- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Airway Management Of Severe Angioedema In Trauma Patient () - Oct 17, 2020 - Abstract #ASA2020ASA_1022;
The pt had a history of HTN and was taking lisinopril...Fiberoptic view was remarkable for significant oropharyngeal edema. The patient tolerated intubation and her angioedema improved during her hospital course.
- |||||||||| meropenem / Generic mfg., Daewon Pharmaceutical
[VIRTUAL] HYDROCHLOROTHIAZIDE-INDUCED PANCREATITIS: A RARE CAUSE OF PANCREATITIS () - Oct 12, 2020 - Abstract #CHEST2020CHEST_1499;
Her pancreatic fluid cultures grew Klebsiella pneumoniae, and she underwent treatment with meropenem...Like our patient, the etiology of the toxicity may have been more related to the hydrochlorothiazide, as no other case reports were found describing lisinopril-induced pancreatitis. Clinicians should have a high index of suspicion for drug-induced pancreatitis in patients without common risk factors for pancreatitis.
- |||||||||| metformin / Generic mfg.
[VIRTUAL] THE METFORMIN GAP () - Oct 12, 2020 - Abstract #CHEST2020CHEST_1359;
Conditions and medications that can predispose a patient to lactic acidosis need to be excluded prior to making a diagnosis of MALA. Early consideration of MALA in patients receiving metformin is important, as early institution of renal replacement therapy can improve survival.
- |||||||||| ticagrelor / Generic mfg.
[VIRTUAL] ANGIOEDEMA SECONDARY TO TICAGRELOR: A RARE COMPLICATION () - Oct 12, 2020 - Abstract #CHEST2020CHEST_871;
P2Y12 inhibitors have bleeding as well as non-bleeding complications. We present a rare case of angioedema secondary to brilinta use with possible contribution from lisinopril.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe
[VIRTUAL] Cytomegalovirus-Associated Collapsing Glomerulopathy in a Renal Transplant Recipient (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_3195;
Serum cytomegalovirus NAAT was positive and the patient was started on IV Valganciclovir (vGCV)...Patient was treated with cVGC for 10 weeks and a low dose lisinopril; serum creatinine and UPC improved to 1.69 mg/dl and 0.9 g/ g cr respectively without requiring renal replacement therapy...Discussion Collapsing glomerulopathy can occur with non-HIV infection, such as CMV in renal transplant recipients. Allograft function may be preserved with appropriate therapy.
- |||||||||| prednisone / Generic mfg., lisinopril / Generic mfg.
[VIRTUAL] Fibromuscular Dysplasia Masquerading as Polyarteritis Nodosa in a Patient with Raynaud Syndrome (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2814;
Notably, she had been on prednisone for a skin rash after poison ivy exposure 5 days prior to presentation...The patient’s creatinine remained stable throughout her hospital stay, and she was initiated on lisinopril prior to discharge...It may manifest as a systemic vascular disease involving multiple vascular beds, mimicking systemic vasculitis. Since treatment of PAN and FMD is vastly different, it is important to consider both differentials and have definitive diagnosis prior to initiation of therapy.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] An Unusual Case of Granulomatous Interstitial Nephritis (GIN) (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2803;
He was started on lisinopril with improvement in BP, but no improvement in renal function & was then started on HD...The unexpected finding of GIN raised the consideration for stimulated immunity & granuloma formation from latent BCG vaccine. While literature documents granuloma formation in other organs, its occurrence in kidneys & potential contribution to progressive CKD seems less common, but should not to be overlooked.
- |||||||||| Arimidex (anastrozole) / AstraZeneca, Remedica
[VIRTUAL] Breast Cancer-Associated Podocytopathy (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2751;
The patient was started on Lisinopril 10mg, however proteinuria worsened to 12.6 grams thereby switch to losartan (100mg daily) with slight improvement in proteinuria...She underwent lobectomy and started on anastrozole...Interestingly, the FSGS diagnosis preceded the diagnosis of the breast cancer. While the proteinuria came into partial remission with conservative management, a dramatic resolution of FSGS was noted post-surgery and hormonal therapy for the breast cancer.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] Coexistence of Bullous Pemphigoid and Membranous Nephropathy (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2276;
He was treated with furosemide and lisinopril...Initiation of prednisone and rituximab resulted in cessation of new bullae and decrease in proteinuria...As the severity of skin lesions decreased, so did the proteinuria, suggesting that progression of bullae may be a sign of worsening MN. This case highlights the importance of thorough history taking, detail review of medications and appropriate outpatient follow up.
- |||||||||| cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] An Atypical Presentation of Lupus Nephritis (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2270;
She showed improvement and was started on Imuran in May 2018 for maintenance...Initially, thought to have C3 nephritis; but later, the diagnosis was confirmed by renal biopsy and electron microscopy. The Full House immunofluorescence pattern seen in this patient is characteristically indicative of lupus nephritis, and she was responsive to immunosuppressive therapy.
- |||||||||| hydroxychloroquine / Generic mfg., prednisone / Generic mfg., lisinopril / Generic mfg.
[VIRTUAL] Collapsing Glomerulopathy in Mixed Connective Tissue Disease: Case Report (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2235;
CG can present in association with autoimmune diseases including but not limited to SLE. This case represents the second such as this case of CG in the setting of MCTD and is notable for its response to immunosuppressive therapy.
- |||||||||| [VIRTUAL] Hypokalemia from ACTH-Secreting Pheochromocytoma (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_1917;
Systematic workup led to diagnosis of ACTH-secreting pheochromocytoma. After resection of ectopic ACTH source, patient became normokalemic and was discharged with steroid replacement.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] An Interesting Case of Hypokalemia (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_1904;
His antihypertensives were lisinopril 40mg and chlorthalidone 25mg daily...It inhibits the conversion of cortisol into inactive cortisone, allowing cortisol to act on the mineralocorticoid receptor. The use of licorice should be explored, whenever one encounters renal potassium wasting with suppressed renin and aldosterone.
- |||||||||| hydroxychloroquine / Generic mfg., azithromycin / Generic mfg., lisinopril / Generic mfg.
[VIRTUAL] Hemodialysis Refractory Hyperkalemia in a Case of SARS-CoV-2 Infection (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_1482;
As viremia cleared, the kidney function improved though it did not return to baseline. In our case, development of hyperkalemia despite hemodialysis makes it more interesting, but it remains unclear how.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Thrombotic Microangiopathy as a Complication of Malignant Hypertension (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_828;
His past medical history is significant for hypertension treated with lisinopril, but the patient is noncompliant with his medication...Renal biopsy revealed acute and chronic TMA in renal blood vessels with focal severe arteriolosclerosis, fibrin, and onion skinning of arteries supporting the diagnosis of malignant nephrosclerosis as the cause of TMA. Arteriolar narrowing with fibrin
- |||||||||| lisinopril / Generic mfg.
Phase classification, Enrollment change: Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease (clinicaltrials.gov) - Sep 23, 2020
P2, N=43, Completed,
Thus, PDE1 appears to be an attractive therapeutic target for the treatment of resistant hypertension, while tachycardia needs to be addressed by further compound structural optimization. Phase classification: P=N/A --> P2 | N=90 --> 43
- |||||||||| Trial initiation date: Centrally Acting ACE Inhibition in SLE (clinicaltrials.gov) - Sep 17, 2020
P2, N=36, Not yet recruiting,
Suspended --> Recruiting Initiation date: Sep 2020 --> Feb 2021
- |||||||||| Flagyl (metronidazole) / SLA
[VIRTUAL] Mesenteric Angioedema Induced by Angiotensin-Converting Enzyme Inhibitor () - Sep 15, 2020 - Abstract #ACG2020ACG_3326;
Case Description/ A 49-year-old-female with past medical history of chronic hypertension presented with new-onset right lower quadrant abdominal pain, and nausea and vomiting for 1 day after receiving oral Prinivil (lisinopril, an ACEI) 20 mg daily for 3 days...Patient received intravenous hydration and metronidazole...Discontinuation of ACEI results in rapid symptomatic improvement, as currently reported. The proper diagnosis can avoid unnecessary bowel resection.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Sprue-Like Enteropathy Secondary to Lisinopril Use () - Sep 15, 2020 - Abstract #ACG2020ACG_3237;
2018, 581‐586). Olmesartan is classically the medication associated with sprue-like enteropathy, and our case highlights that lisinopril should be considered as well.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] Lisinopril-Induced Oroesophageal Pemphigus Vulgaris: A Previously Unreported Side Effect () - Sep 15, 2020 - Abstract #ACG2020ACG_1554;
Fluconazole, Nystatin, and Valganciclovir were initiated without improvement...Lisinopril was discontinued and the patient was started on prednisone and mycophenolate with a subsequent resolution of symptoms...ACEI such as captopril, enalapril, and cilazapril have been associated with DIP...Cessation of ACEI is essential to halt progression while immunotherapy with steroids and other immunomodulators such as rituximab, azathioprine, or mycophenolate are the mainstay of management. A thorough drug reconciliation should be performed on presentation to allow for possibly early discontinuation of the offending agent(s), limit duration, and decrease side-effects of subsequent immunomodulatory therapy.
- |||||||||| simvastatin / Generic mfg., metformin / Generic mfg.
[VIRTUAL] A Rare Presentation of Asymptomatic Eosinophilic Colitis () - Sep 15, 2020 - Abstract #ACG2020ACG_1201;
This case highlights the importance of considering eosinophilic colitis when encountering the endoscopic finding of whitish mucosal exudates even in asymptomatic patients. Perhaps, these patients need to be followed to monitor for development of symptoms later in life.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, Rovi Pharmaceuticals Laboratories
[VIRTUAL] Initiation Of Sacubitril Valsartan In An Inotrope Dependent Patient (Poster Hall - ePosters) - Sep 10, 2020 - Abstract #HFSA2020HFSA_508;
Lisinopril was held right before discharge due to hypotension.The patient returned to the clinic one month after discharge for 2 nd follow-up visit...Two weeks after the initiation of sacubitril/valsartan therapy, the NT-proBNP normalized and the patient was admitted to the cardiac observation unit as planned to discontinue milrinone, followed by same-day discharge...To our knowledge, this is the first case of initiating sacubitril/valsartan in a patient with inotrope-dependent heart failure in the outpatient setting. This approach has the potential to expand the use of sacubitril/valsartan to facilitate the weaning off intravenous inotropic therapy in the outpatient setting.
- |||||||||| carvedilol / Generic mfg., lisinopril / Generic mfg.
[VIRTUAL] Guideline-Directed Therapy In An Elderly Homebound Population Of Heart Failure Patients (Poster Hall - ePosters) - Sep 10, 2020 - Abstract #HFSA2020HFSA_437;
Conclusions : Patients within both younger and older age demographics are able to reach similar daily doses of guideline-directed heart failure medication. Target doses of BBs were less frequently attained probably due to the frequent presence of numerous comorbidities.
- |||||||||| Lopressor (metoprolol tartrate) / Novartis
[VIRTUAL] Rate-related Left Bundle Branch Block Causing Cardiomyopathy (Poster Hall - ePosters) - Sep 10, 2020 - Abstract #HFSA2020HFSA_296;
Heart Failure guideline directed medical therapy was started, including metoprolol succinate, Lisinopril and spironolactone. Rate-related LBBB should be recognized as a potential cause of cardiomyopathy; management is to decrease the "time spent" in LBBB; if this is achieved by rate control alone, CRT can be avoided.
- |||||||||| Journal: Drugs for hypertension. (Pubmed Central) - Sep 8, 2020
Rate-related LBBB should be recognized as a potential cause of cardiomyopathy; management is to decrease the "time spent" in LBBB; if this is achieved by rate control alone, CRT can be avoided. No abstract available
- |||||||||| Clinical, PK/PD data, Journal: Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects. (Pubmed Central) - Sep 5, 2020
No abstract available Oral semaglutide or SNAC alone did not appear to affect the exposure of lisinopril, warfarin, or digoxin, and, based on its wide therapeutic index, the higher metformin exposure with oral semaglutide was not considered clinically relevant.
- |||||||||| simvastatin / Generic mfg., taspoglutide (BIM51077) / Roche
P1 data, Journal: Assessment of Drug-Drug Interactions between Taspoglutide, a Glucagon-Like Peptide-1 Agonist, and Drugs Commonly Used in Type 2 Diabetes Mellitus: Results of Five Phase I Trials. (Pubmed Central) - Sep 5, 2020
Overall, multiple doses of taspoglutide did not result in changes in the pharmacokinetics of digoxin, an oral contraceptive containing ethinylestradiol and levonorgestrel, lisinopril, warfarin, and simvastatin that would be considered of clinical relevance. Therefore, no dose adjustments are warranted upon co-administration.
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