- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Hematuria and Proteinuria in a Patient of Cypriot Descent () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_3807;
He was treated conservatively with Lisinopril 10 mg daily...The main distinguishing features of CFHR5 nephropathy vs. IgAN are its familial nature and absence of IgA deposition. Therefore, family history, renal biopsy, and genetic testing for CFHR5 mutation are critical in establishing a diagnosis of CFHR5 nephropathy.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Is This Primary or Secondary Membranous Nephropathy? () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_3780;
Labs are consistent with nephrotic syndrome, and he is subsequently started on Furosemide and Lisinopril...In the absence of a biopsy, a mutual decision is made to treat the patient with rituximab...The patient is offered an alkylating agent based therapy, but has opted to enroll in an ongoing clinical trial on anti-CD 38 therapy. He remains under surveillance for possible secondary etiologies due to his biopsy findings, while awaiting his response to anti CD-38 therapy.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Fibrillary Glomerulonephritis in a Patient with Long-Standing Hypertension, Proteinuria, and Advanced CKD: Not Everything Is Hypertension () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_3779;
Case Description We present a case of a 65 years-old man with history of diabetes mellitus for 6 years without retinopathy, HTN and chronic kidney disease (CKD) who presented to our hospital with acute kidney injury after increasing dose of lisinopril for uncontrolled hypertension...However, diseases such as FGN although rare should always be considered as part of our differential diagnosis. Whether we should treat with immunosuppression or continue conservative management in this patient with advanced chronic kidney disease is debatable but knowing the diagnosis of FGN will certainly help to establish a better prognosis.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Scleroderma Renal Crisis Sans Scleroderma () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_3659;
She was started on lisinopril 2.5mg when her creatinine level was 3.89 mg/dl...SRC should be considered in the differential diagnosis for patients presenting with AKI, new-onset microscopic hematuria, proteinuria, malignant hypertension and thrombotic microangiopathy. ACE inhibition is crucial for patient survival and can lead to renal recovery, which could take as long as 24 months after a renal crisis.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Will the Real Sodium Stand Up! () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_3257;
Applying the following formula to correct for triglycerides = Measured Na+ (Plasma triglycerides (g/L) x 0.002 ); measured serum sodium would have been expected to be 125 meq. Thus in cases of extremely high lipids, one must consider lab techniques for measuring serum sodium, as well as full lipid panel in the evaluation and treatment of factitious hyponatremia.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Turning the Page on Page Kidney with Dual RAAS Blockade () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2825;
Losartan was added and uptitrated to 100mg PO daily...Historically, a trial of either an ACE or ARB is indicated, with refractory cases being managed surgically. In this case, dual RAAS blockade was required for blood pressure control, which allowed surgical interventions, and their associated risk of morbidity and mortality, to be avoided.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Focal Segmental Glomerulosclerosis: A Rare Cause of Nephrotic Syndrome in Graft vs. Host Disease () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2516;
Home medications were lisinopril 20mg daily, levetiracetam 500mg twice daily and prednisone 10mg daily...Partial remission of NS was achieved at 3 months of treatment with mycophenolate mofetil 500mg twice daily and prednisone 15mg twice daily...FSGS is an extremely rare complication of HCT and very few cases have been reported in the literature linking FSGS to HCT. Further documentation of this phenomenon is important to further characterize the clinical and pathological features of this complication.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Automatic Artificial Intelligence-Assisted Glomerulosclerosis Analysis in Mice Models with Glomerulopathy () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2504;
2) I.V. injection of nephrotoxic anti-GBM serum (NTS) and 3) Adriamycin (ADR) in healthy mice...Conclusion We here demonstrate an automatic AI-assisted image analysis approach for obtaining GS scores in three mouse models with glomerulopathy, and we show that the models display very distinct GS profiles. An AI-assisted approach allows for rapid and reproducible quantification of GS and, as a tool, could help advance future research.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Primary Membranous Nephropathy Flare After COVID-19 Vaccination () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2435;
We present a patient with MN and metastatic breast cancer who developed nephrotic syndrome after receiving her second mRNA-1273 COVID-19 vaccine with positive PLA2R Ab by ELISA suggesting MN flare...She was diagnosed with metastatic breast cancer and started anastrazole transiently...She was treated with lisinopril and furosemide followed by rituximab in May 2021...Our case of primary MN flare after COVID-19 vaccine adds support to a potential association between SARS-CoV-2 antigens and loss of tolerance to the PLA2R antigen. Close follow-up of patients with primary MN and other glomerular diseases after COVID-19 vaccination is warranted.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Added Benefit of SGLT-2 Inhibitor with ACE Inhibition in a Mouse Model of Severe Diabetic Nephropathy () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2023;
Mice were treated with Lisinopril (ACEi) in drinking water and SGLT2i (JNJ39933673) in diet, at a dose of 5 mpk for 8 weeks...Conclusion Our study demonstrates the possibility of testing combinatorial therapies in this translational preclinical model of severe DKD. Residual injury in ACEi+SGLT2i animals should enable testing of novel agents in this model on this new standard of care for CKD.
- |||||||||| pioglitazone / Generic mfg., lisinopril / Generic mfg.
[VIRTUAL] Effect of Lisinopril and Pioglitazone in a Mouse Model of Diabetic Kidney Disease () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_1993;
Pioglitazone and lisinopril both showed a comparable effect in decreasing the severity of mesangial matrix deposition. Conclusion Hence, the UNx-db/db animal model of diabetic kidney disease is a progressive model of renal function decline and limited histopathological damage which responds to both anti-diabetic and anti-hypertensive control agents, and is a valuable model for the assessment of new therapeutic targets for DKD.
- |||||||||| lisinopril / Generic mfg., spironolactone / Generic mfg.
[VIRTUAL] Heterozygous HSD11B2 Gene Mutations and Apparent Mineralocorticoid Excess (AME) in a Patient with Heterozygous ADPKD1 () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_1920;
His BP was 145/91 mmHg, not controlled well with daily dose of oral Lisinopril 40 mg and Amlodipine 10 mg...He was started with low dose of Spironolactone 12.5 mg daily for BP control and proteinuria...He is currently treated with oral Tolvaptan. Discussion This is an unique case which could be the first case report of HSD11B2 mutations with apparent mineralocorticoid excess associated with heterozygous ADPKD1.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] IgA Nephropathy After Receiving the Pfizer COVID-19 Vaccine: A Case Report () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_1806;
Following the biopsy, we prescribed Lisinopril 5 mg daily for control of proteinuria...The virus’ spike protein or other factors may trigger an aberrant mucosal immune IgA response which can then lead to the onset and progression of IgA nephropathy. Further case series are needed to establish a more definitive association of the COVID-19 vaccine with IgA nephropathy.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] IgA Vasculitis with Renal Manifestations in a College-Aged Individual After COVID-19 Infection () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_1793;
He was also placed on Lisinopril and low-salt diet for better control of blood pressure and fish oil for dyslipidemia...This suggests that the vaccine components may induce further activation of disease. This previously healthy patient is believed to have a severe and persistent case of IgAN in part due to his COVID-19 infection.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] An Unusual Case of Tubulointerstitial Nephritis with Uveitis (TINU) Syndrome Associated with Alendronic Acid () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_1184;
Case Description 77 year-old female with a history of hypertension on lisinopril, osteoporosis on alendronic acid for 2 years, baseline creatinine of 0.7 mg/dl, was admitted for worsening renal function...Patient was started on 1 mg/kg of daily prednisone and discharged after 5 days of hospitalization...Prompt recognition of this rare complication and drug discontinuation are crucial to the management. In our patient, since discontinuation of medication did not improve her renal function, we treated her with steroids, with excellent response.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] Renal Failure due to Bilateral Renal Artery Stenosis () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_939;
Initial visit, blood pressure (BP) was controlled on stable doses of metoprolol XR 50 mg qd, amlodipine 10 mg qd, hydrochlorothiazide 25 mg qd and lisinopril 40 mg qd...At follow up, Scr normalized to 1.2, BP controlled on amlodipine 10 mg qd and carvedilol 3.125 mg BID...Individuals at risk for progression of atherosclerotic lesions are elderly individuals, especially those with HLD and DM. Elevated renin levels and Scr, which were rapidly obtainable during our clinic visit, were suggestive of pronounced renal ischemia and prompted quick action of ACEI discontinuation, definitive imaging and overall clinical improvement.
- |||||||||| lisinopril / Generic mfg.
Journal: Long-acting PGE2 and Lisinopril Mitigate H-ARS. (Pubmed Central) - Oct 16, 2021
Finally, sublethal TBI transiently reduced the number of marrow Lin-CD45-CD31+Sca-1- sinusoidal endothelial cells, while combined dmPGE2 and lisinopril treatment, but not single-agent treatment, accelerated their recovery. Taken together, these data support the concept that combined dmPGE2 and lisinopril therapy improves thrombocytopenia and survival by promoting recovery of the MK lineage, as well as the MK niche, in the setting of H-ARS.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca, Invokana (canagliflozin) / J&J, Daiichi Sankyo, Mitsubishi Tanabe
Trial initiation date: CLIgAN: Multicentre Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy. (clinicaltrials.gov) - Oct 13, 2021
P4, N=878, Not yet recruiting,
Taken together, these data support the concept that combined dmPGE2 and lisinopril therapy improves thrombocytopenia and survival by promoting recovery of the MK lineage, as well as the MK niche, in the setting of H-ARS. Initiation date: Jun 2021 --> Jan 2022
- |||||||||| lisinopril / Generic mfg., docetaxel / Generic mfg.
[VIRTUAL] RAPID PROGRESSION OF ILD SECONDARY TO DOCETAXEL USE IN SOUTH ASIAN FEMALE () - Oct 13, 2021 - Abstract #CHEST2021CHEST_2190;
After completing three cycles, she developed dyspnea and a dry cough that was treated with antibiotics and discontinuation of lisinopril... Docetaxel induced ILD is a serious adverse effect and early recognition of symptoms will lead to early diagnosis, prevention of this complication, and consideration for alternative chemotherapy options.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] REINKE'S EDEMA () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1869;
Cigarette smoking is the main risk factor. The mainstay treatment for Reinke's edema is surgical resection with microflap techniques.
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] A RARE RADIOGRAPHIC MANIFESTATION OF A CHRONIC COUGH () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1800;
When present, more common radiographic manifestations include ground glace opacities, reticulations, interlobular septal thickening and even honeycombing (2). Our case was notable for radiographic central bronchial wall thickening and inflammation alone, a rare manifestation [2,3].
- |||||||||| lisinopril / Generic mfg.
[VIRTUAL] ACUTE REVERSAL OF SYSTOLIC HEART FAILURE IN A CASE OF COXSACKIEVIRUS MYOCARDITIS () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1112;
Our case highlights that viral myocarditis has the potency to recover quickly, even from severe systolic dysfunction. This case also emphasizes the importance of repeating an echocardiogram on the same admission rather than waiting for a couple of months to ensure cardiac function recovery, particularly with very low ejection fraction on presentation.
- |||||||||| lisinopril / Generic mfg.
Journal: Lisinopril-Associated Recurrent Hemorrhagic Pancreatitis. (Pubmed Central) - Oct 1, 2021
Co-administration of the plant with lisinopril conferred no significant therapeutic advantage on the serum glucose level and lipid profile. No abstract available
- |||||||||| lisinopril / Generic mfg.
Clinical, Review, Journal: Once- Versus Twice-Daily Angiotensin-Converting Enzyme Inhibitors for Blood Pressure Control in Adult Patients With Hypertension. (Pubmed Central) - Sep 28, 2021
After reviewing the available literature, twice-daily dosing of ACE inhibitors may promote added blood pressure-lowering effects, with the advantages of reducing cost, reducing the risk of drug-drug interactions, reducing polypharmacy, and reducing patient confusion about their medications. Recommendations for twice-daily administration of ACE -inhibitors should be made via shared decision-making with the patient, and clinician judgment, to drive treatment selection.
- |||||||||| phentermine / Generic mfg., lisinopril / Generic mfg.
When Should Patients Stop Taking Phentermine Prior To Surgery? Profound Hypotension And Bradycardia During Total Knee Replacement (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4004;
Upon manipulation of the knee under general endotracheal anesthesia, the patient repeatedly developed profound hypotension and bradycardia requiring glycopyrrolate, atropine, and epinephrine...Further questioning revealed that the patient had stopped phentermine only 5 days prior to surgery. Postoperative cardiac workup was unremarkable, and the surgery was performed uneventfully two weeks later.
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