estradiol valerate / Generic mfg. 
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  • ||||||||||  estradiol valerate / Generic mfg.
    Journal:  The Identification of Six Estrogen Preparations by Combining Thin-Layer Chromatography with Micro-Raman Imaging Spectroscopy. (Pubmed Central) -  Nov 27, 2024   
    Estriol (E3), estradiol (E2), estradiol valerate (EV), estradiol benzoate (EB), nilestriol (CEE), and ethinylestradiol (EE2) were separated by TLC, and their Rf value and localization were determined under a UV lamp at 254 nm, followed by the in situ enrichment of the drug component...Based on the intensity of the minimum characteristic peak, the stability results within 40 min showed that the RSD of each substance is 1.34, 2.06, 1.65, 3.99, 1.16, and 2.71%, respectively. This method has strong specificity, good stability, and high sensitivity, and it can provide a new reference for improving the identification standards of estrogen preparations.
  • ||||||||||  estradiol valerate / Generic mfg.
    Journal:  The impact of vitamin D3 administration and of high fat diet on oxidative stress and inflammation in experimentally induced polycystic ovary syndrome. (Pubmed Central) -  Nov 6, 2024   
    Forty-four female Wistar rats, 180-200 g, 10 weeks old, were randomly allocated into 2 groups (n=22) that received a single dose intramuscular injection of: sesame oil (group I), or estradiol valerate (5 mg) in sesame oil (group II)...HFD induced inflammation in ovaries, evidenced histologically and through increases of COX2 expressions (p<0.05) without significant influences on oxidative stress and on cholesterol levels. Polycystic ovary syndrome is associated with oxidative stress and inflammation in the ovary tissue and in blood with increased levels of insulin, total cholesterol and triglycerides that might be partially mitigated by vitamin D3 oral administration.
  • ||||||||||  Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    Preclinical, Journal:  Multiple Benefits of Empagliflozin in PCOS: Evidence from a Preclinical Rat Model. (Pubmed Central) -  Oct 25, 2024   
    The best effects, which were comparable to the effects of metformin, were achieved in groups receiving the middle and highest applied doses of EMPA. These results may prompt further clinical research on the use of EMPA in patients with PCOS.
  • ||||||||||  estradiol valerate / Generic mfg.
    Journal:  Estradiol Valerate Tablets Caused Rare Severe Drug Eruption: The First Reported Case. (Pubmed Central) -  Oct 21, 2024   
    Early and systemic use of glucocorticoids is beneficial to the outcome and prognosis of the disease. It highlights the need for clinicians to be vigilant about rare but serious adverse drug reactions, even with medications that are generally considered safe.
  • ||||||||||  progesterone / Generic mfg., estradiol valerate / Generic mfg., spironolactone / Generic mfg.
    Journal:  Gender-Affirming Hormone Therapy With Estrogen Causing Gallstone Associated Acute Pancreatitis. (Pubmed Central) -  Oct 7, 2024   
    Most of these were primarily linked to hypertriglyceridemia. High-dose estrogen therapy in transgender women can elevate the risk of AP through the development of gallstones, underscoring the importance of thorough patient evaluation and discussion of risks assessment prior to initiating hormone therapy.
  • ||||||||||  Taltz (ixekizumab) / Eli Lilly, Japan Tobacco
    Periurethral lymphoplasmacytic cell infiltrate in a male-to-female vaginoplasty (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_4355;    
    In gender-affirming surgery patients, the change in the location of the different anatomical structures entails an extra point of difficulty when diagnosing dermatological entities. In this case, a rare complication of a gender- affirming surgery is reported highlighting the need for its knowledge to avoid diagnostic errors.
  • ||||||||||  Visanne (dienogest) / Mochida, Bayer
    Clinical, Observational data, Journal:  Comparison of dienogest or combinations with ethinylestradiol/estradiol valerate on the pain score of women with endometriosis: A prospective cohort study. (Pubmed Central) -  Jul 5, 2024   
    The recommended pain medications are oral hormonal contraceptives, progestin therapy, danazol, gonadotropin-releasing hormone analogs, nonsteroidal anti-inflammatory drugs, and aromatase inhibitors...Patients were divided into 3 groups (20 patients in each medication group) according to the given medication: cyclic DNG (Visanne) or 0.03?mg ethinylestradiol combined with 2?mg DNG (Dienille) or estradiol valerate combined with 2?mg DNG (Qlarista)...However, statistically, significant decreases were seen in the cyst size and VAS score, indicating response to therapy in all groups. In conclusion, we think it is more reasonable to use cost-effective oral contraceptive medications, which also cause common side effects, instead of costing DNG since all drugs have the same efficiency and success.
  • ||||||||||  estradiol valerate / Generic mfg.
    Preclinical, Journal:  Bergenin attenuates triptolide-caused premature ovarian failure in mice based on the antioxidant activity. (Pubmed Central) -  May 30, 2024   
    Mice received bergenin (25, 50, 100?mg/kg, i.g.) or estradiol valerate (EV) (0.1?mg/kg, i.g.) daily, 1?h before triptolide treatment...Together, bergenin counteracts triptolide-caused POF in mice by inhibiting Nrf2-mediated oxidative stress and preventing OGC apoptosis. Combining bergenin with TW preparations may effectively reduce the risk of POF.
  • ||||||||||  Livial (tibolone) / Organon
    Journal:  Effect of tibolone versus hormone replacement therapy on lower urinary tract symptoms and sexual function. (Pubmed Central) -  May 26, 2024   
    Despite the limited effect, tibolone seems to have more benefit in nocturia than HRT. In addition, tibolone seems to have benefits on overall low urinary tract storage symptoms; and both tibolone and HRT seem to have beneficial effects on female sexual function, despite there were no significant differences between tibolone and HRT.
  • ||||||||||  estradiol valerate / Generic mfg.
    Preclinical, Journal:  UPLC-Triple-TOF-MS-based serum metabonomic revealed the alleviating effect of QingYan Formula on perimenopausal syndrome rats. (Pubmed Central) -  May 21, 2024   
    A combination of metabonomic analysis and in vitro pharmacodynamic experiments was employed to achieve this objective.Over a period of 12 weeks, ovariectomized (OVX) rats were orally administered QYF's 70?% ethanol extract or estradiol valerate (EV)...PI3KCA, SRC, and MAPK3 are potential therapeutic targets for QYF therapeutic effects. These findings support the efficacy of QYF in alleviating perimenopausal syndrome and regulating lipid metabolic disorders in OVX rats.
  • ||||||||||  Descovy (emtricitabine/tenofovir alafenamide) / Gilead
    No Significant Interactions From Hormone Therapy on F/TAF-Based PrEP in Trans Women: iFACT3 Study (Poster hall) -  Mar 16, 2024 - Abstract #CROI2024CROI_600;    
    Intracellular TFV-DP and FTC-TP concentrations in rectal tissue were comparable when F/TAF-based PrEP was administered with and without FHT. These findings align with our previously data in the plasma, urine, and PBMCs compartments, indicating no clinically significant drug-drug interactions from FHT towards F/TAF-based oral daily PrEP are anticipated.
  • ||||||||||  estradiol valerate / Generic mfg.
    Enrollment open:  Estradiol and Stress Reactivity in Women (clinicaltrials.gov) -  Mar 12, 2024   
    P=N/A,  N=74, Recruiting, 
    These findings align with our previously data in the plasma, urine, and PBMCs compartments, indicating no clinically significant drug-drug interactions from FHT towards F/TAF-based oral daily PrEP are anticipated. Not yet recruiting --> Recruiting
  • ||||||||||  estradiol valerate / Generic mfg.
    Preclinical, Journal:  Effect of nanocurcumin on fertility in murine model of polycystic ovary syndrome. (Pubmed Central) -  Mar 11, 2024   
    Fifty adult female mice were randomly categorized into five equal groups including non-treated control and PCOS (receiving 0.20 mg estradiol valerate (EV) intra-peritoneally once a day for 21 days) as well as NCC12.50 + PCOS, NCC25 + PCOS and NCC50 + PCOS (receiving respectively 12.50, 25.00 and 50.00 mg kg-1 NCC daily along with EV injection through oral gavages for 21 days) groups...Results showed that NCC in a dose-dependent manner improved ovarian cyto-architectural organization and oxidant/anti-oxidant balance along with IVF rate and pre-implantation embryo development in PCOS mice. These findings revealed that NCC at the doses of 25.00 and 50.00 mg kg-1 could alleviate PCOS-linked reproductive disruptions in female mice.
  • ||||||||||  letrozole / Generic mfg.
    Enrollment open:  Endometrial Preparation in Frozen Embryo Transfer Cycles (clinicaltrials.gov) -  Feb 25, 2024   
    P4,  N=210, Recruiting, 
    These findings revealed that NCC at the doses of 25.00 and 50.00 mg kg-1 could alleviate PCOS-linked reproductive disruptions in female mice. Not yet recruiting --> Recruiting
  • ||||||||||  estradiol valerate / Generic mfg.
    Trial completion date, Trial primary completion date:  Natural Versus Artificial Cycle for Frozen-Thawed Embryo Transfer (clinicaltrials.gov) -  Feb 20, 2024   
    P4,  N=554, Recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: Jun 2023 --> Dec 2024 | Trial primary completion date: Sep 2022 --> Apr 2024
  • ||||||||||  CARDIAC REHABILITATION FOR TRANSGENDER PATIENT: CASE REPORT (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_473;    
    Interestingly, CR did not improve body composition in this patient. Despite the clear positive impact that CR had on exercise capacity, body composition appeared to worsen.
  • ||||||||||  estradiol valerate / Generic mfg.
    Review, Journal:  NR5A1-related 46,XY partial gonadal dysgenesis: A case report and literature review. (Pubmed Central) -  Jan 15, 2024   
    The subsequent treatment would be challenging in patients with combined 17OHD and T2DM, considering the potential contribution of glucocorticoids to diabetic balance and osteoporosis. 46,XY DSD is a rare disease that the development of chromosomal, gonadal, or anatomical sex is discordant, when diagnosed 46,XY DSD, the identification of an NR5A1 variant should be considered.
  • ||||||||||  estradiol valerate / Generic mfg.
    New trial:  Estradiol and Stress Reactivity in Women (clinicaltrials.gov) -  Jan 12, 2024   
    P=N/A,  N=74, Not yet recruiting, 
  • ||||||||||  estradiol valerate / Generic mfg.
    Trial completion date, Trial termination, Trial primary completion date:  Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors (clinicaltrials.gov) -  Jan 8, 2024   
    P=N/A,  N=4, Terminated, 
    This study demonstrates that CHE improves bone loss in PMOP mainly through regulating lipid metabolism pathways, which provides an evidence base for CHE treatment of PMOP. Trial completion date: Dec 2024 --> Jan 2023 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2023 --> Jan 2023; lack of recruitment