Xarelto (rivaroxaban) / J&J 
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  • ||||||||||  Journal:  What Surgeons Should Know About Non-Vitamin K Oral Anticoagulants: A Review. (Pubmed Central) -  Sep 28, 2019   
    A good understanding of these agents' pharmacologic properties is important for surgeons given their marked differences compared with warfarin sodium...A number of uncertainties remain surrounding the use of these agents in the perioperative setting. Ongoing prospective studies and randomized clinical trials will provide greater clarity on these management issues in the near future.
  • ||||||||||  Clinical, Journal:  Perioperative management of trauma surgery patients treated with direct oral anticoagulants (Pubmed Central) -  Sep 27, 2019   
    The perioperative management of these patients who are treated with DOACs is a challenge in the clinical routine and needs special consideration. This article discusses these issues in an interdisciplinary approach and develops strategies for the perioperative management of patients treated with DOACs and undergoing trauma or orthopedic surgery.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    Journal:  Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease. (Pubmed Central) -  Sep 27, 2019   
    P4
    As antithrombotic therapy, rivaroxaban monotherapy was noninferior to combination therapy for efficacy and superior for safety in patients with atrial fibrillation and stable coronary artery disease. (Funded by the Japan Cardiovascular Research Foundation; AFIRE UMIN Clinical Trials Registry number, UMIN000016612; and ClinicalTrials.gov number, NCT02642419.).
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    Massive hemorrhagic choroidal detachment in a patient treated with rivaroxaban () -  Sep 26, 2019 - Abstract #EURETINA2019EURETINA_997;    
    The history is notable for atrial fibrillation treated with rivaroxaban, digoxin and bisoprolol, as well as type-2 diabetes mellitus, hypertension and dyslipidemia...Conservative treatment with oral prednisone was prescribed at 1 mg/kg as well as topical anti-inflammatory treatment, prophylactic antibiotics and a mydriatic... Despite the advantages of new oral anticoagulants on controlling thrombotic events and their decreased risk of major bleeding, we must always keep them in mind even in surgeries with a low rate of hemorrhage such as ophthalmological surgery; even more so since there are currently no specific antidotes for all of these anticoagulants and we cannot always discontinue them in time, as in cases of emergency surgery.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J, Pradaxa (dabigatran etexilate) / Boehringer Ingelheim, Eliquis (apixaban) / BMS
    Journal:  Direct oral anticoagulant use and subsequent start of proton pump inhibitors as proxy for gastric complaints. (Pubmed Central) -  Sep 26, 2019   
    A time-dependent definition of exposure using dispensation data would lead to greater misclassification of warfarin than DOACs use. Proton pump inhibitor initiation occurred frequently in incident DOAC users but more often in patients treated with dabigatran than in those treated with rivaroxaban or apixaban.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    IT'S BURNING UP IN HERE (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_3498;    
    Cholinergic agonists are an important class of medications for patients with a variety of medical conditions including Sjogren's disease and glaucoma, that if accidentally withheld, can have dire consequences.Case Presentation:An 83 year-old female with a history significant for Sjogren's disease on pilocarpine, atrial fibrillation on Rivaroxaban, and recent small bowel obstruction presented to the hospital with abdominal pain and hypoxemia...Pilocarpine is a muscarinic agent chronically used, for example, as a sialagogue in Sjogren's. In the right clinical context, clinicians should maintain a high index of suspicion for pilocarpine withdrawal as it may lead to impaired thermoregulation, elevated body temperature, and death.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    MANAGEMENT OF INCIDENTAL INTRAMURAL AORTIC THROMBUS IN THE SETTING OF HEPARIN-INDUCED THROMBOCYTOPENIA (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_3424;    
    It is important to recognize that thrombi from HIT can form in the arterial circulation, and a clinical suspicion for HIT must be present when investigating the origin of a new thrombus. Currently, there are no clear guidelines on the management of AMT in HIT and further investigation is needed.
  • ||||||||||  medroxyprogesterone injection / generics
    TO CLOT OR NOT TO CLOT (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_2814;    
    She was started on rivaroxaban and discharged to home with close follow up.The patient re-presented 9 days later with similar symptoms. Patient comorbidities, and preferences, must be taken into account for proper management of the potentially deadly pulmonary manifestations of systemic autoimmune disorders.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    PUT ON YOUR THINKING CAPS: PULMONARY HYPERTENSION IN ANTIPHOSPHOLIPID SYNDROME (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 3) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_2773;    
    Patient comorbidities, and preferences, must be taken into account for proper management of the potentially deadly pulmonary manifestations of systemic autoimmune disorders. We present a patient with CAPS, progressive PH, and right heart failure who responded to combined treatment of PH and CAPS.Case Presentation:A 56 year-old woman with a past medical history of systemic lupus erythematosus, pulmonary fibrosis, PH, peripheral vascular disease, and prior pulmonary embolism (PE) on rivaroxaban presented with shortness of breath and hypoxemic respiratory failure requiring intubation...Our case report suggests that PH may be an important feature in the presentation of CAPS and future work should focus on the mechanisms surrounding this observation and early treatment might result in better outcomes.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J, aspirin / Generic Mfg.
    PATENT FORAMEN OVALE PREVENTING PROGRESSION OF SUBMASSIVE PULMONARY EMBOLISM (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 1) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_1948;    
    Lower extremity ultrasound showed bilateral deep vein thromboses.She was started on intravenous heparin infusion and given sublingual nitroglycerin, aspirin, and furosemide...She transitioned to oral Rivaroxaban, with Clopidogrel and Aspirin...The PFO functioned as a pressure release valve, serving as a lifesaving mechanism for the submassive PE, preventing progression to massive PE. Closing the PFO immediately would have caused increased RV pressures with right heart failure.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    PULMONARY TUMOR THROMBOTIC MICROANGIOPATHY: A RARE CAUSE OF PULMONARY HYPERTENSION (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_1926;    
    Closing the PFO immediately would have caused increased RV pressures with right heart failure. During this time, he was also continued on rivaroxaban for anticoagulation...In patients where the severity of pulmonary hypertension is otherwise not explained by the severity of heart or lung disease, PH due to pulmonary artery obstruction needs to be considered in the differential diagnosis.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    COCAINE-INDUCED THROMBOTIC STORM (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_1920;    
    He was continued on heparin for 10 days before being switched to Xarelto...Although recent studies have focused on increased incidence and prevalence of venous thrombosis in setting of cocaine abuse, ours is the first case of documented pulmonary embolism caused by cocaine related venous thrombosis. Further studies are needed to identify patients at higher risk for this complication like rare thrombotic disorders
  • ||||||||||  enoxaparin sodium / generics
    CLOMIPHENE-INDUCED PULMONARY EMBOLISM IN A YOUNG ADULT MALE (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_1897;    
    The patient was started on treatment dose Enoxaparin and transitioned to Rivaroxaban before discharge. Young adult males with no prior medical history or risk factors for hypercoagulability may still be at risk for pulmonary embolism after a short course of Clomiphene.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    RIGHT VENTRICULAR THROMBUS (RVT) AIDING IN DIAGNOSIS OF ADENOCARCINOMA (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 1) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_1793;    
    Young adult males with no prior medical history or risk factors for hypercoagulability may still be at risk for pulmonary embolism after a short course of Clomiphene. Through our case we would like to highlight the association of VTE with occult malignancy and work up of Right Ventricle (RV) mass.Case Presentation:56-year-old male with medical history of Unprovoked Deep Vein Thrombosis (DVT) and Pulmonary embolism (PE) on Rivaroxaban, 60 pack year smoking history presented with 2 weeks of chest pain, shortness of breath and orthopnea.On examination he was tachycardic and was saturating 96% on 2L nasal cannula...Unprovoked thrombosis should always raise a suspicion for malignancy and RV masses are better visualized by CMR.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J, aspirin / Generic Mfg.
    SUCCESSFUL TRANSCATHETER AORTIC VALVE REPLACEMENT IN A PATIENT WITH A COMMON CORONARY OSTIUM (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_1345;    
    This case demonstrates the need for angiography in establishing a diagnosis and treatment course. Special care should be taken when evaluating young individuals and athletes with chest pain resembling angina, since sudden death can occur with an anomalous origin of coronary arteries.
  • ||||||||||  Xarelto (rivaroxaban) / Bayer, J&J
    Journal:  Rivaroxaban: A New Treatment Paradigm in the Setting of Vascular Protection? (Pubmed Central) -  Sep 20, 2019   
    Evidence from Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis In Myocardial Infarction-51 (ATLAS-ACS 2-TIMI 51) supports the use of the direct, oral, factor Xa inhibitor rivaroxaban (2.5 mg twice-daily [bid] and 5 mg bid) in reducing mortality and morbidity in patients with acute coronary syndrome, when combined with antiplatelets. Here, we review the role of rivaroxaban in three clinical trials of CAD and/or PAD: Cardiovascular OutcoMes for People using Anticoagulation StrategieS (COMPASS), Vascular Outcomes studY of ASA alonG with rivaroxaban in Endovascular or surgical limb Revascularization for PAD (VOYAGER PAD) and Cardiovascular Outcome Modification, Measurement AND Evaluation of Rivaroxaban in patients with Heart Failure (COMMANDER HF).