| carbidopa/levodopa / Generic mfg. |
| Ongoing | 4 | 200 | Europe | Sinemet, RVG 08740, Tablet, Sinemet | | There are no medical conditions or diseases under investigation., not applicable, Not possible to specify | | | | |
2008-006278-13: Motor function optimization in advanced Parkinson’s disease patients, combined with galantamine to prevent visual hallucinations. |
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| Ongoing | 4 | 10 | Europe | Reminyl Retard, Sinemet 125 mg, Reminyl Retard, Sinemet 125 mg | UMCG | patients with advanced (>5 years) Parkinson\'s disease and visual hallucinations. | | | | |
2010-019897-33: Brain activation by addition of L-Dopa to normal antipsychotic treatment in patients with schizophrenia |
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| Ongoing | 4 | 50 | Europe | Sinemet, Sinemet, Sinemet | erasmus mc, Erasmus MC | patients with psychotic symptoms, diagnosed with schizophrenia | | | | |
2013-004229-10: Placebo effect in Parkinson\'s disease El efecto placebo en la enfermedad de Parkinson |
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| Ongoing | 4 | 60 | Europe | Sinemet 25/250, Sinemet 25/250 | Raul de la Fuente-Fernandez, Complejo Hospitalario Universitario de Ferrol (CHUF) | Parkinson\'s disease Enfermedad de Parkinson | | | | |
ChiCTR2000039201: Pharmacology of levodopa/carbidopa versus levodopa/benserazide in patients with parkinson's disease |
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| Recruiting | 4 | 20 | | phase I: levodopa/carbidopa; phase II: levodopa/benserazide ;phase I: levodopa/benserazide; phase II: levodopa/carbidopa | The Affiliated Brain Hospital of Nanjing Medical University (Nanjing Brain Hospital); Brain Hospital of Nanjing Medical University, self-raised | Parkinson's disease | | | | |
2020-002754-24: Clinical study in early PD patients to investigate the effect of Opicapone 50mg or Levodopa 100 mg in the treatment of motor fluctuations. Estudio clínico en pacientes con EP temprana para investigar el efecto de Opicapone 50 mg o Levodopa 100 mg en el tratamiento de las fluctuaciones motoras. |
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| Ongoing | 4 | 100 | Europe | Capsule, hard, Tablet, Ongentys 50 mg hard capsules, Madopar 125 mg T, tablets, SINEMET 100 mg + 25 mg tablets | Bial - Portela & Ca, S.A., Bial - Portela & Ca, S.A. | Parkinson's Disease (PD) Enfermedad de Parkinson (EP), Parkinson's Disease (PD) Enfermedad de Parkinson (EP), Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT04742348: Research on Translational Outcomes of Alcohol (Project RETRO) |
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| Withdrawn | 4 | 42 | NA | Carbidopa Levodopa, Placebo | University of Washington | Alcohol Drinking | 08/23 | 08/23 | | |
| Completed | 4 | 20 | US | Carbidopa Levodopa, Sinemet, L-DOPA, Placebo, Placebo tablet | Emory University, National Institute of Mental Health (NIMH) | Depression, Anhedonia | 10/23 | 10/23 | | |
| Recruiting | 4 | 70 | US | Carbidopa Levodopa, Sinemet, L-DOPA, Placebo, Placebo tablet | Emory University, National Institute of Mental Health (NIMH) | Anhedonia, Depression | 01/27 | 01/27 | | |
| Recruiting | 4 | 30 | US | Neurostimulation, Carbidopa 25/Levodopa 100Mg Tab | David Escobar, The Cleveland Clinic | Parkinson Disease | 06/28 | 06/28 | | |
| Recruiting | 3 | 610 | Europe | IMP Levodopa 100mg/Carbidopa 25mg, Matching placebo | University Hospital, Basel, Switzerland, Swiss National Science Foundation | Acute Stroke, Stroke Rehabilitation | 08/24 | 12/28 | | |
| Recruiting | 2/3 | 60 | RoW | levodopa-carbidopa, Montelukast | Mostafa Bahaa | Parkinson Disease | 11/24 | 12/25 | | |
| Ongoing | 2 | 20 | Europe | SINEMET, RVG 08740, Tablet, SINEMET 125 | Centre for Human Drug Research, CHDR | Parkinson's Disease, Parkinson's Disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT03451500: Carbidopa-Levodopa in Dry AMD With Geographic Atrophy |
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| Terminated | 2 | 7 | US | carbidopa-levodopa | Snyder, Robert W., M.D., Ph.D., P.C. | Age Related Macular Degeneration | 10/19 | 10/19 | | |
NCT05463367: Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure |
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| Recruiting | 2 | 80 | US | Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Sinemet, Naproxen 500 Mg, Aleve, Anaprox, Antalgin, Midol Extended Relief, Naprosyn, Soproxen, Synflex, Xenobid, Opioids, hydrocodone/acetaminophen, oxycodone/acetaminophen, oxycodone, oxymorphone, morphine, codeine, tramadol | Northwestern University, Shirley Ryan AbilityLab, National Institutes of Health (NIH) | Opioid Use, Opioid Dependence, Opioid-use Disorder, Narcotic Use, Back Pain, Back Injuries, Chronic Pain, Chronic Low-back Pain, Pain, Chronic, Pain;Back Low;Chronic, Pain, Back | 08/23 | 08/23 | | |
NCT05087914: Novel Non-opioid Post-surgical Pain Treatment in Females |
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| Withdrawn | 2 | 60 | US | Carbidopa-Levodopa (100mg/25mg):, Sinemet, Parcopa, Rytary, Naproxen, Aleve, Anaprox, Naprosyn, Naprelan, Menstridol | Northwestern University, Northwestern Medical Group, National Institutes of Health (NIH) | Acute Pain, Bunionectomy, Toe Fusion | 12/23 | 01/24 | | |
NCT05781711: Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease |
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| Recruiting | 2 | 60 | RoW | levodopa-carbidopa, Metformin | Tanta University, Eman Ibrahim Elberri, Faculty of Pharmacy, Tanta University, Fedaa Abd El-monem Kamal El-deen Kotkata Faculty of Pharmacy, Tanta University, Manal Ali Mahrous Hamouda Faculty of Pharmacy, Menufia University | Parkinson Disease | 09/24 | 11/25 | | |
| Recruiting | 2 | 10 | US | Methylphenidate, carbidopa-levodopa, Placebo | University of Rochester | Chronic Pain | 12/24 | 01/25 | | |
NCT04469959: Dopaminergic Dysfunction in Late-Life Depression |
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| Recruiting | 2 | 100 | US | L-Dopa, carbidopa/levodopa (Sinemet), 25/100 placebo capsules, Placebo | Vanderbilt University Medical Center, Emory University, University of Pittsburgh, University of Pittsburgh Medical Center, Rutgers University | Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment | 04/25 | 06/26 | | |
| Recruiting | 2 | 50 | RoW | carbidopa-levodopa, Pentoxifylline 400 MG | Mostafa Bahaa, Sahar Mohamed El-Haggar clinical pharmacy department, Tanta University, Sahar Kamal Hegazi clinical pharmacy department, Tanta University, Mohanad Omar Khrieba Clinical Pharmacy Department, Faculty of Pharmacy - Horus University | Parkinson Disease | 07/27 | 10/28 | | |
NCT05083260: NE3107 Activity and Safety in Patients With Parkinson's Disease Using Levodopa |
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| Completed | 1/2 | 46 | US | NE3107, placebo | BioVie Inc. | Parkinson Disease | 11/22 | 01/23 | | |
RES, NCT06219915: Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Placebo-Controlled Arm |
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| Completed | 1/2 | 13 | US | Carbidopa 25 mg, Carbidopa-Levodopa 25/100 mg, Sinemet, Placebo 1, Placebo 2 | University of Michigan, National Institute on Aging (NIA) | Parkinsonian Signs in Older Persons | 05/24 | 05/24 | | |
NCT05369533: Dopaminergic Enhancement of Rehabilitation Therapy Early After Stroke |
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| Completed | 1/2 | 30 | US | Telerehabilitation, Sinemet Pill, Placebo | University of California, Los Angeles | Stroke | 03/24 | 03/24 | | |
NCT05976737: Bioequivalence Study of Entacapone,Levodopa and Carbidopa Tablets in Healthy Chinese Subjects |
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| Not yet recruiting | 1 | 68 | NA | Test (T) Entacapone,Levodopa and Carbidopa Tablets (II), Reference (R) Entacapone,Levodopa and Carbidopa Tablets (II) | The Affiliated Hospital of Qingdao University | Healthy | 09/23 | 07/24 | | |
STIMO-PHARMA, NCT04052776: Acute Effects of Pharmacological Neuromodulation on Leg Motor Activity in Patients With SCI Treated With EES |
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| Completed | 1 | 3 | Europe | Buspirone, Levodopa-Carbidopa, Buspirone + Levodopa-Carbidopa, Placebo oral tablet | Centre Hospitalier Universitaire Vaudois, Ecole Polytechnique Fédérale de Lausanne | Spinal Cord Injuries, Drug Effect | 10/23 | 10/23 | | |
NCT06180720: Bioequivalence Study of Entacapone,Levodopa and Carbidopa Tablets in the Postprandial State in Healthy Chinese Subjects |
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| Not yet recruiting | 1 | 36 | NA | Test (T) Entacapone,Levodopa and Carbidopa Tablets (II), Reference (R) Entacapone,Levodopa and Carbidopa Tablets (II) | The Affiliated Hospital of Qingdao University | Healthy | 01/24 | 11/24 | | |
NCT05471609: Sustained Release Oral Formulation for Treatment of Parkinson's Disease |
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| Suspended | 1 | 6 | US | levodopa/carbidopa oral formulation A, levodopa/carbidopa oral formulation B, levodopa/carbidopa oral formulation C | University of Minnesota | Idiopathic Parkinson Disease | 06/25 | 06/25 | | |
NCT00624741: Compassionate Use Study of Pergolide in Patients With Parkinson's Disease |
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| No Longer Available | N/A | | US | Pergolide, Permax | Bausch Health Americas, Inc. | Parkinson Disease | | | | |
ChiCTR2100046218: Pretest of Pharmacokinetic of Carbidopa and Levodopa Sustained-Release Tablets in Healthy Subjects |
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| Recruiting | N/A | 18 | | Fasting test ;Postprandial test | Dongyang Hengdian Hospital; Hangzhou Bio-Sincerity Pharma-Tech Co., Ltd., Institution：Hangzhou Bio-Sincerity Pharma-Tech Co., Ltd. | Pharmacokinetic study | | | | |
| Not yet recruiting | N/A | 30 | NA | Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, L-DOPA, l-3,4-dihydroxyphenylalanine, Sinemet, Citalopram, Celexa | Western University, Canada | Parkinson Disease, Depression | 01/22 | 01/22 | | |
SmIle, NCT06003608: Observational Small Intestine and Blood Fingerprint () Study in Parkinson's Disease |
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| Recruiting | N/A | 100 | Canada | Fluid biopsy capsule, Levodopa-Carbidopa Immediate Release | Nimble Science Ltd., MRM Health N.V. | Parkinson Disease | 08/24 | 09/24 | | |
| Recruiting | N/A | 7500 | US | modafinil, Provigil, d-amphetamine, Dexedrine, L-Dopa, Sinemet, Naltrexone, Revia | The University of Texas Health Science Center, Houston, National Institute on Drug Abuse (NIDA) | Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence, Substance Abuse | 06/26 | 06/26 | | |
| Recruiting | N/A | 120 | US | Anti-Parkinson medication, Carbidopa/levodopa, pramipexole, ropinirole, amantadine, tolcapone, entacapone, Deep Brain Stimulation | Beth Israel Deaconess Medical Center | Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Gait, Frontal, Huntington Disease | 06/25 | 06/25 | | |
| Recruiting | N/A | 40 | US | carbidopa/levodopa, as prescribed by treating physician, Parcopa, Sinemet | University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS) | Parkinson Disease | 02/25 | 02/25 | | |
