- |||||||||| levetiracetam / Generic mfg., lisinopril / Generic mfg., metoprolol succinate / Generic mfg.
Cannabis-Induced Atypical Stress Cardiomyopathy: A Case Report (Great Hall Foyer, Third Floor) - Apr 8, 2022 - Abstract #ASAM2022ASAM_240;
Conclusion More research is warranted to firmly establish the link between cannabis use and the development of SC. It is vital for clinicians to be cognizant of the effects of cannabis on the cardiovascular system.
- |||||||||| lisinopril / Generic mfg.
Journal: Case Report of High-Grade Atrioventricular Block and Takotsubo Cardiomyopathy. (Pubmed Central) - Apr 5, 2022
When AVB or other arrhythmias initiate a TTC, the patient can experience sudden cardiac death and decompensate quickly. Therefore, clinicians should understand this rare but fatal complication because these patients require pacemakers and beta blockers.
- |||||||||| lisinopril / Generic mfg.
Preclinical, Journal: The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats. (Pubmed Central) - Apr 1, 2022
These results indicate that Ang-II, via the AT-1 receptor, plays a facilitating influence on the cardiovascular response caused by RS; facilitates sympathetic activation and reduces parasympathetic activity related to RS; facilitates the baroreflex activation during RS and favors corticosterone release under this stress model. The impairment of Ang-II synthesis, as well as the blockade of AT-1 receptors, may constitute an important pharmacological strategy to treat cardiovascular consequences caused by stress.
- |||||||||| cisplatin / Generic mfg., lisinopril / Generic mfg.
Biomarker, Journal: Genetic variation of pharmacogenomic VIP variants in the Chinese Li population: an updated research. (Pubmed Central) - Mar 31, 2022
The four loci rs1805123 (KCNH2), rs4291 (ACE), rs3093105 (CYP4F2), and rs6413432 (CYP2E1) provided a reliable basis for the prediction of the efficacy of certain drugs. The study complemented the existed pharmacogenomics information, which could provide theoretical basis for predicting the efficacy of certain drugs in the Li population.
- |||||||||| NEPHROTOXIC MEDICATION EXPOSURE IN CHILDREN ON CONTINUOUS RENAL REPLACEMENT THERAPY ([VIRTUAL]) - Mar 23, 2022 - Abstract #SCCM2022SCCM_2378;
While common and largely driven by diuretic and antimicrobials, NTX exposures PRE CRRT or during CRRT were not associated with MAKE-60 in pediatric patients. Outcome associations in different vulnerable groups, such as oncology and transplant need to be further explored to provide insight into potentially actionable modifiable exposure risk.
- |||||||||| sertraline / Generic mfg., lisinopril / Generic mfg., labetalol / Generic mfg.
PRES FROM SERTRALINE TOXICITY PRESENTING AS A HYPERTENSIVE EMERGENCY IN ACUTE LIVER FAILURE ([VIRTUAL]) - Mar 23, 2022 - Abstract #SCCM2022SCCM_1779;
Pertinent past medical history included hypertension managed with lisinopril 5 mg daily, depression managed with sertraline 200 mg daily, and dialysis-dependent chronic kidney disease...The patient’s sertraline doses were held, and an aggressive antihypertensive regimen including a clevidipine infusion and multiple bolus doses of hydralazine and labetalol were effective in drastically improving the patient’s symptoms...Our patient qualified as CTP Class B upon arrival, thereby indicating that sertraline should have been avoided and lending credence to the notion that sertraline toxicity led to a pseudo-serotonin syndrome presenting as a hypertensive emergency leading to PRES. Despite the presence of hyperammonemia, the resolution of symptoms with antihypertensive therapy and the holding of sertraline doses supports our description of the uncommon etiology witnessed in this case of PRES.
- |||||||||| lisinopril / Generic mfg.
IRON OVERLOAD CARDIOMYOPATHY: A PROGRESSIVE SILENT DISEASE LEADING TO END-STAGE HEART FAILURE ([VIRTUAL]) - Mar 23, 2022 - Abstract #SCCM2022SCCM_1365;
Description: A 33-year-old female with 14 year transfusion-dependent anemia diagnosed as Diamond-Blackfan-Anemia, later negative genetic testing with transferrin saturation 62% and serum ferritin >33000 ng/ml on chelation therapy (Deferasirox and Deferoxamine), presented with shortness of breath, orthopnea and leg edema...On home Lisinopril and Carvedilol, she was admitted to the cardiac intensive care unit for acute decompensated heart failure with congestion...Treated with dobutamine and diuresis...On day 4, course complicated by sustained ventricular tachycardia refractory to adenosine and amiodarone requiring cardioversion...Early diagnosis and treatment are important in improving life expectancy. More data are needed to determine if heart transplantation actually improves the clinical outcome.
- |||||||||| lisinopril / Generic mfg.
Trial completion date, Trial suspension, Trial primary completion date: Optimal Management of HIV Infected Adults at Risk for Kidney Complications in Nigeria (clinicaltrials.gov) - Mar 21, 2022
P2, N=280, Suspended,
More data are needed to determine if heart transplantation actually improves the clinical outcome. Trial completion date: Aug 2024 --> Jun 2025 | Recruiting --> Suspended | Trial primary completion date: Feb 2024 --> Apr 2025
- |||||||||| lisinopril / Generic mfg.
TSC2/PKD1 contiguous gene syndrome: Opening the genetic pandora’s box () - Mar 19, 2022 - Abstract #NKFSCM2022NKF_SCM_890;
She was started on Lisinopril and referred for CT imaging of the renal mass...CONCLUSION Negative genetic testing for this condition does not exclude TSC and clinical criteria established by the International Tuberous Sclerosis Complex Consensus Conference allow for the diagnosis of TSC in the absence of this. Renal disease in TSC usually reflects genetic involvement of the PKD1 gene given the proximity of the TSC2 and PKD1 loci
- |||||||||| lisinopril / Generic mfg.
Clinical, Journal: Underreported Risk of Lisinopril-Induced Angioedema in a Veteran Population. (Pubmed Central) - Mar 11, 2022
When estimating the effect of underreporting, the risk of LIA increases to approximately 1.6% or 1 in 63 patients. Because this ADE may affect more patients than previously understood, providers may wish to take LIA into consideration when prescribing lisinopril.
- |||||||||| lisinopril / Generic mfg.
Journal: Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. (Pubmed Central) - Mar 11, 2022
Here we report the synthesis, enzyme kinetic data, and high-resolution crystal structures of these inhibitors bound to nACE and cACE, providing valuable insight into the factors driving potency and selectivity. Overall, these results highlight the importance of the interplay between the S' and S' subsites for ACE domain selectivity, providing guidance for future chemistry efforts toward the development of dual cACE/NEP inhibitors.
- |||||||||| carvedilol controlled-release / Generic mfg.
Enrollment change, Trial termination: Vascular Benefits of Adding CarvedilolCR to Type2 Diabetic Patients on ACEI. (clinicaltrials.gov) - Mar 10, 2022
P4, N=14, Terminated,
Overall, these results highlight the importance of the interplay between the S' and S' subsites for ACE domain selectivity, providing guidance for future chemistry efforts toward the development of dual cACE/NEP inhibitors. N=60 --> 14 | Active, not recruiting --> Terminated
- |||||||||| Audience ARS Question: 64-year-old female with history of hypertension, hyperlipidemia, PAD, Type II Diabetes and NSTEMI 6 months ago - She had stent placement to the proximal LAD - Medications: atorvastatin 80 mg qd, ezetimibe 10 mg qd, lisinopril 20 mg, qd, metoprolol succinate 100 mg qd, aspirin 81 mg qd, clopidogrel 75 qd, metformin 1000 mg bid, empagliflozin 10 mg Labs: LDL-C 76 mg/dL, HDL-C 52 mg/dL, TG 80 mg/dL Total-C 150 mg/dL; HbA1c 6.8 (Room 207B) - Mar 9, 2022 - Abstract #ACC2022ACC_7564;
N=60 --> 14 | Active, not recruiting --> Terminated There is no abstract associated with this presentation.
- |||||||||| A Unique Case of Paraganglioma Unmasked by Intra-op Hypertension and Abdominal Lymphadenopathy () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_679;
BP was elevated to 143/113, refractory to bolus anti-hypertensives and a nitroglycerin infusion; he ultimately required a nicardipine infusion for blood pressure control...Labs at the time of diagnosis included Cr elevated to 1.6 mg/dl, troponin peak 1.3 ng/ml, NT-proBNP 291 pg/ml, TSH 3, free plasma metanephrine 108 pg/ml, normetanephrine 7,987 pg/ml, fractionation of norepinephrine >1,200 pg/ml in the serum and >517 mcg/g in the urine, epinephrine 251 pg/ml serum and 21 mcg/g in urine, dopamine 1,144 pg/ml in serum, and chromogranin A 2,058 ng/ml...His BP was controlled on lisinopril and doxazosin with stable BP outpatient of 114/68...Chemotherapy and radiation can be offered as some cases are not ameable to surgery. Performing germline genetic testing should also be considered in such cases.
- |||||||||| lisinopril / Generic mfg.
Identification of Cubulin (CUBN) Variants Associated with Isolated Benign Persistent Proteinuria: A Case Study () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_660;
Parents refused renal biopsy in both siblings and they were maintained on low dose lisinopril which resulted in a 17% (older sibling, 0.72 vs 0.61) and 15% reduction (younger sibling, 0.72 vs 0.60) in average UPCR...The identified variants affect the C-terminal half of the cubulin protein, which is associated with benign chronic proteinuria in the absence of IGS.2 CONCLUSION The early use of genetic screening in the diagnostic workup of proteinuria in the pediatric setting can minimize the need for further invasive testing even in cases without suspicious family history. Future studies of these patients are necessary to inform long term outcomes and management of proteinuria.
- |||||||||| lisinopril / Generic mfg.
End-stage kidney failure in an Amish family due to a heterozygous pathogenic variant in the INF2 gene encoding inverted formin 2. () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_652;
With this genetic diagnosis, patient was initiated on Lisinopril and thorough genetic counseling was offered including targeted genetic testing for his at-risk family members...Recurrent transplant is not common for monogenic causes of FSGS, however multiple family members of this patient have needed multiple kidney transplants, which deserves further investigation. The prevalence of monogenic kidney disease in the Amish population is not well studied, and to our knowledge this is the first report of INF2-related kidney disease in an Amish family.
- |||||||||| Apparent mineralocorticoid excess from licorice consumption () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_648;
She required 3 antihypertensive medications (hydralazine, lisinopril, and spironolactone) to control her BP on discharge...After stopping these candies, her BP was well controlled on carvedilol alone...CONCLUSION Licorice can cause AME that is reversible after withdrawal of dietary liquorice. Clinicians should be aware of the dietary and medicinal sources of licorice.
- |||||||||| valacyclovir / Generic mfg.
Hemodialysis for valacyclovir induced neurotoxicity and nephrotoxicity () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_647;
Valacyclovir, the prodrug, is rapidly metabolized to acyclovir, the active drug, by first pass intestinal and/or hepatic metabolism...Significant meds included lisinopril, hydrochlorothiazide(HCTZ), metformin and motrin...Here, both the active drug and the prodrug have low volume of distribution and low protein binding, hence dialysis was utilized for rapid removal of the medication to minimize further possible neurotoxicity and nephrotoxicity. Physicians must be reminded that quick diagnosis of valacyclovir toxicity should be made when suspicion is high, and HD can be utilized for drug clearance to reduce further risk of severe toxicity.
- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
De novo IgA Nephropathy following mRNA COVID-19 vaccine () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_642;
She was started on Lisinopril...Subsequently, 2 days after the booster vaccine she developed GH, Upr increased to 2063mg/24h and was started on Dapagliflozin...CONCLUSION The new-onset and recurrence of GH shortly after the COVID-19 vaccines suggests a potential association with the development of IgAN and relapses. Further studies are needed to understand the pathophysiology of the vaccine-associated glomerular diseases, optimize vaccine strategies and guide optimal therapeutic management.
- |||||||||| prednisone / Generic mfg., lisinopril / Generic mfg.
Renal Hemosiderosis secondary to unknown cause of intravascular hemolysis () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_632;
After discontinuation of lisinopril the AKI resolved...Hb is then degraded in the tubular epithelial cells and iron accumulates in lysosomes as hemosiderin that can cause cell injury by the formation of free radicals. Continuous deposition of hemosiderin will cause tubular atrophy and interstitial fibrosis.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
A Novel Case of C1q Nephropathy in an HIV Patient with Kaposi Sarcoma and TTP () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_611;
METHODS A 52-year-old male with HIV diagnosed in 2000 (CD4 303 cells/µL, viral load undetectable), disseminated Kaposi sarcoma (skin, spleen, bone involvement) treated with paclitaxel was hospitalized with disease progression...Treatment with plasma exchange and rituximab normalized his hematologic parameters...Treatment was initiated with lisinopril and urine protein-creatinine improved to 1.7 g/g...The prevalence of non-collapsing FSGS is increasing in patients with HIV receiving antiretroviral therapy. Though C1q nephropathy has not been reported in patients with HIV, we suspect that his presentation of C1q nephropathy was a manifestation of HIV-related kidney disease in the setting of long-standing HIV with multiorgan complications.
- |||||||||| lisinopril / Generic mfg.
An Unusual Case of Interstitial Nephritis () - Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_580;
Other than recently being started on lisinopril, he denied taking any over the counter agents including non-steroidal anti-inflammatory drugs or herbal supplements...This gene is responsible for DNA repair, especially in the kidney. Screening of close relatives may prompt early and aggressive care to delay progression of renal disease in those who inherit this gene mutation.2 Some early manifestations of systemic karyomegaly are recurrent upper respiratory tract infections and elevated liver enzymes which are only present in about 50% of those with KIN.3 Early identification of KIN is important as most cases result in end-stage renal disease before the age of 50.
- |||||||||| ambrisentan / Generic mfg., furosemide / Generic mfg., lisinopril / Generic mfg.
Permissive Systemic Hypertension in the Management of Eisenmenger Syndrome in a Patient with Patent Ductus Arteriosus (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_4748;
She was initiated on ambrisentan and treprostinil with significant symptom improvement...On follow-up, lisinopril was started for stage 2 hypertension but stopped for return of dyspnea and worsening hypoxia...Her hypoxia correlated with systolic blood pressures less than 140mmHg and so she has remained off all anti-hypertensives aside from furosemide...If left uncorrected, patients can develop irreversible PH, shunt flow reversal, and cyanosis, a syndrome known as ES. This case illustrates a unique scenario in which permissive systemic hypertension is essential in minimizing right-to-left shunting in a patient with ES who is already on maximum medical therapy.
|
