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18 Diseases |  |
24 Trials |
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24 Trials |  |
720 News |  |
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- || estradiol valerate / Generic mfg.
Clinical, Journal: Seven Years of Vitrified Blastocyst Transfers: Comparison of 3 Preparation Protocols at a Single ART Center. (Pubmed Central) - May 13, 2021
P=N/A
However, these data need to be confirmed in randomized and prospective studies before definitive conclusions can be drawn. Clinicaltrials.gov ID: NCT03581422.
- | estradiol valerate / Generic mfg., haloperidol / Generic mfg.
Preclinical, Journal: 3-(Para-fluorobenzoyl)-propionic acid; a metabolite of haloperidol, reversed oestradiol valerate-induced uterine hyperplasia via modulation of oestrogen receptor signalling pathways in female Wistar rats. (Pubmed Central) - May 1, 2021
Conclusion This study demonstrated that 3PFBPA ameliorates OV-induced uterine hyperplasia in the female Wistar rat model. The findings warrant further investigation of the antifibrotic effects of 3PFBPA in humans.
- | estradiol valerate / Generic mfg.
Journal: Differential expression of μ-opioid receptors in the nucleus accumbens, amygdala and VTA depends on liking for alcohol, chronic alcohol intake and estradiol treatment. (Pubmed Central) - Apr 29, 2021
Female wild-type rats were selected according to their baseline alcohol intake levels and then exposed to chronic voluntary alcohol consumption after a single injection of either the vehicle or estradiol valerate (EV) to produce a β-endorphin neuronal deficit...These results suggest intrinsic differences in MOR expression related to alcohol consumption levels. Also, the EV treatment and chronic exposure to alcohol produced adaptive changes in MOR expression.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Preventive effects of Polygonum orientale L. on ovariectomy-induced osteoporosis in rats. (Pubmed Central) - Apr 14, 2021
Compared with the OVX group, POE (3.75, 5.0, or 7.5 g/kg/day) treatments significantly increased trabecular bone mineral density by 35.03, 38.42, and 42.02%, respectively. Our findings suggest that POE has potential effects in regulation of bone metabolism and prevention of bone loss in postmenopausal osteoporosis.
- | metformin / Generic mfg., clomifene citrate / Generic mfg.
Preclinical, Journal: Comparison the Effect of Metformin and Clomiphene Citrate on Sirtuin3 gene Expression in the Oocytes of Mice with Polycystic Ovary Syndrome. (Pubmed Central) - Apr 13, 2021
Also, no significant difference was found in the expression of Sirt3 between clomiphene and PCOS group, whereas, in the metformin group, Sirt3 expression had the higher rate of expression in comparison with the PCOS group (P < 0.05). The administration of metformin and clomiphene showed that metformin is capable of preventing the downregulation of the Sirt3 gene in oocytes, collected from PCOS mice.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Influence of Dingkun Dan Combined with Estradiol Valerateon Wnt/β-catenin Signaling Pathway in Rats with Thin Endometrium with Kidney-Yang Deficiency (Pubmed Central) - Apr 10, 2021
Compared with the combination group, the levels of β-catenin was increased significantly, while decreased signicantly in Dingkun Dan group ( P<0.01 or P<0.05). Dingkun Dan combined with estradiol valerateon can increase the thicken of the endometrium by up-regulation of VEGF, while down-regulate of β-catenin, E-cadherin and MMP-9 in rats with Shen-Yang deficiency and thin endometrium.
- | metformin / Generic mfg.
Preclinical, Journal: Both Matricaria chamomilla and Metformin Extract Improved the Function and Histological Structure of Thyroid Gland in Polycystic Ovary Syndrome Rats through Antioxidant Mechanism. (Pubmed Central) - Mar 20, 2021
Both treatments reduced the apoptotic death of thyroid cells as noted by the reduction of caspase-3 immunoexpression (p < 0.01). In conclusion, both Matricariachamomilla extract and metformin ameliorated hypothyroidism associated with PCOS through an antioxidant and antiapoptotic mechanism.
- efavirenz/emtricitabine/tenofovir disoproxil fumarate / Generic mfg., estradiol valerate / Generic mfg., spironolactone / Generic mfg.
[VIRTUAL] FEMINIZING THERAPY DECREASES D-DIMER BUT WORSENS INSULIN SENSITIVITY IN TRANS WOMEN () - Mar 18, 2021 - Abstract #CROI2021CROI_740;
Because PrEP uptake and ART adherence were very low, these effects seem primarily due to FHT use. Further study is needed to better understand cardiometabolic changes in TW by HIV serostatus and to optimize uptake of, and adherence to, HIV prevention and treatment options.
- | febuxostat / Generic mfg.
Preclinical, Journal: PTEN/PI3K/VEGF signaling pathway involved in the protective effect of xanthine oxidase inhibitor febuxostat against endometrial hyperplasia in rats. (Pubmed Central) - Mar 17, 2021
The endometrium showed a regression of the proliferative epithelium with the restoration of PTEN expression and the absence of the atypical features. In conclusion, febuxostat protected the endometrium against estrogen-induced EH and may be beneficial in the management along with the hormonal therapy.
- | metformin / Generic mfg.
Journal, IO biomarker: Potential Therapeutic Effect of Bee Pollen and Metformin Combination on Testosterone and Estradiol Levels, Apoptotic Markers and Total Antioxidant Capacity in A Rat Model of Polycystic Ovary Syndrome. (Pubmed Central) - Mar 10, 2021
On the other hand, TAC and expression of Bax, Cas-3and Sirt1 were increased in the BP- and MET-treated groups (P<0.05). BP and MET synergistically improved serum E2, T and TAC levels, and expression of apoptotic genes.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: QingYan Formula extracts protect against postmenopausal osteoporosis in ovariectomized rat model via active ER-dependent MEK/ERK and PI3K/Akt signal pathways. (Pubmed Central) - Mar 9, 2021
This experiment demonstrated that QYFE had a definite anti-bone loss effect and had potential effect on postmenopausal osteoporosis. The molecular mechanism was related to the activation of estrogen receptor (ER)-dependent mitogen-activated protein kinase kinase (MEK)/ERK and phosphoinositide 3-kinase (PI3K)/Akt signal pathways in osteoblast, down-regulation protein expressions of ER-dependent p-ERK and ER-independent p-Akt in osteoclast.
- | progesterone / Generic mfg., estradiol valerate / Generic mfg.
Trial completion: The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer (clinicaltrials.gov) - Mar 3, 2021
P4, N=112, Completed, Sponsor: Rahem Fertility Center
The molecular mechanism was related to the activation of estrogen receptor (ER)-dependent mitogen-activated protein kinase kinase (MEK)/ERK and phosphoinositide 3-kinase (PI3K)/Akt signal pathways in osteoblast, down-regulation protein expressions of ER-dependent p-ERK and ER-independent p-Akt in osteoclast. Recruiting --> Completed
- | Preclinical, Journal, IO biomarker: Tiao Geng decoction for treating menopausal syndrome exhibits anti-aging effects likely via suppressing ASK1/MKK7/JNK mediated apoptosis in ovariectomized rats. (Pubmed Central) - Feb 27, 2021
Recruiting --> Completed TG-decoction reduces aging-related ultrastructural changes in hypothalamic neurons, likely by suppressing ASK1/MKK7/JNK-mediated apoptosis in neuronal mitochondria or nuclei.
- progesterone / Generic mfg., estradiol valerate / Generic mfg.
[VIRTUAL] SECONDARY AMENORRHEA AND INFERTILITY AS A PRESENTATION OF MOSAICISM 45X/46XX. () - Feb 24, 2021 - Abstract #ICE2021ICE_497;
She presented regular menses induced with combined treatment with estradiol valerate and norgestrel...Clinical The present case illustrates the broad clinical spectrum of 45X/46XX mosaicism in a patient with different degrees of her ovarian function, which started with a normal menarche, followed by ovarian failure with hypergonadotropic secondary amenorrhea. This case demonstrates the importance of the exhaustive study of patients with secondary amenorrhea since the early detection of these cases would lead to the preservation of their fertility as early as adolescence and ensure their fertility
- | cyproterone acetate / Generic mfg., estradiol valerate / Generic mfg., spironolactone / Generic mfg.
Review, Journal: Hormonal Gender Reassignment Treatment for Gender Dysphoria. (Pubmed Central) - Feb 23, 2021
Further prospective studies for the quantification of the risks and benefits of hormonal treatment would be desirable. Potential interactions of the hormone preparations with other medications must always be considered.
- | donepezil / Generic mfg.
Preclinical, Journal: Establishment of the concurrent experimental model of osteoporosis combined with Alzheimer's disease in rat and the dual-effects of echinacoside and acteoside from Cistanche tubulosa. (Pubmed Central) - Feb 20, 2021
The model of osteoporosis combined with Alzheimer's disease in rat was feasible and successfully established. Echinacoside and acteoside also showed some significant effects on this concurrent model, and they could be potential candidates from Cistanche tubulosa with double effects for further study.
- || estradiol valerate / Generic mfg.
Clinical, Journal: Estradiol valerate in COC has more favorable inflammatory profile than synthetic ethinyl estradiol - a randomized trial. (Pubmed Central) - Feb 3, 2021
P4
Echinacoside and acteoside also showed some significant effects on this concurrent model, and they could be potential candidates from Cistanche tubulosa with double effects for further study. EV+DNG and DNG only had a neutral effect on inflammation and lipids, while EE+DNG increased both hs-CRP and PTX-3 levels as well as triglycerides and HDL.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Valeric acid lowers arterial blood pressure in rats. (Pubmed Central) - Jan 28, 2021
Moreover, VA is released from medicines such as estradiol valerate by esterases...The colon-derived VA rapidly penetrates to tissues involved in the control of BP. Further studies are needed to evaluate the effects of endogenous and exogenous VA on the circulatory system.
- | Preclinical, Journal: A circRNA-miRNA-mRNA network plays a role in the protective effect of diosgenin on alveolar bone loss in ovariectomized rats. (Pubmed Central) - Jan 26, 2021
The mechanism of DIO inhibiting alveolar bone loss after OVX is possibly relevant to the simultaneous inhibition of osteogenesis and osteoclastogenesis by mediating the expression of important molecules in the Wnt, PI3K, RANK/RANKL or osteoclastogenic cytokine pathways. The circRNA_016717/miR-501-5p/Sfrp1 axis may play important roles in these processes.
- | estradiol valerate / Generic mfg.
Enrollment closed, Enrollment change: Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors (clinicaltrials.gov) - Jan 14, 2021
P=N/A, N=4, Active, not recruiting, Sponsor: St. Louis University
The circRNA_016717/miR-501-5p/Sfrp1 axis may play important roles in these processes. Recruiting --> Active, not recruiting | N=40 --> 4
- | progesterone / Generic mfg., estradiol valerate / Generic mfg.
Preclinical, Journal: Administration of a VIP-antagonist in vivo modifies ovarian hormone secretion in a rat model with polycystic ovary syndrome. (Pubmed Central) - Jan 14, 2021
The binding of VIP to its receptors differentially regulates steroidogenesis in the cyclic animal in estrus and in the EV-PCOS model. The blocking of VIP signaling produces changes in ovarian catecholamines.
- | letrozole / Generic mfg.
Enrollment change, Trial withdrawal: LEFT: Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS) (clinicaltrials.gov) - Jan 8, 2021
P4, N=0, Withdrawn, Sponsor: CRG UZ Brussel
The blocking of VIP signaling produces changes in ovarian catecholamines. N=242 --> 0 | Not yet recruiting --> Withdrawn
- | estradiol valerate / Generic mfg., dydrogesterone / Generic mfg.
Trial completion date, Trial primary completion date: Estrogen in the Prevention of Adhesion Reformation (clinicaltrials.gov) - Jan 5, 2021
P4, N=186, Enrolling by invitation, Sponsor: Fu Xing Hospital, Capital Medical University
N=242 --> 0 | Not yet recruiting --> Withdrawn Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Aug 2020 --> Aug 2021
- || estradiol valerate / Generic mfg., spironolactone / Generic mfg.
Clinical, Review, Journal: Antiandrogen or estradiol treatment or both during hormone therapy in transitioning transgender women. (Pubmed Central) - Dec 22, 2020
We will include non-controlled cohort studies in the next iteration of this review, as our review has shown that such studies provide the highest quality evidence currently available in the field. We will take into account methodological limitations when doing so.
- | Visanne (dienogest) / Mochida, Bayer
Retrospective data, Journal: Pooled analysis of bleeding profile, efficacy and safety of oral oestradiol valerate/dienogest in women aged 25 and under. (Pubmed Central) - Dec 17, 2020
We also found a similar adjusted Pearl index in the two age groups (0.45 vs 0.57, respectively), similar rates of AEs and HWAS and no difference in discontinuations. Women aged ≤25 and >25 years have a similar experience with an E2V/DNV oral contraceptive, supporting this as an appropriate contraceptive option in younger and older women.
- | estradiol valerate / Generic mfg.
Journal: Protective effect of the olive hydroalcoholic extract on estrogen deficiency-induced bone loss in rats in comparison with estradiol. (Pubmed Central) - Dec 12, 2020
The global, tibia, femur and spine BMD in the group treated with the highest dose of black olive hydroalcoholic and estrogen group were significantly increased compared to the OVX group (P<0.05). Black olive hydroalcoholic extract at the dose of 750 mg/kg, prevented bone loss and augmented bone mineral density and could be a possible candidate for the management of osteoporosis.
- | dexamethasone / Generic mfg.
Journal: Effect of Local Estrogen on Repairing Tympanic Membrane Perforation. (Pubmed Central) - Dec 8, 2020
Statistical analysis among the subgroup of patients with small perforations showed that the success rate of tympanoplasty was significantly higher in the estradiol group, compared to that reported for the control group (P=0.03). Although topical estrogen was generally ineffective in increasing the success rate of tympanoplasty, it improved the success rate among patients with small tympanic membrane perforations.
- | tamoxifen / Generic mfg.
Journal: The Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibits Cell Proliferation Induced by Estradiol on the Uterus and Vagina of Ovariectomized Female Wistar Rats. (Pubmed Central) - Dec 5, 2020
This antiproliferative effect of D. edulis was associated with reduced tissue (uterine) levels of estradiol (p < 0.001). These results suggest that the aqueous extract of D. edulis leaves could be a potential alternative treatment for proliferation-related diseases.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Cajanolactone A, a stilbenoid from cajanus cajan, prevents ovariectomy-induced obesity and liver steatosis in mice fed a regular diet. (Pubmed Central) - Dec 1, 2020
CLA was demonstrated to be a potential non-estrogen-like drug candidate for prevention of postmenopausal obesity and fatty liver. The underlying mechanism might involve the inhibition of lipogenesis and promotion of triglycerides output in the liver, and the promotion of metabolism and mitochondrial functions of visceral white adipose tissue.
- || estradiol valerate / Generic mfg., norethindrone / Generic mfg.
Enrollment change: PROMES: A Clinical Study in Which Researchers Want to Learn More About the Safety Profile of MESIGYNA (Norethisterone Enantate 50 mg and Estradiol Valerate 5 mg) Used as a Medication to Prevent Pregnancy for Adult Women in Reproductive Age in the Peruvian Population at the Outpatient Clinic. (clinicaltrials.gov) - Nov 30, 2020
P=N/A, N=300, Recruiting, Sponsor: Bayer
The underlying mechanism might involve the inhibition of lipogenesis and promotion of triglycerides output in the liver, and the promotion of metabolism and mitochondrial functions of visceral white adipose tissue. N=500 --> 300
- Avelox (moxifloxacin) / Bayer
[VIRTUAL] DIAGNOSIS OF PULMONARY THROMBOEMBOLISM RETARDED BY COEXISTENCE WITH BACTERIAL PNEUMONIA: CASE REPORT () - Nov 26, 2020 - Abstract #HEMO2020HEMO_155;
Thus, it is observed how delayed the diagnosis of PTE can be when it coexists with bacterial pneumonia, since its clinical presentations can overlap. Thus, it is important for doctors and students to be aware of those patients diagnosed with pneumonia, even if their Wells score is low.
- | letrozole / Generic mfg., estradiol valerate / Generic mfg., clomifene citrate / Generic mfg.
New trial: the Effect of Clomiphene Citrate Plus Estradiol Valerate Versus Letrozole on Endometrial Thickness and Pregnancy Rate in Infertile Women (clinicaltrials.gov) - Nov 5, 2020
P=N/A, N=160, Completed, Sponsor: Laylay Mohammed Khalleefah Alhibshi
- estradiol valerate / Generic mfg.
[VIRTUAL] Comparison of bone, metabolic and anthropometric changes in young women with premature ovarian insufficiency or complete androgen insensitivity syndrome with removed gonads using oral estradiol valerate, transdermal estradiol or oral ethinylestradiol. () - Nov 5, 2020 - Abstract #ISGEI2020ISGE-I_72;
Conclusions. Our results suggest that in young women with POI or CAIS oral estradiol valerate or transdermal estradiol are both associated with greater improvement in bone health if compared to oral ethinylestradiol.
- | estradiol valerate / Generic mfg.
Journal: Protective effects of licorice extract on ovarian morphology, oocyte maturation, and embryo development in PCOS-induced mice: An experimental study. (Pubmed Central) - Nov 3, 2020
It appears that the two doses (100 mg and 150 mg) of licorice could decrease ovarian cyst and improve the fertilization rate of oocyte and embryo development in PCOS mice. However, there was no statistically significant difference between the two experimental groups.
- | Preclinical, Journal: Multiple failures in the LH surge generating system in GABAB1KO female mice. (Pubmed Central) - Oct 25, 2020
LH correlated with activated kisspeptin cells in WT mice, while GABAB1KO mice showed high, similar LH levels both in the morning and evening. Taken together, all these alterations point to impairment in the trigger of the preovulatory GnRH surge that entails the reproductive alterations described.
- | Descovy (emtricitabine/tenofovir alafenamide) / Gilead
New trial: Assessment of Drug-drug Interactions Between Feminizing Hormone Therapy and Emtricitabine/Tenofovir Alafenamide Concomitantly for Pre-exposure Prophylaxis Among Transgender Women (clinicaltrials.gov) - Oct 19, 2020
P=N/A, N=20, Recruiting, Sponsor: Thai Red Cross AIDS Research Centre
- | estradiol valerate / Generic mfg.
Journal: A combination of spearmint and flaxseed extract improved endocrine and histomorphology of ovary in experimental PCOS. (Pubmed Central) - Oct 16, 2020
Taken together, all these alterations point to impairment in the trigger of the preovulatory GnRH surge that entails the reproductive alterations described. A combination of flaxseed and spearmint extract improved the endocrine profile and the histomorphometric features of the ovary in the T group compared to the PCOS group.
- || estradiol valerate / Generic mfg.
Looping in the fantastic people delivering my course at @RCPLondon @SRSlater1 @emgraham31 for a different point of view (Twitter) - Oct 13, 2020
- estradiol valerate / Generic mfg.
[VIRTUAL] MORTALITY IN PATIENTS WITH OR WITHOUT OSA WHO REQUIRED INVASIVE MECHANICAL VENTILATION: A PROPENSITY SCORE-MATCHED ANALYSIS () - Oct 12, 2020 - Abstract #CHEST2020CHEST_2579;
Critically-ill patients who required IMV with OSA had lower in-hospital mortality than patients without OSA. CLINICAL IMPLICATIONS: This result might help decreasing hesitancy to place IMV in critically-ill OSA patients.
- | progesterone / Generic mfg., estradiol valerate / Generic mfg.
Enrollment change: The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer (clinicaltrials.gov) - Oct 12, 2020
P4, N=112, Recruiting, Sponsor: Rahem Fertility Center
CLINICAL IMPLICATIONS: This result might help decreasing hesitancy to place IMV in critically-ill OSA patients. N=70 --> 112
- | estradiol valerate / Generic mfg.
Trial completion date, Trial primary completion date: Effectiveness of Estradiol Valerate Pretreatment in Antagonist Protocol for Poor Ovarian Response Patient (clinicaltrials.gov) - Sep 24, 2020
P=N/A, N=450, Recruiting, Sponsor: Reproductive & Genetic Hospital of CITIC-Xiangya
N=70 --> 112 Trial completion date: Dec 2019 --> Jun 2021 | Trial primary completion date: Oct 2019 --> Jun 2021
- | estradiol valerate / Generic mfg.
New trial: Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors (clinicaltrials.gov) - Sep 15, 2020
P, N=40, Recruiting, Sponsor: St. Louis University
- | progesterone / Generic mfg., estradiol valerate / Generic mfg., progesterone / Generic mfg.
Trial completion, Enrollment change, Trial completion date, HEOR: Quality of Life in Premenopausal Women With Heavy Menstrual Bleeding (clinicaltrials.gov) - Sep 3, 2020
P=N/A, N=104, Completed, Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Trial completion date: Dec 2019 --> Jun 2021 | Trial primary completion date: Oct 2019 --> Jun 2021 Recruiting --> Completed | N=150 --> 104 | Trial completion date: Dec 2018 --> Dec 2019
- || estradiol valerate / Generic mfg.
Clinical, Journal: Efficacy of oral estrogen plus testosterone gel to improve sexual function in postmenopausal women. (Pubmed Central) - Sep 2, 2020
Recruiting --> Completed | N=150 --> 104 | Trial completion date: Dec 2018 --> Dec 2019 The addition of low-dose testosterone gel to daily estrogen may improve sexual function in postmenopausal women, but further evaluation and safety data are needed.
- | neosaxitoxin (NeoSTX) / Boston Children's Hospital, Proteus
Preclinical, Journal: In vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats. (Pubmed Central) - Sep 1, 2020
In addition, plasma testosterone levels decreased while those of progesterone increased. Our data strongly suggest that chronic inhibition of sympathetic nerves by a locally applied long-lasting toxin is a new tool to manage the polycystic phenotype in the rat and could be applied to other mammals depending on sympathetic nerve activity.
- | estradiol valerate / Generic mfg.
Journal: Effects of resveratrol and soy isoflavones on learning and memory ability and expression of glucose transporter in aging model rats (Pubmed Central) - Aug 29, 2020
Resveratrol and soy isoflavones alone and in combination can improve the learning and memory ability of aging rat models. The mechanism may be related to up-regulating the expression of GLUT1 and GLUT3 genes and proteins in the hippocampus, promoting the transmembrane transport of glucose and reducing neuronal loss.
- | progesterone / Generic mfg., estradiol valerate / Generic mfg.
Enrollment open: The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer (clinicaltrials.gov) - Aug 20, 2020
P4, N=70, Recruiting, Sponsor: Rahem Fertility Center
The mechanism may be related to up-regulating the expression of GLUT1 and GLUT3 genes and proteins in the hippocampus, promoting the transmembrane transport of glucose and reducing neuronal loss. Not yet recruiting --> Recruiting
- | progesterone / Generic mfg., estradiol valerate / Generic mfg.
New P4 trial: The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer (clinicaltrials.gov) - Aug 9, 2020
P4, N=70, Not yet recruiting, Sponsor: Rahem Fertility Center
- ||| estradiol valerate / Generic mfg.
Preclinical, Journal, Adverse events: Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation. (Pubmed Central) - Jul 29, 2020
All these activities were significantly inhibited by the ER antagonist ICI182,780. QYFE's estrogenic activity maybe mediated by stimulating biosynthesis of estrogen and increasing the quantity of ERs in target tissue and via active ER to ERE-independent gene regulation.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Biochemical and histological evidence of thyroid gland dysfunction in estradiol valerate model of the polycystic ovary in Wistar rats. (Pubmed Central) - Jul 21, 2020
There was also a decrease in the expression of proliferating cell nuclear antigen. In summary, this study provides several effective biochemical and histological evidences for thyroid gland dysfunction in PCO-induced rats.