estradiol valerate / Generic mfg. 
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  • ||||||||||  estradiol valerate / Generic mfg., spironolactone / Generic mfg.
    [VIRTUAL] Hormone Replacement Therapy in Transgender Unmasks Testicular Tumor () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_1829;    
    After 5 months of therapy, she reported that her testosterone level remained elevated, so spironolactone 100 mg BID was subsequently added. If patient is on GnRH agonist, her testosterone level should be almost completely suppressed (T 50 ng/dL while on GnRH therapy should warrant workup for exogenous sources, including testicular cancer and adrenal abnormalities.
  • ||||||||||  estradiol valerate / Generic mfg.
    [VIRTUAL] Estradiol Dose and Concentrations in Transfeminine Individuals () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_1828;    
    There was significant interindividual variability. Estradiol concentration should be interpreted in conjunction with clinical features of feminization and weighed against potential risks of escalating estradiol dose.
  • ||||||||||  estradiol valerate / Generic mfg.
    [VIRTUAL] Pituitary Stem Disruption Syndrome Presenting as Primary Amenorrhea () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_1418;    
    The patient was treated with estradiol valerate and norgestrel as well as with growth hormone. In conclusion, the pituitary stalk interruption syndrome is a rare form of congenital hypopituitarism that should be considered in cases of growth hormone deficiency and primary amenorrhea particularly in the presence of extra pituitary malformations involving the central nervous system.
  • ||||||||||  Tlando (testosterone undecanoate) / Lipocine, estradiol valerate / Generic mfg.
    [VIRTUAL] Sex Hormones Therapy Differentially Modulates HDL Function in Transgender Individuals () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_772;    
    In transmen, testosterone supplementation was associated with a reduction in aqueous diffusion-mediated CEC, an effect potentially dependent to HDL-C changes. In transwomen, estrogen significantly decreased HDL function (CEC), independent of HDL-C levels changes.
  • ||||||||||  estradiol valerate / Generic mfg.
    [VIRTUAL] Estrogen Reverses the Atrophic Effects of Hypogonadism on the Rat Urethra (WEWCC: 147B) -  May 17, 2020 - Abstract #AUA2020AUA_2260;    
    This was associated with an increased GPER1 expression suggesting a mechanistic relationship for this effect. This finding provides a basis for employing estrogen supplementation as an alternative to testosterone replacement therapy in hypogonadal men with prostate cancer in order to optimize surgical outcomes in men at high risk for AUS erosion.
  • ||||||||||  cyclophosphamide intravenous / Generic mfg.
    Journal:  Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure. (Pubmed Central) -  May 14, 2020   
    Organic zinc showed beneficial effects in the EV induced PCOS rats via decreased insulin resistance and mTOR expression, restored the hormonal profile, and decreased the number of cysts in the ovaries. hUCMSCs can repair ovarian tissue damaged by chemotherapy to a certain extent, can improve the degree of apoptosis in ovarian tissue, and can improve the endocrine function of mouse ovaries.
  • ||||||||||  Menopur (menotropin) / Ferring, NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  HRT Versus MOS for Endometrial Preparation Prior to FET in Non PCOS Patients (clinicaltrials.gov) -  Apr 28, 2020   
    P4,  N=150, Recruiting, 
    This may be one of the mechanisms of acupuncture treating premature ovarian failure. Trial completion date: Mar 2020 --> Mar 2021 | Trial primary completion date: Jan 2020 --> Jan 2021
  • ||||||||||  estradiol valerate / Generic mfg., propranolol / Generic mfg.
    Preclinical, Journal:  In rats with estradiol valerate-induced polycystic ovary syndrome, the acute blockade of ovarian β-adrenoreceptors improve ovulation. (Pubmed Central) -  Apr 22, 2020   
    Trial completion date: Mar 2020 --> Mar 2021 | Trial primary completion date: Jan 2020 --> Jan 2021 The results suggest that a single injection into the ovarian bursas of propranolol, a nonselective antagonist of β-adrenoreceptor receptors, decreases the serum testosterone concentration and the formation of ovarian cysts, improving the ovulation rate that accompanies lower levels of tyrosine hydroxylase and dopamine β-hydroxylase in the ovary.
  • ||||||||||  estradiol valerate / Generic mfg.
    Journal:  Effects of clomiphene citrate plus estradiol or progesterone on endometrial ultrastructure: An RCT. (Pubmed Central) -  Apr 21, 2020   
    However, the Serum progesterone levels in group I was higher than the other two groups (p = 0.007) in the same day. Since the addition of EV and progesterone to higher dosages of CC did not change the pinopods concentration and serum estrogen levels on day 21 of the menstrual cycle, and the serum progesterone levels was higher in CC alone group (i.e. group I) compared to other groups, it can be concluded that the anti-estrogenic effects of CC just appear on the endometrium and not on the plasma levels.
  • ||||||||||  estradiol valerate / Generic mfg.
    Cross Sex Hormone Therapy and Breast Cancer in Transgender Male to Female (ENDOExpo) -  Apr 1, 2020 - Abstract #ENDO2020ENDO_3998;    
    More research is need to comment on routine breast cancer screening in this population. However, physicians should remember performing a regular breast exam in MTF individuals looking for a possible mass.
  • ||||||||||  estradiol valerate / Generic mfg., spironolactone / Generic mfg.
    Hormone Replacement Therapy in Transgender Unmasks Testicular Tumor (ENDOExpo, Booth 117) -  Apr 1, 2020 - Abstract #ENDO2020ENDO_3993;    
    After 5 months of therapy, she reported that her testosterone level remained elevated, so spironolactone 100 mg BID was subsequently added. If patient is on GnRH agonist, her testosterone level should be almost completely suppressed (T 50 ng/dL while on GnRH therapy should warrant workup for exogenous sources, including testicular cancer and adrenal abnormalities.
  • ||||||||||  estradiol valerate / Generic mfg.
    Estradiol Dose and Concentrations in Transfeminine Individuals (ENDOExpo, Booth 117) -  Apr 1, 2020 - Abstract #ENDO2020ENDO_3992;    
    There was significant interindividual variability. Estradiol concentration should be interpreted in conjunction with clinical features of feminization and weighed against potential risks of escalating estradiol dose.
  • ||||||||||  Tlando (testosterone undecanoate) / Lipocine, estradiol valerate / Generic mfg.
    Sex Hormones Therapy Differentially Modulates HDL Function in Transgender Individuals (ENDOExpo) -  Apr 1, 2020 - Abstract #ENDO2020ENDO_3804;    
    Total cholesterol and low-density lipoprotein cholesterol (LDL-C) were not affected by testosterone treatment, whilst triglycerides (TG) were raised (+ 11.76%; p = 0.0078) and HDL-C reduced (- 19.6%, p=0.0103). Concerning HDL CEC, only the aqueous diffusion process was lowered (- 9.8%; p = 0.0032), an effect directly correlated with HDL-C changes (r = 0.6242, p = 0.0002).
  • ||||||||||  estradiol valerate / Generic mfg.
    síNdrome de InterrupcióN del Tallo Pituitario Que Se Presenta Como Amenorrea Primaria (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_2961;    
    The patient was treated with estradiol valerate and norgestrel as well as with growth hormone. In conclusion, the pituitary stalk interruption syndrome is a rare form of congenital hypopituitarism that should be considered in cases of growth hormone deficiency and primary amenorrhea particularly in the presence of extra pituitary malformations involving the central nervous system.
  • ||||||||||  estradiol valerate / Generic mfg., spironolactone / Generic mfg.
    Hormone Replacement Therapy in Transgender Unmasks Testicular Tumor (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_2634;    
    After 5 months of therapy, she reported that her testosterone level remained elevated, so spironolactone 100 mg BID was subsequently added. If patient is on GnRH agonist, her testosterone level should be almost completely suppressed (T 50 ng/dL while on GnRH therapy should warrant workup for exogenous sources, including testicular cancer and adrenal abnormalities.
  • ||||||||||  estradiol valerate / Generic mfg.
    Estradiol Dose and Concentrations in Transfeminine Individuals (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_2626;    
    There was significant interindividual variability. Estradiol concentration should be interpreted in conjunction with clinical features of feminization and weighed against potential risks of escalating estradiol dose.
  • ||||||||||  estradiol valerate / Generic mfg., zoledronic acid / Generic mfg., Asahi Kasei
    Journal:  The effects of mumie extract on cell proliferation and enzyme expression of human osteoblast-like cells (MG63). (Pubmed Central) -  Jan 28, 2020   
    Also, BALP enzyme expression was slightly affected by 100 and 200 μg/ml of mumie extract whilst it was significantly decreased by the concentration of 300 μg/ml. This study showed that mumie extract has an increasing effect on proliferation rate and a decreasing effect on the mortality rate of osteoblast cells in low concentrations; however, the higher concentrations of this substance could be toxic and effect inversely.
  • ||||||||||  letrozole / Generic mfg.
    Trial initiation date:  LEFT: Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS) (clinicaltrials.gov) -  Jan 27, 2020   
    P4,  N=242, Not yet recruiting, 
    This study showed that mumie extract has an increasing effect on proliferation rate and a decreasing effect on the mortality rate of osteoblast cells in low concentrations; however, the higher concentrations of this substance could be toxic and effect inversely. Initiation date: Oct 2019 --> Apr 2020
  • ||||||||||  estradiol valerate / Generic mfg.
    Biomarker, Journal:  Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma. (Pubmed Central) -  Dec 28, 2019   
    A range of salivary metabolites were significantly altered in oral leukoplakia and oral squamous cell carcinoma. Further, it is necessary to evaluate the clinical utility of the individual metabolites in preventing malignant transformation of oral leukoplakia and to improve prognosis of oral squamous cell carcinoma.
  • ||||||||||  Clinical, Journal:  Cross-sex hormone therapy in Australia: the prescription patterns of clinicians experienced in adult transgender healthcare. (Pubmed Central) -  Dec 21, 2019   
    Experienced hormone prescribers in Australia largely use medication regimens and monitor sex steroid levels and potential adverse effects of sex hormone therapy in accordance with broad, subjective recommendations listed in international guidelines. Additional practitioner training is necessary, and local Australian-based guidelines would offer specific, relevant guidance to clinicians in the initiation and monitoring of cross-sex hormone therapy for adult transgender individuals.
  • ||||||||||  estradiol valerate / Generic Mfg.
    Preclinical, Journal:  Effects of Guben Zenggu Decoction on Bone Metabolism and Bone Microstructure in Ovariectomized Rats (Pubmed Central) -  Dec 5, 2019   
    This review will provide clear evidence to assess the effectiveness and safety of traditional Chinese herbs for low endometrial receptivity. Guben Zenggu Decoction can improve bone metabolism and bone micro-structure in ovariectomized rats, thus playing a preventive and therapeutic role in postmenopausal osteoporosis.