dacarbazine / Generic mfg. 
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92 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
dacarbazine / Generic mfg.
NCT06831370: A Study of Brentuximab Vedotin With Doxorubicin, Vinblastine and Dacarbazine in Adults With Hodgkin Lymphoma in India

Recruiting
4
124
RoW
Brentuximab Vedotin, Adcetris, Doxorubicin, Adriamycin, Vinblastine, Dacarbazine
Takeda
Hodgkin Lymphoma
03/26
03/26
ChiCTR2400088219: Single-arm, prospective clinical study of adbelizumab combined with dacarbazine and cisplatin in first-line treatment of advanced melanoma

Not yet recruiting
4
30
 
Eligible patients received adbelizumab (1200mg, D1, Q3w) in combination with dacarbazine (250mg/m2, D1-D5, Q3w or 850mg/m2, D1, Q3w) and cisplatin (25mg/m2, D1-D3, Q3w), After 6-8 cycles, adabilimab (1200mg, D1, Q3w) was maintained until PD became intolerable Toxicity, patient withdrawal of informed consent, investigator's decision to discontinue investigational therapy for a maximum of 2 years.
First Affiliated Hospital of Zhengzhou University; First Affiliated Hospital of Zhengzhou University, self-raised
melanoma
 
 
2010-022844-19: Randomized phase III study of a treatment driven by early PET response compared to a treatment not monitored by early PET in patients with Ann Arbor Stage III-IV or high risk IIB Hodgkin lymphoma

Ongoing
3
810
Europe
Bleomycin, Prednisone, Vincristine, Doxorubicin, Cyclophosphamide, Dacarbazine, Etoposide, Procarbazine, Vinblastine, Powder for solution for injection, Tablet, Solution for injection, Powder for solution for infusion, Solution for infusion, Capsule*
CHU de Dijon
Hodgkin Lymphoma not previously treated
 
 
2007-004474-24: HD16 für frühe StadienTherapieoptimierungsstudie in der Primärtherapie des frühen Hodgkin Lymphoms: Therapiestratifizierung mittels FDG-PET

Ongoing
3
1150
Europe
Doxorubicin, Bleomycin, Vinblastine, Dacarbazine, L01DB01, L01DC01, L01CA01, L01AX04, Doxorubicin, Bleomycin, Vinblastine, Dacarbazine
University of Cologne, VU University Medical Center, , Deutsche Krebshilfe
Hodgkin´s Lymphoma early stage
 
 
2010-023484-17: Sarcomas de partes blandas localizados de alto riesgo de extremidades y pared de tronco en adultos: un enfoque integrador que incluye tratamiento con medicamentos antitumorales estándar comparado con tratamientos específicos para las diferentes variedades histológicas como primer tratamiento.

Ongoing
3
250
Europe
epirrubicina, ifosfamida, Gemcitabina, Docetaxel, Etoposido, FARMIBLASTINA, Dacarbazina, epirubicin, ifosfamide, gemcitabine, docetaksel, etoposide, dacarbazine, epirubicin, ifosfamide, gemcitabine, docetaksel, etoposide, dacarbazine
ITALIAN SARCOMA GROUP, Grupo Español de Investigación en Sarcomas, Italian Sarcoma Group, , Grupo Español de Investigación en Sarcomas, NHS (diagnostic and therapeutic procedures), Eurosarc, funded by project/grant FP7
High risk localized soft tissue sarcomas typical of the adult
 
 
RATHL, NCT00678327 / 2007-006064-30: Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma

Completed
3
1202
Europe
bleomycin sulfate, filgrastim, pegfilgrastim, cyclophosphamide, dacarbazine, doxorubicin hydrochloride, etoposide, prednisolone, procarbazine hydrochloride, vinblastine sulfate, vincristine sulfate
University College, London, Cancer Research UK, Cancer Research UK & UCL Cancer Trials Centre
Lymphoma
01/16
05/24
2016-000317-78: Comparison of PV-10 to Chemotherapy or Oncolytic Viral Therapy for Treatment of Malignant Melanoma of the Skin Confronto tra PV-10 verso chemioterapia o terapia virale oncolitica per il trattamento del melanoma cutaneo localmente avanzato

Not yet recruiting
3
225
Europe
PV-10, Temozolomide, Dacarbazine, Temodal 20 mg capsule rigide, Temodal 100 mg capsule rigide, Temozolamide, TEMODAL, NA, Suspension for injection, Powder for solution for injection, Capsule, hard, Solution for injection, DACARBAZINA MEDAC - 200 MG POLVERE PER SOLUZIONE INIETTABILE O PER INFUSIONE 10 FLACONCINI IN VETRO, Temodal 5 mg capsule rigide, Imlygic 10^6 plaque forming units (PFU)/mL solution for injection, DACARBAZINA MEDAC - 500 MG POLVERE PER SOLUZIONE PER INFUSIONE 1 FLACONCINO IN VETRO, TEMODAL - 20 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 20 CAPSULE, TEMODAL - 100 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 5 CAPSULE, TEMODAL - 140 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 5 CAPSULE, TEMODAL - 180 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 20 CAPSULE, TEMODAL - 250 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 5 CAPSULE, Imlygic 10^8 plaque forming units (PFU)/mL solution for injection
PROVECTUS BIOPHARMACEUTICALS, INC., Provectus Biopharmaceuticals, Inc
Locally Advanced Cutaneous Melanoma Melanoma cutaneo localmente avanzato, Malignant melanoma of skin Melanoma maligno della pelle, Diseases [C] - Cancer [C04]
 
 
ECHELON-1 , NCT01712490 / 2011-005450-60: A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma

Checkmark Six year data from ECHELON-1 study for advanced classical Hodgkin lymphoma
Jul 2022 - Jul 2022: Six year data from ECHELON-1 study for advanced classical Hodgkin lymphoma
Checkmark Full data from ECHELON-1 trial in Hodgkin lymphoma at ASCO 2022
May 2022 - May 2022: Full data from ECHELON-1 trial in Hodgkin lymphoma at ASCO 2022
Checkmark Five-year data from ECHELON-1 trial for hodgkin lymphoma at ASH 2020
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Active, not recruiting
3
1334
Europe, Canada, Japan, US, RoW
brentuximab vedotin, ADCETRIS®, SGN-35, doxorubicin, Adriamycin, bleomycin, vinblastine, dacarbazine, DTIC
Takeda, Seagen Inc.
Hodgkin Lymphoma
04/17
01/26
HD16, NCT00736320: for Early Stage Hodgkin Lymphoma

Active, not recruiting
3
1150
Europe
ABVD (Adriamycin, Bleomycin, Vincristine, Dacarbazine), 20 Gy IFRT (Involved Field Radiotherapy)
University of Cologne
Hodgkin Lymphoma
09/18
12/21
2019-003014-13: Interest of peri operative CHemotherapy In patients with CINSARC high-risk localized grade 1 or 2 Soft Tissue Sarcoma. Intérêt de la chimiothérapie péri-opératoire chez les patients porteurs de sarcomes des tissus mous localisés de grade 1 ou 2, définis à HAUT RISQUE par la signature CINSARC.

Not yet recruiting
3
600
Europe
DOXORUBICIN, IFOSFAMIDE, DACARBAZINE, Solution for infusion, Powder for solution for injection, Powder for solution for infusion
INSTITUT CLAUDIUS REGAUD, Direction Générale de l’Offre de Soins (DGOS)
Soft Tissue Sarcoma Sarcome des tissus mous, Soft Tissue Sarcoma Sarcome des tissus mous, Diseases [C] - Cancer [C04]
 
 
FIL-Rouge, NCT03159897 / 2016-002509-21: FIL Study on ABVD DD-DI As Upfront Therapy in HL.

Completed
3
500
Europe
Doxorubicin, Bleomycin, Vinblastine, Dacarbazine
Fondazione Italiana Linfomi - ETS
Hodgkin Lymphoma
11/21
11/24
HD21, NCT02661503 / 2014-005130-55: for Advanced Stages

Active, not recruiting
3
1500
Europe
Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone, Brentuximab Vedotin, Dacarbazine, Dexamethasone
University of Cologne
Classical Hodgkin Lymphoma
12/22
09/25
APROMISS, NCT03016819 / 2017-001655-31: Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma

Active, not recruiting
3
325
Europe, US, RoW
AL3818, Catequentenib, Anlotinib, Dacarbazine, DTIC, AL3818 or placebo
Advenchen Laboratories, LLC
Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma, Soft-Tissue Sarcoma
12/24
06/25
MELATORCH, NCT03430297: A Randomized, Controlled, Multi-center, Phase III Clinical Study to Investigate Recombinant Humanized PD-1 Monoclonal Antibody Injection (JS001) Versus Dacarbazine as the 1st-line Therapy for Unresectable or Metastatic Melanoma

Completed
3
256
RoW
JS001 240mg Q2W, Dacarbazine 1000mg/m2 Q3W
Shanghai Junshi Bioscience Co., Ltd.
Metastatic Melanoma, Unresectable Melanoma
07/23
11/23
HL-Russia-1, NCT04638790: First Line Chemotherapy for Classical Hodgkin Lymphoma in Russia

Recruiting
3
300
RoW
Doxorubicin, ABVD, Bleomycin, Vinblastine, Dacarbazine, Etoposide, EACODD-14, Cyclophosphamide, Vincristine, Dexamethasone
State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Hodgkin Lymphoma, Adult
12/26
12/26
SWOG S1826, NCT03907488: Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

Active, not recruiting
3
994
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN 35, SGN-35, SGN35, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Filgrastim, Filgrastim Biosimilar Filgrastim-sndz, Filgrastim Biosimilar Tbo-filgrastim, Filgrastim XM02, Filgrastim-aafi, Filgrastim-ayow, Filgrastim-sndz, G-CSF, Granix, Neupogen, Neutroval, Nivestim, Nivestym, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, Releuko, rG-CSF, Tbo-filgrastim, Tevagrastim, XM02, Zarxio, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Pegfilgrastim, Dulastin, Filgrastim SD-01, filgrastim-SD/01, Fulphila, Fylnetra, G-Lasta, HSP-130, Jinyouli, Neulasta, Neulastim, Neupopeg, Nyvepria, PEG-filgrastim, Pegcyte, Pegfilgrastim Biosimilar HSP-130, Pegfilgrastim Biosimilar Nyvepria, Pegfilgrastim Biosimilar Pegcyte, Pegfilgrastim Biosimilar PF-06881894, Pegfilgrastim Biosimilar Udenyca, Pegfilgrastim Biosimilar Ziextenzo, Pegfilgrastim-apgf, Pegfilgrastim-bmez, Pegfilgrastim-cbqv, Pegfilgrastim-fpgk, Pegfilgrastim-jmdb, Pegfilgrastim-pbbk, Pegylated G-CSF, Pegylated GCSF, Pegylated Granulocyte Colony Stimulating Factor, PF-06881894, SD-01, SD-01 sustained duration G-CSF, Stimufend, Tripegfilgrastim, Udenyca, Ziextenzo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE
National Cancer Institute (NCI)
Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma, Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma, Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma, Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma, Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma, Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma, Classic Hodgkin Lymphoma, Lymphocyte-Rich Classic Hodgkin Lymphoma
03/24
04/25
SEACRAFT-2, NCT06346067: A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma

Recruiting
3
470
Europe, Canada, US, RoW
Naporafenib, ERAS-254, LXH254, Dacarbazine, DTIC, Temozolomide, Temodar, TMZ, Trametinib, Mekinist
Erasca, Inc.
Advanced or Metastatic NRAS-mutant Melanoma
04/28
12/28
ISG-STS-1001, NCT01710176: Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy

Active, not recruiting
3
550
Europe
epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3), gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8), trabectedin 1.3 mg/m2, high-dose ifosfamide 14 g/m2, given in in 14 days, etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3), gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)
Italian Sarcoma Group, French Sarcoma Group, Grupo Espanol de Investigacion en Sarcomas
Localized High-risk Soft Tissue Sarcomas of the Extremities and Trunk Wall in Adults
06/24
06/24
SUPRAME, NCT06743126: -ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

Recruiting
3
360
US
IMA203, nivolumab plus relatlimab, Opdualag®, lifileucel, AMTAGVI, nivolumab, Opdivo®, pembrolizumab, Keytruda®, ipilimumab, Yervoy, Dacarbazine, DTIC-Dome, temozolomide, Temodar, paclitaxel, Taxol, paclitaxel plus carboplatin, Carbo/Taxol®, Albumin-Bound Paclitaxel, Abraxane®
Immatics US, Inc.
Melanoma, Cutaneous Malignant
01/28
10/31
CIRSARC, NCT03805022 / 2018-000186-36: Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas

Recruiting
3
351
Europe
Doxorubicin, Ifosfamide or dacarbazine, At the discretion of the investigator
Institut Bergonié, Novartis, Chugai Pharma France
Non-metastatic Soft-tissue Sarcoma, Resectable
02/25
02/25
EuroNet-PHL-C2, NCT02684708: Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents

Active, not recruiting
3
2200
Europe, RoW
cyclophosphamide, vincristine, prednisone, dacarbazine, CYC, VCR, PRED, DTIC, cyclo, vcr, pred, dacarb,etop and doxo, CYC, VCR, PRED, DTIC, ETO, DOXO
University of Giessen, Deutsche Krebshilfe e.V., Bonn (Germany), Euronet Worldwide
Classical Hodgkin Lymphoma
09/26
09/26
HR-NBL2, NCT04221035 / 2019-001068-31: High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

Recruiting
3
800
Europe, RoW
Vincristine, L01CA02, Carboplatin, LO1XA02, Etoposide, L01CB01, Vindesine, L01CA03, Dacarbazine, L01AX04, Ifosfamide, Doxorubicin, L01DB01, Busulfan, L01AB01, Melphalan, L01AA03, Thiotepa, L01AC01, Radiotherapy, Dinutuximab Beta, L01XC16, Cisplatin, L01XA01, Temozolomide 100 MG, Irinotecan, Cyclophosphamid
Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe
High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy
11/26
11/32
NCT06008106: Comparing Tunlametinib Capsules and Combination Chemotherapy in Advanced NRAS-mutant Melanoma

Recruiting
3
165
RoW
tunlametinib, paclitaxel +carboplatin, or temozolomide +cisplatin, or dacarbazine +cisplatin
Shanghai Kechow Pharma, Inc.
Melanoma
09/27
09/27
RADAR, NCT04685616: Brentuximab Vedotin in Early Stage Hodgkin Lymphoma

Recruiting
3
1042
Europe, Canada, US, RoW
Involved site radiotherapy, Doxorubicin, Bleomycin, Brentuximab vedotin, Vinblastine, Dacarbazine, Haematopoietic growth factor, Filgrastim, G-CSF, Pegfilgrastim
University College, London, Takeda, University of Miami, European Organisation for Research and Treatment of Cancer - EORTC, Australasian Leukaemia and Lymphoma Group, Seagen Inc., Canadian Cancer Trials Group
Hodgkin Lymphoma
09/30
09/32
AHOD2131, NCT05675410: A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Recruiting
3
1875
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bleomycin Sulfate, Blanoxan, BleMomycine, Blenoxane, Bleo-cell, Bleo-S, Bleocin, Bleolem, Bleomycin Sulfas, Bleomycin Sulphate, Bleomycini Sulfas, Blexane, Oil Bleo, Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN 35, SGN-35, SGN35, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Etoposide Phosphate, Etopophos, Fludeoxyglucose F-18, 18FDG, FDG, Fludeoxyglucose (18F), fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, Involved-site Radiation Therapy, ISRT, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, PT, Prednisolone, (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, .delta.1-Hydrocortisone, Adnisolone, Aprednislon, Capsoid, Cortalone, Cortisolone, Dacortin H, Decaprednil, Decortin H, Delta(1)Hydrocortisone, Delta- Cortef, Delta-Cortef, Delta-Diona, Delta-F, Delta-Phoricol, Delta1-dehydro-hydrocortisone, Deltacortril, Deltahydrocortisone, Deltasolone, Deltidrosol, Dhasolone, Di-Adreson-F, Dontisolon D, Estilsona, Fisopred, Frisolona, Gupisone, Hostacortin H, Hydeltra, Hydeltrasol, Klismacort, Kuhlprednon, Lenisolone, Lepi-Cortinolo, Linola-H N, Linola-H-Fett N, Longiprednil, Metacortandralone, Meti Derm, Meticortelone, Opredsone, Panafcortelone, Precortisyl, Pred-Clysma, Predeltilone, Predni-Coelin, Predni-Helvacort, Prednicortelone, Prednisolonum, Prelone, Prenilone, Sterane, Prednisone, .delta.1-Cortisone, 1, 2-Dehydrocortisone, Adasone, Cortancyl, Dacortin, DeCortin, Decortisyl, Decorton, Delta 1-Cortisone, Delta-Dome, Deltacortene, Deltacortisone, Deltadehydrocortisone, Deltasone, Deltison, Deltra, Econosone, Lisacort, Meprosona-F, Metacortandracin, Meticorten, Ofisolona, Orasone, Panafcort, Panasol-S, Paracort, Perrigo Prednisone, PRED, Predicor, Predicorten, Prednicen-M, Prednicort, Prednidib, Prednilonga, Predniment, Prednisone Intensol, Prednisonum, Prednitone, Promifen, Rayos, Servisone, SK-Prednisone, Procarbazine Hydrochloride, Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI), Ibenzmethyzine hydrochloride, Matulane, MIH hydrochloride, Natulan, Natulanar, Natunalar, NCI C01810, NCI-C01810, NCIC01810, p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride, p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI), PCB, PCB Hydrochloride, PCZ, Ro 4 6467/1, Ro 4-6467/1, Questionnaire Administration, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
National Cancer Institute (NCI)
Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
04/31
04/31
SUNRISELMS, NCT05269355 / 2022-000073-12: A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

Terminated
2/3
360
Europe, Canada, US, RoW
Unesbulin, PTC596, Dacarbazine, DTIC, Placebo
PTC Therapeutics, PTC Therapeutics, Inc.
Leiomyosarcoma
06/24
07/24
NCT06563245: Brentuximab Vedotin for Newly Diagnosed CHL in Chinese CAYA Based on PET/CT Assessment

Recruiting
2/3
96
RoW
Brentuximab Vedotin for Injection, response-adapted radiation, Doxorubicin, Etoposide, Prednisone, Cyclophosphamide, Dacarbazine, Tislelizumab Injection, Bedamustine
Children's Cancer Group, China, Shanghai Children's Medical Center, Najing Children's Hospital, West China Second University Hospital, Qilu Hospital of Shandong University, Tianjin Medical University Cancer Institute and Hospital, Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Xiangya Hospital of Central South University, The First Affiliated Hospital of Zhengzhou University, Second Affiliated Hospital of Anhui Medical University, Children's Hospital of Hebei Province, Children's Hospital of Henan Province, Sun Yat-Sen Memorial Hospital Zhongshan University
Classical Hodgkin Lymphoma, Child, Adolescent, Young Adult, Metabolic Response, Survival, Treatment, Brentuximab Vedotin, PET Scan
11/29
11/39
NCT06624644: A Trial of LNS8801 with or Without Pembrolizumab in Patients with Refractory Melanoma

Not yet recruiting
2/3
135
NA
LNS8801, Pembrolizumab, Chemotherapy (dacarbazine or temozolomide), Immunotherapy (Pembrolizumab), Immunotherapy (nivolumab and relatlimab), Immunotherapy (ipilimumab and nivolumab)
Linnaeus Therapeutics, Inc., Merck Sharp & Dohme LLC
Melanoma (Skin Cancer), Melanoma Stage IIIB-IV, Cutaneous Melanoma, Unresectable Melanoma
08/28
08/30
DAR-UM-2, NCT05987332: IDE196 (Darovasertib) in Combination with Crizotinib As First-line Therapy in Metastatic Uveal Melanoma

Recruiting
2/3
420
Europe, Canada, US, RoW
IDE196, Darovasertib, Crizotinib, XALKORI, Pembrolizumab, Keytruda, Ipilimumab, Yervoy, Nivolumab, Opdivo, Dacarbazine, DTIC-Dome
IDEAYA Biosciences
Metastatic Uveal Melanoma
01/27
01/28
ACTRN12612000137897: Dose-Dense ABVD Study: An accelerated delivery of Adriamycin, Bleomycin, Vinblastin and Dacarbazine for patients with Hodgkin Lymphoma

Not yet recruiting
2
31
 
Queensland Health, Hospira
Early Stage Unfavourable Hodgkin Lymphoma, Advanced Stage Hodgkin Lymphoma
 
 
ACTRN12608000639325: Multicentre clinical study with early treatment intensification in patients with high-risk Hodgkin Lymphoma, identified as 18-F Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) scan positive after two conventional Doxorubicin, Bleomycin, Vinblastine, Dacarbazine (ABVD) courses

Recruiting
2
450
 
Gruppo Italiano Terapie Innovative nei Linfomi (GITIL), Gruppo Italiano Terapia Innovativa nei Linfomi
Hodgkin Lymphoma
 
 
R-2, NCT05898451: Effect of Refnot on Immunity in Cancer Patients

Completed
2
55
NA
Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T), Refnot, Tumor necrosis factor-thymosin alfa 1 recombinant, Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T) and chemotherapy, and Dacarbazine, Lomustine, Cisplatin
Refnot-Pharm Ltd
Solid Tumor
11/11
11/11
2014-001303-52: Treatment of relapsed/refractory leukemia with intravenous administration of Dacarbazine Trattamento della leucemia acuta mieloide recidivata/refrattaria con somministrazione endovenosa di Dacarbazina

Ongoing
2
20
Europe
DACARBAZINA, Powder for solution for infusion, DACARBAZINA
Azienda Ospedaliero-Universitaria di Parma, medac pharma srl, Fondo dipartimento università degli studi di Parma
Relapsed/Refractory acute myeloid leukemia patients Pazienti affetti da leucemia acuta mieloide recidivata/refrattaria, Relapsed/Refractory acute myeloid leukemia patients Pazienti affetti da leucemia acuta mieloide recidivata/refrattaria, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2007-007265-20: A Phase II open label randomized parallel group non comparative trial to assess efficacy and safety of the association of IPH1101 and IL-2 alone and in combination with dacarbazine, in patients with metastatic melanoma

Ongoing
2
6
Europe
Phosphostim 200, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, IPH1101, DTIC, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, poudre pour solution injectable, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, poudre pour solution injectable
Innate Pharma
metastatic melanoma
 
 
2007-007168-94: PHASE II MULTICENTRE CLINICAL STUDY WITH EARLY TREATMENT INTENSIFICATION IN PTS WITH HIGH-RISK HODGKIN LYMPHOMA, IDENTIFIED AS FDG-PET SCAN POSITIVE AFTER TWO CONVENTIONAL ABVD COURSES

Ongoing
2
450
Europe
Dacarbazine, ADRIBLASTINA, BLEOMICINA CRIN, VINBLASTINA BAX, ADRIBLASTINA, BLEOMICINA CRIN, VINBLASTINA BAX
AZIENDA OSPEDALIERA \"S. CROCE E CARLE\"
HD ADVANCED DISEASE
 
 
2010-021885-31: Randomized Phase II Study Using a Non-myeloablative Lymphocyte Depleting Regimen of Chemotherapy Followed by Infusion of Tumor Infiltrating Lymphocytes and Interleukin-2 in Metastatic Melanoma’

Ongoing
2
45
Europe
Tumor Infiltrating Lymphocytes, TIL, dacarbazine, dacarbazine
NKI-AVL
Patients with metastatic (stage IV) melanoma will be randomized to either treatment arm A (dacarbazine) or treatment arm B (TIL) after metastasectomy and feasibility of culturing of TIL.
 
 
2012-001020-35: A clinical phase II trial to compare the efficacy of Bevacizumab monotherapy with standard chemotherapy (dacarbazine) in metastatic melanoma. En fase 2 studie for å sammenligne effekten av Bevacizumab monoterapi med standard kjemoterapi (dacarbazine) ved malignt melanom med metastaser.

Ongoing
2
120
Europe
Bevacizumab, Dacarbazine, Inderal, Renitec, 091652, Avastin (Bevacizumab), Dacarbazine, Inderal (Propranolol), Renitec (Enalapril), Avastin (Bevacizumab), Dacarbazine, Inderal (Propranolol), Renitec (Enalapril)
Helse Bergen HF, Haukeland University Hospital, The Norwegian Cancer Association
Previously treated or untreated histologically confirmed metastatic and unresectable melanoma with radiological (RECIST), clinical or biochemical progressive disease.
 
 
2007-006713-16: Phase II Randomized, Open-Label Study of IMC-1121B With or Without Dacarbazine in Patients with Metastatic Malignant Melanoma

Ongoing
2
10
Europe
IMC-1121B, Dacarbazine, IMC-1121B,
ImClone Systems Incorporated
Metastatic Malignant Melanoma
 
 
2017-001207-68: A study to investigate the efficacy of ramucirumab in combination with dacarbazine in patients with progressive well-differentiated metastatic neuroendocrine tumors of the pancreas Studie zur Untersuchung der Wirksamkeit von Ramucirumab in Kombination mit Dacarbazin bei Patienten mit neuroendokrinen, fortgeschrittenen Tumoren der Bauchspeicheldrüse, welche eventuell schon Absiedlungen (Metastasen) gebildet haben.

Ongoing
2
45
Europe
Concentrate for solution for infusion, Cyramza 10 mg/ml
Martin-Luther-Universität Halle-Wittenberg, Lilly Deutschland GmbH
Progressive well-differentiated metastatic pancreatic neuroendocrine tumors Progrediente, gut differenzierte metastasierte pankreatische neuroendokrine Tumore, Progressive well-differentiated metastatic neuroendocrine tumors of the pancreas Neuroendokriner Tumor der Bauchspeicheldrüse, welcher fortgeschritten ist und eventuell schon Absiedlungen (Metastasen) gebildet hat, Diseases [C] - Cancer [C04]
 
 
NU 16H08, NCT03226249: PET-Directed Therapy With Pembrolizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Classical Hodgkin Lymphoma

Active, not recruiting
2
30
US
Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, computerized tomography, CT, CT SCAN, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Fludeoxyglucose F-18, 18FDG, FDG, fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, Laboratory Biomarker Analysis, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE
Northwestern University, National Cancer Institute (NCI), Merck Sharp & Dohme LLC
Classical Hodgkin Lymphoma, Lymphocyte-Depleted Classical Hodgkin Lymphoma, Lymphocyte-Rich Classical Hodgkin Lymphoma, Mixed Cellularity Classical Hodgkin Lymphoma, Nodular Sclerosis Classical Hodgkin Lymphoma
05/19
10/24
ACCRU, NCT02758717: Nivolumab and Brentuximab Vedotin in Treating Older Patients With Untreated Hodgkin Lymphoma

Checkmark From trial in combination with Opdivo for hodgkin lymphoma at ASH 2019
Dec 2019 - Dec 2019: From trial in combination with Opdivo for hodgkin lymphoma at ASH 2019
Checkmark Presentation of data in combination with Opdivo for 1L Hodgkin lymphoma at ASH 2019
Dec 2019 - Dec 2019: Presentation of data in combination with Opdivo for 1L Hodgkin lymphoma at ASH 2019
Active, not recruiting
2
46
US
Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN-35, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo
Academic and Community Cancer Research United, National Cancer Institute (NCI)
Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage IIIA Hodgkin Lymphoma, Ann Arbor Stage IIIB Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma, Ann Arbor Stage IVA Hodgkin Lymphoma, Ann Arbor Stage IVB Hodgkin Lymphoma, Classic Hodgkin Lymphoma
08/19
09/24
2017-003556-23: Preconditioning of Tumor, Tumor Microenvironment and the Immune System to Immunotherapy (PROMIT) Präkonditionierung von Tumor, Tumormikromilieu und Immunsysten für Immuntherapie

Not yet recruiting
2
38
Europe
Opdivo, Yervoy, Pembrolizumab, Powder and solvent for solution for infusion, Concentrate for solution for infusion, Detimedac, Opdivo, Yervoy, Keytruda
University Hospital of the Friedrich-Alexander University Erlangen-Nürnberg, Deutsche Krebshilfe, University Hospital of the Friedrich-Alexander University Erlangen-Nürnberg
Melanoma, Skin cancer, Diseases [C] - Cancer [C04]
 
 
IMCgp100-202, NCT03070392 / 2015-003153-18: Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma

Active, not recruiting
2
378
Europe, Canada, US, RoW
IMCgp100, Dacarbazine, DTIC-Dome, DTIC, DIC, Imidazole Carboxamide, Ipilimumab, Yervoy, Pembrolizumab, Keytruda
Immunocore Ltd
Uveal Melanoma
10/20
07/25
NCT01920932: Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma

Active, not recruiting
2
77
US
brentuximab vedotin, SGN-35, Adcetris(R), etoposide, VP-16, Vepesid(R), prednisone, prednisolone, doxorubicin, Adriamycin(R), cyclophosphamide, Cytoxan(R), Dacarbazine(R), Dimethyl Triazeno Imidazole Carboximide (DTIC), filgrastim, Neupogen(R), quality of life assessment, radiation therapy, irradiation, radiotherapy, radiation
St. Jude Children's Research Hospital, Seagen Inc.
Stage II Childhood Hodgkin Lymphoma, Stage III Childhood Hodgkin Lymphoma, Stage IV Childhood Hodgkin Lymphoma
11/20
05/28
AMC-085, NCT02298257: A Pilot Trial of AVD and Brentuximab Vedotin (SGN-35) in the Treatment of Stage III-IV HIV-associated Hodgkin Lymphoma

Completed
2
9
Europe
brentuximab vedotin, adcetris, SGN-35, anti-CD30 ADC SGN-35, anti-CD30 antibody-drug conjugate SGN-35, antibody-drug conjugate SGN-35, Doxorubicin Hydrochloride, Vinblastine, Velban, Velsar, VLB, Dacarbazine
The Lymphoma Academic Research Organisation
HIV Infection, HIV-associated Hodgkin Lymphoma, Stage III Adult Hodgkin Lymphoma, Stage IV Adult Hodgkin Lymphoma
12/21
08/22
NCT02501551: Regorafenib, C-kit Mutated Malignant Melanoma, 2nd Line Therapy

Recruiting
2
36
RoW
regorafenib
Yonsei University
Melanoma
05/22
06/22
ACCRU-LY-1601, NCT03233347: Doxorubicin, Vinblastine, Dacarbazine, Brentuximab Vedotin, and Nivolumab in Treating Patients With Stage I-II Hodgkin Lymphoma

Active, not recruiting
2
82
US
Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN-35, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Laboratory Biomarker Analysis, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo, Vinblastine, Vincaleucoblastine, VLB
Academic and Community Cancer Research United, National Cancer Institute (NCI)
Ann Arbor Stage I Hodgkin Lymphoma, Ann Arbor Stage IA Hodgkin Lymphoma, Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Classic Hodgkin Lymphoma
07/22
07/25
NCT06201507: BV-AVD-R Treatment Children Hodgkin's Lymphoma

Enrolling by invitation
2
44
RoW
Brentuximab vedotin, Adcetris, Rituximab, Rituxan, Doxorubicin, Doxil, Adriamycin, Vincristine, Oncovin, Dacarbazine, DTIC
Beijing Children's Hospital
Hodgkin Lymphoma
12/24
12/25
SGN35-027, NCT03646123 / 2020-004027-17: Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma

Checkmark Part B and Part C data from SGN35-027 study in combination with Opdivo for classical Hodgkin Lymphoma at ASH 2022
Dec 2022 - Dec 2022: Part B and Part C data from SGN35-027 study in combination with Opdivo for classical Hodgkin Lymphoma at ASH 2022
Terminated
2
255
Europe, US, RoW
brentuximab vedotin, Adcetris, SGN-35, doxorubicin, vinblastine, dacarbazine, G-CSF, filgrastim, pegfilgrastim, nivolumab, Opdivo
Seagen Inc., Bristol-Myers Squibb
Hodgkin Lymphoma
11/22
08/24
NCT04200040: A Clinical Study to Evaluate the Safety and Efficacy of OrienX010 in Unresectable Malignant Melanoma Patients

Recruiting
2
165
RoW
OrienX010 injection, Recombinant Human GM-CSF Herpes Simplex Virus Injection, Dacarbazine (DTIC)
OrienGene Biotechnology Ltd.
Melanoma (Skin)
12/22
12/22
SGN35-015, NCT01716806 / 2019-003982-17: A Study of Brentuximab Vedotin With Hodgkin Lymphoma (HL) and CD30-expressing Peripheral T-cell Lymphoma (PTCL)

Checkmark Additional data for front-line Hodgkin's lymphoma in elderly patients (ASH 2014)
Nov 2014 - Nov 2014: Additional data for front-line Hodgkin's lymphoma in elderly patients (ASH 2014)
Checkmark For newly diagnosed Hodgkin's lymphoma in elderly patients
Dec 2013 - Dec 2013: For newly diagnosed Hodgkin's lymphoma in elderly patients
Checkmark Elderly chemo-intolerant Hodgkin's lymphoma patients
More
Completed
2
131
Canada, US
brentuximab vedotin, Adcetris; SGN-35, bendamustine, dacarbazine, nivolumab
Seagen Inc., Bristol-Myers Squibb
Hodgkin Disease, Peripheral T Cell Lymphoma
04/23
09/23
NCT04843267: A Multi-center, Non-randomized, Open-label Phase II Clinical Study on the Treatment of Newly Diagnosed Advanced Hodgkin's Lymphoma With PD-1 Antibody (Tislelizumab) Combined With AVD Regimen (Doxorubicin, Vindesine, Dacarbazine) Under the Guidance of PET/CT

Recruiting
2
30
RoW
Tislelizumab
Sun Yat-sen University
Hodgkin Lymphoma, Chemotherapy Effect
05/23
05/25
PROMIT, NCT04225390: Preconditioning of Tumor, Tumor Microenvironment and the Immune System to Immunotherapy

Recruiting
2
38
Europe
Dacarbazine (DTIC), DTIC
University of Erlangen-Nürnberg Medical School, University Hospital Regensburg, Wuerzburg University Hospital
Immunotherapy
06/23
07/23
COBRA, NCT03517137 / 2017-000498-35: Very Early PET-response Adapted Targeted Therapy for Advanced Hodgkin Lymphoma: a Single -Arm Phase II Study

Active, not recruiting
2
150
Europe
Brentuximab Vedotin, Adriamycin, Vinblastine, Dacarbazine, Etoposide, Cyclophosphamide, Radiation Therapy
European Organisation for Research and Treatment of Cancer - EORTC
Advanced Hodgkin Lymphoma
08/23
11/26
KEYNOTE-C11, NCT05008224 / 2021-001244-95: Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/)

Checkmark Presentation of data from KEYNOTE-C11 trial for 1L Classic Hodgkin Lymphoma at ASH 2022
Nov 2022 - Nov 2022: Presentation of data from KEYNOTE-C11 trial for 1L Classic Hodgkin Lymphoma at ASH 2022
Completed
2
146
Europe, Canada, US, RoW
Pembrolizumab, MK-3475, SCH 900475, KEYTRUDA®, Doxorubicin, Adriamycin, DOXIL®, Rubex®, Vinblastine, Alkaban-AQ®, Velban®, Dacarbazine, Dtic-Dome®, Bleomycin, Blenoxane®, Etoposide, Toposar®, VePesid®, Etopophos®, VP-16, Etoposide phosphate, Cyclophosphamide, Neosar®, Cytoxan®, Vincristine, Oncovin®, Vincasar PFS®, Procarbazine, Matulane®, Prednisone, Liquid Pred®, Meticorten®, Orasone®, Deltasone®
Merck Sharp & Dohme LLC, Merck Sharp & Dohme Corp., a subsidiary of Merck & Co.,Inc
Classical Hodgkin Lymphoma
10/23
05/24
NIVAHL, NCT03004833 / 2016-002626-37: Nivolumab and AVD in Early-stage Unfavorable Classical Hodgkin Lymphoma

Completed
2
110
Europe
Nivolumab, Adriamycin, Vinblastine, Dacarbazine
University of Cologne
Classical Hodgkin Lymphoma
08/22
08/22
NCT04067037: Camrelizumab Combined With AVD in the First-line Treatment for Patients With Advanced Classical Hodgkin's Lymphoma

Recruiting
2
60
RoW
Camrelizumab, SHR-1210, Epirubicin, Epirubicin hydrochloride, Vincristine, Oncovin, Dacarbazine
Henan Cancer Hospital
Classical Hodgkin Lymphoma
12/25
12/26
FLASH, NCT04733183 / 2018-004104-19: Efficacy and Safety of L19TNF in Previously Treated Patients with Advanced Stage or Metastatic Soft-tissue Sarcoma

Active, not recruiting
2
98
Europe
Dacarbazine, DTIC, onfekafusp alfa, L19TNF
Philogen S.p.A., Philogen S.p.A.,
Soft Tissue Sarcoma
12/25
12/25
NCT04727242: CytoreductiveSurgery & HIPEC W/Gemcitabine+Chemotherapy W/Dacarbazine in Uterine Leiomyosarcoma

Recruiting
2
25
US
Gemcitabine, Gemzar, Infugem, difluorodeoxycytidine hydrochloride, Dacarbazine, Dimethyl (triazeno) imidazolecarboxamide, Dacarbazine - DTIC, Biocarbazine, Cytoreductive Surgery, Functional Assessment of Cancer Therapy (FACT) G questionnaire, Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) Scan, Gadolinium
Kristen Ganjoo
LMS - Leiomyosarcoma, Uterine Leiomyosarcoma
12/25
12/25
NCT03712202: Brentuximab Vedotin and Nivolumab in Treating Patients With Early Stage Classic Hodgkin Lymphoma

Active, not recruiting
2
155
US
Bleomycin, BLEO, BLM, Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN-35, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo, Quality-of-Life Assessment, Quality of Life Assessment, Vinblastine, Vincaleucoblastine, VLB
City of Hope Medical Center, National Cancer Institute (NCI)
Ann Arbor Stage I Hodgkin Lymphoma, Ann Arbor Stage I Mixed Cellularity Classic Hodgkin Lymphoma, Ann Arbor Stage I Nodular Sclerosis Classic Hodgkin Lymphoma, Ann Arbor Stage IA Hodgkin Lymphoma, Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Classic Hodgkin Lymphoma, Lymphocyte-Rich Classic Hodgkin Lymphoma, Ann Arbor Stage I Lymphocyte-Depleted Classic HL, Ann Arbor Stage II Lymphocyte-Depleted Classic HL, Ann Arbor Stage II Mixed Cellularity Classic HL, Ann Arbor Stage II Nodular Sclerosis Classic HL
12/24
12/24
STRADA, NCT03023124 / 2016-004051-78: Study With Trabectedin Versus Adriamycin Plus Dacarbazine, in Patients With Advanced Solitary Fibrous Tumor

Completed
2
23
Europe
Trabectedin, Adriamycin, Dacarbazine
Italian Sarcoma Group
Solitary Fibrous Tumors
12/24
12/24
NCT06164275: Pembrolizumab Followed by Chemotherapy for the Treatment of Patients With Classical Hodgkin Lymphoma

Recruiting
2
30
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, CT, CT Scan, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, MUGA, Radionuclide Ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Pembrolizumab, BCD-201, Keytruda, Lambrolizumab, MK-3475, Pembrolizumab Biosimilar BCD-201, SCH 900475, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Vinblastine, Vincaleucoblastine, VLB
Northwestern University, National Cancer Institute (NCI)
Classic Hodgkin Lymphoma
12/29
12/31
NCT06377566: A Study of BV-AVD in People With Bulky Hodgkin Lymphoma

Recruiting
2
71
US
Brentuximab vedotin, Doxorubicin, Vinblastine, Dacarbazine, Pembrolizumab, Gemcitabine, Vinorelbine, FDG-PET/CT scan
Memorial Sloan Kettering Cancer Center, Seagen Inc.
Hodgkin Lymphoma
04/27
04/27
NCT05466474: PD-1 Antibody Tislelizumab Combined With Dacarbazine in the Treatment of Advanced Melanoma

Recruiting
2
40
RoW
Tislelizumab Injection, Dacarbazine
Henan Cancer Hospital
Advanced Melanoma
04/24
04/24
TAGGED, NCT04535271: Metronomic Trabectedin, Gemcitabine, and Dacarbazine for Soft Tissue Sarcoma

Recruiting
2
80
US
Trabectedin, Gemcitabine, Dacarbazine
Sarcoma Oncology Research Center, LLC
Leiomyosarcoma
09/28
03/29
MIZAR-003, NCT06703398: A Multicenter, Randomized, Controlled,Open Label, Phase II Trial of Autologous Tumor Infiltrating Lymphocytes (GC101 TIL) in Subjects With Advanced Melanoma

Recruiting
2
98
RoW
GC101 TIL, dacarbazine, temozolomide, paclitaxel ,platinum or cisplatin
Shanghai Juncell Therapeutics
Melanoma
07/26
12/26
NCT06745076: Personalized Reduction of Chemotherapy Intensity Through ctDNA Evaluation for the Treatment of Patients With Advanced Hodgkin Lymphoma

Recruiting
2
125
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNV Scan, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Vinblastine, Vincaleucoblastine, VLB, Questionnaire
University of Washington
Advanced Hodgkin Lymphoma, Classic Hodgkin Lymphoma, Lugano Classification Stage III Hodgkin Lymphoma AJCC v8, Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8
01/32
01/33
TNT-HYPE, NCT06835049: Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma

Not yet recruiting
2
24
Europe
Doxorubicin, Ifosfamide, Dacarbazine, Hyperthermia, Radiotherapy, Surgery
Swiss Group for Clinical Cancer Research
Sarcoma,Soft Tissue
03/28
03/31
NCT05900765: A Study of Zimberelimab(GLS-010) Combined With AVD for Newly Diagnosed Early-stage Hodgkin's Lymphoma

Recruiting
2
54
RoW
Zimberelimab 240mg, GLS-010
Sun Yat-sen University, Guangzhou Gloria Biosciences Co., Ltd.
Classical Hodgkin Lymphoma
06/25
06/26
DTIC, NCT00553618: Adjuvant, Combined Interleukin 2 (Proleukin) and (Dacarbazine) in High-risk Melanoma Patients

Active, not recruiting
2
160
US
Proleukin and Dacarbazine, Proleukin, Dacarbazine
University of Louisville, James Graham Brown Cancer Center
Metastatic Melanoma
08/25
08/26
NCT05922904: PET Adapted Brentuximab Vedotin and Pembrolizumab in Combination With Doxorubicin and Dacarbazine in Classic Hodgkin Lymphoma

Recruiting
2
50
US
Brentuximab vedotin, Doxorubicin Hydrochloride, Adriamycin PFS®, Adriamycin RDF™, Adriamycin®, Rubex®, Pembrolizumab, SGN-35, Adcetris, Dacarbazine, DTIC-Dome®
M.D. Anderson Cancer Center, Merck Sharp & Dohme LLC, Seagen Inc.
Hodgkin Lymphoma
10/25
10/27
ChiCTR2400083074: Bevacizumab combined with toripalimab and dacarbazine in the treatment of advanced melanoma: Prospective, open-label, single-arm, single-center clinical trial

Recruiting
2
30
 
Bevacizumab combined with toripalimab and dacarbazine
Shandong First Medical University Affiliated Cancer Hospital; Shandong First Medical University Affiliated Cancer Hospital, Part of self-raised, part of Qilu Pharmaceutical Co., Ltd.
melanoma
 
 
NCT03755804: Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

Recruiting
2
250
US
bendamustine, TREANDA (R), Etoposide, VP-16, Vepeside, Doxorubicin, Adriamycin (R), Bleomycin, Blenoxane (R), Vincristine, Oncovin (R), Vinblastine, Velban (R), Prednisone, Prednisolone, Filgrastim, Neupogen (R), Brentuximab Vedotin, Adcetris, Cyclophosphamide, Cytoxan (R), DTIC, DACARBAZINE (R), Dimethyl Triazeno Imidazole Carboximide, Quality of Life Measurements, Quality of Life Measurements (QOL), Radiotherapy, radiation therapy, irradiation
St. Jude Children's Research Hospital, Teva Pharmaceuticals USA, Seagen Inc.
Hodgkin Lymphoma
01/27
07/28
KEYNOTE-667, NCT03407144 / 2017-001123-53: Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/)

Active, not recruiting
2
340
Europe, US, RoW
pembrolizumab, MK-3475, doxorubicin, vinblastine, dacarbazine, cyclophosphamide, vincristine, prednisone/prednisolone, bleomycin, etoposide, Etoposide Phosphate, Radiotherapy (RT)
Merck Sharp & Dohme LLC
Hodgkin Lymphoma
02/27
02/27
NCT05404945: Fitness-adapted, Pembrolizumab-based Therapy for Untreated Classical Hodgkin Lymphoma Patients 60 Years of Age and Above

Recruiting
2
44
US
Pembrolizumab, Doxorubicin, Adriamycin, Vinblastine, Dacarbazine, Brentuximab vedotin
University of Virginia, Merck Sharp & Dohme LLC
Classical Hodgkin Lymphoma
10/27
10/27
2005-001161-34: Phase I-II multicenter, randomized, open-label, clinical and pharmacokinetic study of plitidepsin, administered alone or in combination with dacarbazine, as front-line therapy to subjects with unresectable advanced melanoma

Ongoing
1/2
30
Europe
plitidepsin (Aplidin), DTIC-DOME, APL, DTIC-DOME, DTIC-DOME
Pharma Mar SA, Pharma Mar SA, sociedad unipersonal
unresectable advanced melanoma
 
 
NCT02076646: A Phase I/II Dose Escalation Study of the Tumor-targeting Human L19-IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Dacarbazine for Patients With Metastatic Melanoma

Active, not recruiting
1/2
96
Europe
L19IL2 - Ph I, L19IL2 at RD - Ph II, DTIC, DETICENE®
Philogen S.p.A.
Metastatic Melanoma Stage IV
05/16
06/22
C25004, NCT02979522 / 2015-004112-38: A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma

Hourglass Apr 2022 - Mar 2023 : Regulatory approval in Japan for pediatric front-line Hodgkin lymphoma
Active, not recruiting
1/2
59
Europe, Japan, US, RoW
Brentuximab vedotin, Adcetris, Doxorubicin, Adriamycin, Vinblastine, Dacarbazine
Takeda
Hodgkin Disease
05/20
09/29
NCT01771107: Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With Stage II-IV HIV-Associated Hodgkin Lymphoma

Active, not recruiting
1/2
41
Europe, US
Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN 35, SGN-35, SGN35, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Pharmacological Study, Vinblastine, Vincaleucoblastine, VLB
National Cancer Institute (NCI), The Lymphoma Academic Research Organisation
AIDS-Related Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage IIIA Hodgkin Lymphoma, Ann Arbor Stage IIIB Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma, Ann Arbor Stage IVA Hodgkin Lymphoma, Ann Arbor Stage IVB Hodgkin Lymphoma, Classic Hodgkin Lymphoma, HIV Infection
10/21
02/25
NCI-2017-01718, NCT03331341: Doxorubicin Hydrochloride, Pembrolizumab, Vinblastine, and Dacarbazine in Treating Patients With Classical Hodgkin Lymphoma

Active, not recruiting
1/2
50
US
Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Laboratory Biomarker Analysis, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Vinblastine, Vincaleucoblastine, VLB
University of Washington
Classical Hodgkin Lymphoma
12/23
07/29
ImmunoSarc, NCT03277924 / 2016-004040-10: Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas

Completed
1/2
197
Europe
Sunitinib 37.5 MG, Sunitinib 25 MG [Sutent], Sutent, Nivolumab 100 MG/10 ML [Opdivo], Opdivo, Epirubicin, Ifosfamide, Doxorubicin, Dacarbazine, Cisplatin, Methotrexate
Grupo Espanol de Investigacion en Sarcomas
Soft Tissue Sarcoma, Bone Sarcoma
06/24
06/24
NCT02994498: Safety and Efficacy of DCB-BO1301 in Advanced Melanoma

Not yet recruiting
1/2
33
NA
DCB-BO1301
Chung Mei Biopharma Co., Ltd
Advanced Melanoma
09/25
12/25
CA209-447, NCT03033914: A(B)VD Followed by Nivolumab as Frontline Therapy for Higher Risk Patients With Classical Hodgkin Lymphoma (HL)

Active, not recruiting
1/2
82
Canada, US
doxorubicin, Bleomycin, vinblastine, dacarbazine, Nivolumab
Memorial Sloan Kettering Cancer Center, Bristol-Myers Squibb, Barbara Ann Karmanos Cancer Institute, British Columbia Cancer Agency
Hodgkin Lymphoma
01/26
01/26
ChiCTR-TRC-08000115: Multicenter, double-blinding, randomized controlled, phase II clinical trial on combined chemotherapy of Endostar (Recombinant Human Endostatin) for untreated patients with advanced melanoma

Completed
1
140
 
Endostar combined with dacarbazine (add a drug that inhibits neovascularization to chemotherapy) ;Dacarbazine combined with placebo
Expert Committee for Melanoma of CSCO; Melanoma Experts Committee of Chinese Society of Clinical Oncology, Self-financing
Advanced melanoma
 
 
NCT00600496: A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

Checkmark P1 data
Mar 2012 - Mar 2012: P1 data
Active, not recruiting
1
140
US
AZD6244, ARRY-142886, Dacarbazine, Erlotinib, Docetaxel, Taxotere®, Temsirolimus
AstraZeneca
Breast Cancer, Breast Neoplasms, Colon Cancer, Colonic Cancer, Colon Neoplasms, Lung Cancer, Melanoma, Kidney Cancer
08/10
12/24
PTC596-ONC-007-LMS, NCT03761095: A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

Completed
1
41
US
Unesbulin, PTC596, Dacarbazine, DTIC
PTC Therapeutics
Leiomyosarcoma
02/24
02/24
FED_RealBV, NCT06857500: Brentuximab Vedotin with Adriamycin, Vinblastine and Dacarbazine for Patients Aged 18-59 Years with Untreated Advanced-stage Classical Hodgkin Lymphoma: a Real-life Experience

Completed
N/A
200
Europe
Federico II University
Classic Hodgkin Lymphoma, Advanced Hodgkin Lymphoma
01/25
01/25
NCT04893356: Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT)

Active, not recruiting
N/A
75
Europe
O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine treated sarcoma patients
National Cancer Institute, Naples
Sarcoma
02/22
01/25
EuroNet-PHL-C2, NCT02797717: Treatment for Classical Hodgkin Lymphoma in Children and Adolescents

Recruiting
N/A
2200
RoW
Radiotherapy:, Vincristine, Etoposide, Prednisone, Doxorubicin, Dacarbazine, Cyclophosphamide
GALIA AVRAHAMI, University of Giessen
Classical Hodgkins Lymphoma in Children and Adolescents.
12/22
12/27
ChiCTR2400084334: A study of liposomal doxorubicin + dacarbazine in combination with teripulimab in the treatment of unresectable or metastatic cardiac sarcoma

Recruiting
N/A
30
 
PLD+DTIC+Toripalimab
Beijing Cancer Hospital (Peking University Cancer Hospital); Beijing Cancer Hospital (Peking University Cancer Hospital), self-funded
primary cardiac sarcoma
 
 
NCT01868451: Brentuximab Vedotin Combined With AVD Chemotherapy in Patients With Newly Diagnosed Early Stage, Unfavorable Risk Hodgkin Lymphoma

Active, not recruiting
N/A
118
US
Brentuximab vedotin (SGN-35), Doxorubicin HCL, Vinblastine Sulfate, Dacarbazine, Involved-Site Radiation Therapy (ISRT), Interim PET, consolidation volume RT (CVRT)
Memorial Sloan Kettering Cancer Center, Seagen Inc., University of Rochester, City of Hope Medical Center, Stanford University
Hodgkin Lymphoma
05/26
05/26
ACTRN12607000107426: Trial of PI-88 with Dacarbazine in patients Metastatic Melanoma

Active, not recruiting
N/A
114
 
Progen Pharmaceuticals Ltd, Progen Pharmaceuticals Ltd
Metastatic melanoma
 
 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
dacarbazine / Generic mfg.
NCT06831370: A Study of Brentuximab Vedotin With Doxorubicin, Vinblastine and Dacarbazine in Adults With Hodgkin Lymphoma in India

Recruiting
4
124
RoW
Brentuximab Vedotin, Adcetris, Doxorubicin, Adriamycin, Vinblastine, Dacarbazine
Takeda
Hodgkin Lymphoma
03/26
03/26
ChiCTR2400088219: Single-arm, prospective clinical study of adbelizumab combined with dacarbazine and cisplatin in first-line treatment of advanced melanoma

Not yet recruiting
4
30
 
Eligible patients received adbelizumab (1200mg, D1, Q3w) in combination with dacarbazine (250mg/m2, D1-D5, Q3w or 850mg/m2, D1, Q3w) and cisplatin (25mg/m2, D1-D3, Q3w), After 6-8 cycles, adabilimab (1200mg, D1, Q3w) was maintained until PD became intolerable Toxicity, patient withdrawal of informed consent, investigator's decision to discontinue investigational therapy for a maximum of 2 years.
First Affiliated Hospital of Zhengzhou University; First Affiliated Hospital of Zhengzhou University, self-raised
melanoma
 
 
2010-022844-19: Randomized phase III study of a treatment driven by early PET response compared to a treatment not monitored by early PET in patients with Ann Arbor Stage III-IV or high risk IIB Hodgkin lymphoma

Ongoing
3
810
Europe
Bleomycin, Prednisone, Vincristine, Doxorubicin, Cyclophosphamide, Dacarbazine, Etoposide, Procarbazine, Vinblastine, Powder for solution for injection, Tablet, Solution for injection, Powder for solution for infusion, Solution for infusion, Capsule*
CHU de Dijon
Hodgkin Lymphoma not previously treated
 
 
2007-004474-24: HD16 für frühe StadienTherapieoptimierungsstudie in der Primärtherapie des frühen Hodgkin Lymphoms: Therapiestratifizierung mittels FDG-PET

Ongoing
3
1150
Europe
Doxorubicin, Bleomycin, Vinblastine, Dacarbazine, L01DB01, L01DC01, L01CA01, L01AX04, Doxorubicin, Bleomycin, Vinblastine, Dacarbazine
University of Cologne, VU University Medical Center, , Deutsche Krebshilfe
Hodgkin´s Lymphoma early stage
 
 
2010-023484-17: Sarcomas de partes blandas localizados de alto riesgo de extremidades y pared de tronco en adultos: un enfoque integrador que incluye tratamiento con medicamentos antitumorales estándar comparado con tratamientos específicos para las diferentes variedades histológicas como primer tratamiento.

Ongoing
3
250
Europe
epirrubicina, ifosfamida, Gemcitabina, Docetaxel, Etoposido, FARMIBLASTINA, Dacarbazina, epirubicin, ifosfamide, gemcitabine, docetaksel, etoposide, dacarbazine, epirubicin, ifosfamide, gemcitabine, docetaksel, etoposide, dacarbazine
ITALIAN SARCOMA GROUP, Grupo Español de Investigación en Sarcomas, Italian Sarcoma Group, , Grupo Español de Investigación en Sarcomas, NHS (diagnostic and therapeutic procedures), Eurosarc, funded by project/grant FP7
High risk localized soft tissue sarcomas typical of the adult
 
 
RATHL, NCT00678327 / 2007-006064-30: Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma

Completed
3
1202
Europe
bleomycin sulfate, filgrastim, pegfilgrastim, cyclophosphamide, dacarbazine, doxorubicin hydrochloride, etoposide, prednisolone, procarbazine hydrochloride, vinblastine sulfate, vincristine sulfate
University College, London, Cancer Research UK, Cancer Research UK & UCL Cancer Trials Centre
Lymphoma
01/16
05/24
2016-000317-78: Comparison of PV-10 to Chemotherapy or Oncolytic Viral Therapy for Treatment of Malignant Melanoma of the Skin Confronto tra PV-10 verso chemioterapia o terapia virale oncolitica per il trattamento del melanoma cutaneo localmente avanzato

Not yet recruiting
3
225
Europe
PV-10, Temozolomide, Dacarbazine, Temodal 20 mg capsule rigide, Temodal 100 mg capsule rigide, Temozolamide, TEMODAL, NA, Suspension for injection, Powder for solution for injection, Capsule, hard, Solution for injection, DACARBAZINA MEDAC - 200 MG POLVERE PER SOLUZIONE INIETTABILE O PER INFUSIONE 10 FLACONCINI IN VETRO, Temodal 5 mg capsule rigide, Imlygic 10^6 plaque forming units (PFU)/mL solution for injection, DACARBAZINA MEDAC - 500 MG POLVERE PER SOLUZIONE PER INFUSIONE 1 FLACONCINO IN VETRO, TEMODAL - 20 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 20 CAPSULE, TEMODAL - 100 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 5 CAPSULE, TEMODAL - 140 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 5 CAPSULE, TEMODAL - 180 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 20 CAPSULE, TEMODAL - 250 MG - CAPSULA RIGIDA- USO ORALE- CAPSULE IN BUSTINE SIGILLATE INDIVIDUALMENTE 5 CAPSULE, Imlygic 10^8 plaque forming units (PFU)/mL solution for injection
PROVECTUS BIOPHARMACEUTICALS, INC., Provectus Biopharmaceuticals, Inc
Locally Advanced Cutaneous Melanoma Melanoma cutaneo localmente avanzato, Malignant melanoma of skin Melanoma maligno della pelle, Diseases [C] - Cancer [C04]
 
 
ECHELON-1 , NCT01712490 / 2011-005450-60: A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma

Checkmark Six year data from ECHELON-1 study for advanced classical Hodgkin lymphoma
Jul 2022 - Jul 2022: Six year data from ECHELON-1 study for advanced classical Hodgkin lymphoma
Checkmark Full data from ECHELON-1 trial in Hodgkin lymphoma at ASCO 2022
May 2022 - May 2022: Full data from ECHELON-1 trial in Hodgkin lymphoma at ASCO 2022
Checkmark Five-year data from ECHELON-1 trial for hodgkin lymphoma at ASH 2020
More
Active, not recruiting
3
1334
Europe, Canada, Japan, US, RoW
brentuximab vedotin, ADCETRIS®, SGN-35, doxorubicin, Adriamycin, bleomycin, vinblastine, dacarbazine, DTIC
Takeda, Seagen Inc.
Hodgkin Lymphoma
04/17
01/26
HD16, NCT00736320: for Early Stage Hodgkin Lymphoma

Active, not recruiting
3
1150
Europe
ABVD (Adriamycin, Bleomycin, Vincristine, Dacarbazine), 20 Gy IFRT (Involved Field Radiotherapy)
University of Cologne
Hodgkin Lymphoma
09/18
12/21
2019-003014-13: Interest of peri operative CHemotherapy In patients with CINSARC high-risk localized grade 1 or 2 Soft Tissue Sarcoma. Intérêt de la chimiothérapie péri-opératoire chez les patients porteurs de sarcomes des tissus mous localisés de grade 1 ou 2, définis à HAUT RISQUE par la signature CINSARC.

Not yet recruiting
3
600
Europe
DOXORUBICIN, IFOSFAMIDE, DACARBAZINE, Solution for infusion, Powder for solution for injection, Powder for solution for infusion
INSTITUT CLAUDIUS REGAUD, Direction Générale de l’Offre de Soins (DGOS)
Soft Tissue Sarcoma Sarcome des tissus mous, Soft Tissue Sarcoma Sarcome des tissus mous, Diseases [C] - Cancer [C04]
 
 
FIL-Rouge, NCT03159897 / 2016-002509-21: FIL Study on ABVD DD-DI As Upfront Therapy in HL.

Completed
3
500
Europe
Doxorubicin, Bleomycin, Vinblastine, Dacarbazine
Fondazione Italiana Linfomi - ETS
Hodgkin Lymphoma
11/21
11/24
HD21, NCT02661503 / 2014-005130-55: for Advanced Stages

Active, not recruiting
3
1500
Europe
Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone, Brentuximab Vedotin, Dacarbazine, Dexamethasone
University of Cologne
Classical Hodgkin Lymphoma
12/22
09/25
APROMISS, NCT03016819 / 2017-001655-31: Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma

Active, not recruiting
3
325
Europe, US, RoW
AL3818, Catequentenib, Anlotinib, Dacarbazine, DTIC, AL3818 or placebo
Advenchen Laboratories, LLC
Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma, Soft-Tissue Sarcoma
12/24
06/25
MELATORCH, NCT03430297: A Randomized, Controlled, Multi-center, Phase III Clinical Study to Investigate Recombinant Humanized PD-1 Monoclonal Antibody Injection (JS001) Versus Dacarbazine as the 1st-line Therapy for Unresectable or Metastatic Melanoma

Completed
3
256
RoW
JS001 240mg Q2W, Dacarbazine 1000mg/m2 Q3W
Shanghai Junshi Bioscience Co., Ltd.
Metastatic Melanoma, Unresectable Melanoma
07/23
11/23
HL-Russia-1, NCT04638790: First Line Chemotherapy for Classical Hodgkin Lymphoma in Russia

Recruiting
3
300
RoW
Doxorubicin, ABVD, Bleomycin, Vinblastine, Dacarbazine, Etoposide, EACODD-14, Cyclophosphamide, Vincristine, Dexamethasone
State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Hodgkin Lymphoma, Adult
12/26
12/26
SWOG S1826, NCT03907488: Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

Active, not recruiting
3
994
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN 35, SGN-35, SGN35, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Filgrastim, Filgrastim Biosimilar Filgrastim-sndz, Filgrastim Biosimilar Tbo-filgrastim, Filgrastim XM02, Filgrastim-aafi, Filgrastim-ayow, Filgrastim-sndz, G-CSF, Granix, Neupogen, Neutroval, Nivestim, Nivestym, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, Releuko, rG-CSF, Tbo-filgrastim, Tevagrastim, XM02, Zarxio, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Pegfilgrastim, Dulastin, Filgrastim SD-01, filgrastim-SD/01, Fulphila, Fylnetra, G-Lasta, HSP-130, Jinyouli, Neulasta, Neulastim, Neupopeg, Nyvepria, PEG-filgrastim, Pegcyte, Pegfilgrastim Biosimilar HSP-130, Pegfilgrastim Biosimilar Nyvepria, Pegfilgrastim Biosimilar Pegcyte, Pegfilgrastim Biosimilar PF-06881894, Pegfilgrastim Biosimilar Udenyca, Pegfilgrastim Biosimilar Ziextenzo, Pegfilgrastim-apgf, Pegfilgrastim-bmez, Pegfilgrastim-cbqv, Pegfilgrastim-fpgk, Pegfilgrastim-jmdb, Pegfilgrastim-pbbk, Pegylated G-CSF, Pegylated GCSF, Pegylated Granulocyte Colony Stimulating Factor, PF-06881894, SD-01, SD-01 sustained duration G-CSF, Stimufend, Tripegfilgrastim, Udenyca, Ziextenzo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE
National Cancer Institute (NCI)
Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma, Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma, Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma, Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma, Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma, Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma, Classic Hodgkin Lymphoma, Lymphocyte-Rich Classic Hodgkin Lymphoma
03/24
04/25
SEACRAFT-2, NCT06346067: A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma

Recruiting
3
470
Europe, Canada, US, RoW
Naporafenib, ERAS-254, LXH254, Dacarbazine, DTIC, Temozolomide, Temodar, TMZ, Trametinib, Mekinist
Erasca, Inc.
Advanced or Metastatic NRAS-mutant Melanoma
04/28
12/28
ISG-STS-1001, NCT01710176: Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy

Active, not recruiting
3
550
Europe
epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3), gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8), trabectedin 1.3 mg/m2, high-dose ifosfamide 14 g/m2, given in in 14 days, etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3), gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)
Italian Sarcoma Group, French Sarcoma Group, Grupo Espanol de Investigacion en Sarcomas
Localized High-risk Soft Tissue Sarcomas of the Extremities and Trunk Wall in Adults
06/24
06/24
SUPRAME, NCT06743126: -ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

Recruiting
3
360
US
IMA203, nivolumab plus relatlimab, Opdualag®, lifileucel, AMTAGVI, nivolumab, Opdivo®, pembrolizumab, Keytruda®, ipilimumab, Yervoy, Dacarbazine, DTIC-Dome, temozolomide, Temodar, paclitaxel, Taxol, paclitaxel plus carboplatin, Carbo/Taxol®, Albumin-Bound Paclitaxel, Abraxane®
Immatics US, Inc.
Melanoma, Cutaneous Malignant
01/28
10/31
CIRSARC, NCT03805022 / 2018-000186-36: Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas

Recruiting
3
351
Europe
Doxorubicin, Ifosfamide or dacarbazine, At the discretion of the investigator
Institut Bergonié, Novartis, Chugai Pharma France
Non-metastatic Soft-tissue Sarcoma, Resectable
02/25
02/25
EuroNet-PHL-C2, NCT02684708: Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents

Active, not recruiting
3
2200
Europe, RoW
cyclophosphamide, vincristine, prednisone, dacarbazine, CYC, VCR, PRED, DTIC, cyclo, vcr, pred, dacarb,etop and doxo, CYC, VCR, PRED, DTIC, ETO, DOXO
University of Giessen, Deutsche Krebshilfe e.V., Bonn (Germany), Euronet Worldwide
Classical Hodgkin Lymphoma
09/26
09/26
HR-NBL2, NCT04221035 / 2019-001068-31: High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

Recruiting
3
800
Europe, RoW
Vincristine, L01CA02, Carboplatin, LO1XA02, Etoposide, L01CB01, Vindesine, L01CA03, Dacarbazine, L01AX04, Ifosfamide, Doxorubicin, L01DB01, Busulfan, L01AB01, Melphalan, L01AA03, Thiotepa, L01AC01, Radiotherapy, Dinutuximab Beta, L01XC16, Cisplatin, L01XA01, Temozolomide 100 MG, Irinotecan, Cyclophosphamid
Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe
High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy
11/26
11/32
NCT06008106: Comparing Tunlametinib Capsules and Combination Chemotherapy in Advanced NRAS-mutant Melanoma

Recruiting
3
165
RoW
tunlametinib, paclitaxel +carboplatin, or temozolomide +cisplatin, or dacarbazine +cisplatin
Shanghai Kechow Pharma, Inc.
Melanoma
09/27
09/27
RADAR, NCT04685616: Brentuximab Vedotin in Early Stage Hodgkin Lymphoma

Recruiting
3
1042
Europe, Canada, US, RoW
Involved site radiotherapy, Doxorubicin, Bleomycin, Brentuximab vedotin, Vinblastine, Dacarbazine, Haematopoietic growth factor, Filgrastim, G-CSF, Pegfilgrastim
University College, London, Takeda, University of Miami, European Organisation for Research and Treatment of Cancer - EORTC, Australasian Leukaemia and Lymphoma Group, Seagen Inc., Canadian Cancer Trials Group
Hodgkin Lymphoma
09/30
09/32
AHOD2131, NCT05675410: A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Recruiting
3
1875
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bleomycin Sulfate, Blanoxan, BleMomycine, Blenoxane, Bleo-cell, Bleo-S, Bleocin, Bleolem, Bleomycin Sulfas, Bleomycin Sulphate, Bleomycini Sulfas, Blexane, Oil Bleo, Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN 35, SGN-35, SGN35, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Etoposide Phosphate, Etopophos, Fludeoxyglucose F-18, 18FDG, FDG, Fludeoxyglucose (18F), fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, Involved-site Radiation Therapy, ISRT, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, PT, Prednisolone, (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, .delta.1-Hydrocortisone, Adnisolone, Aprednislon, Capsoid, Cortalone, Cortisolone, Dacortin H, Decaprednil, Decortin H, Delta(1)Hydrocortisone, Delta- Cortef, Delta-Cortef, Delta-Diona, Delta-F, Delta-Phoricol, Delta1-dehydro-hydrocortisone, Deltacortril, Deltahydrocortisone, Deltasolone, Deltidrosol, Dhasolone, Di-Adreson-F, Dontisolon D, Estilsona, Fisopred, Frisolona, Gupisone, Hostacortin H, Hydeltra, Hydeltrasol, Klismacort, Kuhlprednon, Lenisolone, Lepi-Cortinolo, Linola-H N, Linola-H-Fett N, Longiprednil, Metacortandralone, Meti Derm, Meticortelone, Opredsone, Panafcortelone, Precortisyl, Pred-Clysma, Predeltilone, Predni-Coelin, Predni-Helvacort, Prednicortelone, Prednisolonum, Prelone, Prenilone, Sterane, Prednisone, .delta.1-Cortisone, 1, 2-Dehydrocortisone, Adasone, Cortancyl, Dacortin, DeCortin, Decortisyl, Decorton, Delta 1-Cortisone, Delta-Dome, Deltacortene, Deltacortisone, Deltadehydrocortisone, Deltasone, Deltison, Deltra, Econosone, Lisacort, Meprosona-F, Metacortandracin, Meticorten, Ofisolona, Orasone, Panafcort, Panasol-S, Paracort, Perrigo Prednisone, PRED, Predicor, Predicorten, Prednicen-M, Prednicort, Prednidib, Prednilonga, Predniment, Prednisone Intensol, Prednisonum, Prednitone, Promifen, Rayos, Servisone, SK-Prednisone, Procarbazine Hydrochloride, Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI), Ibenzmethyzine hydrochloride, Matulane, MIH hydrochloride, Natulan, Natulanar, Natunalar, NCI C01810, NCI-C01810, NCIC01810, p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride, p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI), PCB, PCB Hydrochloride, PCZ, Ro 4 6467/1, Ro 4-6467/1, Questionnaire Administration, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
National Cancer Institute (NCI)
Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
04/31
04/31
SUNRISELMS, NCT05269355 / 2022-000073-12: A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

Terminated
2/3
360
Europe, Canada, US, RoW
Unesbulin, PTC596, Dacarbazine, DTIC, Placebo
PTC Therapeutics, PTC Therapeutics, Inc.
Leiomyosarcoma
06/24
07/24
NCT06563245: Brentuximab Vedotin for Newly Diagnosed CHL in Chinese CAYA Based on PET/CT Assessment

Recruiting
2/3
96
RoW
Brentuximab Vedotin for Injection, response-adapted radiation, Doxorubicin, Etoposide, Prednisone, Cyclophosphamide, Dacarbazine, Tislelizumab Injection, Bedamustine
Children's Cancer Group, China, Shanghai Children's Medical Center, Najing Children's Hospital, West China Second University Hospital, Qilu Hospital of Shandong University, Tianjin Medical University Cancer Institute and Hospital, Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Xiangya Hospital of Central South University, The First Affiliated Hospital of Zhengzhou University, Second Affiliated Hospital of Anhui Medical University, Children's Hospital of Hebei Province, Children's Hospital of Henan Province, Sun Yat-Sen Memorial Hospital Zhongshan University
Classical Hodgkin Lymphoma, Child, Adolescent, Young Adult, Metabolic Response, Survival, Treatment, Brentuximab Vedotin, PET Scan
11/29
11/39
NCT06624644: A Trial of LNS8801 with or Without Pembrolizumab in Patients with Refractory Melanoma

Not yet recruiting
2/3
135
NA
LNS8801, Pembrolizumab, Chemotherapy (dacarbazine or temozolomide), Immunotherapy (Pembrolizumab), Immunotherapy (nivolumab and relatlimab), Immunotherapy (ipilimumab and nivolumab)
Linnaeus Therapeutics, Inc., Merck Sharp & Dohme LLC
Melanoma (Skin Cancer), Melanoma Stage IIIB-IV, Cutaneous Melanoma, Unresectable Melanoma
08/28
08/30
DAR-UM-2, NCT05987332: IDE196 (Darovasertib) in Combination with Crizotinib As First-line Therapy in Metastatic Uveal Melanoma

Recruiting
2/3
420
Europe, Canada, US, RoW
IDE196, Darovasertib, Crizotinib, XALKORI, Pembrolizumab, Keytruda, Ipilimumab, Yervoy, Nivolumab, Opdivo, Dacarbazine, DTIC-Dome
IDEAYA Biosciences
Metastatic Uveal Melanoma
01/27
01/28
ACTRN12612000137897: Dose-Dense ABVD Study: An accelerated delivery of Adriamycin, Bleomycin, Vinblastin and Dacarbazine for patients with Hodgkin Lymphoma

Not yet recruiting
2
31
 
Queensland Health, Hospira
Early Stage Unfavourable Hodgkin Lymphoma, Advanced Stage Hodgkin Lymphoma
 
 
ACTRN12608000639325: Multicentre clinical study with early treatment intensification in patients with high-risk Hodgkin Lymphoma, identified as 18-F Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) scan positive after two conventional Doxorubicin, Bleomycin, Vinblastine, Dacarbazine (ABVD) courses

Recruiting
2
450
 
Gruppo Italiano Terapie Innovative nei Linfomi (GITIL), Gruppo Italiano Terapia Innovativa nei Linfomi
Hodgkin Lymphoma
 
 
R-2, NCT05898451: Effect of Refnot on Immunity in Cancer Patients

Completed
2
55
NA
Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T), Refnot, Tumor necrosis factor-thymosin alfa 1 recombinant, Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T) and chemotherapy, and Dacarbazine, Lomustine, Cisplatin
Refnot-Pharm Ltd
Solid Tumor
11/11
11/11
2014-001303-52: Treatment of relapsed/refractory leukemia with intravenous administration of Dacarbazine Trattamento della leucemia acuta mieloide recidivata/refrattaria con somministrazione endovenosa di Dacarbazina

Ongoing
2
20
Europe
DACARBAZINA, Powder for solution for infusion, DACARBAZINA
Azienda Ospedaliero-Universitaria di Parma, medac pharma srl, Fondo dipartimento università degli studi di Parma
Relapsed/Refractory acute myeloid leukemia patients Pazienti affetti da leucemia acuta mieloide recidivata/refrattaria, Relapsed/Refractory acute myeloid leukemia patients Pazienti affetti da leucemia acuta mieloide recidivata/refrattaria, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2007-007265-20: A Phase II open label randomized parallel group non comparative trial to assess efficacy and safety of the association of IPH1101 and IL-2 alone and in combination with dacarbazine, in patients with metastatic melanoma

Ongoing
2
6
Europe
Phosphostim 200, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, IPH1101, DTIC, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, poudre pour solution injectable, PROLEUKIN 18 MUI, Dacarbazine Mayne 600 mg, poudre pour solution injectable
Innate Pharma
metastatic melanoma
 
 
2007-007168-94: PHASE II MULTICENTRE CLINICAL STUDY WITH EARLY TREATMENT INTENSIFICATION IN PTS WITH HIGH-RISK HODGKIN LYMPHOMA, IDENTIFIED AS FDG-PET SCAN POSITIVE AFTER TWO CONVENTIONAL ABVD COURSES

Ongoing
2
450
Europe
Dacarbazine, ADRIBLASTINA, BLEOMICINA CRIN, VINBLASTINA BAX, ADRIBLASTINA, BLEOMICINA CRIN, VINBLASTINA BAX
AZIENDA OSPEDALIERA \"S. CROCE E CARLE\"
HD ADVANCED DISEASE
 
 
2010-021885-31: Randomized Phase II Study Using a Non-myeloablative Lymphocyte Depleting Regimen of Chemotherapy Followed by Infusion of Tumor Infiltrating Lymphocytes and Interleukin-2 in Metastatic Melanoma’

Ongoing
2
45
Europe
Tumor Infiltrating Lymphocytes, TIL, dacarbazine, dacarbazine
NKI-AVL
Patients with metastatic (stage IV) melanoma will be randomized to either treatment arm A (dacarbazine) or treatment arm B (TIL) after metastasectomy and feasibility of culturing of TIL.
 
 
2012-001020-35: A clinical phase II trial to compare the efficacy of Bevacizumab monotherapy with standard chemotherapy (dacarbazine) in metastatic melanoma. En fase 2 studie for å sammenligne effekten av Bevacizumab monoterapi med standard kjemoterapi (dacarbazine) ved malignt melanom med metastaser.

Ongoing
2
120
Europe
Bevacizumab, Dacarbazine, Inderal, Renitec, 091652, Avastin (Bevacizumab), Dacarbazine, Inderal (Propranolol), Renitec (Enalapril), Avastin (Bevacizumab), Dacarbazine, Inderal (Propranolol), Renitec (Enalapril)
Helse Bergen HF, Haukeland University Hospital, The Norwegian Cancer Association
Previously treated or untreated histologically confirmed metastatic and unresectable melanoma with radiological (RECIST), clinical or biochemical progressive disease.
 
 
2007-006713-16: Phase II Randomized, Open-Label Study of IMC-1121B With or Without Dacarbazine in Patients with Metastatic Malignant Melanoma

Ongoing
2
10
Europe
IMC-1121B, Dacarbazine, IMC-1121B,
ImClone Systems Incorporated
Metastatic Malignant Melanoma
 
 
2017-001207-68: A study to investigate the efficacy of ramucirumab in combination with dacarbazine in patients with progressive well-differentiated metastatic neuroendocrine tumors of the pancreas Studie zur Untersuchung der Wirksamkeit von Ramucirumab in Kombination mit Dacarbazin bei Patienten mit neuroendokrinen, fortgeschrittenen Tumoren der Bauchspeicheldrüse, welche eventuell schon Absiedlungen (Metastasen) gebildet haben.

Ongoing
2
45
Europe
Concentrate for solution for infusion, Cyramza 10 mg/ml
Martin-Luther-Universität Halle-Wittenberg, Lilly Deutschland GmbH
Progressive well-differentiated metastatic pancreatic neuroendocrine tumors Progrediente, gut differenzierte metastasierte pankreatische neuroendokrine Tumore, Progressive well-differentiated metastatic neuroendocrine tumors of the pancreas Neuroendokriner Tumor der Bauchspeicheldrüse, welcher fortgeschritten ist und eventuell schon Absiedlungen (Metastasen) gebildet hat, Diseases [C] - Cancer [C04]
 
 
NU 16H08, NCT03226249: PET-Directed Therapy With Pembrolizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Classical Hodgkin Lymphoma

Active, not recruiting
2
30
US
Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, computerized tomography, CT, CT SCAN, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Fludeoxyglucose F-18, 18FDG, FDG, fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, Laboratory Biomarker Analysis, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE
Northwestern University, National Cancer Institute (NCI), Merck Sharp & Dohme LLC
Classical Hodgkin Lymphoma, Lymphocyte-Depleted Classical Hodgkin Lymphoma, Lymphocyte-Rich Classical Hodgkin Lymphoma, Mixed Cellularity Classical Hodgkin Lymphoma, Nodular Sclerosis Classical Hodgkin Lymphoma
05/19
10/24
ACCRU, NCT02758717: Nivolumab and Brentuximab Vedotin in Treating Older Patients With Untreated Hodgkin Lymphoma

Checkmark From trial in combination with Opdivo for hodgkin lymphoma at ASH 2019
Dec 2019 - Dec 2019: From trial in combination with Opdivo for hodgkin lymphoma at ASH 2019
Checkmark Presentation of data in combination with Opdivo for 1L Hodgkin lymphoma at ASH 2019
Dec 2019 - Dec 2019: Presentation of data in combination with Opdivo for 1L Hodgkin lymphoma at ASH 2019
Active, not recruiting
2
46
US
Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN-35, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo
Academic and Community Cancer Research United, National Cancer Institute (NCI)
Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage IIIA Hodgkin Lymphoma, Ann Arbor Stage IIIB Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma, Ann Arbor Stage IVA Hodgkin Lymphoma, Ann Arbor Stage IVB Hodgkin Lymphoma, Classic Hodgkin Lymphoma
08/19
09/24
2017-003556-23: Preconditioning of Tumor, Tumor Microenvironment and the Immune System to Immunotherapy (PROMIT) Präkonditionierung von Tumor, Tumormikromilieu und Immunsysten für Immuntherapie

Not yet recruiting
2
38
Europe
Opdivo, Yervoy, Pembrolizumab, Powder and solvent for solution for infusion, Concentrate for solution for infusion, Detimedac, Opdivo, Yervoy, Keytruda
University Hospital of the Friedrich-Alexander University Erlangen-Nürnberg, Deutsche Krebshilfe, University Hospital of the Friedrich-Alexander University Erlangen-Nürnberg
Melanoma, Skin cancer, Diseases [C] - Cancer [C04]
 
 
IMCgp100-202, NCT03070392 / 2015-003153-18: Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma

Active, not recruiting
2
378
Europe, Canada, US, RoW
IMCgp100, Dacarbazine, DTIC-Dome, DTIC, DIC, Imidazole Carboxamide, Ipilimumab, Yervoy, Pembrolizumab, Keytruda
Immunocore Ltd
Uveal Melanoma
10/20
07/25
NCT01920932: Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma

Active, not recruiting
2
77
US
brentuximab vedotin, SGN-35, Adcetris(R), etoposide, VP-16, Vepesid(R), prednisone, prednisolone, doxorubicin, Adriamycin(R), cyclophosphamide, Cytoxan(R), Dacarbazine(R), Dimethyl Triazeno Imidazole Carboximide (DTIC), filgrastim, Neupogen(R), quality of life assessment, radiation therapy, irradiation, radiotherapy, radiation
St. Jude Children's Research Hospital, Seagen Inc.
Stage II Childhood Hodgkin Lymphoma, Stage III Childhood Hodgkin Lymphoma, Stage IV Childhood Hodgkin Lymphoma
11/20
05/28
AMC-085, NCT02298257: A Pilot Trial of AVD and Brentuximab Vedotin (SGN-35) in the Treatment of Stage III-IV HIV-associated Hodgkin Lymphoma

Completed
2
9
Europe
brentuximab vedotin, adcetris, SGN-35, anti-CD30 ADC SGN-35, anti-CD30 antibody-drug conjugate SGN-35, antibody-drug conjugate SGN-35, Doxorubicin Hydrochloride, Vinblastine, Velban, Velsar, VLB, Dacarbazine
The Lymphoma Academic Research Organisation
HIV Infection, HIV-associated Hodgkin Lymphoma, Stage III Adult Hodgkin Lymphoma, Stage IV Adult Hodgkin Lymphoma
12/21
08/22
NCT02501551: Regorafenib, C-kit Mutated Malignant Melanoma, 2nd Line Therapy

Recruiting
2
36
RoW
regorafenib
Yonsei University
Melanoma
05/22
06/22
ACCRU-LY-1601, NCT03233347: Doxorubicin, Vinblastine, Dacarbazine, Brentuximab Vedotin, and Nivolumab in Treating Patients With Stage I-II Hodgkin Lymphoma

Active, not recruiting
2
82
US
Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN-35, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Laboratory Biomarker Analysis, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo, Vinblastine, Vincaleucoblastine, VLB
Academic and Community Cancer Research United, National Cancer Institute (NCI)
Ann Arbor Stage I Hodgkin Lymphoma, Ann Arbor Stage IA Hodgkin Lymphoma, Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Classic Hodgkin Lymphoma
07/22
07/25
NCT06201507: BV-AVD-R Treatment Children Hodgkin's Lymphoma

Enrolling by invitation
2
44
RoW
Brentuximab vedotin, Adcetris, Rituximab, Rituxan, Doxorubicin, Doxil, Adriamycin, Vincristine, Oncovin, Dacarbazine, DTIC
Beijing Children's Hospital
Hodgkin Lymphoma
12/24
12/25
SGN35-027, NCT03646123 / 2020-004027-17: Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma

Checkmark Part B and Part C data from SGN35-027 study in combination with Opdivo for classical Hodgkin Lymphoma at ASH 2022
Dec 2022 - Dec 2022: Part B and Part C data from SGN35-027 study in combination with Opdivo for classical Hodgkin Lymphoma at ASH 2022
Terminated
2
255
Europe, US, RoW
brentuximab vedotin, Adcetris, SGN-35, doxorubicin, vinblastine, dacarbazine, G-CSF, filgrastim, pegfilgrastim, nivolumab, Opdivo
Seagen Inc., Bristol-Myers Squibb
Hodgkin Lymphoma
11/22
08/24
NCT04200040: A Clinical Study to Evaluate the Safety and Efficacy of OrienX010 in Unresectable Malignant Melanoma Patients

Recruiting
2
165
RoW
OrienX010 injection, Recombinant Human GM-CSF Herpes Simplex Virus Injection, Dacarbazine (DTIC)
OrienGene Biotechnology Ltd.
Melanoma (Skin)
12/22
12/22
SGN35-015, NCT01716806 / 2019-003982-17: A Study of Brentuximab Vedotin With Hodgkin Lymphoma (HL) and CD30-expressing Peripheral T-cell Lymphoma (PTCL)

Checkmark Additional data for front-line Hodgkin's lymphoma in elderly patients (ASH 2014)
Nov 2014 - Nov 2014: Additional data for front-line Hodgkin's lymphoma in elderly patients (ASH 2014)
Checkmark For newly diagnosed Hodgkin's lymphoma in elderly patients
Dec 2013 - Dec 2013: For newly diagnosed Hodgkin's lymphoma in elderly patients
Checkmark Elderly chemo-intolerant Hodgkin's lymphoma patients
More
Completed
2
131
Canada, US
brentuximab vedotin, Adcetris; SGN-35, bendamustine, dacarbazine, nivolumab
Seagen Inc., Bristol-Myers Squibb
Hodgkin Disease, Peripheral T Cell Lymphoma
04/23
09/23
NCT04843267: A Multi-center, Non-randomized, Open-label Phase II Clinical Study on the Treatment of Newly Diagnosed Advanced Hodgkin's Lymphoma With PD-1 Antibody (Tislelizumab) Combined With AVD Regimen (Doxorubicin, Vindesine, Dacarbazine) Under the Guidance of PET/CT

Recruiting
2
30
RoW
Tislelizumab
Sun Yat-sen University
Hodgkin Lymphoma, Chemotherapy Effect
05/23
05/25
PROMIT, NCT04225390: Preconditioning of Tumor, Tumor Microenvironment and the Immune System to Immunotherapy

Recruiting
2
38
Europe
Dacarbazine (DTIC), DTIC
University of Erlangen-Nürnberg Medical School, University Hospital Regensburg, Wuerzburg University Hospital
Immunotherapy
06/23
07/23
COBRA, NCT03517137 / 2017-000498-35: Very Early PET-response Adapted Targeted Therapy for Advanced Hodgkin Lymphoma: a Single -Arm Phase II Study

Active, not recruiting
2
150
Europe
Brentuximab Vedotin, Adriamycin, Vinblastine, Dacarbazine, Etoposide, Cyclophosphamide, Radiation Therapy
European Organisation for Research and Treatment of Cancer - EORTC
Advanced Hodgkin Lymphoma
08/23
11/26
KEYNOTE-C11, NCT05008224 / 2021-001244-95: Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/)

Checkmark Presentation of data from KEYNOTE-C11 trial for 1L Classic Hodgkin Lymphoma at ASH 2022
Nov 2022 - Nov 2022: Presentation of data from KEYNOTE-C11 trial for 1L Classic Hodgkin Lymphoma at ASH 2022
Completed
2
146
Europe, Canada, US, RoW
Pembrolizumab, MK-3475, SCH 900475, KEYTRUDA®, Doxorubicin, Adriamycin, DOXIL®, Rubex®, Vinblastine, Alkaban-AQ®, Velban®, Dacarbazine, Dtic-Dome®, Bleomycin, Blenoxane®, Etoposide, Toposar®, VePesid®, Etopophos®, VP-16, Etoposide phosphate, Cyclophosphamide, Neosar®, Cytoxan®, Vincristine, Oncovin®, Vincasar PFS®, Procarbazine, Matulane®, Prednisone, Liquid Pred®, Meticorten®, Orasone®, Deltasone®
Merck Sharp & Dohme LLC, Merck Sharp & Dohme Corp., a subsidiary of Merck & Co.,Inc
Classical Hodgkin Lymphoma
10/23
05/24
NIVAHL, NCT03004833 / 2016-002626-37: Nivolumab and AVD in Early-stage Unfavorable Classical Hodgkin Lymphoma

Completed
2
110
Europe
Nivolumab, Adriamycin, Vinblastine, Dacarbazine
University of Cologne
Classical Hodgkin Lymphoma
08/22
08/22
NCT04067037: Camrelizumab Combined With AVD in the First-line Treatment for Patients With Advanced Classical Hodgkin's Lymphoma

Recruiting
2
60
RoW
Camrelizumab, SHR-1210, Epirubicin, Epirubicin hydrochloride, Vincristine, Oncovin, Dacarbazine
Henan Cancer Hospital
Classical Hodgkin Lymphoma
12/25
12/26
FLASH, NCT04733183 / 2018-004104-19: Efficacy and Safety of L19TNF in Previously Treated Patients with Advanced Stage or Metastatic Soft-tissue Sarcoma

Active, not recruiting
2
98
Europe
Dacarbazine, DTIC, onfekafusp alfa, L19TNF
Philogen S.p.A., Philogen S.p.A.,
Soft Tissue Sarcoma
12/25
12/25
NCT04727242: CytoreductiveSurgery & HIPEC W/Gemcitabine+Chemotherapy W/Dacarbazine in Uterine Leiomyosarcoma

Recruiting
2
25
US
Gemcitabine, Gemzar, Infugem, difluorodeoxycytidine hydrochloride, Dacarbazine, Dimethyl (triazeno) imidazolecarboxamide, Dacarbazine - DTIC, Biocarbazine, Cytoreductive Surgery, Functional Assessment of Cancer Therapy (FACT) G questionnaire, Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) Scan, Gadolinium
Kristen Ganjoo
LMS - Leiomyosarcoma, Uterine Leiomyosarcoma
12/25
12/25
NCT03712202: Brentuximab Vedotin and Nivolumab in Treating Patients With Early Stage Classic Hodgkin Lymphoma

Active, not recruiting
2
155
US
Bleomycin, BLEO, BLM, Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN-35, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo, Quality-of-Life Assessment, Quality of Life Assessment, Vinblastine, Vincaleucoblastine, VLB
City of Hope Medical Center, National Cancer Institute (NCI)
Ann Arbor Stage I Hodgkin Lymphoma, Ann Arbor Stage I Mixed Cellularity Classic Hodgkin Lymphoma, Ann Arbor Stage I Nodular Sclerosis Classic Hodgkin Lymphoma, Ann Arbor Stage IA Hodgkin Lymphoma, Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Classic Hodgkin Lymphoma, Lymphocyte-Rich Classic Hodgkin Lymphoma, Ann Arbor Stage I Lymphocyte-Depleted Classic HL, Ann Arbor Stage II Lymphocyte-Depleted Classic HL, Ann Arbor Stage II Mixed Cellularity Classic HL, Ann Arbor Stage II Nodular Sclerosis Classic HL
12/24
12/24
STRADA, NCT03023124 / 2016-004051-78: Study With Trabectedin Versus Adriamycin Plus Dacarbazine, in Patients With Advanced Solitary Fibrous Tumor

Completed
2
23
Europe
Trabectedin, Adriamycin, Dacarbazine
Italian Sarcoma Group
Solitary Fibrous Tumors
12/24
12/24
NCT06164275: Pembrolizumab Followed by Chemotherapy for the Treatment of Patients With Classical Hodgkin Lymphoma

Recruiting
2
30
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, CT, CT Scan, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, MUGA, Radionuclide Ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Pembrolizumab, BCD-201, Keytruda, Lambrolizumab, MK-3475, Pembrolizumab Biosimilar BCD-201, SCH 900475, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Vinblastine, Vincaleucoblastine, VLB
Northwestern University, National Cancer Institute (NCI)
Classic Hodgkin Lymphoma
12/29
12/31
NCT06377566: A Study of BV-AVD in People With Bulky Hodgkin Lymphoma

Recruiting
2
71
US
Brentuximab vedotin, Doxorubicin, Vinblastine, Dacarbazine, Pembrolizumab, Gemcitabine, Vinorelbine, FDG-PET/CT scan
Memorial Sloan Kettering Cancer Center, Seagen Inc.
Hodgkin Lymphoma
04/27
04/27
NCT05466474: PD-1 Antibody Tislelizumab Combined With Dacarbazine in the Treatment of Advanced Melanoma

Recruiting
2
40
RoW
Tislelizumab Injection, Dacarbazine
Henan Cancer Hospital
Advanced Melanoma
04/24
04/24
TAGGED, NCT04535271: Metronomic Trabectedin, Gemcitabine, and Dacarbazine for Soft Tissue Sarcoma

Recruiting
2
80
US
Trabectedin, Gemcitabine, Dacarbazine
Sarcoma Oncology Research Center, LLC
Leiomyosarcoma
09/28
03/29
MIZAR-003, NCT06703398: A Multicenter, Randomized, Controlled,Open Label, Phase II Trial of Autologous Tumor Infiltrating Lymphocytes (GC101 TIL) in Subjects With Advanced Melanoma

Recruiting
2
98
RoW
GC101 TIL, dacarbazine, temozolomide, paclitaxel ,platinum or cisplatin
Shanghai Juncell Therapeutics
Melanoma
07/26
12/26
NCT06745076: Personalized Reduction of Chemotherapy Intensity Through ctDNA Evaluation for the Treatment of Patients With Advanced Hodgkin Lymphoma

Recruiting
2
125
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNV Scan, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Vinblastine, Vincaleucoblastine, VLB, Questionnaire
University of Washington
Advanced Hodgkin Lymphoma, Classic Hodgkin Lymphoma, Lugano Classification Stage III Hodgkin Lymphoma AJCC v8, Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8
01/32
01/33
TNT-HYPE, NCT06835049: Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma

Not yet recruiting
2
24
Europe
Doxorubicin, Ifosfamide, Dacarbazine, Hyperthermia, Radiotherapy, Surgery
Swiss Group for Clinical Cancer Research
Sarcoma,Soft Tissue
03/28
03/31
NCT05900765: A Study of Zimberelimab(GLS-010) Combined With AVD for Newly Diagnosed Early-stage Hodgkin's Lymphoma

Recruiting
2
54
RoW
Zimberelimab 240mg, GLS-010
Sun Yat-sen University, Guangzhou Gloria Biosciences Co., Ltd.
Classical Hodgkin Lymphoma
06/25
06/26
DTIC, NCT00553618: Adjuvant, Combined Interleukin 2 (Proleukin) and (Dacarbazine) in High-risk Melanoma Patients

Active, not recruiting
2
160
US
Proleukin and Dacarbazine, Proleukin, Dacarbazine
University of Louisville, James Graham Brown Cancer Center
Metastatic Melanoma
08/25
08/26
NCT05922904: PET Adapted Brentuximab Vedotin and Pembrolizumab in Combination With Doxorubicin and Dacarbazine in Classic Hodgkin Lymphoma

Recruiting
2
50
US
Brentuximab vedotin, Doxorubicin Hydrochloride, Adriamycin PFS®, Adriamycin RDF™, Adriamycin®, Rubex®, Pembrolizumab, SGN-35, Adcetris, Dacarbazine, DTIC-Dome®
M.D. Anderson Cancer Center, Merck Sharp & Dohme LLC, Seagen Inc.
Hodgkin Lymphoma
10/25
10/27
ChiCTR2400083074: Bevacizumab combined with toripalimab and dacarbazine in the treatment of advanced melanoma: Prospective, open-label, single-arm, single-center clinical trial

Recruiting
2
30
 
Bevacizumab combined with toripalimab and dacarbazine
Shandong First Medical University Affiliated Cancer Hospital; Shandong First Medical University Affiliated Cancer Hospital, Part of self-raised, part of Qilu Pharmaceutical Co., Ltd.
melanoma
 
 
NCT03755804: Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

Recruiting
2
250
US
bendamustine, TREANDA (R), Etoposide, VP-16, Vepeside, Doxorubicin, Adriamycin (R), Bleomycin, Blenoxane (R), Vincristine, Oncovin (R), Vinblastine, Velban (R), Prednisone, Prednisolone, Filgrastim, Neupogen (R), Brentuximab Vedotin, Adcetris, Cyclophosphamide, Cytoxan (R), DTIC, DACARBAZINE (R), Dimethyl Triazeno Imidazole Carboximide, Quality of Life Measurements, Quality of Life Measurements (QOL), Radiotherapy, radiation therapy, irradiation
St. Jude Children's Research Hospital, Teva Pharmaceuticals USA, Seagen Inc.
Hodgkin Lymphoma
01/27
07/28
KEYNOTE-667, NCT03407144 / 2017-001123-53: Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/)

Active, not recruiting
2
340
Europe, US, RoW
pembrolizumab, MK-3475, doxorubicin, vinblastine, dacarbazine, cyclophosphamide, vincristine, prednisone/prednisolone, bleomycin, etoposide, Etoposide Phosphate, Radiotherapy (RT)
Merck Sharp & Dohme LLC
Hodgkin Lymphoma
02/27
02/27
NCT05404945: Fitness-adapted, Pembrolizumab-based Therapy for Untreated Classical Hodgkin Lymphoma Patients 60 Years of Age and Above

Recruiting
2
44
US
Pembrolizumab, Doxorubicin, Adriamycin, Vinblastine, Dacarbazine, Brentuximab vedotin
University of Virginia, Merck Sharp & Dohme LLC
Classical Hodgkin Lymphoma
10/27
10/27
2005-001161-34: Phase I-II multicenter, randomized, open-label, clinical and pharmacokinetic study of plitidepsin, administered alone or in combination with dacarbazine, as front-line therapy to subjects with unresectable advanced melanoma

Ongoing
1/2
30
Europe
plitidepsin (Aplidin), DTIC-DOME, APL, DTIC-DOME, DTIC-DOME
Pharma Mar SA, Pharma Mar SA, sociedad unipersonal
unresectable advanced melanoma
 
 
NCT02076646: A Phase I/II Dose Escalation Study of the Tumor-targeting Human L19-IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Dacarbazine for Patients With Metastatic Melanoma

Active, not recruiting
1/2
96
Europe
L19IL2 - Ph I, L19IL2 at RD - Ph II, DTIC, DETICENE®
Philogen S.p.A.
Metastatic Melanoma Stage IV
05/16
06/22
C25004, NCT02979522 / 2015-004112-38: A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma

Hourglass Apr 2022 - Mar 2023 : Regulatory approval in Japan for pediatric front-line Hodgkin lymphoma
Active, not recruiting
1/2
59
Europe, Japan, US, RoW
Brentuximab vedotin, Adcetris, Doxorubicin, Adriamycin, Vinblastine, Dacarbazine
Takeda
Hodgkin Disease
05/20
09/29
NCT01771107: Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With Stage II-IV HIV-Associated Hodgkin Lymphoma

Active, not recruiting
1/2
41
Europe, US
Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN 35, SGN-35, SGN35, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Pharmacological Study, Vinblastine, Vincaleucoblastine, VLB
National Cancer Institute (NCI), The Lymphoma Academic Research Organisation
AIDS-Related Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage IIIA Hodgkin Lymphoma, Ann Arbor Stage IIIB Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma, Ann Arbor Stage IVA Hodgkin Lymphoma, Ann Arbor Stage IVB Hodgkin Lymphoma, Classic Hodgkin Lymphoma, HIV Infection
10/21
02/25
NCI-2017-01718, NCT03331341: Doxorubicin Hydrochloride, Pembrolizumab, Vinblastine, and Dacarbazine in Treating Patients With Classical Hodgkin Lymphoma

Active, not recruiting
1/2
50
US
Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Laboratory Biomarker Analysis, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Vinblastine, Vincaleucoblastine, VLB
University of Washington
Classical Hodgkin Lymphoma
12/23
07/29
ImmunoSarc, NCT03277924 / 2016-004040-10: Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas

Completed
1/2
197
Europe
Sunitinib 37.5 MG, Sunitinib 25 MG [Sutent], Sutent, Nivolumab 100 MG/10 ML [Opdivo], Opdivo, Epirubicin, Ifosfamide, Doxorubicin, Dacarbazine, Cisplatin, Methotrexate
Grupo Espanol de Investigacion en Sarcomas
Soft Tissue Sarcoma, Bone Sarcoma
06/24
06/24
NCT02994498: Safety and Efficacy of DCB-BO1301 in Advanced Melanoma

Not yet recruiting
1/2
33
NA
DCB-BO1301
Chung Mei Biopharma Co., Ltd
Advanced Melanoma
09/25
12/25
CA209-447, NCT03033914: A(B)VD Followed by Nivolumab as Frontline Therapy for Higher Risk Patients With Classical Hodgkin Lymphoma (HL)

Active, not recruiting
1/2
82
Canada, US
doxorubicin, Bleomycin, vinblastine, dacarbazine, Nivolumab
Memorial Sloan Kettering Cancer Center, Bristol-Myers Squibb, Barbara Ann Karmanos Cancer Institute, British Columbia Cancer Agency
Hodgkin Lymphoma
01/26
01/26
ChiCTR-TRC-08000115: Multicenter, double-blinding, randomized controlled, phase II clinical trial on combined chemotherapy of Endostar (Recombinant Human Endostatin) for untreated patients with advanced melanoma

Completed
1
140
 
Endostar combined with dacarbazine (add a drug that inhibits neovascularization to chemotherapy) ;Dacarbazine combined with placebo
Expert Committee for Melanoma of CSCO; Melanoma Experts Committee of Chinese Society of Clinical Oncology, Self-financing
Advanced melanoma
 
 
NCT00600496: A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

Checkmark P1 data
Mar 2012 - Mar 2012: P1 data
Active, not recruiting
1
140
US
AZD6244, ARRY-142886, Dacarbazine, Erlotinib, Docetaxel, Taxotere®, Temsirolimus
AstraZeneca
Breast Cancer, Breast Neoplasms, Colon Cancer, Colonic Cancer, Colon Neoplasms, Lung Cancer, Melanoma, Kidney Cancer
08/10
12/24
PTC596-ONC-007-LMS, NCT03761095: A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

Completed
1
41
US
Unesbulin, PTC596, Dacarbazine, DTIC
PTC Therapeutics
Leiomyosarcoma
02/24
02/24
FED_RealBV, NCT06857500: Brentuximab Vedotin with Adriamycin, Vinblastine and Dacarbazine for Patients Aged 18-59 Years with Untreated Advanced-stage Classical Hodgkin Lymphoma: a Real-life Experience

Completed
N/A
200
Europe
Federico II University
Classic Hodgkin Lymphoma, Advanced Hodgkin Lymphoma
01/25
01/25
NCT04893356: Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT)

Active, not recruiting
N/A
75
Europe
O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine treated sarcoma patients
National Cancer Institute, Naples
Sarcoma
02/22
01/25
EuroNet-PHL-C2, NCT02797717: Treatment for Classical Hodgkin Lymphoma in Children and Adolescents

Recruiting
N/A
2200
RoW
Radiotherapy:, Vincristine, Etoposide, Prednisone, Doxorubicin, Dacarbazine, Cyclophosphamide
GALIA AVRAHAMI, University of Giessen
Classical Hodgkins Lymphoma in Children and Adolescents.
12/22
12/27
ChiCTR2400084334: A study of liposomal doxorubicin + dacarbazine in combination with teripulimab in the treatment of unresectable or metastatic cardiac sarcoma

Recruiting
N/A
30
 
PLD+DTIC+Toripalimab
Beijing Cancer Hospital (Peking University Cancer Hospital); Beijing Cancer Hospital (Peking University Cancer Hospital), self-funded
primary cardiac sarcoma
 
 
NCT01868451: Brentuximab Vedotin Combined With AVD Chemotherapy in Patients With Newly Diagnosed Early Stage, Unfavorable Risk Hodgkin Lymphoma

Active, not recruiting
N/A
118
US
Brentuximab vedotin (SGN-35), Doxorubicin HCL, Vinblastine Sulfate, Dacarbazine, Involved-Site Radiation Therapy (ISRT), Interim PET, consolidation volume RT (CVRT)
Memorial Sloan Kettering Cancer Center, Seagen Inc., University of Rochester, City of Hope Medical Center, Stanford University
Hodgkin Lymphoma
05/26
05/26
ACTRN12607000107426: Trial of PI-88 with Dacarbazine in patients Metastatic Melanoma

Active, not recruiting
N/A
114
 
Progen Pharmaceuticals Ltd, Progen Pharmaceuticals Ltd
Metastatic melanoma
 
 

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