| megestrol / Generic mfg. |
ChiCTR1800017953: Proton pump inhibitor (esomeprazole /omeprazole /pantoprazole) Combined with Megestrol for Preventing Highly Emetogenic Chemotherapy Induced Nausea and Vomiting |
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| Recruiting | 4 | 100 | | four-way antiemetic regimen ;Routine treatment | Henan Cancer Hospital; Henan Cancer Hospital, self-raising | Tumor | | | | |
NCT03963752: Clinical Trial of Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western Medicine |
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| Completed | 4 | 126 | RoW | Ziyinxiehuo Granules Herbs, nourishing"Yin"-removing"Fire" Granules, Megestrol Acetate Tablet, Leuprorelin Acetate 3.75mg Injection | Children's Hospital of Fudan University | Idiopathic Precocious Puberty | 08/22 | 09/22 | | |
iKanEat, NCT03815019: IKanEat: a Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children |
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| Active, not recruiting | 4 | 71 | US | Megestrol Acetate, Megace, Megestrol, iKanEat Behavioral Intervention | University of Kansas Medical Center | Feeding Behavior, Feeding Disorder of Infancy or Early Childhood | 06/25 | 06/25 | | |
2010-019831-36: A phase III randomized trial comparing two regimens for treatment of cancer anorexia / cachexia syndrome(CACS). |
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| Ongoing | 3 | 148 | Europe | CARNITENE, CELEBREX, FLUIFORT*30BUST GRAT 2,7G, MEGACE*30CPR 160MG, CARNITENE, CELEBREX, FLUIFORT*30BUST GRAT 2,7G, MEGACE*30CPR 160MG | AZIENDA OSPEDALIERO UNIVERSITARIA DI CAGLIARI | Cancer anorexia / cachexia syndrome in patients with advanced tumors of different sites | | | | |
NCT04939090: Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients |
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| Recruiting | 3 | 360 | US | Olanzapine, Megestrol Acetate, Questionnaire Administration | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI) | Advanced Malignant Solid Neoplasm, Anorexia, Hematopoietic and Lymphoid Cell Neoplasm | 05/26 | 12/26 | | |
| Recruiting | 3 | 300 | RoW | Megestrol Acetate and olanzapine, Starch powder 50 mg | Qingdao Central Hospital | Nutrition Disorders, Immunotherapy, Cancer, Survival, Prosthesis | 05/25 | 05/27 | | |
NCT04897217: Levonorgestrel-Releasing Intrauterine System (LNG-IUS) in the Management of Atypical Endometrial Hyperplasia |
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| Withdrawn | 3 | 40 | NA | Megestrol Acetate, Levonorgestrel Drug Implant | Wake Forest University Health Sciences, National Cancer Institute (NCI) | Endometrial Hyperplasia | 10/24 | 11/26 | | |
NCT06671548: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids |
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| Not yet recruiting | 3 | 120 | RoW | Relugolix, megestrol acetate, medroxyprogesterone acetate, Relugolix placebo, megestrol acetate placebo, medroxyprogesterone acetate placebo | Qilu Pharmaceutical Co., Ltd. | Heavy Menstrual Bleeding, Uterine Fibroids | 12/26 | 02/27 | | |
NCT05316467: Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma |
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| Recruiting | 2/3 | 89 | RoW | Intensive Lifestyle Intervention (ILI), Weight Management, Megestrol Acetate 160 MG Oral Tablet, yilizhi | Xiaojun Chen | Endometrial Carcinoma, Obese, Overweight, Fertility Issues | 02/25 | 02/26 | | |
NCT05316493: Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia |
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| Recruiting | 2/3 | 172 | RoW | Intensive Lifestyle Intervention (ILI), Weight Management, Megestrol Acetate 160 MG Oral Tablet, yilizhi, Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg, manyuele | Xiaojun Chen | Atypical Endometrial Hyperplasia, Fertility Issues, Overweight and Obesity | 02/25 | 02/26 | | |
| Recruiting | 2/3 | 1615 | Europe, Canada | Olaparib, Lynparza, Pelvic external beam radiotherapy, EBRT, Chemotherapy, Cisplatin, Carboplatin, Paclitaxel, Durvalumab, Imfinzi, Medroxyprogesterone Acetate, Progestogen, Megestrol Acetate, Vaginal brachytherapy, Observation | Leiden University Medical Center, Institute Gustave Roussy (sponsor p53abn-RED trial), Leiden University Medical center (sponsor MMRd-GREEN trial), University College London (sponsor NSMP-ORANGE trial), Canadian Clinical Trials Group (sponsor POLEmut-BLUE trial), Dutch Gynaecological Oncology Group, Comprehensive Cancer Centre The Netherlands, Cancer Research UK & UCL Cancer Trials Centre, Dutch Cancer Society, AstraZeneca, National Cancer Institute, France, Canadian Institutes of Health Research (CIHR) | Endometrial Cancer | 01/30 | 01/31 | | |
PIONEER, NCT03306472 / 2016-003752-79: A Pre-operative Window Study of Letrozole Plus PR Agonist (Megestrol Acetate) Versus Letrozole Alone in Post-menopausal Patients With ER-positive Breast Cancer |
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| Completed | 2 | 198 | Europe | Megestrol Acetate 40 MG, Megace, Megestrol Acetate 160 MG, Letrozole | Cambridge University Hospitals NHS Foundation Trust, Anticancer Fund, Belgium | Breast Cancer | 10/22 | 10/23 | | |
2020-004530-38: PROSPECTIVE, PHASE II STUDY TO EVALUATE THE EFFICACY OF ADDITION OF PROGESTERONE TO STANDARD CHEMOTHERAPY ACCORDING TO EDP SCHEME PLUS MITOTANE IN PATIENTS WITH ADVANCED ADRENAL CORTICAL (PESETA TRIAL) Studio prospettico, di fase II volto a valutare l’efficacia dell’aggiunta di progesterone alla chemioterapia standard secondo schema EDP + mitotane nei pazienti affetti da carcinoma della corticale del surrene avanzato. |
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| Not yet recruiting | 2 | 80 | Europe | megace, [megace], Tablet, MEGACE - 160 MG COMPRESSE 30 COMPRESSE | AZIENDA SOCIO SANITARIA TERRITORIALE DEGLI SPEDALI CIVILI DI BRESCIA, UNIVERSITA' DEGLI STUDI DI BRESCIA_ BANDO AIRC | advanced/ metastatic patients with ACC carcinoma della corticale del surrene avanzato, advanced/ metastatic patients with ACC carcinoma della corticale del surrene avanzato, Diseases [C] - Cancer [C04] | | | | |
NCT05380479: Mirtazapine Versus Megestrol Acetate in Treatment of Anorexia-cachexia in Advanced Cancer Patients. |
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| Recruiting | 2 | 80 | RoW | Mirtazapine, Megestrol Acetate | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Anorexia | 01/23 | 02/23 | | |
NCT05492487: A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore |
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| Recruiting | 2 | 60 | RoW | Mirena, Megace | KK Women's and Children's Hospital | Endometrial Hyperplasia, Fertility Issues, Disease Regression, Treatment Side Effects | 03/23 | 03/23 | | |
NCT04491643: Megestrol Acetate Plus Rosuvastatin in Young Women With Early Endometrial Carcinoma |
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| Recruiting | 2 | 48 | RoW | Megestrol Acetate, Rosuvastatin | Fudan University | Endometrial Carcinoma Stage I | 08/25 | 08/25 | | |
NCT03671811: Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy |
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| Active, not recruiting | 2 | 44 | US | Megestrol Acetate, 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, 17.alpha.-Acetoxy-6-methylpregna-4,6-diene-3,20-dione, 6-Dehydro-6-methyl-17.alpha.-acetoxyprogesterone, 6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone, BDH 1298, BDH-1298, Maygace, Megace, Megestat, Megestil, Niagestin, Ovaban, Pallace, SC-10363, Pterostilbene, 3'',5''-Dimethoxy-4-stilbenol, 3,5-Dimethoxy-4''-hydroxystilbene, Trans-3,5-dimethoxy-4-hydroxystilbene | City of Hope Medical Center, National Cancer Institute (NCI) | Atypical Endometrial Hyperplasia, Endometrial Carcinoma | 03/25 | 03/25 | | |
NCT05247268: Gonadotropin-releasing Hormone Agonist (GnRHa) Plus Letrozole in Young Women with Early Endometrial Cancer |
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| Recruiting | 2 | 104 | RoW | Megestrol Acetate 160 MG Oral Tablet, Megestrol Acetate, Medroxyprogesterone Acetate 500 MG, Medroxyprogesterone Acetate, Triprorelin Acetate, Letrozole 2.5mg, Letrozole | Fudan University, Peking Union Medical College Hospital | Endometrial Neoplasm Malignant Stage I | 03/25 | 03/25 | | |
NCT04576104: Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer |
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| Recruiting | 2 | 50 | US | Biopsy, BIOPSY_TYPE, Bx, Extended Release Metformin Hydrochloride, ER Metformin Hydrochloride, Extended-release Metformin Hydrochloride, Glucophage XR, Glumetza, Metformin Hydrochloride Extended Release, Megestrol Acetate, 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, 17.alpha.-Acetoxy-6-methylpregna-4,6-diene-3,20-dione, 6-Dehydro-6-methyl-17.alpha.-acetoxyprogesterone, 6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone, BDH 1298, BDH-1298, Maygace, Megace, Megestat, Megestil, Niagestin, Ovaban, Pallace, SC 10363, SC-10363, Questionnaire Administration | National Cancer Institute (NCI) | Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, Endometrial Carcinoma | 11/24 | 11/24 | | |
ChiCTR2200055624: Levonorgestrel-releasing intrauterine device and megestrol acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and endometrial carcinoma: a prospective, randomised, blinded-endpoint design trial protocol |
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| Recruiting | 2 | 80 | | LNG-IUD plus metformin ;megestrol acetate plus metformin | Shenyang Women's and Children's Hospital; Level of the institution：, Shenyang Young and Middle-Aged Scientific and Technological Innovation Talents Support Program | atypical endometrial hyperplasia and endometrial carcinoma | | | | |
PESETA, NCT05913427: Evaluation of the Efficacy of Addition of Progesterone to Standard Chemotherapy in Adrenocortical Carcinoma (ACC) |
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| Recruiting | 2 | 80 | Europe | Etoposide, doxorubicin, cisplatin and Mitotane plus Megestrol Acetate 160 MG, Megace, Etoposide, doxorubicin, cisplatin and Mitotane plus Placebo, placebo | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | Adrenocortical Carcinoma | 06/27 | 06/27 | | |
NRG-GY028, NCT05538897: Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers |
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| Recruiting | 1/2 | 96 | US | Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ipatasertib, GDC 0068, GDC-0068, GDC0068, RG 7440, RG-7440, RG7440, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Megestrol Acetate, 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, 17.alpha.-Acetoxy-6-methylpregna-4,6-diene-3,20-dione, 6-Dehydro-6-methyl-17.alpha.-acetoxyprogesterone, 6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone, BDH 1298, BDH-1298, Maygace, Megace, Megestat, Megestil, Niagestin, Ovaban, Pallace, SC 10363, SC-10363 | National Cancer Institute (NCI), NRG Oncology | FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma, Metastatic Endometrial Endometrioid Adenocarcinoma, Recurrent Endometrial Endometrioid Adenocarcinoma | 01/27 | 01/27 | | |
NCT06147908: Clinical Trial to Evaluate the Pharmacokinetic Characteristics of DW5221 and DW5221-R |
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| Completed | 1 | 54 | RoW | DW5221, Test, DW5221-R, Reference | Daewon Pharmaceutical Co., Ltd. | Apetite Stimulants | 10/22 | 11/22 | | |
| Terminated | 1 | 5 | Canada | Megestrol Acetate, MEGESTROL, Megace | Sunnybrook Health Sciences Centre, Ontario Institute for Cancer Research | Endometrial Cancer | 10/23 | 10/23 | | |
ChiCTR2300075943: Megestrol acetate plus palonosetron versus dexamethasone plus palonosetron in preventing chemotherapy-induced nausea and vomiting induced by moderate-emetogenic chemotherapy in patients with gastric cancer:A randomized, multi-center, phase 3 trial |
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| Not yet recruiting | 1 | 326 | | Megestrol acetate 160mg orally once a day d1-3+Palonosetron 0.25mg IV infusion completed within 30 minutes before chemotherapy, d1.; Dexamethasone 10 mg d1,5mg d2,d3 orally once a day + palonosetron 0.25 mg IV infusion completed within 30 minutes before chemotherapy d1. | West China Hospital of Sichuan University; West China Hospital of Sichuan University, Clinical Research Fund in West China Hospital of Sichuan University | gastric cancer, chemotherapy-induced nausea and vomiting | | | | |
| Completed | N/A | 180 | | Traditional chemotherapy ;Traditional chemotherapy+Bevacizumab ;Traditional chemotherapy+CIK ;chemotherapy+Bevacizumab+CIK ;Traditional chemotherapy+Megestrol ;Traditional chemotherapy+Bevacizumab+CIK+Megestrol | First Affiliated Hospital, Shenzhen University, Futian District, Shenzhen, Guangdong Province; Level of the institution：, Shenzhen Innovation Committee | Inoperable hepatocellular carcinoma | | | | |
ChiCTR1800016626: Prognostic study of nutritional intervention by Gastrostomy in ALS patients |
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| Recruiting | N/A | 30 | | Abbott Ensure Complete ;Megestrol | Dahua Hospital; Dahua Hospital, self-financing | ALS, amyotrophic lateral sclerosis | | | | |
ChiCTR2000030783: Real World Study for Megestrol Acetate on Cachexia of Patients with Cancer |
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| Recruiting | N/A | 500 | | N/A | Anhui Provincial Cancer Hospital; Huangshan Mandixin Pharmaceutical Co., Ltd., Self-raised | Cachexia | | | | |
NCT02556619: Randomized Control Trial (RCT) of Early Palliative Care for HCC |
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| Recruiting | N/A | 72 | US | Early Palliative Care/Symptom Control | The University of Texas Health Science Center, Houston, American Cancer Society, Inc. | Carcinoma, Hepatocellular | 09/21 | 09/21 | | |
ChiCTR2100049007: A single-center prospective cohort study of megestrol combined with oral nutritional supplements in the treatment of malnourished lung cancer |
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| Not yet recruiting | N/A | 100 | | Megestrol Acetate ;Megestrol Acetate Combined with Oral Nutrition Supplement | Shaanxi Provincial People's Hospital; Shaanxi Provincial People's Hospital, self-funded | Lung cancer | | | | |
NCT06417736: Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women |
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| Recruiting | N/A | 75 | RoW | Megestrol Acetate 40 MG, membrane-inhibiting formula | Women's Hospital School Of Medicine Zhejiang University | Endometrial Cancer Stage I, Endometrial Hyperplasia | 07/25 | 12/26 | | |
NCT05945407: Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer |
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| Recruiting | N/A | 57 | RoW | Indication-extended Fertility-sparing Therapy | Peking University People's Hospital, Peking University Third Hospital, Peking Union Medical College Hospital, Third Military Medical University, Tianjin Medical University General Hospital, Tongji Hospital, Qilu Hospital of Shandong University, Shengjing Hospital, Beijing Chao Yang Hospital, Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences | Endometrial Neoplasms, Endometrial Neoplasm Malignant, Endometrial Neoplasm Malignant Stage I, Carcinoma, Endometrioid, Fertility Preservation | 12/23 | 12/27 | | |
NCT06549855: PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer |
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| Not yet recruiting | N/A | 10 | RoW | Sintilimab or Pembrolizumab and medroxyprogesterone acetate (MPA)/ megestrol acetate (MA), Sintilimab or Pembrolizumab and MPA/MA | Peking University People's Hospital, Peking Union Medical College Hospital, Peking University Third Hospital, Huazhong University of Science and Technology, Tianjin Medical University, Shandong University, Shengjing Hospital, Beijing Chao Yang Hospital | Endometrial Cancer, Endometrioid Carcinoma, Mismatch Repair Deficiency | 07/29 | 10/29 | | |
