- |||||||||| Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
Enrollment closed, Monotherapy, PD(L)-1 Biomarker: Study of Nivolumab (BMS-936558) in Combination With Gemcitabine/Cisplatin, Pemetrexed/Cisplatin, Carboplatin/Paclitaxel, Bevacizumab Maintenance, Erlotinib, Ipilimumab or as Monotherapy in Subjects With Stage IIIB/IV Non-small Cell Lung Cancer (NSCLC) (CheckMate 012) (clinicaltrials.gov) - Aug 20, 2015 P1, N=412, Active, not recruiting, Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- |||||||||| epacadostat (INCB024360) / Incyte
Trial primary completion date, Combination therapy, Metastases: A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma (clinicaltrials.gov) - Aug 13, 2015 P1/2, N=136, Active, not recruiting, Active, not recruiting --> Recruiting Trial primary completion date: Oct 2014 --> Feb 2016
- |||||||||| Yervoy (ipilimumab) / BMS
Trial primary completion date, Metastases: Ipilimumab + Temozolomide in Metastatic Melanoma (clinicaltrials.gov) - Aug 13, 2015 P2, N=64, Active, not recruiting, Trial primary completion date: Oct 2014 --> Feb 2016 Trial primary completion date: May 2016 --> May 2017
- |||||||||| Trial initiation date, Trial primary completion date: Adoptive Therapy Using Antigen-Specific CD4 T-Cells (clinicaltrials.gov) - Aug 13, 2015
P1, N=12, Not yet recruiting, Initiation date: Sep 2014 --> Oct 2013 Initiation date: Jul 2015 --> Nov 2015 | Trial primary completion date: Jul 2018 --> Nov 2018
- |||||||||| Yervoy (ipilimumab) / BMS
Enrollment closed, Metastases: Ipilimumab and Imatinib Mesylate in Advanced Cancer (clinicaltrials.gov) - Aug 11, 2015 P1, N=96, Active, not recruiting, Phase classification: P=N/A --> P1 Recruiting --> Active, not recruiting
- |||||||||| relatlimab (BMS-986016) / BMS, Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
New P2 trial, Checkpoint inhibition: Neoadjuvant and Adjuvant Checkpoint Blockade (clinicaltrials.gov) - Aug 10, 2015 P2, N=40, Not yet recruiting,
- |||||||||| lirilumab (BMS-986015) / Innate, BMS, Ono Pharma, Yervoy (ipilimumab) / BMS
Trial completion, Enrollment change, Trial primary completion date, Combination therapy, Metastases: Safety Study of BMS-986015 (Anti-KIR) in Combination With Ipilimumab in Subjects With Selected Advanced Tumor (clinicaltrials.gov) - Jul 22, 2015 P1, N=22, Completed, Not yet recruiting --> Recruiting Active, not recruiting --> Completed | N=125 --> 22 | Trial primary completion date: Mar 2016 --> Apr 2015
- |||||||||| Yervoy (ipilimumab) / Ono Pharma, BMS
Trial initiation date: YERVOY (clinicaltrials.gov) - Jul 20, 2015 P=N/A, N=158, Active, not recruiting, Active, not recruiting --> Completed | N=125 --> 22 | Trial primary completion date: Mar 2016 --> Apr 2015 Initiation date: Mar 2015 --> Jul 2015
- |||||||||| Proleukin (aldesleukin) / Merck (MSD), Novartis, Iovance Biotherap
Enrollment change, Trial termination, Trial primary completion date, Metastases: PROCLIVITY 02: HD IL-2 + Ipilimumab in Patients With Metastatic Melanoma (clinicaltrials.gov) - Jul 17, 2015 P4, N=29, Terminated, Suspended --> Recruiting N=100 --> 29 | Recruiting --> Terminated | Trial primary completion date: Jan 2018 --> Jul 2015; slow accrual & early closure
- |||||||||| Yervoy (ipilimumab) / BMS
Enrollment closed, Enrollment change, Trial primary completion date: Study of Ipilimumab in the Immune System (clinicaltrials.gov) - Jul 16, 2015 P=N/A, N=4, Active, not recruiting, N=100 --> 29 | Recruiting --> Terminated | Trial primary completion date: Jan 2018 --> Jul 2015; slow accrual & early closure Not yet recruiting --> Active, not recruiting | N=30 --> 4 | Trial primary completion date: Oct 2014 --> Oct 2015
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