- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Drugs for bipolar disorder. (Pubmed Central) - Apr 9, 2024
Thus, to conclude, low-dose amisulpride can be a potential monotherapy in PSD with a favourable clinical outcome and safety profile (ClinicalTrials.gov ID: NCT04876521). No abstract available
- |||||||||| lithium carbonate ER / Generic mfg.
Trial termination, HEOR: Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies (clinicaltrials.gov) - Feb 15, 2024
P=N/A, N=1037352, Terminated,
No abstract available Completed --> Terminated; Per PI, this study is not a clinical trial and was inadvertently entered in the system
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Drugs for depressionr. (Pubmed Central) - Dec 26, 2023
Completed --> Terminated; Per PI, this study is not a clinical trial and was inadvertently entered in the system No abstract available
- |||||||||| A Rare Case of Acute Disseminated Encephalomyelitis: A Case Report () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_673;
Case Diagnosis: Acute disseminated encephalomyelitis (ADEM) diagnosed in a middle-age, adult male.Case Description or Program Description: A 46-year-old male with a history of depression, latent TB, and previous psych admission presented to the hospital for acute disseminated encephalomyelitis (ADEM) seen on MRI and treated with acyclovir...The patient was initially admitted with altered mental status and rhabdomyolysis, deemed not to have capacity, and advised to continue on home olanzapine and fluoxetine...During rehabilitation admission, the patient's dosage of seroquel and gabapentin were adjusted and subsequently the patient's impulsivity significantly improved and thus was able to better participate in therapy.Setting: Nassau University Medical Center inpatient PM&R floorAssessment/ Upon discharge, the patient was able to ambulate 150 feet with distant supervision without an assistive device... This case report was written to highlight a rare incidence of ADEM outside the typical pediatric population, while emphasizing the significant role of effective psychiatric care in facilitating the patient's rehabilitation recovery.
- |||||||||| olanzapine/fluoxetine / Generic mfg., clozapine / Generic mfg.
Enrollment change: National Pregnancy Registry for Psychiatric Medications (clinicaltrials.gov) - Nov 13, 2023
P=N/A, N=5000, Recruiting,
This case report was written to highlight a rare incidence of ADEM outside the typical pediatric population, while emphasizing the significant role of effective psychiatric care in facilitating the patient's rehabilitation recovery. N=2500 --> 5000
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Spravato (esketamine intranasal) / J&J, Rexulti (brexpiprazole) / Lundbeck, Otsuka
Journal: Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions. (Pubmed Central) - Sep 15, 2023
Some second-generation antipsychotics (e.g., aripiprazole, brexpiprazole, cariprazine, quetiapine XR) are proven effective as adjunctive treatments to antidepressants in partial responders, but only the olanzapine-fluoxetine combination has been studied in FDA-defined TRD...Manual-based psychotherapies are not established as efficacious on their own in TRD, but offer significant symptomatic relief when added to conventional antidepressants. Digital therapeutics are under study and represent a potential future clinical vista in this population.
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda
Trial completion, Enrollment change, Trial primary completion date: Vortioxetine Adjunctive Treatment in Bipolar Depression (clinicaltrials.gov) - Sep 14, 2023
P4, N=131, Completed,
Digital therapeutics are under study and represent a potential future clinical vista in this population. Recruiting --> Completed | N=100 --> 131 | Trial primary completion date: Feb 2023 --> Jun 2023
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Caplyta (lumateperone) - Intra / Cellular Therapies
Retrospective data, Review, Journal: Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis. (Pubmed Central) - Aug 23, 2023
Olanzapine plus fluoxetine, quetiapine, olanzapine, lurasidone, lumateperone, cariprazine, and lamotrigine were found to be more efficacious than placebo in adults with acute bipolar depression, with good confidence in the evidence, and to differ in their side-effect profiles. These findings can inform evidence-based care and the development of treatment guidelines internationally.
- |||||||||| Journal: Rilmazafone: A designer benzodiazepine pro-drug involved in fatal intoxications. (Pubmed Central) - Jun 22, 2023
Rilmazafone metabolizes into active compounds by a ring closure resulting in a triazolo benzodiazepine structure similar to alprazolam...Additional toxicological findings included the medications haloperidol, alimemazine, fluoxetine, olanzapine, and acetaminophen...Additional toxicological findings included loperamide, alimemazine, and pregabalin. The intake of rilmazafone was determined as the cause of death in Case 1 and contributed in the Case 2.
- |||||||||| lithium carbonate ER / Generic mfg.
Case Management Challenges in Geriatric Patients With Bipolar Disorder (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_355;
There are very few clinical trials dedicated to geriatric BD, and most of the data are extrapolated from studies with adults. The clinician should consider the pharmacokinetic, pharmacodynamic, and clinical particularities of this population.
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
Journal: Cariprazine (Vraylar) for adjunctive treatment of depression. (Pubmed Central) - May 26, 2023
The clinician should consider the pharmacokinetic, pharmacodynamic, and clinical particularities of this population. No abstract available
- |||||||||| olanzapine/fluoxetine / Generic mfg.
Treatment Challenges in Patient With Avoidant Restrictive Food Intake Disorder (ARFID) With Underlying Mood Disorder (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_789;
Bipolar Disorder (BD) depression can be treated with combination of Olanzapine/Fluoxetine...Conclusion -A literature search revealed that even though a recent estimate of the comorbidity of these conditions was about 20% (5), the pharmacological treatment of both conditions simultaneously required further review. Further quantitative research should be done in both pediatric and adult populations.
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Rexulti (brexpiprazole) / Lundbeck, Otsuka
Review, Journal: Pharmacotherapy for Treatment-Resistant Depression: Antidepressants and Atypical Antipsychotics. (Pubmed Central) - May 11, 2023
Atypical antipsychotics are the most widely studied augmentation agent and aripiprazole, brexpiprazole, cariprazine, quetiapine extended-release, and olanzapine-fluoxetine combination are approved for depression. Benefits of using atypical antipsychotics for TRD has to be weighted against their potential adverse events, such as weight gain, akathisia, and tardive dyskinesia.
- |||||||||| Vyvanse (lisdexamfetamine) / Shionogi, Takeda
Journal: Through the Looking Glass: Skin Signs that Help Diagnose Eating Disorders. (Pubmed Central) - Mar 7, 2023
Management requires a multidisciplinary approach that focuses on psychotherapy combined with attention to medical complications, nutritional needs, and such non-psychiatric findings such as cutaneous manifestations. Psychotropic medications that are currently used in EDs include pimozide and atypical antipsychotic agents, such as aripiprazole and olanzapine, fluoxetine, and lisdexamfetamine.
- |||||||||| lithium carbonate ER / Generic mfg.
Combination therapy for bipolar disorder (08. Room Passy) - Mar 2, 2023 - Abstract #EPA2023EPA_242;
Adjunctive treatment of olanzapine with fluoxetine may be necessary in a depression with mixed features... Rational polytherapy allows better and faster control over symptoms of bipolar disorder and should be considered after a detailed discussion of risks and benefits.
- |||||||||| Review, Journal: Pharmacotherapies for Treatment-Resistant Depression: How Antipsychotics Fit in the Rapidly Evolving Therapeutic Landscape. (Pubmed Central) - Mar 1, 2023
Pragmatic clinical trials are needed to compare the effectiveness of atypical antipsychotics with TRD-specific pharmacotherapies and neuromodulation treatments and to identify the optimal sequencing of these varied approaches for patients with MDD. When using atypical antipsychotics, clinicians and patients are encouraged to use a shared decision-making approach by personalizing treatment selection based on anticipated side effects, tolerability, cost, and feasibility.
- |||||||||| olanzapine/fluoxetine / Generic mfg., clozapine / Generic mfg.
Trial completion date, Trial primary completion date: National Pregnancy Registry for Psychiatric Medications (clinicaltrials.gov) - Feb 10, 2023
P=N/A, N=2500, Recruiting,
When using atypical antipsychotics, clinicians and patients are encouraged to use a shared decision-making approach by personalizing treatment selection based on anticipated side effects, tolerability, cost, and feasibility. Trial completion date: Dec 2025 --> Dec 2033 | Trial primary completion date: Dec 2025 --> Dec 2033
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Psychopharmacological Treatment Algorithms of Manic/Mixed and Depressed Episodes in Pediatric Bipolar Disorder. (Pubmed Central) - Dec 7, 2022
We offer an update to the 2005 AACAP algorithms for the treatment of pediatric bipolar mixed/manic episodes and added an evidence-based algorithm for the treatment of depression in PBD. In addition to treatment algorithms, we review current evidence for efficacy of agents proposed in the AACAP algorithm and provide tables summarizing medication side effects and efficacy.
- |||||||||| olanzapine / Generic mfg., fluoxetine / Generic mfg.
Journal: Olanzapine add-on treatment promotes neuronal differentiation of neural stem cells compared with fluoxetine alone. (Pubmed Central) - Oct 21, 2022
The combination of olanzapine and fluoxetine has no profound effect on NSCs proliferation compared with fluoxetine alone, but olanzapine add-on treatment produces a greater number and percentage of differentiated neurons from NSCs. Further investigations are needed to explore the underlying mechanisms of the increased neurogenesis caused by the combination of olanzapine with fluoxetine.
- |||||||||| lithium carbonate ER / Generic mfg.
Pharmacologic and Psychotherapeutic Treatments for Pediatric Bipolar Depression () - Oct 19, 2022 - Abstract #AACAP2022AACAP_1344;
Quetiapine immediate release (IR) and extended release (ER) did not show a statistically significant improvement in the symptoms of bipolar depression compared to placebo...Lurasidone and the olanzapine-fluoxetine combination are evidence-based treatments for pediatric bipolar depression. There are several evidence-based therapies for pediatric bipolar depression, and there is a need for more research on the pharmacologic treatment of pediatric bipolar depression.
- |||||||||| fluoxetine / Generic mfg., lurasidone / Generic mfg.
Augmentation strategy fluoxetine and lurasidone in the treatment of obsessive-compulsive disorder with comorbid restrictive anorexia nervosa – a case report (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_920;
Lurasidone is a second-generation antipsychotic with good efficacy and lower metabolic and cardiovascular side effects if compared with other SGAs, but there is currently brief experience about its use in treatment of OCD, especially whereas comorbid anorexia nervosa- restrictive type (AN-r) is present. Objective: This Case Report presents the effect of augmentation strategy with lurasidone (37 mg daily bedtime) in a 45-years old woman with a relapse episode of severe OCD with comorbid AN-r, previously treated with combined fluoxetine and olanzapine treatment, subsequently interrupted. During the first visit to our psychiatric clinic the patient was provided self- and hetero-administered assessment with Yale-Brown Obsessive Compulsive Scale (Y-BOCS-II), Clinical Global Impression-Severity (CGI-S), Symptom Checklist-90 (SCL-90) and Eating Disorder Inventory-3 (EDI-3)...The management of this clinical case demonstrates a possible indication of lurasidone as augmentation strategy in tr-OCD. Nevertheless, further longitudinal and real-world effectiveness studies are needed to confirm effectiveness in attenuating OC symptomatology, in tr-OCD and whereas a comorbid AN-r is present.
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda
Enrollment open: Vortioxetine Adjunctive Treatment in Bipolar Depression (clinicaltrials.gov) - Aug 12, 2022
P4, N=100, Recruiting,
Effective treatments with either beneficial or physically neutral profiles should be prioritized. Active, not recruiting --> Recruiting
- |||||||||| NexoBrid (bromelain) / MediWound, Kaken Pharma, Teva
Pineapple Predisposing Pyrexia: Pineapple Induced Serotonin Syndrome (Room 3009/3011 (West Building, Level 3), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_2040;
The patient is a 21-year-old female with past medical history of depression and anxiety on fluoxetine and olanzapine...This enzyme inhibits CYP2C9 activity while the cysteine protease inhibitor, E-64, is also blocked by bromelain...In patients taking selective serotonin reuptake inhibitors and presenting with altered mental status, hemodynamic instability and neuromuscular abnormalities, serotonin syndrome must be considered. Furthermore, attention should be paid to the patient’s dietary choices as fruits such as pineapple can inhibit the cytochrome pathway which will lead to the inability of the body to metabolize serotonergic drugs and result in potentially lethal complications.
- |||||||||| Rexulti (brexpiprazole) / Lundbeck, Otsuka
Clinical, Journal: Efficacy and Tolerability of Combination Treatments for Major Depression: Antidepressants plus Second-Generation Antipsychotics vs. Esketamine vs. Lithium. (Pubmed Central) - Feb 3, 2022
Individually, aripiprazole, olanzapine+fluoxetine, risperidone, and ziprasidone all were more effective (all NNT < 10) than quetiapine (NNT = 13), brexpiprazole (16), or cariprazine (16), with overlapping NNT CIs...Several modern antipsychotics and esketamine appeared to be useful adjuncts to antidepressants for acute major depressive episodes, but lithium was somewhat more effective and better tolerated. Most trials of adding lithium involved older, mainly tricyclic, antidepressants, and the dosing of adjunctive treatments were not optimized.
- |||||||||| olanzapine/fluoxetine / Generic mfg., olanzapine / Generic mfg., fluoxetine / Generic mfg.
PK/PD data, Preclinical, Journal: P-glycoprotein mediates the pharmacokinetic interaction of olanzapine with fluoxetine in rats. (Pubmed Central) - Jan 1, 2022
In conclusion, P-gp plays an important role in the pharmacokinetic interaction between olanzapine and fluoxetine in rats. This study may provide a reference for the clinical safety of olanzapine combined with fluoxetine.
- |||||||||| Review, Journal: Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences. (Pubmed Central) - Nov 17, 2021
Acute anxiety or suicidality may warrant benzodiazepine treatment with lorazepam...Therapeutic drug monitoring, pharmacogenomic testing, a more restrictive use of "pro re nata" (PRN) medication, an interdisciplinary treatment approach, shared decision making (SDM) and the formulation of common treatment goals by the patients, their family or carers and clinicians could improve treatment success and safety. Novel genetic, immunological, microbiome and brain imaging research as well as new pharmacological developments like the use of psychedelics, stimulants, novel monoaminergic drugs, hormone analogues and drugs which enhance the effects of psychotherapy may extend our therapeutic options in the near future.
- |||||||||| lithium carbonate ER / Generic mfg.
Trial completion, HEOR: Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies (clinicaltrials.gov) - Oct 7, 2021
P=N/A, N=1037352, Completed,
Novel genetic, immunological, microbiome and brain imaging research as well as new pharmacological developments like the use of psychedelics, stimulants, novel monoaminergic drugs, hormone analogues and drugs which enhance the effects of psychotherapy may extend our therapeutic options in the near future. Enrolling by invitation --> Completed
- |||||||||| olanzapine/fluoxetine / Generic mfg., clozapine / Generic mfg.
Trial completion date, Trial primary completion date: National Pregnancy Registry for Psychiatric Medications (clinicaltrials.gov) - Aug 31, 2021
P=N/A, N=2500, Recruiting,
Patients who were taking both fluoxetine + olanzapine or fluoxetine + risperidone had higher percentage of hyponatremia. Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2022 --> Dec 2025
- |||||||||| olanzapine/fluoxetine / Generic mfg., quetiapine / Generic mfg.
[VIRTUAL] Mechanism of antidepressant effect in the treatment of bipolar depression () - May 31, 2021 - Abstract #WFSBP2021WFSBP_180;
Currently only quetiapine and the olanzapine-fluoxetine combination are officially approved by the FDA against this condition. Our exhaustive review is compatible with a complex model with multiple levels of interaction between the major neurotransmitter systems without a single target being either necessary or sufficient to elicit the antidepressant effect in bipolar derpession.
- |||||||||| lurasidone / Generic mfg.
Journal: Is it depression or is it bipolar depression? (Pubmed Central) - May 27, 2021
Primary care providers who can differentiate presenting symptoms of bipolar depression from unipolar depression and offer appropriate treatment options will optimize patient care in clinical practice. Relevant information for this review was identified through a multistep literature search of PubMed using the terms bipolar depression/bipolar disorder plus other relevant terms.
|
