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18 Diseases |  |
24 Trials |
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24 Trials |  |
720 News |  |
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- | Visanne (dienogest) / Mochida, Bayer
Journal: Effects of estradiol- and ethinylestradiol-based contraceptives on adrenal steroids: A randomized trial. (Pubmed Central) - Sep 12, 2022
P4
In COCs, EV had a milder effect on circulating CBG and adrenal steroid levels than EE; however, further research is necessary to determine the long-term effects.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Therapeutic Effects of Eugenol in Polycystic Ovarian Rats Induced by Estradiol Valerate: A Histopathological and A Biochemical Study. (Pubmed Central) - Aug 28, 2022
It showed beneficial effects on serum glucose, serum insulin, fat profile, reproductive hormones, liver activity, oxidative stress, expression of Cox-2 and Ppar-α genes, as well as restoration of normal ovulation in the PCOS animals. Eugenol could represent a promising natural product to prevent PCOS or reduce its symptoms.
- sildenafil / Generic mfg., pentoxifylline / Generic mfg., estradiol valerate / Generic mfg.
EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA TREATMENT ON REFRACTORY THIN ENDOMETRIUM DURING THE FROZEN-EMBRYO TRANSFER CYCLE: A SINGLE ARM SELF-CONTROLLED TRIAL IN 100 PATIENTS (Anaheim Convention Center - Poster Hall in Expo Hall) - Aug 21, 2022 - Abstract #ASRM2022ASRM_374;
IMPACT STATEMENT: Autologous PRP treatment could improve the pregnancy outcomes of women with refractory thin endometrium with repeated implantation failure (RIF). This treatment could be a promising option for the treatment of refractory thin endometrium.
- progesterone / Generic mfg.
VERY HIGH SERUM PROGESTERONE LEVELS ON THE DAY OF EMBRYO TRANSFER DO NOT HAVE AN IMPACT ON OUTCOMES IN ARTIFICIALLY PREPARED FROZEN EMBRYO TRANSFER CYCLES (Anaheim Convention Center - Poster Hall in Expo Hall) - Aug 21, 2022 - Abstract #ASRM2022ASRM_371;
Patients were treated with 6mg/d of estradiol valerate and then with 2x50mg subcutaneous progesterone once endometrium was ≥7mm. Our results indicate that excess serum progesterone on day of ET do not have detrimental effects on clinical pregnacy rates IMPACT STATEMENT: P4 levels > 60 ng/mL on the day of ET do not exert any effect on clinical outcomes in artificially prepared FRET cycles.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment. (Pubmed Central) - Aug 14, 2022
Group B received a single dose of 4 mg/kg body weight (bwt) i.p estradiol valerate (EV)...Ageratum conyzoides improved insulin sensitivity, antioxidant activities, hormonal imbalance, inflammatory makers, and histological changes in PCOS rats. Therefore AGC can be used as a potential adjuvant agent in the treatment of PCOS.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Genistein Blunted Detrimental Effects of Polycystic Ovary Syndrome on the Ovarian Tissue of Rats by Improving Follicular Development and Gonadotropin Secretion. (Pubmed Central) - Aug 11, 2022
Therefore AGC can be used as a potential adjuvant agent in the treatment of PCOS. This study indicated that genistein treatment exerted a beneficial effect on the ovarian tissue of rats with PCOS by improving follicular growth and hormone balance.
- | chloroquine phosphate / Generic mfg., estradiol valerate / Generic mfg., sirolimus / Generic mfg.
Journal: Effect of Neiyi Prescription of QIU on autophagy and angiogenic ability of endometriosis via the PPARγ/NF-κB signaling pathway. (Pubmed Central) - Aug 7, 2022
This study indicated that genistein treatment exerted a beneficial effect on the ovarian tissue of rats with PCOS by improving follicular growth and hormone balance. Collectively, these findings indicate that NYPQ has therapeutic potential in experimentally induced peritoneal endometriosis, and its mechanism may be related to the activation of the PPARγ/NF-κB signaling pathway.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats. (Pubmed Central) - Jul 29, 2022
The administration of estradiol valerate caused significant changes during the examined period in hematological and hemorheological parameters. Our results draw attention to the possible usefulness of micro-rheological investigations in further studies on PCOS.
- | Mifeprex (mifepristone) / Danco Laboratories
Retrospective data, Journal: A retrospective study of estrogen in the pretreatment for medical management of early pregnancy loss and the inference from intrauterine adhesion. (Pubmed Central) - Jul 27, 2022
Mifepristone followed by carboprost methylate suppositories was likelihood of the ideal medical scheme in early pregnancy loss. IUA decreased the complete expulsion rate of medical management, it is cautious about medical management for early pregnancy loss with risk of IUA.
- | estradiol valerate / Generic mfg.
holy shit that is ridiculous. is switching to estradiol valerate an option? (Twitter) - Jul 27, 2022
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Interplay between polycystic ovary syndrome and hypothyroidism on serum testosterone, oxidative stress and StAR gene expression in female rats. (Pubmed Central) - Jul 27, 2022
The results of this study illustrate that the presence of both PCOS and hypothyroidism alters the situation more than just PCOS. They also indicate that this situation is associated with imbalanced oxidative/antioxidative status.
- | progesterone / Generic mfg., estradiol valerate / Generic mfg.
New trial: Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle. (clinicaltrials.gov) - Jul 25, 2022
P=N/A, N=40, Not yet recruiting, Sponsor: ART Fertility Clinics LLC
- | Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Anti-inflammatory and hemostatic effects of total extract, saponins, and flavonoids of Clinopodium chinense in female rats with abnormal uterine bleeding and mechanism (Pubmed Central) - Jul 23, 2022
Then the AUB rats were randomized into model group, TEC group, TSC group, TFC group, Yimucao Granules(LG) group, and estradiol valerate(EV) group, with 8 rats in each group...TSC exerts the effects by enhancing the coagulation function and promoting endometrial repair, and TFC by regulating estrogen levels and reducing inflammatory response. This study reveals the mechanism of C. chinense against AUB and also explains the holistic characteristics of Chinese medicine.
- || progesterone / Generic mfg., estradiol valerate / Generic mfg.
Clinical, Journal: Effects of Pelvic Floor Muscle Massage on the Pregnancy Outcome of Frozen Embryo Transfer in Patients with Thin Endometrium. (Pubmed Central) - Jul 13, 2022
The incidence of biochemical pregnancy in the control group was significantly higher than that in the study group, but there was no significant difference in the incidence of early abortion and ectopic pregnancy between the two groups (P > 0.05). Pelvic floor muscle massage can improve endometrial thickness and subendometrial blood flow, so as to improve the pregnancy rate of frozen thawed embryo transfer patients.
- Apretude (cabotegravir extended-release injectable suspension) / ViiV Healthcare
Transgender women (TGW) in HPTN 083: an evaluation of safety, efficacy, and gender affirming hormonal therapy (GAHT) interactions with long-acting cabotegravir (CAB-LA) () - Jul 2, 2022 - Abstract #AIDS2022AIDS_3905;
CAB-LA is a safe and effective HIV prevention strategy for TGW. Initial findings suggest there is no impact of GAHT on CAB concentrations.
- | methylphenidate tablet / Generic mfg., estradiol valerate / Generic mfg., amphetamine / Generic mfg.
Journal: Effects of Early Life Exposure to Sex Hormones on Neurochemical and Behavioral Responses to Psychostimulants in Adulthood: Implications in Drug Addiction. (Pubmed Central) - Jul 2, 2022
Here, we studied the long-lasting effects of neonatal exposure to sex hormones on behavioral and neurochemical responses to amphetamine (AMPH) and methylphenidate (MPD)...Using in vivo fast-scan cyclic voltammetry in striatum, MPD-induced DA reuptake was higher in EV than control rats. In summary, our results show that early life exposure to sex hormones modulates mesolimbic and nigrostriatal DA neurons producing opposite neurochemical effects induced by psychostimulant drugs in NAcc or striatum.
- | estradiol valerate / Generic mfg.
Retrospective data, Journal: Comparison of the Reproductive Outcome Between 2 and 4 mg Daily Doses of Estradiol After Hysteroscopic Adhesiolysis: A Propensity Score Matching Analysis-Retrospective Cohort Study. (Pubmed Central) - Jul 1, 2022
The multivariable regression analyses both before and after PSM also showed that there was no significant difference in the menstrual improvement and clinical pregnancy rates between the two groups. We suggest the use of a lower dose (2 mg/day) of estradiol valerate as an adjuvant therapy for IUAs to minimize estrogen-related side effects.
- | estradiol valerate / Generic mfg.
Journal: Estradiol Valerate Vs. Ethinylestradiol In Combined Oral Contraceptives: Effects On The Pituitary-Ovarian Axis. (Pubmed Central) - Jun 22, 2022
We suggest the use of a lower dose (2 mg/day) of estradiol valerate as an adjuvant therapy for IUAs to minimize estrogen-related side effects. Compared with EE + DNG, treatment with EV + DNG resulted in milder pituitary downregulation and reduced induction of hepatic SHBG synthesis-potentially carrying more beneficial health effects.
- | estradiol valerate / Generic mfg., triptorelin / Generic mfg.
Trial completion: Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT (clinicaltrials.gov) - Jun 22, 2022
P=N/A, N=220, Completed, Sponsor: Mansoura Integrated Fertility Center
Compared with EE + DNG, treatment with EV + DNG resulted in milder pituitary downregulation and reduced induction of hepatic SHBG synthesis-potentially carrying more beneficial health effects. Unknown status --> Completed
- Visanne (dienogest) / Mochida, Bayer
Benign gynecological disorders and hormonal contraceptives: a strategic approach (Van Eyck) - Jun 3, 2022 - Abstract #ESCRH2022ESCRH_24;
The only pill presently on label for HMB without an organic disease (fibroids, adenomyosis, endometrial polyps, etc.) is the quadriphasic estradiol valerate (E2V)/ DNG...Therefore, progestins with strong anti-androgenic activity such as DNG, cyproterone acetate, CMA, drospirenone (DRSP) or norgestimate (with its skin 5-α reductase inhibition) are preferable...Finally, in the presence of premenstrual syndrome or more serious premenstrual dysphoric disorder (PMDD), combinations containing long half-life progestins, such as DRSP, seem more effective, probably due to its anti-mineralocorticoid property and to its central effects. “Listen to what she is telling you and ask about what she may not be telling you”: you can make her even happier with her contraceptive method!
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Astragalus hamosus Acts as an Insulin Sensitizer Through the Treatment of Polycystic Ovary Syndrome Rat Models by Affecting IRS1 Expression. (Pubmed Central) - May 26, 2022
“Listen to what she is telling you and ask about what she may not be telling you”: you can make her even happier with her contraceptive method! This study indicated the impact of Astragalus hamosus extract on PCOS by clarifying the increased levels of IRS1 expression in the treated groups compared to the PCOS group.
- | progesterone / Generic mfg., estradiol valerate / Generic mfg.
Retrospective data, Journal: Comparison of two endometrial preparation methods for frozen-thawed embryo transfer in anovulatory PCOS patients: impact on miscarriage rate. (Pubmed Central) - May 26, 2022
This study indicated the impact of Astragalus hamosus extract on PCOS by clarifying the increased levels of IRS1 expression in the treated groups compared to the PCOS group. In anovulatory PCOS women, the type of endometrial preparation does not influence FET outcomes, specifically regarding the miscarriage rate.
- || Mifeprex (mifepristone) / Danco Laboratories
Review, Journal: Medical methods for first trimester abortion. (Pubmed Central) - May 25, 2022
Some results are limited by the small numbers of participants on which they are based. Almost all studies were conducted in settings with good access to emergency services, which may limit the generalisability of these results.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats. (Pubmed Central) - May 24, 2022
Almost all studies were conducted in settings with good access to emergency services, which may limit the generalisability of these results. RD extract seems to have the potential therapeutic effect of alleviating PCOS complications, and IGF-1 signaling may be involved in the beneficial effects of RD on PCOS.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Choosing the right protocol for establishment of MCF-7 tumor xenograft in nude mice. (Pubmed Central) - May 20, 2022
RD extract seems to have the potential therapeutic effect of alleviating PCOS complications, and IGF-1 signaling may be involved in the beneficial effects of RD on PCOS. Our findings revealed that estradiol valerate, which is way less expensive than estradiol pellets, can be used as a tumor proliferator to establish MCF-7 tumors with the highest yield when MCF-7 tumors have been used for xenograft.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Efficacy of Bushen Culuan decoction on ovarian follicle and follicular granulosa cells in mice with premature ovarian insufficiency induced by tripterygium wilfordii polyglycoside. (Pubmed Central) - May 6, 2022
Our findings revealed that estradiol valerate, which is way less expensive than estradiol pellets, can be used as a tumor proliferator to establish MCF-7 tumors with the highest yield when MCF-7 tumors have been used for xenograft. BCD treatment could attenuate pathological process in POI ovaries, suppress GC apoptosis, probably through promoting BMP-7 expression and following inhibiting caspase-3 activation.
- | Retrospective data, Journal: Hormone Concentrations in Transgender Women Who Self-Prescribe Gender Affirming Hormone Therapy: A Retrospective Study. (Pubmed Central) - May 6, 2022
Hormone Concentrations in Transgender Women Who Self-Prescribe Gender Affirming Hormone Therapy: A Retrospective Study. J Sex Med 2022;19:864-871.
- estradiol valerate / Generic mfg.
The Role of Soy Isoflavone in The Genitourinary Syndrome, Vaginal Maturation Index, and Female Sexual Function Index of Menopausal Women ([Virtual]) - Apr 29, 2022 - Abstract #ISGE2022ISGE_552;
Soy isoflavone for 90 days can reduce genitourinary symptoms and improve sexual function in menopausal women without affecting the vaginal maturation index. Keywords : Genitourinary symptoms of menopause, Menopause, Phytoestrogens, Soy isoflavone, Urogenital, Vaginal atrophy
- progesterone / Generic mfg., estradiol valerate / Generic mfg.
Impact of hormonal endometrial preparation for transferring frozen embryos in patients with adenomyosis: an observational prospective study (Hall 4) - Apr 29, 2022 - Abstract #ISGE2022ISGE_358;
Vaginal progesterone gel (90mg/day) was added if endometrial thickness was ≥7 mm...Only in HP group, there was also an increased size of focal adenomyosis foci (p =0.021), size (p =0.043) and number of myometrial cysts (p =0.035), which negatively impacted the subjective evaluation of endometrial thickness (p < 0.001). Conclusion In women with diffuse adenomyosis, hormonal endometrial preparation for frozen embryo transfers seems to be characterized by worsen fertility outcomes and to a worsening of symptoms and of ultrasonographic characteristics.
- progesterone / Generic mfg.
Serum progesterone levels on the day of artificial frozen blastocyst transfer and pregnancy outcome (POSTER Area) - Apr 29, 2022 - Abstract #ISGE2022ISGE_13;
This study suggests a cut-off value 5 ng/ml of the serum P on the day of FET, below which pregnancy was not achieved, but with significant improvement of OPR with the levels over 10 ng/ml. Further research is needed to precise P dosage and value.
- | metformin / Generic mfg.
Preclinical, Journal: Synergic effect of bee pollen and metformin on proliferation and apoptosis of granulosa cells: Rat model of polycystic ovary syndrome. (Pubmed Central) - Apr 21, 2022
On the contrary, apoptosis increased in the groups treated with BP compared to the untreated group (p < .01). BP individually or synergistically with metformin improved the symptoms of PCOS.
- | letrozole / Generic mfg.
Enrollment open: Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS (clinicaltrials.gov) - Apr 21, 2022
P=N/A, N=1078, Recruiting, Sponsor: Reproductive & Genetic Hospital of CITIC-Xiangya
BP individually or synergistically with metformin improved the symptoms of PCOS. Not yet recruiting --> Recruiting
- | estradiol valerate / Generic mfg.
Journal: Preparation and characterization of 3D printed PLA microneedle arrays for prolonged transdermal drug delivery of estradiol valerate. (Pubmed Central) - Apr 9, 2022
The results showed that 3D printed PLA MNAs can penetrate into the skin without reaching to the dermal nerves and puncture of blood vessels. In conclusion, in the current study, we explored the practicability of the preparation of drug loaded reservoir-based BPMNAs using the combination of FDM 3D printing and injection volume filling techniques for painless and prolonged transdermal drug delivery.
- | carbamazepine / Generic mfg.
Preclinical, Journal: Carbamazepine protects the endometrium against negative effects of estrogen in rats. (Pubmed Central) - Apr 8, 2022
The effect likely is probably due to the CYP3A4 enzyme activator effect. CMZ may be protective against EH in high risk women, although confirmation is required.
- | minocycline / Generic mfg.
Preclinical, Journal: Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline. (Pubmed Central) - Apr 5, 2022
The mice were then divided into six groups (n=8 per group, mean body weight 17.77± 0.26): control (received normal saline), PCOS model, control for minocycline, minocycline treated PCOS (50 mg/kg), letrozole treated PCOS (0.5 mg/kg), and metformin-treated PCOS (300 mg/kg)...Minocycline may improve ovulation in PCOS model by returning E2 to a normal level and increasing CL number (ovulation signs). These beneficial outcomes may be related to the changes in CMKLR1 and INSR gene expression involved in glucose metabolism and inflammation.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Estradiol valerate enhances cardiac function via the Nrf2 signaling pathway to protect against oxidative stress by the Nrf2 signaling pathway in an ovariectomized rat model. (Pubmed Central) - Mar 29, 2022
These beneficial outcomes may be related to the changes in CMKLR1 and INSR gene expression involved in glucose metabolism and inflammation. The present study demonstrated that estrogen may protect cardiac function by regulating antioxidant capacity through the Nrf2 pathway.
- | estradiol valerate / Generic mfg., dydrogesterone / Generic mfg.
New P1 trial: The Effect of Pretreatment With Dydrogesterone Vs Combined Estradiol Valerate and Dydrogestrone on Clinical Pregnancy Outcome of ICSI in PCOS Patients" (clinicaltrials.gov) - Mar 28, 2022
P1, N=500, Not yet recruiting, Sponsor: Sohag University
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Efficacy of Bushen Culuan decoction on ovarian follicle and follicular granulosa cells in mice with premature ovarian insufficiency induced by tripterygium wilfordii polyglycoside. (Pubmed Central) - Mar 25, 2022
The present study demonstrated that estrogen may protect cardiac function by regulating antioxidant capacity through the Nrf2 pathway. BCD treatment could attenuate pathological process in POI ovaries, suppress GC apoptosis, probably through promoting BMP-7 expression and following inhibiting caspase-3 activation.
- | sildenafil / Generic mfg.
Journal: Efficacy of subcutaneous granulocyte colonystimulating factor infusion for treating thin endometrium. (Pubmed Central) - Mar 9, 2022
Subcutaneous G-CSF infusion improved the thickness of the endometrium when it was thin. To the best of our knowledge, this is the first documented study to clearly demonstrate the benefits of subcutaneous G-CSF infusion for treating thin endometrium.
- spironolactone / Generic mfg.
Short Term Acute Ischemic Stroke after Initiation of Gender-Affirming Hormone Therapy: A Case Report (Poster Hall) - Mar 6, 2022 - Abstract #AAN2022AAN_3340;
Considering the patient´s young age and unremarkable comprehensive workup, her stroke could be attributed to estrogenic effects that occurred in the short term due to supratherapeutic dosing. This evidences the need for further awareness of the health challenges this population faces.
- | progesterone / Generic mfg., estradiol valerate / Generic mfg.
Preclinical, Journal: Modulatory effects of R10 fraction of garlic (Allium sativum L.) on hormonal levels, T cell polarization, and fertility-related genes in mice model of polycystic ovarian syndrome. (Pubmed Central) - Mar 5, 2022
Treatment with R10 fraction, isolated from garlic, was performed and the alterations in hormonal levels (estradiol, progesterone, and testosterone), T cell polarization markers (IFN-γ, IL-4, and IL-17), and expression of fertility-related genes (Gpx3 and Ptx3) were evaluated...Our study elucidated that R10 fraction of garlic possess immunomodulatory effects alleviating PCOS symptoms. This approach could be adjusted to give rise the optimum therapeutic results and considered as a candidate therapeutic approach for PCOS.
- | cyclophosphamide / Generic mfg.
Journal: Zuogui pills maintain the stemness of oogonial stem cells and alleviate cyclophosphamide-induced ovarian aging through Notch signaling pathway. (Pubmed Central) - Feb 27, 2022
This approach could be adjusted to give rise the optimum therapeutic results and considered as a candidate therapeutic approach for PCOS. In conclusion, the mechanism of ZGP on treating ovarian aging may be relevant to maintain the stemness of OSCs by up-regulating Notch signaling pathway, which added the mechanism of ZGP on the perspective of OSCs at first time.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Polycystic ovary rat model exposure to 150 kHz intermediate frequency: hypothalamic-pituitary-ovarian axis at the receptor, cellular, tissue, and hormone levels. (Pubmed Central) - Feb 26, 2022
There are still many limitations to this study. If properly evaluated, the results of this experiment could help develop a new non-invasive treatment option for women with PCOS in the near future.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: Mechanism analysis of repeatedly steamed and sundried Rehmanniae Radix Praeparata in delaying brain aging in ovariectomized mice based on proteomics (Pubmed Central) - Feb 25, 2022
After ovariectomy, the mice were randomly divided into a model group, an estradiol valerate group(0.3 mg·kg~(-1)), and low-(1.0 g·kg~(-1)), medium-(2.0 g·kg~(-1)), and high-dose(4.0 g·kg~(-1)) RRP groups, and a sham operation group was also set up, with 15 mice in each group...The number of proteins involved in the dopaminergic synapse signaling pathway was the largest, with 13 proteins involved. In summary, RRP can delay brain aging presumedly by increasing the level of estrogen, mediating the dopaminergic synapse signaling pathway, and improving cholinergic function.
- ||| estradiol valerate / Generic mfg., norethindrone / Generic mfg.
Trial completion: PROMES: A Clinical Study in Which Researchers Want to Learn More About the Safety Profile of MESIGYNA (Norethisterone Enantate 50 mg and Estradiol Valerate 5 mg) Used as a Medication to Prevent Pregnancy for Adult Women in Reproductive Age in the Peruvian Population at the Outpatient Clinic. (clinicaltrials.gov) - Feb 25, 2022
P=N/A, N=303, Completed, Sponsor: Bayer
In summary, RRP can delay brain aging presumedly by increasing the level of estrogen, mediating the dopaminergic synapse signaling pathway, and improving cholinergic function. Active, not recruiting --> Completed
- | cyclophosphamide / Generic mfg.
Preclinical, Journal: Efficacy of needling acupoints of Guanyuan (CV4), Sanyinjiao (SP6), Zusanli (ST36), Pishu (BL20), Shenshu (BL23), Zigong (EX-CA1) on expression of p38 mitogen-activated protein kinase in ovarian tissue in rats with premature ovarian failure induced by cyclophosphamide. (Pubmed Central) - Feb 24, 2022
Active, not recruiting --> Completed Acupuncture has the same effect as estrogen in interfering POF caused by cyclophosphamide, and its mechanism may be related to inhibiting the expression of p38MAPK protein in ovarian tissue and affecting the activation of p38MAPK signaling pathway.
- | estradiol valerate / Generic mfg.
Preclinical, Journal: A high dose of estrogen can improve renal ischemia-reperfusion-induced pulmonary injury in ovariectomized female rats. (Pubmed Central) - Feb 22, 2022
A total of 60 female Wistar rats were divided into six groups: (i) intact sham, (ii) OV sham, (iii) OV sham + estradiol valerate (E), (iv) intact ischemia, (v) OV ischemia, and (vi) OV ischemia + E. Bilateral ischemia was performed for 45 min in all groups except sham...The severity of renal and lung damage in ischemic groups increased significantly, and estrogen improved this injury. Estrogen as an antioxidant agent can reduce oxidative stress and may improve renal function and ameliorating lung damage caused by RIR.
- || estradiol valerate / Generic mfg.
Clinical, Journal: Appropriate Age for Height Control Treatment in Patients With Marfan Syndrome. (Pubmed Central) - Feb 11, 2022
This retrospective study included patients with MFS who underwent height control treatment with estradiol valerate...When height change was observed for a minimum of 6 months after completion of estrogen treatment, the average growth was 0.6 (0.2, 2.1) cm. Initiating height control treatment before the age of 10.5 years is effective in female patients with MFS.
- | letrozole / Generic mfg.
New trial: Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS (clinicaltrials.gov) - Feb 7, 2022
P=N/A, N=1078, Not yet recruiting, Sponsor: Reproductive & Genetic Hospital of CITIC-Xiangya
- | estradiol valerate / Generic mfg.
Journal: The effect of LH rise during artificial frozen-thawed embryo transfer (FET) cycles. (Pubmed Central) - Feb 5, 2022
Endometrium preparation was achieved by administration of 2 mg three times per day estradiol valerate tablets...This study found no difference in pregnancy rates between FET cycles where the LH doubled compared to cycles without such a rise in LH. Larger, prospective studies should be conducted to assess the impact of LH elevation on pregnancy outcomes.