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- | Saphris (asenapine) / Lundbeck, Meiji Seika, AbbVie
Retrospective data, Journal: Lurasidone compared to other atypical antipsychotic monotherapies for adolescent schizophrenia: a systematic literature review and network meta-analysis. (Pubmed Central) - Oct 16, 2020
Rates of EPS and akathisia were similar for lurasidone and other atypical antipsychotics. In this network meta-analysis of atypical antipsychotics in adolescent schizophrenia, lurasidone was associated with similar efficacy, less weight gain, and lower risk of all-cause discontinuation compared to other oral atypical antipsychotics.
- [VIRTUAL] The Comparative Pharmacoeconomic Analysis of Using Tetrabenazine for Patients with Huntington's Disease in Russia () - Oct 3, 2020 - Abstract #ISPOREU2020ISPOR-EU_359;
Analysis of the published clinical trials was conducted to evaluate comparative efficacy and safety of using different types of drugs for the treatment of chorea in HD used in Russia – tetrabenazine and neuroleptics (tiapride, olanzapine, risperidone, aripiprazole, ziprasidone and quetiapine). Using tetrabenazine for treating chorea in patients with HD was effective and economically justified treatment option in Russia.
- | Reimbursement, Journal: PERSPECTIVES: Insurance markets, labor markets, and the mental health services delivery system. (Pubmed Central) - Jun 8, 2020
This work demonstrated, using a price adjustment process, that there is no viable price that would make aripiprazole cost-effective for incorporation in the Brazilian public health system in the first-line of treatment of schizophrenia. The drug can be useful in specific cases, since individual variability of response to antipsychotic drugs is important.
- || ziprasidone / Generic mfg.
Clinical, PK/PD data, Journal: Physiologically-based pharmacokinetics of ziprasidone in pregnant women. (Pubmed Central) - May 15, 2020
The drug can be useful in specific cases, since individual variability of response to antipsychotic drugs is important. The PBPK model predicted the impact of physiological changes during pregnancy on PK and exposure of ziprasidone, suggesting that dose adjustment is not necessary in this special population.
- Akathisia and Atypical antipsychotics: Exploring Associations to Suicidality and Agitation (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_453;
Conclusion Akathisia is still a prevalent phenomenon in a substantial proportion of patients treated with atypical antipsychotics. Special attention is called for regarding the association towards suicidality.
- | Clinical, PK/PD data, Review, Journal: Clinical Pharmacokinetics of Atypical Antipsychotics: An Update. (Pubmed Central) - Nov 2, 2019
This review concentrates on the clinical pharmacokinetic data related to clozapine, risperidone, paliperidone, olanzapine, quetiapine, amisulpride, ziprasidone, aripiprazole, sertindole, asenapine, iloperidone, lurasidone, brexpiprazole and cariprazine and briefly considers the main aspects of their pharmacodynamics. Optimal plasma concentration ranges are proposed for clozapine, risperidone, paliperidone and olanzapine because the studies of quetiapine, amisulpride, asenapine, iloperidone and lurasidone provide only limited information and there is no direct evidence concerning ziprasidone, aripiprazole, sertindole, brexpiprazole and cariprazine: the few reported investigations need to be confirmed and extended.
- | lurasidone / Generic mfg., ziprasidone / Generic mfg.
Retrospective data, Review, Journal: Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. (Pubmed Central) - Oct 24, 2019
These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. They should consider the importance of each outcome, the patients' medical problems, and preferences.
- | Geodon (ziprasidone) / RaQualia, Meiji Seika, Pfizer
Journal: Ziprasidone-loaded arabic gum modified montmorillonite-tailor-made pectin based gastroretentive composites. (Pubmed Central) - Jul 13, 2019
The SEM studies revealed the spherical morphology of the composites. Thus, the newly developed DGP-AG-MMT composites are appropriate for gastroretentive ZIP delivery over an extended period of time.
- | Latuda (lurasidone oral) / Sumitomo Dainippon, Geodon (ziprasidone) / RaQualia, Meiji Seika, Pfizer
Retrospective data, Review, Journal: Lurasidone compared to other atypical antipsychotic monotherapies for bipolar depression: A systematic review and network meta-analysis. (Pubmed Central) - Apr 28, 2019
Thus, the newly developed DGP-AG-MMT composites are appropriate for gastroretentive ZIP delivery over an extended period of time. In this network meta-analysis, lurasidone was found to be more efficacious than aripiprazole and ziprasidone, and was associated with less weight gain than quetiapine and olanzapine and less somnolence than quetiapine and ziprasidone.