- |||||||||| INX 189 / BMS, GS-6620 / Gilead
Journal: Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2. (Pubmed Central) - Aug 3, 2022
We employed a Quadratic Unbounded Binary Optimization (QUBO) model, to search for compounds similar to Remdesivir, the first antiviral against SARS-CoV-2 approved for human use, using a quantum-inspired device...While GS-6620 was the top compound predicted by both models, the QUBO model predicted BMS-986094 as second best...While Tanimoto may be employed when performing relatively small comparisons, QUBO is also accurate and may be well suited for very complex problems where computational resources may limit the number and/or complexity of possible combinations to evaluate. Our quantum-inspired screening method can therefore be employed in future searches for novel pharmacologic inhibitors, thus providing an approach for accelerating drug deployment.
- |||||||||| GS-6620 / Gilead
Journal: An alternative splicing signature in human Crohn's disease. (Pubmed Central) - Nov 11, 2021
Our study provided a landscape of AS events in CD, especially as the first study focused on a Chinese cohort. Our data suggest that dysregulation of AS may be a new mechanism that contributes to the pathogenesis of CD.
- |||||||||| GS-6620 / Gilead
Journal: Bioinformatics analysis for the identification of key genes and long non-coding RNAs related to bone metastasis in breast cancer. (Pubmed Central) - Jul 31, 2021
We screened differentially expressed genes and lncRNAs between normal breast and breast cancer bone metastasis samples using the GSE66206 dataset from the Gene Expression Omnibus...The role of core driver genes and lncRNAs in the network implies their biological functions in regulating bone development and remodeling. Thus, targeting the core driver genes and lncRNAs in the network may be a promising therapeutic strategy to manage bone metastasis.
- |||||||||| Review, Journal: New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections. (Pubmed Central) - Jan 15, 2020
Four out of the eight compounds (galidesivir, GS-6620, remdesivir and pyrazofurin) are C-nucleosides, and two of them (GS-6620, remdesivir) also contain a phosphoramidate part. The C-nucleoside and phosphoramidate (and for the adenine analogues the 1'-cyano group as well) may be considered as essential attributes for their antiviral activity.
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