omega-3 ethylester concentrate / Generic mfg. 
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  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Preferential retention of algal carbon in benthic invertebrates: Stable isotope and fatty acid evidence from an outdoor flume experiment. (Pubmed Central) -  Jul 3, 2020   
    By contrast, the n-3 PUFA content of Ecdyonurus decreased as a consequence of declining algal supply.Results from compound-specific stable isotope analysis provided evidence that the long-chain n-3 PUFA eicosapentaenoic acid (EPA) in both consumers was more enriched in C than the short-chain n-3 PUFA α-linolenic acid, suggesting that EPA was taken up directly from algae and not from heterotrophic biofilms on leaf litter. Both consumers depended on algae as their carbon and EPA source and retained their EPA from high-quality algae.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Effects of a n-3 PUFA enriched diet on embryo production in dairy cows. (Pubmed Central) -  Jul 2, 2020   
    In conclusion, n-3 PUFA supplementation enhanced oocyte quality and modified their lipid composition. Further studies are necessary to investigate the potential link of these lipid modifications with enhanced oocyte quality.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation. (Pubmed Central) -  Jul 2, 2020   
    Interestingly, n-3PUFA increased the infiltration of CD4 and CD8 T cells but did not alter the erythemal response, either the sunburn threshold or the resolution of erythema, as assessed by spectrophotometric hemoglobin index readings. As EPA and DHA differentially impact cutaneous inflammation through changes in the network of epidermal lipids and dendritic and infiltrating immune cells, they should be considered separately when designing interventions for cutaneous disease.-Kendall, A. C., Pilkington, S. M., Murphy, S. A., Del Carratore, F., Sunarwidhi, A. L., Kiezel-Tsugunova, M., Urquhart, P., Watson, R. E. B., Breitling, R., Rhodes, L. E., Nicolaou, A. Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Trial completion:  Specified Drug-use Survey of the Granular Capsule Formulation of Omega-3 Fatty Acid Ethyl Esters: OCEAN3 (clinicaltrials.gov) -  Jul 1, 2020   
    P=N/A,  N=15330, Completed, 
    As EPA and DHA differentially impact cutaneous inflammation through changes in the network of epidermal lipids and dendritic and infiltrating immune cells, they should be considered separately when designing interventions for cutaneous disease.-Kendall, A. C., Pilkington, S. M., Murphy, S. A., Del Carratore, F., Sunarwidhi, A. L., Kiezel-Tsugunova, M., Urquhart, P., Watson, R. E. B., Breitling, R., Rhodes, L. E., Nicolaou, A. Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation. Active, not recruiting --> Completed
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Concurrent EPA and DHA Supplementation Impairs Brown Adipogenesis of C2C12 Cells. (Pubmed Central) -  Jul 1, 2020   
    Maternal dietary supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is considered to play positive roles in fetal neuro system development...Genomic and proteomic changes were accompanied by mitochondrial dysfunction, represented by significantly reduced oxygen consumption rate, ATP production, and proton leak (P < 0.05). This study suggested that EPA and DHA may alter the BAT fate of myoblasts by inhibiting mitochondrial biogenesis and activity and induce white-like adipogenesis, shifting the metabolism from lipid oxidation to synthesis.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Preclinical, Journal:  Generation of Fad2 and Fad3 transgenic mice that produce n-6 and n-3 polyunsaturated fatty acids. (Pubmed Central) -  Jun 28, 2020   
    However, the majority of mammals, including humans, are incapable of synthesizing n-6 and n-3 PUFAs...Compared with wild-type mice, these Fad transgenic mice have their own n-3 and n-6 PUFAs biosynthetic pathways. Thus, we have established a simple and efficient method for in vivo synthesis of PUFAs.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Effect of Dietary n-3 Source on Rabbit Male Reproduction. (Pubmed Central) -  Jun 28, 2020   
    However, such an increased amount of PUFA negatively affected the sperm oxidative status, which was mainly correlated with the generation of F-NeuroPs with respect to F-IsoPs. Accordingly, the latter cannot be considered a good marker of oxidation when diets rich in n-3 PUFA are provided.
  • ||||||||||  gemfibrozil / Generic mfg., omega-3 ethylester concentrate / Generic mfg.
    [VIRTUAL] Management of Severe Gestational Hypertriglyceridemia () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_760;    
    Due to the rarity of this condition, there is limited data on the safety of treatments for hypertriglyceridemia in pregnant women. This case demonstrates the use of gemfibrizol is appropriate when the hypertriglyceridemia threatens the health of the mother and baby.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Preclinical, Journal:  The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach. (Pubmed Central) -  Jun 11, 2020   
    HHTg animals exhibited qualitative changes in NEFA fatty acid composition, represented by an increased proportion of saturated fatty acids (P < 0.05) and a decreased proportion of n-3 PUFA (P < 0.01)...Our results confirm dyslipidemia and ectopic lipid accumulation to be key contributors in the development of metabolic syndrome-associated renal dysfunction. Assessing urinary secretion of proinflammatory cytokines and epidermal growth factor can help in detecting early development of metabolic syndrome-associated renal dysfunction.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Preclinical, Journal:  In vitro lipolysis and lymphatic absorption of n-3 long-chain polyunsaturated fatty acids in the rat: influence of the molecular lipid species as carrier. (Pubmed Central) -  Jun 10, 2020   
    Assessing urinary secretion of proinflammatory cytokines and epidermal growth factor can help in detecting early development of metabolic syndrome-associated renal dysfunction. 2,7-dichlorofluorescein (2,7-DCF), 2-monoglycerides (2-MG), alpha-linolenic acid (ALA), chylomicrons (CM), docosahexaenoic acid (DHA), ethyl esters (EE), eicosapentaenoic acid (EPA), fatty acids (FA), fatty acid methyl esters (FAME), free fatty acids (FFA), heptadecanoic acid (FFA 17:0), flame ionization detector (FID), glycerol-3-phosphate (G3P), gas chromatography (GC), lysophospholipids (lysoPL), monounsaturated fatty acids (MUFA), n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), n-3 polyunsaturated fatty acids (n-3 PUFA), n-6 polyunsaturated fatty acids (n-6 PUFA), nuclear magnetic resonance (NMR), 1,2-diheptadecanoyl-sn-glycero-3-phosphatidylcholine (PC 17:0), phospholipase A2 (PLA2), phospholipids (PL), polyunsaturated fatty acids (PUFA), red blood cells (RBS), saturated fatty acids (SFA), triglycerides (TG), 1,2,3-triheptadecanoyl-sn-glycerol (TG 17:0), thin layer chromatography (TLC).
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Prenatal Oxidative Balance and Risk of Asthma and Allergic Disease in Adolescence. (Pubmed Central) -  Jun 10, 2020   
    Trial registration: ClinicalTrials.gov NCT01367145. We identified potential protective prenatal nutrients (Vitamin D, n-3 PUFAs), as well as adverse prenatal pro-oxidant exposures that may alter risk of asthma and allergic disease into adolescence.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Clinical, Journal:  Impact of aerobic exercise and fatty acid supplementation on global and gene-specific DNA methylation. (Pubmed Central) -  Jun 8, 2020   
    In conclusion, we demonstrate that acute exercise and dietary supplementation of n-3 PUFAs and EVOO induce DNA methylation changes in leukocytes, potentially via the modulation of DNMT mRNA expression. Future studies are required to further elucidate the impact of lifestyle interventions on DNA methylation.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Season and Cooking May Alter Fatty Acids Profile of Polar Lipids from Blue-Back Fish. (Pubmed Central) -  Jun 4, 2020   
    The four species analyzed in this study presented very low n-6/n-3 fatty acid ratios and highly favorable nutritional indices, emphasizing their PoL qualities and promoting their role in increasing human n-3 PUFA intake. The four species can be considered as superior sources of n-3 PUFA and can be employed as supplements in functional food manufacturing and in pharmaceutical and cosmetic industries.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Interlaboratory Assessment of Dried Blood Spot Fatty Acid Compositions. (Pubmed Central) -  Jun 4, 2020   
    By standardized reporting, no outliers were identified for EPA or docosahexaenoic acid (DHA, 22:6n-3), and %CV decreased from 8.6% to 6.0% and 9.1% to 6.6% for EPA and 10.5% to 7.2% and 10.5% to 6.6% for DHA in the low and high n-3 PUFA sample, respectively. In conclusion, fatty acid profiles yielded few outliers, and standardization of reporting reduced the variability between laboratories.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Preclinical, Journal:  Effects of Dietary Fat Profile on Gut Microbiota in Valproate Animal Model of Autism. (Pubmed Central) -  Jun 3, 2020   
    Polyunsaturated fatty acids (PUFAs) and n-3 fatty acids (n-3 PUFA) are structurally and functionally crucial components for the brain, and the state of n-3 PUFAs also affects the gut microbiota...In conclusion, n-3/n6 PUFAs (1:5) diet supplementation may alter gut microbiota composition in VPA-exposed rats. This study put forward a new strategy for the intervention and treatment of autism by n-3/n-6 PUFAs ratio supplementation intakes.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Journal:  Feeding to Produce n-3 Fatty Acid-enriched Table Eggs. (Pubmed Central) -  May 29, 2020   
    Significant differences were observed in the content of ALA, DHA, ∑n-3 PUFA (mg/100 g) and the n-6/n-3 PUFA ratio between the C and E1/E2 egg groups (P<0.001). The results of the study indicate that it is sufficient to use a lower level of fish oil and the microalgae Schizochytrium limacinum in hens' feed to achieve a satisfactory increase in n-3 PUFA in eggs, while maintaining optimal values of egg quality and freshness indicators.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Clinical, Journal:  Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis. (Pubmed Central) -  May 28, 2020   
    The results of the study indicate that it is sufficient to use a lower level of fish oil and the microalgae Schizochytrium limacinum in hens' feed to achieve a satisfactory increase in n-3 PUFA in eggs, while maintaining optimal values of egg quality and freshness indicators. The observed complex alterations in the FA signatures could have both contributed to but also limited the inflammatory processes and cartilage destruction in the RA and OA knees.
  • ||||||||||  omega-3 ethylester concentrate / Generic mfg.
    Preclinical, Journal:  Dietary n-6 and n-3 PUFA alter the free oxylipin profile differently in male and female rat hearts. (Pubmed Central) -  May 28, 2020   
    Overall, heart oxylipins were higher in female rats, but this depended on dietary treatment: the female oxylipin:male oxylipin ratio was higher in rats provided the ALA compared with the DHA diet, with other diet groups having ratios in between. In conclusion, individual PUFA and sex have unique and interactive effects on the rat heart free oxylipin profile.