sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Surgery:  DELICATE: Delirium Reduction by Volatile Anesthesia in Cardiac Surgery (clinicaltrials.gov) -  Jan 16, 2024   
    P4,  N=353, Completed, 
    Shortly thereafter, halothane was completely displaced from pediatric anesthesia practice in North America. Recruiting --> Completed | N=672 --> 353 | Trial completion date: Jan 2023 --> Jan 2024 | Trial primary completion date: Dec 2022 --> Jan 2024
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  SIRT1 is a regulator of autophagy: implications for the progression and treatment of myocardial ischemia-reperfusion. (Pubmed Central) -  Jan 15, 2024   
    For example, resveratrol, sevoflurane, quercetin, and melatonin in the ischemic stage, coptisine, curcumin, berberine, and some miRNAs during reperfusion, were involved in regulating the SIRT1-autophagy axis, exerting a cardioprotective effect. Here, we summarize the possible mechanisms of autophagy regulation by SIRT1 in myocardial I/R injury and the related molecular drug applications to identify strategies for treating myocardial I/R injury.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    Journal:  Global Trends in Research Related to Emergence Agitation From 1978 to 2023: A Bibliometric Analysis. (Pubmed Central) -  Jan 14, 2024   
    The study mapped the knowledge structure of EA and identified six prominent research directions, four drugs of significant research interest, and emerging thematic trends. These findings offer insights into the current state of research on EA, providing a comprehensive view of the field's landscape.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Clinical, Retrospective data, Journal:  Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials. (Pubmed Central) -  Jan 9, 2024   
    This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Chronic outpatient treatment with topical sevoflurane in patientes with vascular ulcers. (Pubmed Central) -  Jan 9, 2024   
    Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence. Topical application of sevoflurane is an analgesic and re-epithelializing strategy for vascular ulcers with a successful safety profile.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Phoenixin-20 ameliorates Sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of the PKA/CREB signaling. (Pubmed Central) -  Jan 8, 2024   
    Moreover, the brain-derived neurotrophic factor (BDNF), protein kinase A (PKA), and phospho-cAMP response element binding protein/cAMP response element binding protein (p-CREB/CREB) levels were markedly decreased in Sevoflurane-treated rats, which were memorably increased by PNX-20. Our results indicated that PNX-20 ameliorated Sevoflurane inhalation-induced POCD in rats via the activation of PKA/CREB signaling, which might supply a new treatment approach for POCD.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    FLUR-ishing: Inhalational Anesthetics in the ICU (North-122) -  Dec 24, 2023 - Abstract #SCCM2024SCCM_118;    
    Beyond ICU sedation, other indications of interest have emerged with broader use, including treatment of refractory bronchospasm. Learning Objectives: Discuss mechanisms of action and adverse effects of inhalational anesthetics in the ICU Analyze the evidence regarding use of inhalational anesthetics in the ICU Summarize the methods of administration of inhalational anesthetics during mechanical ventilation in the ICU
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion:  PROSEVNOL: NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane (clinicaltrials.gov) -  Dec 20, 2023   
    P4,  N=60, Completed, 
    According to our findings, it is clear that fullerenol C60 administered intraperitoneally 30 min before ischemia, alone or together with sevoflurane, reduces oxidative stress in distant organ damage caused by lower extremity IRI, and reduces liver and kidney tissue damage in histopathologic examinations. Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Trial termination:  SPIDERMAN: Sevoflurane PharmacokInetics in ARDS (clinicaltrials.gov) -  Dec 19, 2023   
    P=N/A,  N=37, Terminated, 
    No abstract available Recruiting --> Terminated; Recruitment difficulties
  • ||||||||||  sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Trial completion date, Trial primary completion date:  Preoperative Anxiolysis With Intravenous Midazolam on Intraoperative Sevoflurane Gas Consumption (clinicaltrials.gov) -  Dec 15, 2023   
    P4,  N=80, Recruiting, 
    Our findings may lead to new approaches for perioperative neuroprotection of MCI patients. Trial completion date: Aug 2023 --> Dec 2023 | Trial primary completion date: Aug 2023 --> Dec 2023
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Sustainability Standards in Pediatric Anesthesia: Quality Initiative to Reduce Costly Environmentally Harmful Volatile Anesthetics. (Pubmed Central) -  Dec 13, 2023   
    This QI project successfully decreased GHG emissions over 3 years by simultaneously reducing the use of costly and environmentally harmful volatile anesthetic, Desflurane, and increasing the use of low-flow anesthesia. This study addresses our anesthesia practices and healthcare system's impact on the pediatric population and proposes simple interventions to mitigate the negative consequences of current practices.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Dopamine D2-receptor neurons in nucleus accumbens regulate sevoflurane anesthesia in mice. (Pubmed Central) -  Dec 13, 2023   
    Furthermore, the activation of NAc neurons projecting into the ventral pallidum (VP) via optogenetics demonstrated a shortened induction time for mice under sevoflurane anesthesia. In conclusion, our research outcomes suggest that NAc neurons play a promotive role in the sevoflurane general anesthesia process in mice, and their activation can reduce the induction time of anesthesia via the ventral pallidum (VP).
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Perioperative considerations for adult patients with Dravet syndrome in regional centres. (Pubmed Central) -  Dec 11, 2023   
    Her perioperative care was optimised for seizure prevention with continuation of antiepileptic medications, strict temperature monitoring and control, optimised anaesthetic agents encompassing induction with propofol and fentanyl with maintenance sevoflurane, followed by attentive postoperative care and monitoring. This case demonstrates that general anaesthesia can safely be delivered to adult patients with DS in rural and regional areas with thorough perioperative planning.