megestrol / Generic mfg. 
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 138 Diseases   26 Trials   26 Trials   791 News 


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  • ||||||||||  pentoxifylline / Generic mfg., megestrol / Generic mfg., thalidomide / Generic mfg.
    Review, Journal:  Interconnection between Cardiac Cachexia and Heart Failure-Protective Role of Cardiac Obesity. (Pubmed Central) -  Apr 13, 2022   
    Several therapeutic procedures are discussed including exercise, nutritional proposals, myostatin antibodies, ghrelin, anabolic steroids, anti-inflammatory substances, beta-adrenergic agonists, medroxyprogesterone acetate, megestrol acetate, cannabinoids, statins, thalidomide, proteasome inhibitors and pentoxifylline. However, to this date, there is no cure for cachexia.
  • ||||||||||  metformin / Generic mfg., megestrol / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Metformin Plus Megestrol Acetate As a Fertility-sparing Treatment in Patients with Atypical Endometrial Hyperplasia (clinicaltrials.gov) -  Apr 5, 2022   
    P2/3,  N=12, Terminated, 
    N=192 --> 12 | Trial completion date: Feb 2027 --> Jun 2021 | Recruiting --> Terminated | Trial primary completion date: Aug 2024 --> Jun 2021; Our clinical trial NCT03241888 showed LNG-IUS had a better treatment efficacy than Megestrol Acetate (MA) alone. The median CR time for MA group, LNG-IUS group and MA plus LNG-IUS group was 7.0
  • ||||||||||  megestrol / Generic mfg.
    Journal:  Characterizing the Drug-Release Enhancement Effect of Surfactants on Megestrol-Acetate-Loaded Granules. (Pubmed Central) -  Feb 27, 2022   
    Mathematical characterization and kinetic model fitting supported the fast drug-release mechanism of polymeric micelles over micelles. The value-added polymeric micelle-containing formulation developed can be successfully administered perorally and the enhanced drug release offers the possibility of greater drug absorption in the gastrointestinal tract.
  • ||||||||||  cisplatin / Generic mfg.
    Review, Journal:  Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia. (Pubmed Central) -  Feb 27, 2022   
    As for the mechanisms of action, the roles of serotonin and its receptors, cytokines, white blood cells, ghrelin, and leptin were investigated. Based on these results, we suggest that herbal medicines could be considered a useful treatment method for cisplatin-induced anorexia.
  • ||||||||||  tamoxifen / Generic mfg., desogestrel / Generic mfg., norethindrone / Generic mfg.
    Clinical, Review, Journal, Adverse events, HEOR:  Association of Hormonal Contraceptive Use With Adverse Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials and Cohort Studies. (Pubmed Central) -  Feb 24, 2022   
    Search terms included hormonal contraception, contraceptive agents, progesterone, desogestrel, norethindrone, megestrol, algestone, norprogesterones, and levonorgestrel combined with terms such as systematic review or meta-analysis...The association between the use of a levonorgestrel-releasing intrauterine system and reductions in endometrial polyps associated with tamoxifen use (odds ratio [OR], 0.22; 95% CI, 0.13-0.38) was graded as having high-quality evidence, and this evidence ranking was retained in the subgroup analysis...The results of this umbrella review supported preexisting understandings of the risks and benefits associated with hormonal contraceptive use. Overall, the associations between hormonal contraceptive use and cardiovascular risk, cancer risk, and other major adverse health outcomes were not supported by high-quality evidence.
  • ||||||||||  tamoxifen / Generic mfg., megestrol / Generic mfg.
    A Curious Case of Cavitary Lung Lesions (Area D, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_3357;    
    This should be considered even after resolution of the primary malignancy, and a biopsy should be expedited. We further suggest oncologic screening beyond five years to evaluate for recurrent or metastatic disease.
  • ||||||||||  A Unique Presentation of Airway Compromise in Myxedema Coma (Area G, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1165;    
    Infections and discontinuation of thyroid supplements are the most common precipitating factors, followed by: hypothermia, burns, and drugs, such as sedatives, anesthetics, and amiodarone...Home medications included calcium acetate, megestrol, and pantoprazole...The patient was started on broad-spectrum antibiotics, vancomycin and cefepime, for suspected pneumonia and admitted to the stepdown unit for further management...Endocrinology was consulted and the patient was treated for myxedema coma with IV levothyroxine and stress dose steroids...This patient had a unique and atypical presentation, with a swollen lower lip and face, which is normally seen in cases of angioedema rather than myxedema coma. This highlights the need for physician awareness of potential complicated airway management in the treatment of myxedema coma.
  • ||||||||||  dronabinol oral / Generic mfg.
    Review, Journal:  A review of the efficacy of appetite stimulating medications in hospitalized adults. (Pubmed Central) -  Jan 26, 2022   
    Key words: hysteroscopic resection, megestrol acetate, endometrial cancer, early stage, curative effect. Current data lack standardization, generalizability, and comparability, and higher quality evidence is needed before conclusions can be identified on the efficacy of dronabinol, megestrol acetate, and mirtazapine in the inpatient setting.
  • ||||||||||  everolimus / Generic mfg.
    Trial completion date, Trial termination, Trial primary completion date, Metastases:  Phase II Study of Everolimus Beyond Progression (clinicaltrials.gov) -  Jan 21, 2022   
    P2,  N=3, Terminated, 
    Current data lack standardization, generalizability, and comparability, and higher quality evidence is needed before conclusions can be identified on the efficacy of dronabinol, megestrol acetate, and mirtazapine in the inpatient setting. Trial completion date: Nov 2021 --> Jan 2021 | Active, not recruiting --> Terminated | Trial primary completion date: Nov 2021 --> Jan 2021; Slow to accrual
  • ||||||||||  nifedipine immediate release / Generic mfg., megestrol / Generic mfg.
    Journal:  Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor. (Pubmed Central) -  Dec 23, 2021   
    Clinical outcomes of the ongoing trials are warranted to evaluate the therapeutic use of metformin in EC. The results suggest that megestrol acetate is a specific inducer of CYP3A4 mediated by hPXR and therefore has the potential to cause drug interactions, especially in the co-administration with drugs that are substrates of CYP3A4.
  • ||||||||||  metformin / Generic mfg., megestrol / Generic mfg.
    Clinical, Review, Journal:  Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview. (Pubmed Central) -  Dec 18, 2021   
    The metformin usage and hysteroscopic assessment is still under debate, despite promising results. Particularly strict and imperious attention should be given to the follow-up and psychological wellbeing of women, especially because of the double detrimental impairment: both EC and EC-related infertility consequences.
  • ||||||||||  megestrol / Generic mfg.
    Fertility sparing treatment in young women with Endometrial Cancer Grading G2: a new frontier in gynaecological oncology () -  Oct 26, 2021 - Abstract #ESGE2021ESGE_198;    
    Our aim is to report the safety and effectiveness of the combination of hysteroscopic resection of the endometrial lesion followed by Levonorgestrel Intra Uterine Device (LNG-IUD) and/or oral megestrol acetate for the fertility-sparing treatment in patients with IA G2 EAC...A fair pregnancy rate was observed in women attempting to conceive. Nevertheless, new trials are needed to clarify the medium- and long-term outcomes in this kind of patient.
  • ||||||||||  megestrol / Generic mfg.
    Fertility preservation in endometrial cancer: perinatal and oncologic outcomes () -  Oct 1, 2021 - Abstract #ESGO2021ESGO_601;    
    Hormone therapy with megestrol acetate was carried out in 4 patients (66.6%)...During the follow-up no recurrences were detected and overall survival was 100% Conclusion* Conservative management with progestins of young patients with AH or EC grade 1 limited to the endometrium is an acceptable possibility given the high remission rate and live birth rates achieved. However, definitive surgical treatment cannot be avoided given the high recurrence rate described in the literature.
  • ||||||||||  megestrol / Generic mfg.
    Trial primary completion date:  Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer (clinicaltrials.gov) -  Sep 17, 2021   
    P2,  N=50, Not yet recruiting, 
    There was no difference in groups between the three arms, with no benefit seen over placebo with anorexia improving in all arms.Trail registration: The trial was registered on 19/08/2008 with the Australian New Zealand Clinical Trials Registry (ACTRN12608000405314). Trial primary completion date: Jul 2023 --> Oct 2023
  • ||||||||||  megestrol / Generic mfg.
    Clinical, Review, Journal:  Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review). (Pubmed Central) -  Sep 14, 2021   
    Particular attention is paid to progesterone, megestrol acetate, medroxyprogesterone acetate due to broadening of their spectrum of action. The possibilities of using gestagens as neuroprotectors, immunomodulators, and chemosensitizers are considered.