| estradiol valerate / Generic mfg. |
NCT03620929: Estrogen in the Prevention of Adhesion Reformation |
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| Enrolling by invitation | 4 | 186 | RoW | Estradiol Valerate, dydrogesterone | Fu Xing Hospital, Capital Medical University | Asherman Syndrome | 08/18 | 12/22 | | |
ChiCTR1900022110: A randomized controlled clinical study for endometrial repair with estradiol gel after intrauterine adhesion separation |
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| Not yet recruiting | 4 | 60 | | Estradiol gel ;estradiol valerate | West China Second University Hospital; West China Second University Hospital, China population welfare foundation for women and children care fund | Intrauterine Adhesion | | | | |
ChiCTR2300073146: Comparison of menopausal hormone therapy with different routes: a multicenter, randomized, open, prospective controlled clinical study |
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| Completed | 4 | 257 | | ingested 2mg estradiol valerate daily and oral micronized progesterone 200mg daily for 14 days each month ;used the oestrogel 2.5g daily, and oral micronized progesterone 200mg daily for 14 days each month | Peking Union Medical College Hospital; Peking Union Medical College Hospital, National Key Research and Development Program | menopausal disease | | | | |
| Recruiting | 4 | 554 | Europe | Natural cycle, Estradiol Valerate, Artificial cycle, Micronized progesterone | Universitaire Ziekenhuizen KU Leuven, GZA Ziekenhuizen Campus Sint-Augustinus, Imelda Hospital, Bonheiden, Jessa Hospital | Embryo Transfer | 04/24 | 12/24 | | |
ChiCTR2200066611: A Multicenter, Randomized, Open-label, Paralle-controlled Clinical Trial of Efficacy and Safety of Weini'an (Nilestriol Tablets) in the Treatment of Menopause-related Symptoms in Postmenopausal Women |
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| Not yet recruiting | 4 | 218 | | Nilestriol Tablets (Weini'an) + Dydrogesterone Tablets (Duphaston) ;Estradiol Valerate Tablets (Progynova) + Dydrogesterone Tablets (Duphaston) | Peking Union Medical College Hospital ; Peking Union Medical College Hospital, Shanghai New Hualian Pharmaceutical Co., Ltd | Menopause-related symptoms | | | | |
NCT06181305: Endometrial Preparation in Frozen Embryo Transfer Cycles |
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| Recruiting | 4 | 210 | RoW | estradiol valerate and letrozole, letrozole 2,5 mg tablet | Rahem Fertility Center | IVF | 11/24 | 12/24 | | |
NCT02330757: HRT Versus MOS for Endometrial Preparation Prior to FET in Non PCOS Patients |
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| Recruiting | 4 | 150 | RoW | Estradiol valerate, Cycloprogynova (white tablets), Sequential Clomiphene citrate and Gonadotropin, Sequential Clomid and Menogon | Mansoura University | Infertility | 12/24 | 12/24 | | |
ChiCTR2400085422: Compared the clinical outcomes of natural cycle and hormone replacement cycle for endometrial preparation in frozen embryo transfer: a prospective randomized controlled trial of single center |
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| Recruiting | 4 | 926 | | estradiol valerate; no | The Third Affiliated Hospital of Sun Yat-sen University; The Third Affiliated Hospital of Sun Yat-sen University, no | Infertility | | | | |
| Terminated | 4 | 362 | Europe | Estradiol Valerate, Progynova, Micronized progesterone, Utrogestan | CRG UZ Brussel | Miscarriage, Frozen Embryo Transfer, Natural Cycle, Hormone Replacement Therapy Cycle, Preimplantation Genetic Screening, Euploid Embryos | 01/25 | 01/25 | | |
ChiCTR2400084571: The treatment of thin endometrial related infertility (spleen and kidney Yang deficiency) |
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| Not yet recruiting | 4 | 300 | | Menstrual regulation and pregnancy promotion pill, oral, 5g (50 pills), twice a day. Take it for 20 consecutive days from the 5th day of the menstrual cycle for 3 consecutive menstrual cycles.In the course of treatment, clinical pregnancy can be terminated in advance.; Estradiol valerate tablets: Patients with regular menstruation began to take estradiol valerate tablets on the 9th day of menstruation, 2mg/ day, and have been taking until 2 weeks after ovulation.After that, HCG test was performed to determine whether clinical pregnancy was confirmed. If the pregnancy test was positive, the treatment could be terminated in advance or followed the doctor's advice. If the pregnancy test was negative, the treatment could be entered into the next treatment cycle.And so on to complete 3 menstrual cycles of treatment.Dydrogesterone tablets: A dose of 20mg/ day of dydrogesterone tablets should be taken 24-36h after ovulation until 2 weeks after ovulation.1 course of treatment for 1 menstrual cycle, continuous treatment for 3 menstrual cycles.If clinical pregnancy is detected in the course of treatment, the treatment can be terminated in advance. | Peking University Third Hospital; Scientific Research Institute of Beijing Tongrentang Co., LTD, Scientific Research Institute of Beijing Tongrentang Co., LTD | Thin endometrium-related infertility (deficiency of spleen and kidney Yang) | | | | |
ChiCTR2400088811: A multicenter, randomized, double-blind, placebo-controlled, parallel-design phase III clinical study to evaluate the efficacy and safety of oral relugoli tablets in the treatment of heavy menstrual bleeding associated with uterine fibroids |
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| Not yet recruiting | 3 | 120 | | Relugolide tablets 40 mg+ estradiol valerate tablets 1 mg+ medroxyprogesterone acetate tablets 2 mg; Relugolide tablets 40 mg placebo + estradiol valerate tablets 1 mg placebo + medroxyprogesterone acetate tablets 2 mg placebo | Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Qilu Pharmaceutical Co., Ltd | Uterine fibroids related to the large amount of menstrual bleeding | | | | |
NCT04283435: Endometrial Effects of Sildenafil in Frozen-Thawed Cycles in Women With Thin Endometrium |
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| Not yet recruiting | 1 | 100 | RoW | Sildenafil Citrate, Placebo, Pregnacare vitamins (Vitabiotics,UK), Estradiol Valerate | Cairo University | IVF, Endometrial Receptivity | 03/22 | 03/22 | | |
NCT05300841: The Effect of Pretreatment With Dydrogesterone Vs Combined Estradiol Valerate and Dydrogestrone on Clinical Pregnancy Outcome of ICSI in PCOS Patients" |
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| Not yet recruiting | 1 | 500 | NA | dydrogesterone 20 mg /d (Duphaston, Abott Healthcare , Egypt), estradiol valerate 2 mg /d (white tablets of cycloprognova, Bayer Shering, Germany) | Sohag University | PCOS, ICSI | 04/23 | 05/23 | | |
ChiCTR2400083684: Clinical study on the treatment of thin endometrium by Tonifying-kidney and Relieving-depression method combined with Baliao Point electroacupuncture |
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| Completed | 1 | 112 | | (1) Oral Traditional Chinese Medicine,Method: Take continuously for 3 months.(2) Acupuncture and moxibustion at Baliao,Method:Electroacupuncture therapy: Start treatment after the menstrual cycle is clean, twice a week, suspend treatment during the menstrual period, and continue treatment for 3 months.; Estradiol valerate tablets were given on the fifth day of the Menstrual cycle, once a day, 2mg each time, for 21 consecutive days; From the 12th day after oral administration of Estradiol valerate tablets, add progesterone capsules twice a day, 100mg each time, for 10 consecutive days; On the 5th day of menstruation, oral aspirin enteric coated tablets 100mg/d were administered continuously for 20 days per cycle for three months. | The Beijing Gulou Hospital of Traditional Chinese Medicine; The Beijing Gulou Hospital of Traditional Chinese Medicine, Capital's Funds for Health Improvemen and Research | Gynecology of traditional Chinese medicine | | | | |
NCT05980091: Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration. |
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| Recruiting | 1 | 316 | RoW | Transvaginal ultrasound, Serum LH, E2, P4, Estradiol Valerate 2 MG, Estradiol Valerate, Progesterone 100 Mg Vaginal Insert, Progesterone 100 mg, Serum P4 day of ET, Embryo transfer, ET | ART Fertility Clinics LLC | Infertility, Fertility Issues, Infertility, Female | 04/24 | 09/24 | | |
NCT06312033: Estradiol's Effect on Brain Volume and Connectivity |
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| Completed | N/A | 32 | Europe | Estradiol Valerate, Progynova21, Placebo | International Research Training Group 2804, University Hospital Tübingen, German Research Foundation, Werner Reichardt Centrum für Integrative Neurowissenschaften (CIN) | Emotion Regulation, Estradiol | 07/19 | 12/21 | | |
ChiCTR1800020342: A study for Clinical application of optimized corpus luteum support program after embryo transfer |
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| Not yet recruiting | N/A | 300 | | on the basis of conventional luteal support treatment plus the addition of estradiol valerate 4mg / d orally, until HCG blood test day. ;On the third day of the membrane transformation day, HCG2000IU was administered intramuscularly once every other day for 5 consecutive times. | Northwest Women's and Children's Hospital; Northwest Women's and Children's Hospital, Shaanxi Provincial Health Research Fund | Infertility | | | | |
ChiCTR2100046503: Analysis on the etiology and outcome of missed abortion caused by uterine environment |
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| Recruiting | N/A | 96 | | Mifepristone combined with estradiol valerate ;Estradiol valerate ;Mifepristone ;Basic medicine | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, NO | Early pregnancy loss | | | | |
ChiCTR1900027652: Intervention study of different preconditioning regimens on IVF pregnancy outcome in patients with low prognosis |
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| Not yet recruiting | N/A | 800 | | After ovulation, oral estradiol valerate tablets (Bujiale, 1mg / tablet, Bayer Pharmaceuticals) 4 capsules, Qd, to the menstrual cramps day. ;Oral estradiol tablets/estradiol dydrogesterone tablets after ovulation (Fentongtong, white tablets are 1 mg of estradiol tablets, gray tablets are estradiol dydrogesterone tablets, ie estradiol 1 mg and dexamethasone Ketone 10mg, Abbott Pharmaceutical), white tablets 2 tablets Qd, gray tablets 2 tablets Qd × 14 days, ;On the third day of menstruation, oral drospirenone ethinyl estradiol tablets (Yi Siming, each containing drospirenone 3 mg and ethinyl estradiol 0.03 mg, Bayer Medicine), 1 tablet, Qd × 21 days, until the menstrual cramps. ;On the third day of menstruation, oral estradiol tablets/estradiol dydrogesterone tablets (fentopine, white tablets are 1 mg of estradiol tablets, gray tablets are estradiol dydrogesterone tablets (estradiol 1 mg and ground) 屈progesterone 10mg), Abbott Pharmaceuticals), 2 tablets of white tablets, Qd × 14 days, 2 table ;No pretreatment is required before COS. ;Each group of patients was treated with menstrual cramps on the next menstrual cycle, and the start of rFSH (recombinant follicle stimulating hormone) was determined according to the patient's body mass index (BMI) and pre-ovarian reactive individualization. Dose, the FSH, E2, P levels and the maximum follicle& | Affiliated Hospital of Shandong University of Traditional Chinese Medicine; Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Bethune Young and Middle-aged Doctors Talent Development Program | (poor ovarian response | | | | |
ChiCTR2300072157: A single center, randomized, open label, two-formulations, two-sequence, two-period, crossover bioequivalence trial of estradiol valerate tablets (strength: 1mg) administered orally on a single dosage under fasting and fed conditions in healthy Chinese menopausal female subjects |
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| Completed | N/A | 54 | | Fasting condition: the test formulation was given in the first period, and reference formulation was given in the second period ;Fasting condition: the reference formulation was given in the first period, and test formulation was given in the second period ;Fed condition: the test formulation was given in the first period, and reference formulation was given in the second period ;Fed condition: the reference formulation was given in the first period, and test formulation was given in the second period | Deyang People's Hospital; Zhejiang Xianju Pharmaceutical Co., Ltd, Zhejiang Xianju Pharmaceutical Co., Ltd | Estrogen deficiency: vasoconstrictive diseases (hot flashes), reproductive and urinary tract nutritional diseases (vulvovaginal atrophy, difficulty in sexual intercourse, urinary incontinence), and psychiatric diseases (sleep disorders, weakness) | | | | |
NCT04590417: Assessment of Drug-drug Interactions Between Feminizing Hormone Therapy and Emtricitabine/Tenofovir Alafenamide Concomitantly for Pre-exposure Prophylaxis Among Transgender Women |
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| Active, not recruiting | N/A | 20 | RoW | Estradiol valerate 2 mg, cyproterone acetate 25 mg | Thai Red Cross AIDS Research Centre | Drug Interaction | 01/24 | 10/25 | | |
NCT05112692: Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI Cycles |
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| Not yet recruiting | N/A | 200 | NA | Dydrogesterone Tablets, cetrorelix 0.25mg, human menopausal gonadotropin, triptorelin 0.1 mg, human chorionic gonadotropin, cryopreservation, Estradiol Valerate and progesterone | Mansoura University | PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries | 11/23 | 12/23 | | |
ChiCTR2400082026: Evaluation of therapeutic effect of acupoint catgut embedding therapy on POI with yin deficiency of liver and kidney based on the theory of "deep acceptance but long stay" |
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| Completed | N/A | 68 | | Artificial cycle therapy: Estradiol valerate tablets (Guangzhou Branch of Bayer Healthcare Co., Ltd. National Medicine Standard: J20080036) 1mg/ day, taken continuously for 21 days. On the 12th day of the medication cycle, progesterone capsules (Yimaxin, Zhejiang Xianyi Pharmaceutical Co., Ltd., National Medicine Zhunzi: H20041902) were taken 100 mg/time, twice a day for 10 days. If you have menstrual cramps, start the second cycle of treatment on the fifth day of menstruation; if you don't have menstrual cramps, start the next medication cycle one week after stopping taking medicine.; Acupoint catgut embedding in the experimental group mainly refers to the selection criteria of amenorrhea and menoxenia in Acupuncture, a textbook of the 12th Five-Year Plan of the Ministry of Health edited by Shi Xuemin, combined with clinical experience. | Dongzhimen Hospital Beijing University of Chinese Medicine; Dongzhimen Hospital Beijing University of Chinese Medicine, Project of Beijing University of Chinese Medicine's New Olympic Award Fund | premature ovarian insufficiency ,POI | | | | |
NCT04551144: Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors |
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| Terminated | N/A | 4 | US | testosterone cypionate, Estradiol Valerate | St. Louis University | Gender Incongruence, Transgenderism | 01/23 | 01/23 | | |
LBR-DTEW, ChiCTR2100041917: Live birth rate of women with different duration of estradiol supplementation in hormonal replacement cycles for frozen-thawed embryo transfer: a prospective, randomized, controlled, non-inferiority study |
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| Recruiting | N/A | 600 | | withdrawl estradiol valerate at 6 weeks of gestation ;continuing estradiol valerate until 10 weeks of gestation | The Third Affiliated Hospital of Guangzhou Medical University; The Third Affiliated Hospital of Guangzhou Medical University, School (hospital) Joint General Project Funds, Guangzhou Key Disciplines Funds, Merck Sherano Sponsored drugs: Crinone 90mg * 28 / patient * 600 cases | live birth rate in frozen-thawed embryo transfer | | | | |
NCT05473273: Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle. |
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| Recruiting | N/A | 40 | RoW | Endometrin 100Mg Vaginal Insert, Estradiol Valerate | ART Fertility Clinics LLC | Infertility, Female | 12/23 | 01/24 | | |
| Recruiting | N/A | 74 | Europe | Estradiol Valerate, Progynova21, Placebo, P-Tabletten | International Research Training Group 2804, University Hospital Tuebingen, German Research Foundation, Uppsala University | Stress vs. Control, Estradiol vs. Placebo | 07/25 | 12/25 | | |
NCT05227391: Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS |
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| Recruiting | N/A | 1078 | RoW | Oral Letrozole, Oral estradiol valerate | Reproductive & Genetic Hospital of CITIC-Xiangya | PCOS | 06/24 | 12/24 | | |
ChiCTR2100050959: Pelvic-sacral septum ginger fire therapy in the treatment of thin endometrium with kidney deficiency and blood stasis: a single-center randomized controlled trial |
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| Recruiting | N/A | 60 | | Ginger fire therapy for pelvic and sacral septum ;Oral estradiol valerate | The Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine; The Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, self-funded | thin endometrium | | | | |
ChiCTR2400087131: A prospective, randomised controlled study of retention enema-assisted treatment of uterine adhesions with Chinese medicine |
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| Not yet recruiting | N/A | 290 | | Decocting the enema, drawing 100ml of the liquid medicine with an empty needle, adjusting the temperature of the liquid medicine to 39~41℃, connecting the wave transmitter and discharging the air, cutting off the needle of the infusion device, pruning it, and applying paraffin oil for lubrication. The patient took the right lateral position, raised the hip 10cm, and put the end of the infusion device coated with lubricating oil. Slowly insert 10-15cm into the rectum from the anus, and the liquid surface is no more than 30cm away from the anus. Then, slowly open the regulator valve of the infusion set, and let the drug drop in at a rate of 60-70 drops/minute. When the drug drops are finished, remove the infusion set, wipe the anus, and try to keep the drug in the body for more than 1 hour to ensure that the drug is fully absorbed.
Treatment cycle: 5-7 days after hysteroscopic surgery (after the removal of the balloon) start enema treatment, no enema during the menstrual period. The treatment cycle is 1-2 menstrual cycles after surgery.; Estradiol valerate was administered 2-3mg/ day, twice a day, for a total of 28-30 days, and progesterone was added to transform the intima from the 21st day. The medication regimen was dydrogesterone 20mg/ day, once a day, for a total of 7-10 days. | Peking University Third Hospital; Peking University Third Hospital, Flagship Hospital Pilot Unit on Collaboration of Chinese and Western Medicines in 2024 Construction of a Special Fund for the Project "Boca-Collective" | intrauterine adhesion | | | | |
ChiCTR2400079652: Clinical efficacy of Modified Gengnianchun Formula (Bushen Shugan Huoxue formula) combined with artificial cycle of western medicine on Stress-Induced Diminished Ovarian Reserve |
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| Not yet recruiting | N/A | 192 | | Oral Modified Gengnianchun Formula (MGNC); Oral estradiol valerate + dydrogesterone; Oral Modified Gengnianchun Formula (MGNC) and estradiol valerate + dydrogesterone | Obstetrics and Gynecology Hospital of Fudan University; Obstetrics and Gynecology Hospital of Fudan University, Shanghai Municipal Committee of Science and Technology | diminished ovarian reserve | | | | |
