- |||||||||| Xarelto (rivaroxaban) / Bayer, J&J, Plavix (clopidogrel) / BMS, Sanofi
Retrospective data, Journal: Effect and safety of antithrombotic therapies for secondary prevention after acute coronary syndrome: a network meta-analysis. (Pubmed Central) - Mar 28, 2019 Treatment with aspirin + new P2Y12 inhibitors reduced all-cause deaths (OR: 0.91, 95% credibility interval: 0.84-0.98) and cardiac death risk (OR: 0.86, 95% credibility interval: 0.79-0.93). We concluded the following from our study: 1) an aspirin + new P2Y12 inhibitor/ clopidogrel conversion treatment strategy was not inferior to aspirin + new P2Y12 inhibitor; 2) compared with aspirin + clopidogrel, the conversion strategy may further reduce the risk of myocardial infarction without increasing the risk of bleeding; and 3) compared with aspirin + clopidogrel, treatment with aspirin + new P2Y12 inhibitors may result in reduced risk of death.
- |||||||||| enoxaparin sodium / generics
Clinical, Journal: Extended Venous Thromboembolism Prophylaxis in Medically Ill Patients. (Pubmed Central) - Mar 25, 2019 A recent trial of a new direct factor Xa inhibitor, betrixaban, demonstrated a reduction in VTE events with extended prophylaxis, without significantly increasing the risk of major bleeding. Understanding appropriate patient selection, dosing, and outcomes associated with betrixaban will be important to potentially reducing the continued risk of VTE in patients with acute medical illness.
- |||||||||| Xarelto (rivaroxaban) / Bayer, J&J, Pradaxa (dabigatran etexilate) / Boehringer Ingelheim, Eliquis (apixaban) / BMS
Clinical, Journal: Comparison of different oral anticoagulant regimens in patients with atrial fibrillation undergoing ablation or cardioversion. (Pubmed Central) - Mar 23, 2019 In logistic regression analysis neither oral anticoagulation regimen predicted LAA thrombus in TOE whereas maximal LAA emptying velocity was the only parameter independently associated with the presence of thrombus. CONCLUSIONS In the studied group, the choice of anticoagulation didn't depend on patients' thromboembolic or bleeding risk.
- |||||||||| Xarelto (rivaroxaban) / Bayer, J&J
PK/PD data, Journal: Effects of Verapamil and Diltiazem on the Pharmacokinetics and Pharmacodynamics of Rivaroxaban. (Pubmed Central) - Mar 22, 2019 The slope of prothrombin time vs. rivaroxaban plasma concentration in rats was retrospectively found to be insensitive by about 5.4-fold compared to than in humans. More than a 67% dose reduction in rivaroxaban is suggested in terms of both a pharmacokinetic point of view, and the sensitivity differences on the prolongation of prothrombin time when used concomitantly with verapamil.
- |||||||||| rivaroxaban / Generic mfg., warfarin / Generic mfg., apixaban / Generic mfg.
Enrollment closed, Adverse events: SiERRA UK: Study to Learn More About the Benefits and Side-effects of Drugs Rivaroxaban and Apixaban Compared to the Drug Warfarin for Stroke Prevention in Patients With Rapid and Irregular Heartbeat Which is Not Due to a Heart-valve Fault (Non-valvular Atrial Fibrillation) in the UK Routine Clinical Practice (clinicaltrials.gov) - Mar 20, 2019 P=N/A, N=40000, Active, not recruiting, More than a 67% dose reduction in rivaroxaban is suggested in terms of both a pharmacokinetic point of view, and the sensitivity differences on the prolongation of prothrombin time when used concomitantly with verapamil. Not yet recruiting --> Active, not recruiting
- |||||||||| rivaroxaban / Generic mfg.
Clinical, Journal: Rivaroxaban in Patients with Heart Failure. Reply. (Pubmed Central) - Mar 18, 2019 The general consistency between this real-world study and those from phase III randomized trial data of rivaroxaban should provide additional reassurance to clinicians regarding the use of rivaroxaban in NVAF patients with HF. No abstract available
- |||||||||| rivaroxaban / Generic mfg., warfarin / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date, Surgery: Rivaroxaban vs. Warfarin for Post Cardiac Surgery Atrial Fibrillation (clinicaltrials.gov) - Mar 11, 2019 P3, N=200, Not yet recruiting, Trial completion date: Oct 2019 --> Oct 2020 | Trial primary completion date: Oct 2019 --> Oct 2020 Trial completion date: Jan 2022 --> May 2022 | Initiation date: Nov 2018 --> Apr 2019 | Trial primary completion date: Nov 2021 --> Apr 2022
- |||||||||| rivaroxaban / Generic mfg.
Clinical, Clinical Trial,Phase I, Clinical Trial,Phase II, Clinical Trial,Phase III, Journal: Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer. (Pubmed Central) - Mar 2, 2019 P3 During the intervention period, rivaroxaban led to a substantially lower incidence of such events, with a low incidence of major bleeding. (Funded by Janssen and others; CASSINI ClinicalTrials.gov number, NCT02555878.).
- |||||||||| rivaroxaban / Generic mfg., apixaban / Generic mfg.
Trial completion date, Trial primary completion date, Monotherapy: MATHVTE: Monotherapy Anticoagulation To Expedite Home Treatment of Venous Thromboembolism (clinicaltrials.gov) - Feb 26, 2019 P=N/A, N=850, Recruiting, (Funded by Janssen and others; CASSINI ClinicalTrials.gov number, NCT02555878.). Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Dec 2020
- |||||||||| rivaroxaban / Generic mfg., dabigatran etexilate / Generic mfg., apixaban / Generic mfg.
Retrospective data, Journal, HEOR, Real-world evidence: Meta-analysis of real-world evidence comparing non-vitamin K antagonist oral anticoagulants with vitamin K antagonists for the treatment of patients with non-valvular atrial fibrillation. (Pubmed Central) - Feb 19, 2019 Apixaban was associated with a lower risk of ICH than VKAs (HR = 0.41, 95% CI = 0.28-0.60), but was not different to VKAs in terms of IS (HR = 1.01, 95% CI = 0.87-1.17) or non-persistence (HR = 1.08, 95% CI = 0.81-1.45). NOACs appear to be at least as effective and safe as VKAs for stroke prevention in patients with NVAF.
- |||||||||| rivaroxaban / Generic mfg.
Trial completion, Enrollment change: The Effect of Rivaroxaban in Sickle Cell Disease (clinicaltrials.gov) - Feb 11, 2019 P2, N=14, Completed, Trial completion date: Jan 2022 --> Oct 2020 | Trial primary completion date: Jan 2022 --> Oct 2020 Enrolling by invitation --> Completed | N=34 --> 14
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