octreotide acetate / Generic mfg. 
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 141 Diseases   27 Trials   27 Trials   1501 News 


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  • ||||||||||  Lutathera (lutetium Lu 177 dotatate) / Novartis
    Developing a Lutathera Treatment Program in an Ambulatory Oncology Department (Henry B. Gonzalez Convention Center - Tower View Registration) -  Feb 17, 2020 - Abstract #ONS2020ONS_836;    
    Innovation As treatment options become more sophisticated and complex, many program and treatments are being evaluated as to their appropriateness and safety to be administered in the ambulatory setting. Ensuring proper training and preparation can facilitate successful implementation of programs such as Lutathera in an ambulatory setting.
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Journal:  Pore change during degradation of octreotide acetate-loaded PLGA microspheres: The effect of polymer blends. (Pubmed Central) -  Feb 7, 2020   
    In general, our data indicate that pore formation is unevenly distributed throughout PLGA MS prepared using polymer blends, and the use of polymer blends is instructive for the development of sustained smooth release microspheres. Therefore, the octreotide MS described in this study has a good clinical application potential for the treatment of acromegaly.
  • ||||||||||  Prolia (denosumab) / Amgen, Daiichi Sankyo, GSK, Sandostatin LAR Depot (octreotide acetate) / Novartis
    I'm Not Crazy! I Get a Headache When I Pee: A Case of Metastatic Bladder Paraganglioma (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_3102;    
    Because they are likely to recur and to metastasize, annual follow up with a measurement of plasma and urinary catecholamine levels and cystoscopy are essential. A functional imaging study (Ga-DOTATE scan) should be done to locate recurrence if symptoms reappear or catecholamine resurgence occurs.
  • ||||||||||  prednisone / Generic mfg., Sandostatin LAR Depot (octreotide acetate) / Novartis
    Successful Long-Term Medical Management of Insulinomas (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_2658;    
    Long-term survival data of patients with metastatic insulinoma indicates that prolonged survival is unlikely; however, most data is from the 1990s or earlier. It does not incorporate new medical treatments, or advancements in technology and the field of medicine.
  • ||||||||||  exemestane / Generic mfg., Sandostatin LAR Depot (octreotide acetate) / Novartis
    Invasive Neuroendocrine Breast Carcinoma Presenting as Liver Metastases (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_2269;    
    It does not incorporate new medical treatments, or advancements in technology and the field of medicine. Patients with neuroendocrine carcinoma of the breast rarely present with clinical conditions related to hormonal hypersecretion as in neuroendocrine carcinoma of the GI tract but respond to treatment with somatostatin analogs.
  • ||||||||||  olanzapine / Generic mfg., Afinitor (everolimus) / Novartis
    A Rare Case of Metastatic Insulinoma in a Patient with Huntington's Disease. (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_1899;    
    She has no history of diabetes, and only home medication is Zyprexa...Patient remains on Octreotide LAR injection every 4 weeks...Other treatment modalities include injection of octreotide, EUS-aided alcohol ablation, radio-frequency ablation or embolization of insulinoma, as well as targeted therapy with everolimus or sunitinib...Diagnosis of insulinoma is often delayed or missed as symptoms may be attributed to psychiatric, cardiac or neurological disorders or medication misuse. Clinicians should be aware of insulinoma as a cause of life-threatening hypoglycemia.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Localization and Treatment of the Ectopic ACTH Syndrome Using Somatostatin Analogues (ENDOExpo) -  Feb 7, 2020 - Abstract #ENDO2020ENDO_1893;    
    In summary, this patient with EAS had severe clinical manifestations of hypercortisolism and could not safely undergo surgical intervention. This case demonstrates the value of SS analogues (gallium-68 dotatate PET/CT and Sandostatin LAR) in localizing and confirming the source of ectopic ACTH production and markedly improving the clinical and biochemical features of the EAS.
  • ||||||||||  Leukine (sargramostim) / Partner Therap, SurVaxM (SVN53-67/M57-KLH peptide vaccine) / MimiVax
    Trial primary completion date, Metastases:  Survivin Long Peptide Vaccine in Treating Patients With Metastatic Neuroendocrine Tumors (clinicaltrials.gov) -  Jan 8, 2020   
    P1,  N=10, Recruiting, 
    Low doses used in this study may reduce cost of treatment and increase tolerance to medication. Trial primary completion date: Dec 2019 --> Mar 2020
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Clinical, Journal:  The Outcome of Primary Hepatic Neuroendocrine Tumors: A Single-Center Experience. (Pubmed Central) -  Jan 2, 2020   
    Four patients underwent surgery, and three patients received Sandostatin LAR for tumor recurrence after procedure...Surgical resection is the curative treatment. TACE is a favorable option in unresectable tumors.
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Journal:  Control of octreotide release from silk fibroin microspheres. (Pubmed Central) -  Dec 23, 2019   
    Poly(d,l-lactide-co-glycolide) (PLGA) microspheres have been used as an injectable depot for prolonged release of octreotide (Sandostatin LAR®), a peptide drug for the treatment of acromegaly and gastrointestinal tumors...The rebound octreotide level likely reflected degradation of the SF matrix which released tightly bound/trapped octreotide. Therefore, SF microspheres can deliver octreotide over a long period of time with release kinetics and the mechanism different from PLGA microsphere system.
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Long acting Octreotide depot in the management of Chylous ascites (P3) -  Nov 24, 2019 - Abstract #APDW2019APDW_930;    
    She was given a single dose of Sandostatin LAR 20 mg IM. Long acting Octreotide depot was effective in treating post operative chylous ascites not responding to therapy with dietary modification and diuretics.
  • ||||||||||  Avastin (bevacizumab) / Roche, Lutathera (lutetium Lu 177 dotatate) / Novartis, Afinitor (everolimus) / Novartis
    Efficacy of 177Lu-Dotatate therapy in recurrent anaplastic meningioma (Ballroom Lawn) -  Oct 29, 2019 - Abstract #SNO2019SNO_521;    
    The transient increase in tumor volume after the first dose in this case may have represented delayed treatment effect or pseudoprogression. A phase II clinical trial is currently being activated to determine the progression-free survival associated with 177Lu-Dotatate in patients with recurrent meningioma.
  • ||||||||||  Afinitor (everolimus) / Novartis
    Combined multimodal treatment regimen in recurrent meningiomas (Ballroom Lawn) -  Oct 29, 2019 - Abstract #SNO2019SNO_520;    
    Multimodal therapy may prolong mPFS in recurrent meningiomas. Our pilot data supports further clinical trials in combined multimodal treatments.
  • ||||||||||  Somavert (pegvisomant) / Pfizer, Signifor LAR (pasireotide) / Novartis, Sandostatin LAR Depot (octreotide acetate) / Novartis
    Clinical, Journal, Combination therapy:  Pasireotide-LAR in acromegaly patients treated with a combination therapy: a real-life study. (Pubmed Central) -  Sep 15, 2019   
    Initiation date: Aug 2019 --> Nov 2019 Pasireotide-LAR may represent a suitable therapeutic alternative in a subset of acromegalic patients requiring combination therapy involving a 1gSRL.
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Octreotide: Prevention of Recurrent Gastrointestinal Bleeding in LVAD Patients () -  Sep 9, 2019 - Abstract #HFSA2019HFSA_366;    
    With the initiation of octreotide injections, the number of GI bleeds was decreased by one half, with 16 bleeds prior to initiation and seven bleeds post. Six of the bleeds occurred in one patient, another patient re-bled once after a year of therapy.
  • ||||||||||  Afinitor (everolimus) / Novartis
    Journal:  Refractory Metastatic Insulinoma Treated with Everolimus, Complicated by Cryptogenic Organizing Pneumonia. (Pubmed Central) -  Aug 16, 2019   
    ...Her disease was initially managed with diazoxide 100 mg orally every 8 hours, octreotide LAR 30 mg intramuscularly every month, and sunitinib 12.5 mg orally three times a day...She was started on prednisone 1 mg/kg/day and within 48 hours, her symptoms and hypoxemia improved to SpO2 of 98-99% at room air and her repeat CT chest showed marked disease improvement...In addition to presenting this case, we will also do a thorough review of the literature surrounding the available therapeutic options of metastatic insulinoma. This will include surgery, somatostatin analogs, antimicrobials, potassium channel activators, VEGF-A inhibitors, alkylating agents and mTOR inhibitors to provide a more in-depth picture of how we treat metastatic insulinoma.
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Enrollment open, Combination therapy:  Tolvaptan-Octreotide LAR Combination in ADPKD (clinicaltrials.gov) -  Jul 5, 2019   
    P2,  N=20, Recruiting, 
    Clinical Trial Registration http://www.clinicaltrials.gov, NCT0030928. Not yet recruiting --> Recruiting
  • ||||||||||  Leukine (sargramostim) / Partner Therap, SurVaxM (SVN53-67/M57-KLH peptide vaccine) / MimiVax
    Enrollment open, Metastases:  Survivin Long Peptide Vaccine in Treating Patients With Metastatic Neuroendocrine Tumors (clinicaltrials.gov) -  Jun 20, 2019   
    P1,  N=10, Recruiting, 
    The history we report, therefore, confirms previous experiences reporting a possible favourable outcome of pregnancy in patients affected by acromegaly and adds further information about the behaviour of giant pituitary tumors in patients underwent pregnancy. Not yet recruiting --> Recruiting
  • ||||||||||  Sandostatin LAR Depot (octreotide acetate) / Novartis
    Clinical, Journal:  Octreotide use for rescue of vision in a pregnant patient with acromegaly. (Pubmed Central) -  May 23, 2019   
    ...She was commenced on octreotide LAR 40 mg and referred for surgery...Treatment options for tumour expansion in pregnancy include both medical and surgical options. Somatostatin analogues may be a viable medical alternative to surgery in patients with tumour expansion during pregnancy.