- |||||||||| Proleukin (aldesleukin) / Merck (MSD), Novartis, Iovance Biotherap, Yervoy (ipilimumab) / BMS
Enrollment open, Enrollment change, Metastases: CD8+ Antigen-Specific T Cells, Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Melanoma (clinicaltrials.gov) - Sep 7, 2016 P2, N=30, Recruiting, Trial primary completion date: Sep 2017 --> May 2018 Active, not recruiting --> Recruiting | N=14 --> 30
- |||||||||| Trial primary completion date, PD(L)-1 Biomarker, IO biomarker: Sequential Combo Immuno and Target Therapy (SECOMBIT) Study (clinicaltrials.gov) - Sep 2, 2016
P2, N=230, Not yet recruiting, Active, not recruiting --> Recruiting | N=14 --> 30 Trial primary completion date: Dec 2020 --> Apr 2021
- |||||||||| Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
Biomarker, Enrollment closed, Checkpoint inhibition, PD(L)-1 Biomarker: STARVE-PC: Biomarker-Driven Therapy With Nivolumab and Ipilimumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Expressing AR-V7 (clinicaltrials.gov) - Sep 2, 2016 P2, N=15, Active, not recruiting, Trial primary completion date: Dec 2020 --> Apr 2021 Recruiting --> Active, not recruiting
- |||||||||| plozalizumab (TAK-202) / Takeda, Ojemda (tovorafenib) / Day One Biopharma, Entyvio (vedolizumab) / Takeda
Phase classification, Checkpoint inhibition: Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma (clinicaltrials.gov) - Aug 31, 2016 P1b, N=156, Recruiting, Recruiting --> Active, not recruiting Phase classification: P1 --> P1b
- |||||||||| Blincyto (blinatumomab) / Astellas, Amgen, Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
New P1 trial, Checkpoint inhibition, PD(L)-1 Biomarker, IO biomarker: NCI-2016-01300: Blinatumomab and Nivolumab With or Without Ipilimumab in Treating Patients With Poor-Risk Relapsed or Refractory CD19+ Precursor B-Lymphoblastic Leukemia (clinicaltrials.gov) - Aug 26, 2016 P1, N=30, Not yet recruiting,
- |||||||||| Proleukin (aldesleukin) / Merck (MSD), Novartis, Iovance Biotherap, Yervoy (ipilimumab) / BMS
Enrollment closed, Enrollment change, Metastases: CD8+ Antigen-Specific T Cells, Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Melanoma (clinicaltrials.gov) - Aug 22, 2016 P2, N=14, Active, not recruiting, Trial primary completion date: Jan 2020 --> Jul 2018 Recruiting --> Active, not recruiting | N=20 --> 14
- |||||||||| ViraferonPeg (peginterferon-?-2b) / Merck (MSD), Yervoy (ipilimumab) / BMS
Trial primary completion date: Yervoy With Sylatron Unresectable Stage 3 or 4 Melanoma (clinicaltrials.gov) - Aug 19, 2016 P1, N=31, Active, not recruiting, Recruiting --> Active, not recruiting | N=20 --> 14 Trial primary completion date: Nov 2016 --> Mar 2017
- |||||||||| Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
Enrollment open: RATIO: Rational Approach To Immuno-Oncology (clinicaltrials.gov) - Aug 19, 2016 P=N/A, N=100, Recruiting, N=242 --> 352 Not yet recruiting --> Recruiting
- |||||||||| Yervoy (ipilimumab) / BMS
Trial completion, Trial primary completion date, Metastases: Ipilimumab + Temozolomide in Metastatic Melanoma (clinicaltrials.gov) - Aug 17, 2016 P2, N=64, Completed, Not yet recruiting --> Recruiting Active, not recruiting --> Completed | Trial primary completion date: May 2017 --> Aug 2016
- |||||||||| Firmagon (degarelix) / Astellas, Ferring, Yervoy (ipilimumab) / BMS
Enrollment closed, Enrollment change, Metastases: Combining Ipilimumab, Degarelix, and Radical Prostatectomy in Men With Newly Diagnosed Metastatic Castration Sensitive Prostate Cancer or Ipilimumab and Degarelix in Men With Biochemically Recurrent Castration Sensitive Prostate Cancer After Radical Prostatectomy (clinicaltrials.gov) - Aug 11, 2016 P2, N=16, Active, not recruiting, Active, not recruiting --> Completed | Trial primary completion date: Jun 2015 --> Aug 2016 Recruiting --> Active, not recruiting | N=53 --> 16
- |||||||||| Trial initiation date, Trial primary completion date: Adoptive Therapy Using Antigen-Specific CD4 T-Cells (clinicaltrials.gov) - Aug 10, 2016
P1, N=12, Not yet recruiting, Trial primary completion date: Sep 2016 --> Mar 2017 Initiation date: May 2016 --> Dec 2016 | Trial primary completion date: May 2019 --> Dec 2019
- |||||||||| Yervoy (ipilimumab) / Ono Pharma, BMS
New trial, Adverse events: Yervoy Pregnancy Surveillance Study (clinicaltrials.gov) - Aug 3, 2016 P=N/A, N=10, Not yet recruiting,
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