tazarotene topical / Generic mfg. 
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  • ||||||||||  Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
    Clinical, Journal:  Tazarotene is as effective and tolerable as imiquimod in the treatment of verruca plana, a comparative randomized clinical trial. (Pubmed Central) -  Apr 15, 2024   
    Ceramide and niacinamide-containing moisturizer in combination with anti-acne medication can significantly improve acne lesions and decrease cutaneous irritations toward a satisfactory treatment outcome of mild to moderate acne vulgaris. Compared to imiquimod, tazarotene 0.1% gel for the treatment of plane warts seems to offer equivalent treatment response, maintained efficacy without recurrence, safer profile regarding dyspigmentation with an advantageous cheaper cost.
  • ||||||||||  Winlevi (clascoterone cream 1%) / Cassiopea
    Journal:  Guidelines of care for the management of acne vulgaris. (Pubmed Central) -  Apr 15, 2024   
    Compared to imiquimod, tazarotene 0.1% gel for the treatment of plane warts seems to offer equivalent treatment response, maintained efficacy without recurrence, safer profile regarding dyspigmentation with an advantageous cheaper cost. These guidelines provide evidence-based recommendations for the management of acne vulgaris.
  • ||||||||||  tazarotene topical / Generic mfg.
    Review, Journal:  Vitamins for the Management of Nail Disease: A Literature Review. (Pubmed Central) -  Apr 4, 2024   
    We found overall limited evidence for treatment of other nail disorders with vitamin/vitamin derivatives, and further research is needed to support their use. Besides topical tazarotene and vitamin D analogs for nail psoriasis treatment, there is limited evidence for treatment of nail disorders with topical, oral, and intralesional vitamin/vitamin derivatives.
  • ||||||||||  tazarotene topical / Generic mfg.
    Journal:  An Adaptable Drug Delivery System Facilitates Peripheral Nerve Repair by Remodeling the Microenvironment. (Pubmed Central) -  Feb 20, 2024   
    Notably, the hydrogel exhibits obvious temperature sensitivity at a concentration of 6 wt?%, and the nanoparticles possess concentration-dependent H2O2-response capability with a controlled release profile in 48 h. The combined strategy promoted the repair of injured peripheral nerves, attributed to the dual role of the materials, which mainly involved providing structural support, modulating the immune microenvironment, and enhancing angiogenesis. Overall, this study opens up intriguing prospects in tissue engineering.
  • ||||||||||  Aklief (trifarotene) / Galderma
    Retinoids and Risk: A FAERS Database Study of Tretinoin, Adapalene, Trifarotene, and Tazarotene () -  Feb 20, 2024 - Abstract #AAD2024AAD_3304;    
    We found that there are marked differences in both the gender and median age of individuals experiencing adverse drug associated with retinoids. These findings may guide dermatologists in personalizing retinoid therapy to minimize adverse reactions in specific patient populations.
  • ||||||||||  tazarotene topical / Generic mfg., hydroquinone / Generic mfg.
    Highlighting the Link between Lichen Planus Pigmentosus and Frontal Fibrosing Alopecia: A Case Series of 3 Patients () -  Feb 20, 2024 - Abstract #AAD2024AAD_3041;    
    These cases of concomitant LPPigm and FFA further support that post-menopausal women with darker skin tones are an at-risk population. Furthermore, given the variable timing of onset for each and the speed of progression, awareness of this connection may improve outcomes through proper monitoring and early initiation of treatment.
  • ||||||||||  Review, Journal:  A focused review on laser- and energy-assisted drug delivery for nail disorders. (Pubmed Central) -  Jan 23, 2024   
    Laser-assisted drug delivery for nail disease is a newer approach for onychomycosis and nail psoriasis with several benefits and drawbacks. Dermatologists should discuss the option of LADD with their patients who have recalcitrant onychomycosis or nail psoriasis.
  • ||||||||||  tazarotene topical / Generic mfg.
    Journal:  Transdermal Drug Delivery of Tazarotene: Determining Tazarotene's Potential in Local Transdermal Therapy. (Pubmed Central) -  Jan 23, 2024   
    The detection of tazarotene and tazarotenic acid in both the in vitro permeation studies and the pilot study on porcine joints validate the drug's potential therapeutic use for hand osteoarthritis. This study lays the groundwork for future research, contributing insights into tazarotene's potential for transdermal drug delivery and guiding further exploration in topical retinoid applications.
  • ||||||||||  tazarotene topical / Generic mfg., apremilast / Generic mfg.
    Journal:  Psoriasis: Recognition and Management Strategies. (Pubmed Central) -  Jan 16, 2024   
    Systemic treatment with nonbiologic and biologic agents and ultraviolet B phototherapy are used for moderate to severe disease, with the exception of apremilast, a systemic agent approved for mild psoriasis...The Psoriasis Area and Severity Index is a tool to assess severity and monitor treatment effectiveness over time. Special consideration is needed for treatment of children and patients who are pregnant, breastfeeding, or trying to conceive.
  • ||||||||||  Review, Journal:  Noncorticosteroid Topical Therapies for the Treatment of Plaque Psoriasis: A Narrative Review. (Pubmed Central) -  Sep 25, 2023   
    Data Sources: A literature search of the PubMed database was performed (January 1978 to May 2023) using the keywords plaque psoriasis, tapinarof, benvitimod, Vtama, roflumilast, Zoryve, pimecrolimus, tacrolimus, tazarotene, tacalcitol, calcitriol, Vectical, calcipotriene, Dovonex, tacalcitol, vitamin D analogs, salicylic acid, non-corticosteroid topical, Investigator's Global Assessment, and Physician's Global Assessment...The percentage of patients with plaque psoriasis who achieved Investigator's Global Assessment (IGA) success after 8 weeks of treatment with tacalcitol, calcipotriene/betamethasone dipropionate compound, tazarotene/halobetasol propionate, and roflumilast was 17.9%, 39.9%, 40.7%, and 42.4%, respectively...Each topical was efficacious in treating plaque psoriasis and had an adequate safety profile. Despite several treatment options for plaque psoriasis, medication adherence is a limiting factor.
  • ||||||||||  tazarotene topical / Generic mfg.
    Journal:  Influence of Season on Efficacy and Tolerability of Tazarotene 0.045% Lotion for the Treatment of Acne. (Pubmed Central) -  Sep 18, 2023   
    Tazarotene 0.045% lotion was efficacious and well tolerated for acne treatment, regardless of season. Year-round tolerability of tazarotene 0.045% lotion may be due to its lower tazarotene concentration and polymeric emulsion technology, which simultaneously delivers moisturizers/humectants/emollients to skin.
  • ||||||||||  tazarotene topical / Generic mfg., adapalene / Generic mfg.
    Journal:  Topical Treatments for Photoaged Skin. (Pubmed Central) -  Sep 12, 2023   
    Prescription topical retinoids are the most potent treatment option for photoaging, though their use may be limited by irritation concerns. Tazarotene 0.045% polymeric emulsion lotion has recently demonstrated significant photoaging improvements with 12 weeks of once-daily treatment, with a favorable safety and tolerability profile.
  • ||||||||||  Therapeutics in immune-mediated diseases and fertility: what is the evidence of safety? (e-Poster Hall) -  Aug 30, 2023 - Abstract #EADV2023EADV_4415;    
    Tazarotene 0.045% polymeric emulsion lotion has recently demonstrated significant photoaging improvements with 12 weeks of once-daily treatment, with a favorable safety and tolerability profile. The evidence are mostly dependent on low level evidence and will be demonstrated but it is certain that more studies and even case series need to be conducted in this area.
  • ||||||||||  tacrolimus topical / Generic mfg., tazarotene topical / Generic mfg.
    Work- associated median canaliform dystrophy of Heller : about a case (e-Poster Hall) -  Aug 30, 2023 - Abstract #EADV2023EADV_3487;    
    The pathophysiology remains poorly elucidated, but most hypotheses converge on the notion of a lack of keratinocyte adhesion to the nail matrix, which leads to low resistance of the latter and consequently to the appearance of furrows, This lack of adhesion and low resistance are favored by the use of oral retinoids or especially by trauma, either self-induced if psychological disorders or, as in the case of our patient, by chronic local microtrauma due to her profession. The positive diagnosis is clinical, by revealing a median longitudinal groove which starts under the cuticle and ends at the free edge of the nail, with parallel transverse ridges giving a very characteristic fir tree aspect, the ungual damage is often bilateral and symmetrical Several treatments have been tested, such as topical tacrolimus, retinoids including tazarotene and also intralesional injections of triamcinolone, but these treatments often give very modest and unsatisfactory results.
  • ||||||||||  tazarotene topical / Generic mfg.
    Preclinical, Journal:  Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion: In vitro and in vivo evaluation. (Pubmed Central) -  Jul 3, 2023   
    The in vivo study results of the infected mice ears induced by P. acnes revealed that our selected MEs successfully reached a high level of ear thickness reduction of 67.1% and 47.4% for Jas and Joj selected MEs, respectively, versus only 4% for the market product. Finally, the findings confirmed the ability to use essential oil-based ME, particularly with Jas, as a promising carrier for topical TZR delivery in the treatment of acne vulgaris.
  • ||||||||||  methotrexate / Generic mfg., hydrocortisone / Generic mfg., tazarotene topical / Generic mfg.
    Controlled drug delivery using smart functional nanofibers for efficient therapy of psoriasis () -  Jul 3, 2023 - Abstract #WCD2023WCD_6202;    
    Electrospinning imparted multiple functions to the resulting fabrics and therefore such materials have potential to achieve better efficacy with improved safety profile. The integration of drug delivery technologies with smart functionalized electrospun magnetic nanofibers is a versatile strategy to increase possibilities of psoriasis therapy and may have numerous clinical applications
  • ||||||||||  Folliculotropic Mycosis Fungoides: Current Guidance and Experience from Clinical Practice (Level 3 - Room 320) -  Apr 24, 2023 - Abstract #WCD2023WCD_3356;    
    Advanced forms assume characteristics similar to classic MF, whilst early stages present in a wide range of clinical forms (acneiform lesions, follicular-like keratoses, erythematous patches). As for therapeutic options, in absence of specific guidelines, a high number of treatments are described in clinical practice, with variable results.
  • ||||||||||  tazarotene topical / Generic mfg.
    Prospective single-arm study on the effect, safety and tolerability of topical 0.1% tazarotene gel in onychomycosis treatment (Level 3 - Room 323) -  Apr 24, 2023 - Abstract #WCD2023WCD_2664;    
    As for therapeutic options, in absence of specific guidelines, a high number of treatments are described in clinical practice, with variable results. Topical treatment with topical 0.1% tazarotene gel has been found to be effective, safe and tolerated in the treatment of onychomycosis, pave the way for further studies about retinoids in fungal infections and in the management of drug-resistance infection in a one-health prospective
  • ||||||||||  tazarotene topical / Generic mfg.
    Review, Journal:  Challenges in Psoriatic Disease Addressed by Fixed-Combination Halobetasol Propionate 0.01% and Tazarotene 0.045% Lotion. (Pubmed Central) -  Mar 25, 2023   
    Limitations include the small sample sizes of open-label reports of HP/TAZ; larger studies are needed to confirm findings. Taken together, this evidence suggests that HP/TAZ may address unmet needs in psoriatic disease as a therapy for patients with all levels of psoriasis severity who experience daily challenges associated with their disease and that it may be a candidate for treating a variety of forms of psoriasis.
  • ||||||||||  Stivarga (regorafenib) / Bayer
    Enrollment change, Trial completion date, Trial termination:  Topical Tazarotene Vs Placebo In Hand-Foot-Skin Reactions (clinicaltrials.gov) -  Dec 6, 2022   
    P2,  N=8, Terminated, 
    2022;21:12(Suppl):s5-14. N=70 --> 8 | Trial completion date: Mar 2023 --> Jul 2022 | Recruiting --> Terminated; Difficulty with patient recruitment