmonary Capillaritis- a Rare Cause of Diffuse Alveolar Hemorrhage (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area H) - Mar 15, 2020 - Abstract #ATS2020ATS_9190;
Her home medications include levothyroxine, lisinopril, ferrous sulfate and albuterol nebulization...She was treated with vancomycin, cefepime, oxygen, non-invasive ventilation in ICU with preliminary diagnosis of acute hypoxemic respiratory failure secondary to hospital acquired pneumonia...Despite antibiotics and solumedrol, she did not improve clinically...After multidisciplinary discussion, she was given pulse dose of steroids and started on IV cyclophosphamide in addition to prednisone for three months followed by methotrexate...Our case also demonstrates its response to steroid and cyclophosphamide and maintenance methotrexate therapy. Further studies are needed to understand the pathogenesis and to establish the treatment guidelines for the disease.
- |||||||||| Lisinopril Induced Acute Emphysematous Pancreatitis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area E) - Mar 15, 2020 - Abstract #ATS2020ATS_8101;
Specifically, captopril and enalapril were identified as culprits in those reports...His home medications included lisinopril, metformin and aspirin...He initially improved with IV fluids and IV vancomycin and cefepime for suspected sepsis...Antibiotics were escalated to meropenem and metronidazole...More study is needed to identify the pathophysiology of ACE inhibitor-induced pancreatitis. This report can serve to alert providers to consider lisinopril as a potential cause of pancreatitis.
- |||||||||| Diffuse Stenosis of Mid Left Anterior Descending Artery from Spontaneous Dissection (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area K) - Mar 15, 2020 - Abstract #ATS2020ATS_6738;
Patient was placed on IV integrilin and heparin...She was discharged on aspirin, clopidogrel, metoprolol, lisinopril, spironolactone, atorvastatin and was advised to avoid pregnancy.Some registries have reported incidence of SCAD to be between 0.07 to 1.1% of coronary angiographies...CABG surgery should be the most preferred treatment in extensive SCAD involving left main artery or proximal LAD. Medical therapy alone may be an option in mid or distal SCAD, without lumen diameter limitation >50%, and with TIMI 2 or 3 flow.
- |||||||||| ceftriaxone / Generic mfg.
Reversed Takotsubo Cardiomyopathy in a Young Patient with Vaping-Induced Acute Lung Injury (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area F) - Mar 15, 2020 - Abstract #ATS2020ATS_5574;
For his vaping induced acute lung injury, five days of intravenous methylprednisolone followed by an eight day oral prednisone taper allowed him to be weaned off oxygen...He was started on lisinopril, spironolactone, and metoprolol for goal-directed medical management of new onset systolic heart failure...However, review of the literature revealed a few cases suggesting a link between marijuana use and takotsubo cardiomyopathy. Given the rising popularity of vaping and legalization of marijuana across the United States, it is important for healthcare providers to understand the hazards associated with both practices
- |||||||||| metformin / Generic mfg., amitriptyline / Generic mfg., Januvia (sitagliptin) / Merck (MSD)
Metformin Associated Lactic Acidosis in the ICU: A Rare Condition Mimicking Sepsis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_5414;
and sitagliptin 100 mg daily...He had been started on Lisinopril 5 mg and amitriptyline 25 mg four weeks prior to admission and had normal creatinine at that time...Treatment is restricted to supportive measures, although hemodialysis may offer a protective effect1, 2. Our case demonstrates that even in extreme cases of MALA, prompt and adequate supportive measures can produce a favorable outcome.
- |||||||||| A Case of Isolated Upper Lip Angioedema (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area K) - Mar 15, 2020 - Abstract #ATS2020ATS_5010;
Approximately five months prior, he started 10 mg of lisinopril twice-daily treatment of his hypertension...Initially, he was provided 3 liters of normal saline fluid resuscitation, epinephrine injections, methylprednisolone 125 mg, and diphenhydramine 25 mg...Administration of glucocorticoids, sympathomimetics, and antihistamine in this setting is likely not helpful and could cause unforeseen complications related to their individual side effects. Developing a way to risk stratify those patients presenting with angioedema could potentially prevent harm while enhancing cost-effective management in cases of isolated angioedema.
- |||||||||| A Case of Refractory Angiotensin Coverting Enzyme Inhibitor Induced Angioedema (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area K) - Mar 15, 2020 - Abstract #ATS2020ATS_5002;
The patient was given intramuscular epinephrine, intravenous methylprednisolone, intravenous diphenhydramine and intravenous famotidine without improvement...The failure of FFP and tranexamic acid in this case raise concerns that these treatments are not universally effective for bradykinin-mediated angioedema. The lack of improvement over 14 days also raises concern for ongoing bradykinin generation despite cessation of ACE inhibitor therapy.
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