labetalol Trials - LARVOL Sigma

Trial + Data / Events

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Primary compl

Study compl

labetalol / Generic mfg.

2011-005545-12: ENCHANTED: A Trial to assess the effects of low- vs standard-dose clot-busting and intensive vs standard blood pressure-lowering treatments on outcome after acute ischaemic stroke

Ongoing

5000

Europe

Actilyse, Labetalol, Glyceryl trinitrate, Glyceryl Trinitrate, Powder and solvent for solution for infusion, Powder and solvent for solution for injection/infusion, Solution for injection, Transdermal patch, Solution for infusion, Actilyse, Labetalol

University of Leicester, National Health and Medical Research Council

Acute Ischaemic Stroke, Stroke or 'Brain Attack' caused by a clot., Diseases [C] - Nervous System Diseases [C10]

NCT04767061: Impact of Beta-blockers on Physical Function in HFpEF

Completed

Beta blockers, atenolol, betaxolol, bisoprolol, metoprolol, nebivolol, nadolol, propranolol, acebutolol, penbutolol, pindolol, carvedilol, labetalol, sotalol, metoprolol succinate, metoprolol tartrate

Weill Medical College of Cornell University, The New York Community Trust

Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease

04/22

04/23

EVA, NCT02531490: Early Vascular Adjustments During Hypertensive Pregnancy

Recruiting

368

Europe

Labetalol, Trandate, Nifedipine, Adalat, Methyldopa, Aldomet

Maastricht University Medical Center

Hypertension, Pregnancy-Induced, Pre-Eclampsia

02/23

04/23

NCT04757584: Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF

Completed

Weill Medical College of Cornell University, National Institute on Aging (NIA)

Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease

04/23

NCT05309460: Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial

Recruiting

600

Labetalol Oral Tablet, Normodyne, Trandate, NIFEdipine ER, Procardia XL

Nebraska Methodist Health System

Postpartum Preeclampsia, Hypertension in Pregnancy

05/24

12/24

HOPE, NCT04892511: Hemodynamic Optimization of Cerebral Perfusion After Endovascular Therapy in Patients With Acute Ischemic Stroke

Recruiting

814

Europe

Adjusted medication, Labetalol, Urapidil, Phenylephrine, Sodium Nitroprusside, Physiological saline or Plasmalyte®

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Acute Ischemic Stroke

06/24

09/24

NCT06752863: Labetalol Infusion and Dexmedetomidine Infusion in Hypotensive Anesthesia

Recruiting

RoW

Hypotensive anesthesia in ear, nose and throat surgeries using labetalol and dexmedetomidine infusions

Ain Shams University

Hypotensive Anesthesia, Ear, Nose and Throat Procedure

10/25

12/25

NCT04205305: Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control (OPTIMAL-BP)

Completed

306

RoW

conventional blood pressure control (labetalol, nicardipine), intensive blood pressure control (labetalol, nicardipine)

Yonsei University

Ischemic Stroke

07/23

NCT06093893: Hypotensive Anesthesia for Orthognathic Surgery

Not yet recruiting

Dexmedetomidine, Precedex, Nicardipine, Cardene, Labetalol, Labetalol hydrochloride injection

Boston Medical Center

Hypotensive Anesthesia, Orthognathic Surgery

12/25

2006-005654-77: Labetalol versus MgSO4 for the Prevention of Eclampsia Trial

Ongoing

200

Europe

Trandate 200 mg, Sulfate de Magnesium Renaudin, Trandate injectable, Trandate 200 mg, Sulfate de Magnesium Renaudin, Trandate injectable, Trandate 200 mg, Sulfate de Magnesium Renaudin, Trandate injectable

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)

Femmes enceintes présentant une prééclampsie

2015-005811-34: Pregnancy reLated Acute hyperTension INtervention Action: a randomized trial comparing labetalol and nicardipine in women with acute hypertension in pregnancy (Platina-trial)

Ongoing

472

Europe

Labetalol, Nicardipine, C07AG01, C08CA04, Infusion, Nicardipine

VU Medical Center, Amsterdam, VUmc

To asses optimal treatment of hypertension of hypertensive disorders in pregnancy, To asses optimal treatment of hypertension of hypertensive disorders in pregnancy, Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]

P-PAT, NCT04298034: Preeclampsia Postpartum Antihypertensive Treatment

Recruiting

300

Labetalol, Nifedipine, Procardia, Trandate, Normodyne

Medical College of Wisconsin

Preeclampsia, Hypertension in Pregnancy

06/25

OPTIMAL-BP 2, NCT06677970: Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2

Recruiting

176

RoW

BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)

Yonsei University

Acute Ischemic Stroke

12/28

SCARPH, NCT05551104: Safest Choice of Antihypertensive Regimen for Postpartum Hypertension

Recruiting

500

Oral Nifedipine, Procardia, Procardia XL, Oral Labetalol, Trandate

Loma Linda University

Postpartum Complication, Maternal Hypertension, High Blood Pressure

12/27

BEST-II, NCT04116112: Blood Pressure After Endovascular Stroke Therapy-II

Completed

120

Nicardipine, Cardene, Labetalol, Hydralazine, Apresoline

University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), Vanderbilt University Medical Center

Acute Stroke, Endovascular Thrombectomy

07/22

12/22

DETECT, NCT04484350: Blood Pressure Management in Stroke Following Endovascular Treatment

Completed

Canada

Labetalol, Hydralazine, Enalapril

Hamilton Health Sciences Corporation

Stroke, Acute, Vessels; Occlusion, Blood Pressure, Endovascular Thrombectomy, Mechanical Thrombectomy

02/23

05/23

ICH-ADAPT II, NCT02281838: The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II

Terminated

142

Canada

labetalol/hydralazine/enalapril

University of Alberta

Intracerebral Hemorrhage

11/21

12/21

NCT05955040: Treatment of Elevated Blood Pressures in Early Pregnancy

Terminated

Nifedipine, Labetalol

Marshall University

Elevated Blood Pressure, Pregnancy Induced Hypertension

05/24

CHAP2, NCT05989581: Chronic Hypertension and Pregnancy 2 () Pilot Project

Recruiting

Labetalol or Nifedipine

University of Alabama at Birmingham

Hypertension in Pregnancy

04/25

06/25

NCT04755764: Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy

Recruiting

N/A

Labetalol, Normodyne, Trandate, Atenolol, Tenormin, Nifedipine, Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL

Marshall University

Systolic Hypertension, Pregnancy Related, Diastolic Hypertension, Cardiac Output, Low, Cardiac Output, High

04/24

12/24

NCT06259760: AKI Risk Factors Analysis After Intentional Hypotensive Anesthesia

Recruiting

N/A

RoW

Nitroglycerin, labetalol

Kaohsiung Medical University Chung-Ho Memorial Hospital

Acute Kidney Injury (Nontraumatic), Hypotension Drug-Induced

12/26

NCT06346561: The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study

Recruiting

N/A

RoW

Dexmedetomidine, Labetalol

Sohag University

Nasolacrimal Duct Obstruction

08/24

POPS or POP02, NCT04278404: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Recruiting

N/A

5000

Canada, US

The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:, Aminocaproic acid, Amiodarone, Bosentan, Budesonide, Cefdinir, Cefepime, Ceftazidime, Clindamycin, Clobazam, Dexamethasone, Dexmedetomidine, Dextroamphetamine/Amphetamine, Fosfomycin, Furosemide, Gabapentin, Guanfacine, Hydrocortisone, Labetalol, Meropenem, Metformin, Milrinone, Nalbuphine, Nicardipine, Nifedipine, Oseltamivir, Oxycodone, Risperidone, Sertraline, Sevelamer Carbonate / Sevelamer Hydrochloride, Spironolactone, Terbutaline, Tranexamic acid, Voriconazole, Zolpidem, Azithromycin, Lopinavir/Ritonavir, Ribavirin, Tocilizumab, Anakinra, Aspirin, Canakinumab, Colchicine, Interferon, Remdesivir, Ruxolitinib, Sarilumab, Abatacept, Infliximab

Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Hemophilia, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome

09/26

09/27

NCT03511118: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting

N/A

1600

Canada, US

Tranexamic acid (TXA), labetalol, metformin, nifedipine, clindamycin, oxycodone, azithromycin, escitalopram, sertraline, ondansetron, Ciprofloxacin, Doxycycline, Levofloxacin, Methylphenidate, Sumatriptan, Citalopram, Cyclobenzaprine, Furosemide, Gabapentin, Hydrochlorothiazide, Hydroxyurea, Rosuvastatin, Topiramate, Trazodone, Valganciclovir, Venlafaxine, Verapamil, Remdesivir, Anakinra, Tocilizumab, Fluvoxamine, Amoxicillin, Bupropion, Duloxetine, Hydrocodone, Levetiracetam, Paroxetine, Buprenorphine

Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI

07/26

07/27



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