megestrol / Generic mfg. 
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 138 Diseases   26 Trials   26 Trials   791 News 


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  • ||||||||||  Xalkori (crizotinib) / Pfizer, Votrient (pazopanib) / Novartis, BeiGene
    Review, Journal:  Antiangiogenics in Malignant Granular Cell Tumors: Review of the Literature. (Pubmed Central) -  Nov 14, 2023   
    Dasatinib and megestrol were ineffective in two other different patients. Pazopanib has been demonstrated to be active in advanced GCTs and may be considered as a preferable treatment option.
  • ||||||||||  megestrol / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date, Surgery:  MA-EEC: Study of Megestrol Acetate in Grade 2 Endometrioid Endometrial Cancer (clinicaltrials.gov) -  Nov 3, 2023   
    P1,  N=5, Terminated, 
    These data support the potential use of low-dose megestrol as an inexpensive and well-tolerated means of improving aromatase inhibitor efficacy. N=73 --> 5 | Trial completion date: Sep 2024 --> Oct 2023 | Recruiting --> Terminated | Trial primary completion date: Apr 2024 --> Oct 2023; Slow enrollment
  • ||||||||||  megestrol / Generic mfg.
    Trial completion date, Trial primary completion date:  Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer (clinicaltrials.gov) -  Oct 6, 2023   
    P2,  N=50, Recruiting, 
    Compared with dexamethasone, megestrol acetate can significantly improve the quality of life, especially in terms of decreasing the dyspnea and appetite loss. Trial completion date: Oct 2023 --> May 2024 | Trial primary completion date: Oct 2023 --> May 2024
  • ||||||||||  bortezomib / Generic mfg.
    PERIPHERAL AND SEVERE AUTONOMIC NEUROPATHY CHARACTERIZED BY DIZZINESS, ORTHOSTATIC HYPOTENSION AND WEIGHT LOSS CAUSED BY BORTEZOMIB. (Trianti Upper Foyer; In Person) -  Sep 10, 2023 - Abstract #IMW2023IMW_752;    
    Severe AN characterized by weight loss, dizziness, OH in association with painful neuropathy is an under recognized complication of B. Transplantation without resolution of symptoms could possibly worsen the morbidity and delay post-transplant recovery. To the best of our knowledge, we are the first group to report a series of patients with this symptom complex and strongly feel it should be studied further in a larger cohort of patients.
  • ||||||||||  megestrol / Generic mfg.
    Journal:  Simplified Liquid Chromatography-Mass Spectrometry Methods for Gestagen Analysis in Animal Fat and Liver. (Pubmed Central) -  Jun 16, 2023   
    The Canadian Food Inspection Agency analyzes progestogens melengestrol acetate (MGA), megestrol acetate, and chlormadinone acetate using liquid chromatography-mass spectrometry (LC-MS)...With LC-FAIMS-MS, chemical background for each gestagen was virtually eliminated, resulting in a quantitative liver method having the desired 0.6 ng/g LLOQ and estimated limits of detection (LODs) up to 140 times lower than LC-MS. Incurred MGA samples, analyzed using kidney fat and liver methods from the same animal, show levels within the quantitative ranges of both methods.
  • ||||||||||  megestrol / Generic mfg.
    Trial completion date, Trial primary completion date:  IKanEat: a Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children (clinicaltrials.gov) -  May 16, 2023   
    P4,  N=60, Recruiting, 
    Incurred MGA samples, analyzed using kidney fat and liver methods from the same animal, show levels within the quantitative ranges of both methods. Trial completion date: Jun 2023 --> Jun 2024 | Trial primary completion date: Jan 2023 --> Jun 2024
  • ||||||||||  A Curious Case of Psychosis (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_1927;    
    Two of her medications, gabapentin and mirtazapine were thought to be the contributors and were stopped upon admission, however with little improvement...She was ultimately started on hydrocortisone replacement therapy, with subsequent improvement and stabilization of her mental status, mood, and behavior; and was discharged with outpatient Endocrinology follow-up.This case highlights the importance of the broad differentials to consider for mental and behavioral changes...The exact mechanism of neuropsychiatric symptoms (which may precede metabolic abnormalities) is unknown but is hypothesized to involve elevated levels of endorphins and electrophysiological disturbances as glucocorticoid receptors are widely distributed in the brain, specifically in the hippocampus. Megestrol is an established cause of secondary adrenal insufficiency, and monitoring is essential with long-term use.
  • ||||||||||  megestrol / Generic mfg.
    Megestrol-Induced Adrenal Insufficiency (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_809;    
    SAI is often associated with prolonged glucocorticoid use but can also be seen in patients with pituitary tumors, pituitary surgery, or granulomatous disease. SAI can cause hyponatremia, hypoglycemia, and fatigue but is not typically associated with hypotension or hyperkalemia as the mineralocorticoid function of the adrenals remains intact.
  • ||||||||||  megestrol / Generic mfg., olanzapine / Generic mfg.
    Trial completion date, Trial primary completion date, Metastases:  Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients (clinicaltrials.gov) -  Mar 24, 2023   
    P3,  N=360, Recruiting, 
    She was treated conservatively with high dose oral progestin (megestrol acetate, 160 Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Apr 2023 --> Apr 2024
  • ||||||||||  Journal:  Multi-target analysis of cytostatics in hospital effluents over a 9-month period. (Pubmed Central) -  Mar 2, 2023   
    Recruiting --> Active, not recruiting | N=28 --> 44 Eleven cytostatics out of thirteen pharmaceuticals were studied, including flutamide, mycophenolate mofetil and mycophenolic acid, which have never been monitored before...All pharmaceuticals were detected in at least one sample, bicalutamide being the one found with higher frequency (detected in all samples), followed by mycophenolic acid, which was also the compound detected at higher concentrations (up to 5340
  • ||||||||||  megestrol / Generic mfg.
    Trial primary completion date, Head-to-Head:  Levonorgestrel-Releasing Intrauterine System (LNG-IUS) in the Management of Atypical Endometrial Hyperplasia (clinicaltrials.gov) -  Feb 9, 2023   
    P3,  N=40, Recruiting, 
    Eleven cytostatics out of thirteen pharmaceuticals were studied, including flutamide, mycophenolate mofetil and mycophenolic acid, which have never been monitored before...All pharmaceuticals were detected in at least one sample, bicalutamide being the one found with higher frequency (detected in all samples), followed by mycophenolic acid, which was also the compound detected at higher concentrations (up to 5340 Trial primary completion date: Jul 2023 --> Oct 2023
  • ||||||||||  megestrol / Generic mfg.
    Review, Journal:  Fertility-sparing treatment for cervical mullerian adenosarcoma: A case report and literature review. (Pubmed Central) -  Dec 9, 2022   
    After discharge, she was treated with megestrol 200 mg per day for 3 years...Cervical mullerian adenosarcoma in non-sexual women is easily misdiagnosed as ovulation dysfunction abnormal uterine bleeding. The necessity of hysteroscopy should be emphasized, and for patients with low-grade early-stage lesions who wish to retain fertility, local resection could be chosen, but attention is paid to lifelong follow-up to exclude long-term recurrence.