- |||||||||| Rituxan (rituximab) / Roche
NELL-1 positive Membranous Nephropathy () - Mar 13, 2025 - Abstract #NKFSCM2025NKF_SCM_701;
He was started on Eliquis...Patient's lisinopril was increased to highest tolerated dose, and vitamin supplements he was taking were stopped...Finally, NELL-1 MN is more resistant to treatment and more likely to recur (1). Patient's proteinuria has decreased to 2.7 mg/mg after two sessions of rituximab, but he has not achieved remission yet.
- |||||||||| Rituxan (rituximab) / Roche
Rituximab Use in Nonlupus Full-House Nephropathy: A Case Series () - Mar 13, 2025 - Abstract #NKFSCM2025NKF_SCM_544;
At 10 months, she had achieved partial remission with stable SCr of 1.9 mg/dL and downtrending proteinuria (24hUP 3.8g/24h, UPCR 3.1g/g).Results Nonlupus FHN is a rare disease with a broad range of etiologies, including idiopathic, secondary, or a prodrome of SLE.Conclusion Standardized treatments for nonlupus FHN are lacking in the literature. Rituximab use in nonlupus FHN should be systematically studied to evaluate its effects in varied clinical presentations.
- |||||||||| imatinib / Generic mfg.
Imatinib as a Cause of Severe Rhabdomyolysis () - Mar 13, 2025 - Abstract #NKFSCM2025NKF_SCM_475;
Management of rhabdomyolysis requires early recognition, hydration, and close monitoring of renal function.Conclusion Imatinib-induced rhabdomyolysis is a rare but serious complication that requires prompt recognition and management. Clinicians should be aware of the potential for rhabdomyolysis in patients with chronic kidney disease and multiple comorbidities, and monitor closely for signs of muscle weakness, elevated CK levels, and renal dysfunction.
- |||||||||| lisinopril / Generic mfg.
Journal: CARDIAC ASSESSMENTS AND IMPLANTABLE LOOP RECORDER PLACEMENT IN THREE MALE GELADAS (THEROPITHECUS GELADA). (Pubmed Central) - Mar 12, 2025
Due to the abnormalities on ECG and echo, he was treated with metoprolol and lisinopril...Implantable loop recorders greatly enhance the ability to diagnose and treat arrhythmias in primates and understand the mechanisms behind sudden cardiac deaths. Further studies are needed to establish cTnI, echocardiogram, and electrocardiogram reference ranges for this species, as well as appropriate treatment protocols.
- |||||||||| nifedipine immediate release / Generic mfg., losartan / Generic mfg., lisinopril / Generic mfg.
Journal: Trends in antihypertensive use among privately insured hypertensive clients in Ghana. (Pubmed Central) - Feb 27, 2025
Most single medicine products was generic (76.5% in 2016; 79.9% in 2017 and 83.1% in 2018) whiles most fixed combination products were branded (73.0% in 2016; 89.7% in 2017 and 91.3% in 2018). The patterns of AHM use are clinically expected although the Ghana Standard Treatment guidelines are not directive about lines of treatment.
- |||||||||| Journal: Drug-Induced Complete Atrioventricular Block in an Elderly Patient: A Case Report Highlighting Digoxin-Beta Blocker Interactions and a Paradoxical State. (Pubmed Central) - Feb 26, 2025
Her medical history included atrial fibrillation, hypertension, and heart failure, with a medication regimen of digoxin 0.25 mg given daily 5 days out of 7, metoprolol 50 mg twice daily, lisinopril 10 mg daily, furosemide 40 mg daily, and spironolactone 50 mg daily...Bisoprolol was introduced for rate control, and hemodynamic stability was achieved...This case emphasizes the importance of recognizing drug interactions as a reversible cause of AV block and using drug interaction checkers to manage polypharmacy, especially in elderly patients with multiple comorbidities. It also highlights the rare and paradoxical combination of atrial flutter and complete AV block.
- |||||||||| Journal: Double Trouble in the Basement! A Case of PLA2R-Associated Membranous Nephropathy with Atypical Anti-Glomerular Basement Membrane Disease. (Pubmed Central) - Feb 24, 2025
Despite intense chemotherapy with cisplatin, gemcitabine, and immunotherapy, the patient's cholangiocarcinoma progressed, and he transitioned to hospice care...The lack of temporal association with the malignancy is consistent with the biopsy findings of PLA2R-associated membranous nephropathy. While there is not an established guideline for atypical anti-GBM disease, our case demonstrates the utility of rituximab for the management of concurrent atypical anti-GBM disease with membranous nephropathy.
- |||||||||| Trial completion date, Trial primary completion date: WARRIOR: Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD (clinicaltrials.gov) - Feb 6, 2025
P4, N=2476, Active, not recruiting,
This case underscores the potential of hydroxocobalamin as an effective treatment for vasoplegia, particularly following ACE inhibitor use in cardiac surgery patients. Trial completion date: Dec 2024 --> Sep 2025 | Trial primary completion date: Sep 2024 --> Feb 2025
- |||||||||| lisinopril / Generic mfg.
Journal: Another Crohn's Disease Mimicker: A Case of Angiotensin-Converting Enzyme Inhibitor-Induced Intestinal Angioedema. (Pubmed Central) - Feb 4, 2025
We present a 32-year-old White woman with Crohn's disease on lisinopril experiencing 1 year of episodic abdominal pain, nausea, and vomiting, prompting multiple steroid tapers and a switch in biologic therapy...Initial imaging showed marked small bowel wall thickening and free fluid in the abdomen. She had rapid symptomatic and radiographic improvement after only 24 hours and was diagnosed with angiotensin-converting enzyme inhibitor-induced intestinal angioedema, an important Crohn's disease mimicker that may lead to unwanted management if unrecognized.
- |||||||||| Enrollment closed: Centrally Acting ACE Inhibition in SLE (clinicaltrials.gov) - Feb 3, 2025
P2, N=36, Active, not recruiting,
Clinical considerations provide additional context for physicians and other clinicians. Recruiting --> Active, not recruiting
- |||||||||| everolimus / Generic mfg.
Acquired Angioedema in a Patient on Everolimus Post-Heart Transplant (Poster Hall) - Jan 19, 2025 - Abstract #ISHLT2025ISHLT_318;
There was no known prior history of drug or food allergies and the patient had chronically taken lisinopril in the past without adverse effects...He was treated with intravenous Solumedrol and tranexamic acid with a good response...Our case underscores the importance of patient education and close monitoring when administering high-risk medications. Consideration should be given to switching from an ACEi to an alternative anti-hypertensive agent at the earliest sign of adverse reaction.
- |||||||||| lisinopril / Generic mfg.
Journal: Investigating the Transfer of Lisinopril into Human Milk: A Quantitative Analysis. (Pubmed Central) - Jan 17, 2025
The Relative Infant Dose (RID) was 0.06% for lisinopril, more than 100 times lower than the standard 10% safety threshold. The minimal transfer of lisinopril into human milk in this study suggests the drug is unlikely to pose a clinically significant risk to healthy breastfed infants.
- |||||||||| lisinopril / Generic mfg., telmisartan / Generic mfg.
Journal: Developing Topics. (Pubmed Central) - Jan 12, 2025
Ongoing experiments are being completed to increase sample sizes and investigate the potential benefits of telmisartan and lisinopril to mitigate neuropathological and cognitive impairment in Tg-SwDI mice. If findings support our hypothesis, this will demonstrate that these drugs could be repurposed to prevent and/or treat CAA, reducing the worldwide burden of stroke and dementia.
- |||||||||| chlorthalidone / Generic mfg.
Journal: Utility of a Systolic Blood Pressure Polygenic Risk Score With Chlorthalidone Response. (Pubmed Central) - Dec 11, 2024
SBP PRS may also identify individuals with HTN harboring a higher risk of treatment-resistant HTN. Overall, SBP PRS demonstrates potential to identify those who may have greater benefit from chlorthalidone, but future research is needed to determine if PRS can inform initiation and choice of treatment among individuals with HTN.
- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Journal: Has APOL1 kidney disease treatment been hiding in plain sight? (Pubmed Central) - Nov 23, 2024
By contrast, hydralazine and dapagliflozin had no effect. This study highlights the potential therapeutic utility of angiotensin-converting enzyme inhibitor in apolipoprotein L1 kidney disease.
- |||||||||| loratadine / Generic mfg., lisinopril / Generic mfg.
Recurrent Exertional Rhabdomyolysis () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5336;
There is a strong and significant risk association between HLA-B*35:01 and DILI due to Anti-HTN, in particular a-methyldopa DILI. No family history.Meds: lisinopril 2.5mg, loratadine 10mg, omeprozole 20mg dailyAM labs after the morning run:UA: dark brown color, protein 100mg/dL, Heme >1.0 mg/dL, RBC <1/hpf.Renal panel: Na 135, K 4.2, Cr 1.0.Myoglobin-Urine 3574 H Ng/Ml (ref 0 - 13)Myoglobin-Serum 72 Ng/Ml (ref 28 - 72)CK 484 H U/L (ref 46
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, Nucala (mepolizumab) / GSK
A Is for Adult: Nonclassic Presentation of IgA Vasculitis () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5315;
Patient with history of T2DM, autoimmune hemolytic anemia, eosinophilic asthma on mepolizumab, and chronic sinusitis...She was started on high dose steroid taper and mycophenolate, alongside lisinopril and empagliflozin in the setting of her proteinuria...Biopsy of the dermis or kidney is indicated in unusual presentations or with concern for renal involvement. Pursuing a tissue biopsy to make the diagnosis of IgAV in adults is of notable consequence as adults are at increased risk of recurrent disease and IgAV-associated end stage kidney disease..
- |||||||||| Beyond the Bowel: A Case of Ulcerative Colitis-Associated Membranous Nephropathy () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5308;
Transition to Ustekinumab led to improved UC symptoms and reduced proteinuria...This case emphasizes the challenges in managing UC-related glomerulonephritis and highlights the importance of multidisciplinary care. Early recognition of extraintestinal manifestations is crucial for optimizing patient outcomes, warranting further studies for better therapeutic strategies..
- |||||||||| C3 Glomerulonephritis in Intravenous (IV) Drug Use () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5287;
A 30 year old male patient with past medical history of asthma, GERD, anxiety and IV fentanyl and cocaine use presented with complaints of intermittent fever, chills and dark urine since 3 months...Patient was started on vancomycin and cefepime while awaiting cultures...He was started on suboxone for opiate use disorder...The patient was started on lisinopril and offered immunosuppressive therapy but wanted to complete COVID19 vaccination first...This raises an important question of whether transient bacteremia or an inflammatory state brought on by IV drug use can induce C3 glomerulopathy.. . .
- |||||||||| Rituxan (rituximab) / Roche
NELL-1-Positive Membranous Nephropathy () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5269;
He was started on Eliquis...Patient's lisinopril was increased to highest tolerated dose, and vitamin supplements he was taking were stopped...Patient's proteinuria has decreased to 2.7 mg/mg after two sessions of rituximab, but he has not achieved remission yet.. . .
- |||||||||| lisinopril / Generic mfg., ibuprofen / Generic mfg.
A Patient with Minimal Change Disease with AKI () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5251;
Rapid progression into nephrotic syndrome and anuric AKI are uncommon in MCD. The patient had a history of using Ibuprofen daily for arthritis, which has been associated with MCD in rare cases, though there was no concurrent interstitial nephritis seen on kidney biopsy a common accompanying finding in NSAIDs-induced MCD ..
- |||||||||| chlorthalidone / Generic mfg., lisinopril / Generic mfg., spironolactone / Generic mfg.
A Rare Find of Glucocorticoid-Remediable Aldosteronism () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5219;
Since then, her BP has not been controlled on maximum doses of amlodipine, chlorthalidone, and lisinopril...She responded to low dose prednisone and spironolactone 50 mg twice a day...Pre-ACTHPost-ACTHIVCR Adrenal VeinL Adrenal VeinIVCR Adrenal VeinL Adrenal VeinAldosterone (ng/dL)114144155055279Cortisol (mcg/dL)1.754.310.5321.6320.7. .
- |||||||||| nifedipine immediate release / Generic mfg., lisinopril / Generic mfg., spironolactone / Generic mfg.
Amphotericin-Induced Apparent Mineralocorticoid Excess (AME) () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5188;
After review of all medications given in the Hospital, the only one with a clear temporal relation with the onset of hypertension was amphotericin B. This medication has a different mechanism of action than azoles, and to our knowledge, this is the first case report of amphotericin-induced apparent mineralocorticoid excess syndrome. Hypokalemia is a known side effect of hypokalemia secondary to amphotericin B, which is known to be secondary to tubular toxicity causing concentration gradients between the cytoplasm of distal tubule cells and the tubular lumen.This case can potentially explain a different mechanism of hypokalemia..
- |||||||||| sodium valproate / Generic mfg.
Chronic Hypokalemia Secondary to Distal Renal Tubular Acidosis Induced by Sodium Valproate () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5164;
This case emphasizes the importance of recognizing valproate-induced distal renal tubular acidosis as a rare but potentially serious complication of long-term valproic acid therapy. Prompt diagnosis and appropriate management are vital for the patient's well-being..
- |||||||||| lisinopril / Generic mfg.
Journal: An Unusual Complication of Lisinopril: A Report of Iatrogenic Henoch-Sch (Pubmed Central) - Oct 1, 2024
After excluding infectious, autoimmune, and neoplastic pathologies, the possibility of HSP associated with taking lisinopril, which had been recently initiated after hospitalization for acute heart failure, was assumed. Angiotensin-converting enzyme (ACE) inhibitor suspension and treatment with systemic corticosteroids lead to significant clinical regression, supporting our suspicion.
- |||||||||| lisinopril / Generic mfg.
Journal: The Impact of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Metabolic Rate in Drosophila melanogaster. (Pubmed Central) - Sep 29, 2024
Finally, we showed that knocking down Ance, the ortholog of mammalian ACE in Malpighian/renal tubules and the nervous system, leads to opposite changes in metabolic rate, and that the effect of lisinopril depends on Ance in these systems, but in a sex- and age-specific manner. In conclusion, our results regarding D. melanogaster support existing evidence of a connection between ACEI drugs and metabolic rate while offering new insights into this relationship.
- |||||||||| famotidine / Generic mfg., diphenhydramine / Generic mfg., lisinopril / Generic mfg.
A CASE OF POST-SURGICAL PERIORBITAL EDEMA MASQUERADING AS ANGIOEDEMA (Monitor 6; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1178;
In this case, subgaleal lipoma excision in a patient receiving an ACE-inhibitor was complicated by a forehead hematoma and galeal tract bleeding, which clinically mimicked bradykinin-mediated angioedema. While prompt recognition and management of angioedema is crucial, it is important to recognize the broader differential for acute periorbital swelling which can include post-surgical hematoma following forehead and eyelid surgeries.
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