nitazoxanide / Generic mfg. 
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  • ||||||||||  nitazoxanide / Generic mfg.
    Journal:  Oxfendazole Nitazoxanide combination in experimental neurocysticercosis - anti-inflammatory and cysticidal effects. (Pubmed Central) -  Apr 28, 2024   
    In contrast, the combination treatment showed a lower observation of PMN and MN inflammatory infiltration in comparison to the other treatments and to the control one. These results show that indeed the association of benzimidazole derivatives which present both anti-helminthic and anti-inflammatory properties with other cysticidal drugs are beneficial for the NCC treatment in which the aim is to destroy parasite without inducing inflammatory damage in the brain tissue.
  • ||||||||||  nitazoxanide / Generic mfg.
    Preclinical, Journal:  In silico and in vivo evaluation of the anti-cryptosporidial activity of eugenol. (Pubmed Central) -  Mar 22, 2024   
    The in silico bioinformatics analysis was used to predict and determine the binding affinities and intermolecular interactions of EUG and Nitazoxanide (NTZ) toward several Cryptosporidium parvum (C...Moreover, mice received EUG showed marked reduction of the expression of iNOS in ileal tissues. Based on the results, the present study signified a basis for utilizing EUG as an affordable, safe, and alternative therapy combined with NTZ in the management of cryptosporidiosis.
  • ||||||||||  nitazoxanide / Generic mfg.
    Journal:  Anthelmintic efficacy of nitazoxanide in dogs naturally infected with Toxocara canis. (Pubmed Central) -  Mar 20, 2024   
    Based on faecal egg counts, the number of T. canis eggs decreased by 100.00%, and the percentage of dogs cleared with residual worms achieved 90.00% after 7 days of treatment in the 150-mg/kg NTZ treatment group. In general, NTZ showed great potential to be applied as an anthelmintic against T. canis.
  • ||||||||||  nitazoxanide / Generic mfg.
    Optimization of phosphoinositol-4-kinase (PI4K) inhibitors for cryptosporidiosis | Poster Board #832 (In-person; Poster Board #832; Hall C (Ernest N. Morial Convention Center)) -  Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_12647;    
    Unfortunately, at present, only the antiparasitic drug nitazoxanide is approved to treat these infections, despite only having a wide range of efficacy between 56-80% in immune-competent patients...Preliminary structure-activity relationship (SAR) studies have shown that naphthyridine and pyridopyrimidine cores and an 8-position morpholine group give better potency. Synthesis and anti- Cryptosporidium SAR of this series of naphthyridines and pyridopyrimidines will be discussed.
  • ||||||||||  ivermectin oral / Generic mfg.
    DRUGS USED FOR COVID-19, IMPLICATIONS TO THE RENAL FUNCTION, AND PROSPECTS (TUE-092; Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_984;    
    Medicines used without proof may have had negative consequences for the population, not just by the nephrologic diseases, but to the other areas of health, including the drop in supply. Furthermore, research has evolved to reduce mortality rates through the most diverse pharmacological routes, however, the only safe way to combat the disease still remains prevention.
  • ||||||||||  Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
    Journal:  Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids. (Pubmed Central) -  Mar 4, 2024   
    Moreover, molnupiravir and NHC block HRV viroplasm formation, but do not alter its size or subcellular localization. Taken together, molnupiravir inhibits both HuNoV and HRV replication, suggesting that the drug could be a candidate for the treatment of patients chronically infected with either one of these diarrhea causing viruses.
  • ||||||||||  nitazoxanide / Generic mfg.
    Journal:  Transcriptional Differential Analysis of Nitazoxanide-Mediated Anticanine Parvovirus Effect in F81 Cells. (Pubmed Central) -  Feb 28, 2024   
    Moreover, when the cell cycle was regulated with cell cycle checkpoint kinase 1 (Chk1) inhibitor MK-8776 or Prexasertib HCl, both inhibitors inhibited the CPV. In summary, the transcriptome differential analysis results presented in this paper lay the foundation for further research on the molecular mechanism and potential targets of NTZ anti-CPV.
  • ||||||||||  nitazoxanide / Generic mfg.
    Hemorrhagic Pulmonary Cryptosporidiosis in an Immunocompetent Adult: A Rare Case Entity (Marriott Marquis San Diego Marina, Pacific Ballroom 15-17 (Ground Floor, North Tower)) -  Feb 20, 2024 - Abstract #ATS2024ATS_8166;    
    This case demonstrates that even in an immunocompetent host, cryptosporidiosis can occur, and with a large enough inoculum, may even lead to pulmonary cryptosporidiosis even in such an unlikely host. It also demonstrated that nitazoxanide in an immunocompetent host can lead to quick resolution.
  • ||||||||||  nitazoxanide / Generic mfg.
    Review, Journal:  Use of nanoparticles, a modern means of drug delivery, against cryptosporidiosis. (Pubmed Central) -  Feb 19, 2024   
    Nitazoxanide (NTZ), which is an anti-protozoan and anti-viral drug, can be used to control helminths, viruses, and protozoan parasites as a broad-spectrum antibiotic and has been approved by the food and drug authority (FDA)...Implementing tiny particles for the purification of consuming water from Cryptosporidium is an economical and environmentally sustainable process. However, the use of nanoparticles in medicine requires more research.
  • ||||||||||  nitazoxanide / Generic mfg.
    Review, Journal:  Anti-Cryptosporidial Drug-Discovery Challenges and Existing Therapeutic Avenues: A "One-Health" Concern. (Pubmed Central) -  Jan 23, 2024   
    Nitazoxanide is the only FDA-approved drug, effective only in immunocompetent adults, and is not safe for infants...The current review is organized to address the treatment and prevention of cryptosporidiosis. An anti-cryptosporidial drug that is effective in immunocompromised individuals and infants is a necessity of our time.
  • ||||||||||  fluoxetine / Generic mfg., nitazoxanide / Generic mfg.
    Journal:  Combined Treatment of Progressive Encephalitis in an X-linked Agammaglobulinemia Patient. (Pubmed Central) -  Dec 12, 2023   
    In most of the cases the evolution of the progressive encephalitis is complicated and catastrophic. Based on our experience and the review of the literature, we propose the use of this combined treatment to control this devastating complication.
  • ||||||||||  nitazoxanide / Generic mfg.
    Journal:  The African Kelleni's roadmap using nitazoxanide and broad-spectrum antimicrobials to abort returning to COVID-19 square one. (Pubmed Central) -  Dec 4, 2023   
    Kelleni's protocol, including nitazoxanide as an integral component, is continuing to perfectly save lives of patients infected with many viruses, including SARS CoV-2 and the author stresses that respiratory RNA viruses are best managed with early pharmacological treatment. Broad-spectrum antimicrobials as nitazoxanide and azithromycin together with other therapeutics as non-steroidal anti-inflammatory drugs and the antihistaminic loratadine should be considered first to personalize the clinical management of COVID-19 and selected other alarming viral infections.
  • ||||||||||  Journal:  Common Intestinal Parasites. (Pubmed Central) -  Nov 24, 2023   
    Trichinella infection is diagnosed by serum antibody testing, and severe symptoms are treated with albendazole in patients older than one year. Pinworm infections are diagnosed visually or by a tape test or paddle test; albendazole and pyrantel pamoate are both effective treatments.
  • ||||||||||  Enrollment closed:  AGILE (Early Phase Platform Trial for COVID-19) (clinicaltrials.gov) -  Nov 18, 2023   
    P1/2,  N=600, Active, not recruiting, 
    Pinworm infections are diagnosed visually or by a tape test or paddle test; albendazole and pyrantel pamoate are both effective treatments. Recruiting --> Active, not recruiting
  • ||||||||||  nitazoxanide / Generic mfg.
    Journal:  Newly fabricated zinc oxide nanoparticles loaded materials for therapeutic nano delivery in experimental cryptosporidiosis. (Pubmed Central) -  Nov 15, 2023   
    This study targets to fabricate and investigate the efficiency of zinc oxide nanoparticles (ZnO-NPs), nitazoxanide (NTZ)-loaded ZnO-NPs, and Allium sativum (A...In conclusion, this study is the first to report ZnO-NPs as an effective therapy for treating cryptosporidiosis, especially when combined with other treatments that enhance their antioxidant activity. It provides an economical and environment-friendly approach to novel delivery synthesis for antiparasitic applications.
  • ||||||||||  albendazole / Generic mfg., nitazoxanide / Generic mfg.
    Co-infection with Cryptosporidium meleagridis and Enterocytozoon bieneusi in an HIV+ Colombian patient (ePosters) -  Oct 8, 2023 - Abstract #EACS2023EACS_1484;    
    and other microsporidian species. Our results have demonstrated that molecular-based testing improves the detection of opportunistic pathogens that are difficult to detect by routine microscopy, allows for transmission dynamics investigations, and assists in choosing the best chemotherapeutical option.
  • ||||||||||  albendazole / Generic mfg., nitazoxanide / Generic mfg.
    Co-infection with Cryptosporidium meleagridis and Enterocytozoon bieneusi in an HIV+ Colombian patient (ePosters) -  Oct 8, 2023 - Abstract #EACS2023EACS_1483;    
    and other microsporidian species. Our results have demonstrated that molecular-based testing improves the detection of opportunistic pathogens that are difficult to detect by routine microscopy, allows for transmission dynamics investigations, and assists in choosing the best chemotherapeutical option.
  • ||||||||||  nitazoxanide / Generic mfg., favipiravir / Generic mfg.
    Journal:  Norovirus Infection in Children with Acute Lymphoblastic Leukemia. (Pubmed Central) -  Oct 5, 2023   
    Two of those children didn't respond to nitazoxanide and succumbed to the illness. The third patient who received nitazoxanide and favipiravir, is currently well on chemotherapy.
  • ||||||||||  atazanavir/ritonavir / Generic mfg., nitazoxanide / Generic mfg.
    Trial completion:  Pharmacokinetic Interaction Between Nitazoxanide and Atazanavir/Ritonavir in Healthy Volunteers (clinicaltrials.gov) -  Sep 13, 2023   
    P=N/A,  N=17, Completed, 
    Altogether the results indicate that nitazoxanide, due to its broad-spectrum anti-coronavirus activity, may represent a readily available useful tool in the treatment of seasonal coronavirus infections. Active, not recruiting --> Completed
  • ||||||||||  nitazoxanide / Generic mfg.
    Journal:  Tizoxanide as a novel theraputic candidate for osteoarthritis. (Pubmed Central) -  Sep 7, 2023   
    In vivo, intra-articular injection of Tiz could significantly alleviate the progression of cartilage damage in rat OA model. Briefly, our study demonstrated the therapeutic potential of Tiz in OA, suggesting that Tiz administration might serve as a promising strategy in OA therapy.