octreotide acetate / Generic mfg. 
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 141 Diseases   27 Trials   27 Trials   1501 News 


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  • ||||||||||  Somavert (pegvisomant) / Pfizer
    Trial completion date, Trial primary completion date:  Acromegaly Combination Treatment Study (clinicaltrials.gov) -  Jan 31, 2019   
    P=N/A,  N=51, Recruiting, 
    Trial completion date: Dec 2019 --> Mar 2020 | Trial primary completion date: Dec 2018 --> Mar 2020
  • ||||||||||  octreotide acetate / Generic mfg.
    Trial completion, Phase classification:  Ultrasound Guided Octreotide LAR Injection in Acromegaly (clinicaltrials.gov) -  Sep 11, 2018   
    P4,  N=15, Completed, 
    Trial completion date: Dec 2019 --> Mar 2020 | Trial primary completion date: Dec 2018 --> Mar 2020 Recruiting --> Completed | Phase classification: PN/A --> P4
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Journal:  Surgical debulking of pituitary adenomas improves responsiveness to octreotide lar in the treatment of acromegaly. (Pubmed Central) -  Jun 27, 2018   
    Pituitary surgery alone was more effective than primary medical treatment (p = 0.006), and the combination of surgery followed by medical therapy was even more effective (p < 0.0001). Subjects treated with medical therapy after surgical debulking had a significant improvement in response rate compared to matched subjects treated with primary medical therapy.
  • ||||||||||  Inlyta (axitinib) / Pfizer
    Enrollment closed, Enrollment change, Combination therapy, Metastases:  Sandostatin LAR and Axitinib vs Pbo in Pnts With Advanced Well-differentiated Non-pancreatic Neuroendocrine Carcinomas (clinicaltrials.gov) -  Jun 11, 2018   
    P2/3,  N=105, Active, not recruiting, 
    Subjects treated with medical therapy after surgical debulking had a significant improvement in response rate compared to matched subjects treated with primary medical therapy. Recruiting --> Active, not recruiting | N=253 --> 105
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    New P2 trial, Combination therapy:  Tolvaptan-Octreotide LAR Combination in ADPKD (clinicaltrials.gov) -  May 31, 2018   
    P2,  N=20, Not yet recruiting, 
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Enrollment closed, Trial completion date, Trial primary completion date:  Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber (clinicaltrials.gov) -  Apr 20, 2018   
    P2,  N=15, Active, not recruiting, 
    Recruiting --> Active, not recruiting | N=253 --> 105 Recruiting --> Active, not recruiting | Trial completion date: Dec 2017 --> Oct 2018 | Trial primary completion date: Oct 2017 --> Jul 2018
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Trial completion date, Trial primary completion date:  OCEAN: Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anemia Due to Angiodysplasias (clinicaltrials.gov) -  Apr 19, 2018   
    P2/3,  N=62, Recruiting, 
    Recruiting --> Active, not recruiting | Trial completion date: Dec 2017 --> Oct 2018 | Trial primary completion date: Oct 2017 --> Jul 2018 Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Nov 2018 --> Nov 2019
  • ||||||||||  Lutathera (lutetium Lu 177 dotatate) / Novartis, Sandostatin LAR Depot (octreotide acetate) / Novartis
    Review, Journal:  Radionuclide Therapy for Neuroendocrine Tumors. (Pubmed Central) -  Sep 1, 2017   
    Recently, the phase III, randomized NETTER-1 trial has compared (177)Lu-DOTATATE versus high-dose octreotide LAR in patients with progressive, metastatic midgut NETs, demonstrating exceptional tolerability and efficacy. This review summarizes recent developments in the field of radionuclide therapy for gastroenteropancreatic and lung NETs and considers possible strategies to further enhance its clinical efficacy.
  • ||||||||||  Inlyta (axitinib) / Pfizer, octreotide acetate / Generic mfg.
    Enrollment open, Phase classification, Enrollment change, Trial primary completion date, Combination therapy, Metastases:  Sandostatin LAR and Axitinib vs Pbo in Pnts With Advanced Well-differentiated Non-pancreatic Neuroendocrine Carcinomas (clinicaltrials.gov) -  Aug 24, 2017   
    P2/3,  N=253, Recruiting, 
    Conclusion No significant differences in PFS were observed between the bevacizumab and IFN arms, which suggests that these agents have similar antitumor activity among patients with advanced NETs. Active, not recruiting --> Recruiting | Phase classification: P2 --> P2/3 | N=80 --> 253 | Trial primary completion date: Jul 2015 --> Nov 2019
  • ||||||||||  Signifor LAR (pasireotide long acting release) / Recordati, Sandostatin LAR Depot (octreotide acetate) / Novartis
    Trial primary completion date:  Safety and Efficacy of Pasireotide Long Acting Release (LAR) vs. Octreotide LAR in Patients With Active Acromegaly (clinicaltrials.gov) -  Jul 4, 2017   
    P3,  N=358, Completed, 
    As with the other the International Study Group on Pancreatic Surgery consensus statements, this classification should facilitate communication and evaluation of different approaches to the prevention and treatment of this complication. Trial primary completion date: Dec 2010 --> Mar 2016
  • ||||||||||  everolimus / Generic mfg.
    Journal:  Everolimus Effect on Gastrin and Glucagon in Pancreatic Neuroendocrine Tumors. (Pubmed Central) -  Jun 28, 2017   
    Trial primary completion date: Dec 2010 --> Mar 2016 In addition to prolonging progression-free survival in patients with pNET, everolimus down-regulates excess production of 2 gastrointestinal hormones, which may help control their associated clinical syndromes.
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Journal:  Frequency of carcinoid syndrome at neuroendocrine tumour diagnosis: a population-based study. (Pubmed Central) -  Jun 11, 2017   
    This population-based analysis reveals that carcinoid syndrome is significantly associated with tumour grade, stage, and primary tumour site, and leads to shorter survival compared with those patients without carcinoid syndrome. An improved understanding of the heterogeneity of presenting symptoms among patients with NETs might permit more tailored assessment and management than at present and enable future research into the effect of carcinoid syndrome control on patient survival.
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Trial primary completion date, Metastases:  EVERLAR: Phase II Study of Everolimus Combined With Octreotide LAR to Treat Advanced GI NET (clinicaltrials.gov) -  May 31, 2017   
    P2,  N=43, Active, not recruiting, 
    Inter-modality changes were three times more likely than intra-modality changes underlining the clinical impact of SSTR PET/CT. Trial primary completion date: Apr 2014 --> Sep 2014
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Enrollment open:  Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber (clinicaltrials.gov) -  Mar 31, 2017   
    P2,  N=15, Recruiting, 
    Trial primary completion date: Mar 2017 --> Jun 2017 Not yet recruiting --> Recruiting
  • ||||||||||  Somavert (pegvisomant) / Pfizer
    Trial primary completion date:  Acromegaly Combination Treatment Study (clinicaltrials.gov) -  Feb 1, 2017   
    P=N/A,  N=51, Recruiting, 
    Results in the well-differentiated carcinoid tumors are thought provoking. Trial primary completion date: Dec 2017 --> Dec 2018
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Journal:  Phase 3 Trial of (177)Lu-Dotatate for Midgut Neuroendocrine Tumors. (Pubmed Central) -  Jan 20, 2017   
    P3
    Methods We randomly assigned 229 patients who had well-differentiated, metastatic midgut neuroendocrine tumors to receive either (177)Lu-Dotatate (116 patients) at a dose of 7.4 GBq every 8 weeks (four intravenous infusions, plus best supportive care including octreotide long-acting repeatable [LAR] administered intramuscularly at a dose of 30 mg) ((177)Lu-Dotatate group) or octreotide LAR alone (113 patients) administered intramuscularly at a dose of 60 mg every 4 weeks (control group)...Clinically significant myelosuppression occurred in less than 10% of patients in the (177)Lu-Dotatate group. (Funded by Advanced Accelerator Applications; NETTER-1 ClinicalTrials.gov number, NCT01578239 ; EudraCT number 2011-005049-11 .).
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Biomarker, New trial, Circulating tumor cells, Tumor cell:  Circulating Tumor Cells and Tumor DNA in HCC and NET (clinicaltrials.gov) -  Nov 25, 2016   
    P=N/A,  N=130, Recruiting,