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138 Diseases |  |
26 Trials |
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26 Trials |  |
791 News |  |
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- | Journal: An Improved LC-MS/MS Method for the Analysis of Thirteen Cytostatics on Workplace Surfaces. (Pubmed Central) - Aug 29, 2021
Method application in a Portuguese university hospital (28 samples) identified the presence of seven cytostatics, at concentrations below 100 pg/cm, except for three samples. The widespread presence of cyclophosphamide evinces the necessity to review implemented procedures.
- Syndros (dronabinol oral solution) / Insys Therap
Limited benefit and high financial burden of drugs used to manage cancer-associated anorexia/cachexia syndrome (CACS). () - Aug 26, 2021 - Abstract #ASCOQC2021ASCO_QC_80;
Overall there is limited data supporting use of drugs for managing CACS. Thus, our findings can help guide patient-clinician discussions about the risk/benefit ratio of a prescription for managing CACS, while highlighting the importance of seeking less expensive formulations when possible.
- | megestrol / Generic mfg., rosuvastatin / Generic mfg.
Enrollment change: Megestrol Acetate Plus Rosuvastatin in Young Women With Atypical Endometrial Hyperplasia (clinicaltrials.gov) - Aug 22, 2021
P2/3, N=36, Recruiting, Sponsor: Fudan University
Thus, our findings can help guide patient-clinician discussions about the risk/benefit ratio of a prescription for managing CACS, while highlighting the importance of seeking less expensive formulations when possible. N=174 --> 36
- |||| megestrol / Generic mfg.
Clinical, Pricing: A10 Even for patients, out-of-pocket costs can be massive. Here is megestrol (brand name, Megace) on @GoodRx. A 30-day supply can cost $1,200!! And this is a ‘’discounted price.’’ #PancChat (Twitter) - Aug 17, 2021
- ||| megestrol / Generic mfg.
Reimbursement, Medicare: A10 These drugs are also not cheap! @TimothyJBrownMD et al have shown that Medicare spending on megestrol products is approx. $30 million per year! For a drug we know doesn’t work great. @MASCC_JSCC #PancChat https://t.co/llQor9tN5g (Twitter) - Aug 17, 2021
- |||| megestrol / Generic mfg.
Adverse events: A10 In fact, medications can cause harms. Megestrol, for example, can cause blood clots, edema, adrenal insufficiency, and was even associated with an increased risk of death! #PancChat https://t.co/9GhtegxcBj (Twitter) - Aug 17, 2021
- || megestrol / Generic mfg.
A10 One reason is that medications have not consistently improved function—medications such as megestrol (Megace) have been shown to increase body weight by 1-2 kg, but this is largely fluid/ fat weight. It is not meaningful muscle tissue or other outcomes. #PancChat (Twitter) - Aug 17, 2021
- || megestrol / Generic mfg.
Rx is from a lack of options, desperation, a desire to "do something". I think we should be advocating for great coverage for supportive care - dietitians, counselors, etc. Would be more helpful than megace (Twitter) - Aug 17, 2021
- |||| megestrol / Generic mfg., dronabinol oral / Generic mfg.
Clinical, FDA event: A10. There are no FDA-approved medications for the cancer #cachexia syndrome but there are several in development. There are several FDA approved drugs for anorexia in pts with AIDS (megestrol acetate and dronabinol) that are widely used in patients with cancer #pancchat (Twitter) - Aug 17, 2021
- || megestrol / Generic mfg.
Clinical, Journal: PPOS Protocol Effectively Improves the IVF Outcome Without Increasing the Recurrence Rate in Early Endometrioid Endometrial Cancer and Atypical Endometrial Hyperplasia Patients After Fertility Preserving Treatment. (Pubmed Central) - Aug 14, 2021
All patients received megestrol acetate which was initiated immediately after AEH or EEC diagnosis by hysteroscopy...In the adjusted model of multivariate logistic regression analysis, the age (P = 0.014) at ovulation induction and treatment time of endometrial lesions (P < 0.001) were significantly correlated with the recurrence of endometrial disease. The PPOS protocol is a feasible and safe strategy to stimulate ovulation during IVF after fertility preservation therapy, and the age at ovulation induction and treatment time of endometrial lesions are two stable predictors of recurrence in endometrial diseases.
- | Epogen (epoetin alfa) / Amgen
Journal: Screening medications for association with progression to wet age-related macular degeneration (AMD). (Pubmed Central) - Aug 1, 2021
The PPOS protocol is a feasible and safe strategy to stimulate ovulation during IVF after fertility preservation therapy, and the age at ovulation induction and treatment time of endometrial lesions are two stable predictors of recurrence in endometrial diseases. This exploratory drug screening study identified several potential targets for follow up studies to further evaluate and determine if they may prevent or delay progression to advanced AMD.
- megestrol / Generic mfg.
[VIRTUAL] COMBINED ORAL MEGESTROL ACETATE/ LEVONORGESTREL-INTRAUTERINE SYSTEM FOR ATYPICAL ENDOMETRIAL HYPERPLASIA: A SINGLE-CENTER PROSPECTIVE RANDOMIZED CONTROLLED PILOT STUDY (Hall 3) - Jul 29, 2021 - Abstract #IGCS2021IGCS_128;
P2/3
This exploratory drug screening study identified several potential targets for follow up studies to further evaluate and determine if they may prevent or delay progression to advanced AMD. LNG-IUS significantly improved CR time compared with that for MA, with less adverse events, and might be an alternative treatment option for AEH patients.
- | dronabinol oral / Generic mfg.
Journal: Appetite Stimulants for Treatment of Protein Energy Wasting of Chronic Kidney Disease. (Pubmed Central) - Jul 29, 2021
The International Society of Renal Nutrition and Metabolism suggests appetite stimulants, including megestrol, dronabinol, mirtazapine, and cyproheptadine, as adjunctive treatment options in addition to parenteral or oral nutritional supplementation. This article reviews the evidence for use of these drugs as appetite stimulants and discusses their use in patients with chronic kidney disease.
- ||| megestrol / Generic mfg., gabapentin / Generic mfg.
If you find yourself prescribing gabapentin for neuropathy or megace for cachexia & become frustrated when they do not work Remember to support the fellows and colleagues who want better solutions @fischmd @guptaarjun90 @arifkamalmd @IshwariaMD @edubru (Twitter) - Jul 28, 2021
- || megestrol / Generic mfg.
Clinical, Journal: Risk factors for recurrence in patients with atypical endometrial hyperplasia and endometrioid adenocarcinoma after fertility-sparing treatments. (Pubmed Central) - Jul 7, 2021
Regular oral progestin also significantly prolonged the PFS time (RR 4.726, 95% CI 2.672~8.359). The progestin type used in treatment and regular maintenance treatment of young patients with atypical endometrial hyperplasia and early-stage endometrioid adenocarcinoma after complete remission might be correlated with disease recurrence.
- Revlimid (lenalidomide) / BMS, Nexavar (sorafenib) / Bayer, Amgen
[VIRTUAL] CONSTRUCTION OF AN INFORMATION GUIDE FOR THE MANAGEMENT OF ANTINEOPLASTIC AND SUPPORT DRUGS VIA PROBE. () - Jul 2, 2021 - Abstract #ICUC2021ICUC_306;
The information provided by the information guide is intended to support oncology professionals in prescribing and correctly administering oral solids via enteral tube. In the literature review, important points such as the use of an oral meter, a device that ensures accuracy and reduces waste, and the correct location of the probe were emphasized in this guide.
- || megestrol / Generic mfg.
Clinical, Journal: DESLORELIN (SUPRELORIN) USE IN NORTH AMERICAN AND EUROPEAN ZOOS AND AQUARIUMS: TAXONOMIC SCOPE, DOSING, AND EFFICACY. (Pubmed Central) - Jun 30, 2021
However, the stimulatory phase can be prevented by treatment with megestrol acetate for 7 d before and 7 d after implant insertion...The data indicate that Suprelorin is an effective and safe contraceptive option for female mammals, although it may not be effective in males of some mammalian species. Further research is needed to ascertain its usefulness in nonmammalian taxa.
- megestrol / Generic mfg., mirtazapine / Generic mfg.
[VIRTUAL] PROPENSITY SCORE-MATCHING ANALYSIS COMPARING SAFETY OUTCOMES OF APPETITE-STIMULATING MEDICATIONS IN ONCOLOGY PATIENTS () - Jun 29, 2021 - Abstract #MASCCISOO2021MASCC_ISOO_416;
Conclusions Both megestrol acetate and mirtazapine are commonly used appetite stimulating agents in the elderly oncology population. There were no safety differences revealed when evaluating both of these agents.
- || Zolinza (vorinostat) / Merck (MSD)
Clinical, Journal, IO biomarker: Integrative Analysis of a Novel Eleven-Small Nucleolar RNA Prognostic Signature in Patients With Lower Grade Glioma. (Pubmed Central) - Jun 25, 2021
We also found that high- and low-risk score phenotypes of LGG patients have significant differences in immune infiltration and cancer immune microenvironment. The present study identified a novel eleven-snoRNA prognostic signature of LGG and performed a integrative analysis of its molecular mechanisms and relationship with tumor immunity.
- | megestrol / Generic mfg., olanzapine / Generic mfg.
New P3 trial, Metastases: Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients (clinicaltrials.gov) - Jun 25, 2021
P3, N=360, Not yet recruiting, Sponsor: Alliance for Clinical Trials in Oncology
- || Megace (megestrol) / BMS, SOBI
Review, Journal: Conservative management of grade 2 stage IA endometrial carcinoma and literature review. (Pubmed Central) - Jun 22, 2021
Fertility-sparing treatment for stage IA grade 2 endometrial carcinoma patients is worth exploration. Megestrol acetate with or without metformin combined with hysteroscopic lesion ablation may be an effective therapy.
- || Megace (megestrol) / BMS, SOBI
Clinical, Journal: iKanEat: protocol for a randomized controlled trial of megestrol as a component of a pediatric tube weaning protocol. (Pubmed Central) - Jun 22, 2021
Megestrol acetate with or without metformin combined with hysteroscopic lesion ablation may be an effective therapy. This trial will provide data regarding whether megestrol is a safe and effective component of the iKanEat tube weaning protocol, as well as important data on how the tube weaning process impacts parent stress and parent and child quality of life.
- | Megace (megestrol) / BMS, SOBI
Journal: Hydrophilic and Functionalized Nanographene Oxide Incorporated Faster Dissolving Megestrol Acetate. (Pubmed Central) - Jun 22, 2021
Additionally, studies done in intestinal media have revealed T did not dissolve for 92.0 min. This work shows promise in incorporating functionalized nanoparticles into the crystal lattice of poorly soluble drugs to improve dissolution rate.
- | Megace (megestrol) / BMS, SOBI
Journal, Combination therapy: Determination of acetylgestagens in animal-derived matrix samples using enhanced matrix removal lipid clean-up in combination with ultra performance liquid chromatography-tandem mass spectrometry. (Pubmed Central) - Jun 22, 2021
A robust and confirmative method was established for the determination of six acetylgestagen residues, namely, flurogestone acetate (FGA), megestrol (MA), melengestrol acetate (MGA), chlormadinone acetate (CMA), medroxyprogesterone (MPA), and hydroxyprogesterone acetate (HPA) in animal-derived matrix samples by utilizing enhanced matrix removal lipid (EMR-lipid) clean-up in combination with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...The recoveries were between 61.0% and 114.8%, and the relative standard deviations (RSDs) were below 12%. The method was calibrated in a matrix-assisted standard solution in various linear ranges for the analytes and matrices, and the correlation coefficients (R) exceeded 0.99 for all the matrices.
- | megestrol / Generic mfg.
New P3 trial, Head-to-Head: Levonorgestrel-Releasing Intrauterine System (LNG-IUS) in the Management of Atypical Endometrial Hyperplasia (clinicaltrials.gov) - May 20, 2021
P3, N=40, Not yet recruiting, Sponsor: Wake Forest University Health Sciences
- | megestrol / Generic mfg.
Trial primary completion date: Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer (clinicaltrials.gov) - May 17, 2021
P2, N=50, Not yet recruiting, Sponsor: National Cancer Institute (NCI)
The method was calibrated in a matrix-assisted standard solution in various linear ranges for the analytes and matrices, and the correlation coefficients (R) exceeded 0.99 for all the matrices. Trial primary completion date: Apr 2023 --> Sep 2023
- || Megace (megestrol) / BMS, SOBI
Retrospective data, Review, Journal: Efficacy and safety of pharmacological cachexia interventions: systematic review and network meta-analysis. (Pubmed Central) - May 14, 2021
Our findings suggest that several pharmacological interventions have potential to offer benefits in treatment of cachexia especially Megace_H and short-term use corticosteroids. Nonetheless, high-quality comparative studies to compare safety and efficacy are warranted for better management of cachexia.
- Megace (megestrol) / BMS, SOBI
[VIRTUAL] Effect of multimodal intervention care on cachexia in patients with advanced cancer compared to conventional management (MIRACLE): An open-label, phase 2 trial. () - Apr 28, 2021 - Abstract #ASCO2021ASCO_3472;
CPC included basic nutritional counselling for two times provided by National Health Insurance Service, and megestrol acetate as needed (ie, anorexia ≥ Grade 2)...At the time of submission, 26 patients were enrolled . Planned period of enrollment is 18 months.
- tamoxifen / Generic mfg.
[VIRTUAL] Evaluating the role of aromatase inhibitors (AIs) in the treatment of endometrial stromal sarcomas (ESS). () - Apr 28, 2021 - Abstract #ASCO2021ASCO_2189;
P2
We found the ORR to be more modest than previously reported . The majority of pts had prolonged stable disease with a DCR of 58% even in stage 4 disease .
- Revlimid (lenalidomide) / BMS, Avastin (bevacizumab) / Roche
[VIRTUAL] Anticancer drugs associated with venous thromboembolic event: Analysis of the WHO pharmacovigilance database. () - Apr 28, 2021 - Abstract #ASCO2021ASCO_901;
P
Recognition of AD most likely to cause VTE can help raise practitioner awareness and lead to earlier diagnosis and treatment . Futures studies should include ADs in VTE risk evaluation and evaluate the management of VTE when recurrences occur under AD favoring VTE .
- | NN1213 / Novo Nordisk
Trial completion date, Trial primary completion date, Metastases: Randomized Control Trial (RCT) of Early Palliative Care for HCC (clinicaltrials.gov) - Apr 27, 2021
P=N/A, N=72, Recruiting, Sponsor: The University of Texas Health Science Center, Houston
Futures studies should include ADs in VTE risk evaluation and evaluate the management of VTE when recurrences occur under AD favoring VTE . Trial completion date: Sep 2020 --> Sep 2021 | Trial primary completion date: Sep 2020 --> Sep 2021
- | Megace (megestrol) / BMS, SOBI
Journal: Upper Gastrointestinal Bleeding, Genital Ulcers, Bacteriuria, Megestrol, Atopic Dermatitis. (Pubmed Central) - Apr 16, 2021
Trial completion date: Sep 2020 --> Sep 2021 | Trial primary completion date: Sep 2020 --> Sep 2021 No abstract available
- | Megace (megestrol) / BMS, SOBI
Journal: Association of Megestrol Use With the Development of New Psychiatric Diagnoses. (Pubmed Central) - Apr 15, 2021
The findings suggest that megestrol, like other glucocorticoid agonists, is associated with an increased risk of developing a psychiatric disorder. This risk should be considered when determining the risk-to-benefit ratio of megestrol use in patients.
- | Megace (megestrol) / BMS, SOBI
Journal, Combination therapy: Prognostic impact of hysteroscopic resection of endometrial atypical hyperplasia/endometrioid intraepithelial neoplasia and early-stage cancer in combination with megestrol acetate. (Pubmed Central) - Apr 7, 2021
We found that hysteroscopic resection of EAH/EIN or EEC in combination with oral progestin therapy was significantly associated with shorter treatment duration to achieve CR and longer time to relapse, compared to patients treated with progestin therapy alone. This large, single-institution study provides convincing data on the efficacy of MA plus hysteroscopic resection in conservative treatment of both EAH/EIN and EC patients, which will have to be confirmed in a prospective multi-institutional trial.
- || Megace (megestrol) / BMS, SOBI
Clinical, Review, Journal: Synchronous Well-differentiated Endometrioid Adenocarcinoma and Leiomyosarcoma of the Uterus With Pulmonary metastasis in a 50-Yr-Old Woman: A Case Report and Review of Literature. (Pubmed Central) - Mar 30, 2021
This is the first reported case of concomitant uterine malignancies with pulmonary metastases and a long follow-up of 9 yr. It is important to rule out carcinosarcoma as a differential diagnosis in such patients.
- | Victoza (liraglutide) / Novo Nordisk
Enrollment change, Trial withdrawal: Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia (clinicaltrials.gov) - Mar 24, 2021
P2/3, N=0, Withdrawn, Sponsor: Xiaojun Chen
It is important to rule out carcinosarcoma as a differential diagnosis in such patients. N=28 --> 0 | Not yet recruiting --> Withdrawn
- || Megace (megestrol) / BMS, SOBI
Clinical, Journal, IO biomarker: Comprehensive investigation of the clinical significance of long non-coding RNA HOXA-AS2 in acute myeloid leukemia using genome-wide RNA sequencing dataset. (Pubmed Central) - Mar 24, 2021
Functional enrichment analysis of HOXA-AS2-co-expressed genes revealed that HOXA-AS2 may act a part in AML by regulating nuclear factor-κB transcription factor activity, DNA methylation, angiogenesis, apoptosis, cell migration, Toll-like receptor 4, and Wnt signaling pathways. Our findings suggest that HOXA-AS2 is up-regulated in the bone marrow in patients with AML, and may serve as a novel prognostic biomarker for AML.
- || Megace (megestrol) / BMS, SOBI
Retrospective data, Review, Journal: Effectiveness and safety of herbal medicine for cancer-related fatigue in lung cancer survivors: A systematic review and meta-analysis. (Pubmed Central) - Mar 23, 2021
As monotherapy, HM significantly improved ADL compared with megestrol...Limited evidence suggests that HM could be effective and safe for CRF in LCP. However, further high-quality RCTs are needed to confirm these findings owing to the small number and low methodological quality of the included studies.
- || progesterone / Generic mfg.
PK/PD data, Journal: LC-MS/MS Quantification of Progesterone in Ovariectomized Miniature Swine and Its Application for Preliminary Pharmacokinetic Study of a Novel Vaginal Sustained Release System. (Pubmed Central) - Mar 18, 2021
However, further high-quality RCTs are needed to confirm these findings owing to the small number and low methodological quality of the included studies. All the study produced reliable results for the measurement of PGT concentration in miniature swine plasma and the method was successfully applied to a PK study for PGT vaginal ring in miniature pigs, which may lay the foundation for further research on the progesterone preparations intended for in assisted reproductive technology.
- || Megace (megestrol) / BMS, SOBI
Review, Journal: Fertility-sparing management for endometrial cancer: review of literature. (Pubmed Central) - Mar 12, 2021
The addition of Metformin and hysteroscopic resection seems to provide some improvements. However, fertility preservation is not the standard approach for staging and treatment, potentially worsening oncologic outcomes.
- | megestrol / Generic mfg.
Trial completion date, Trial primary completion date, IO biomarker: Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy (clinicaltrials.gov) - Mar 10, 2021
P2, N=36, Recruiting, Sponsor: City of Hope Medical Center
However, fertility preservation is not the standard approach for staging and treatment, potentially worsening oncologic outcomes. Trial completion date: Dec 2020 --> Dec 2022 | Trial primary completion date: Dec 2020 --> Dec 2022
- |||| Megace (megestrol) / BMS, SOBI
Clinical: I think this was a big one comparing megestrol acetate, dexamethasone, and placebo in patients with advanced cancer and cachexia. Even negative studies can be practice-changing. Thank you Dr. Currow et al! https://t.co/xFhwraly8a (Twitter) - Mar 4, 2021
- | Megace (megestrol) / BMS, SOBI
Preclinical, Journal: A standardized herbal combination of Astragalus membranaceus and Paeonia japonica, protects against muscle atrophy in a C26 colon cancer cachexia mouse model. (Pubmed Central) - Mar 2, 2021
Our data indicate the potential of an herbal formula, APX as an anti-cachexia agent; the effect of APX was superior to that of megestrol acetate overall especially for muscle atrophy. The underlying mechanisms of this herbal formula may involve the modulation of muscle atrophy-promoting molecules including p38, NFκB, TNF-α and TWEAK.
- ||| Megace (megestrol) / BMS, SOBI
Clinical: This is the second trial comparing dex with megestrol(first with placebo arm) with not much difference in either trial. Time for a #medicalmarijuana arm What do you think @LPeppone ? (Twitter) - Feb 27, 2021
- || Megace (megestrol) / BMS, SOBI
Time to look at medical cannabis in a RCT. I rarely if ever use megestrol acetate anymore and only occasionally dex. Standardizing a medical cannabis intervention will be challenging but such a trial is long overdue. (Twitter) - Feb 27, 2021
- |||| Megace (megestrol) / BMS, SOBI
Clinical: Maybe the take home message is to stop the ubiquitous prescribing of Megace to cancer patients ;-) ? (Twitter) - Feb 26, 2021
- | cisplatin / Generic mfg.
Journal: Paeonia lactiflora extract suppresses cisplatin-induced muscle wasting via downregulation of muscle-specific ubiquitin E3 ligases, NF-κB signaling, and cytokine levels. (Pubmed Central) - Feb 26, 2021
The underlying mechanisms of this herbal formula may involve the modulation of muscle atrophy-promoting molecules including p38, NFκB, TNF-α and TWEAK. RP restored skeletal muscle function and mass in cisplatin-treated mice by restoring the muscle levels of MyHC and MyoD proteins via downregulation of muscle-specific ubiquitin E3 ligases as well as muscle NF-κB signaling and cytokine levels.
- ||| Megace (megestrol) / BMS, SOBI
A2. Unfortunately chemo still a major tool for endometrial cancer. BUT: endometrioid cancer, anti estrogen therapy is appropriate. I prefer Megace alternating with tamoxifen as initial treatment then. #GynOncChat (Twitter) - Feb 24, 2021
- | megestrol / Generic mfg.
Enrollment change, HEOR: Megestrol Acetate for the Improvement of Quality of Life in Esophageal Cancer With Chemoradiotherapy (clinicaltrials.gov) - Feb 17, 2021
P3, N=184, Completed, Sponsor: The First Affiliated Hospital of Henan University of Science and Technology
RP restored skeletal muscle function and mass in cisplatin-treated mice by restoring the muscle levels of MyHC and MyoD proteins via downregulation of muscle-specific ubiquitin E3 ligases as well as muscle NF-κB signaling and cytokine levels. N=84 --> 184