sevoflurane / Generic mfg. 
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  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Clinical, Journal:  Livedo reticularis by hypothermia during anesthesia for dental treatment in Down's syndrome patient (Pubmed Central) -  Aug 3, 2019   
    Compared with sevoflurane, the use of propofol during cardiac surgery with CPB can efficiently improve postoperative cognitive function without increasing the risk of adverse reactions. This report evidences the need for thermal control of patients undergoing anesthesia, as well as the manifestation of livedo reticularis as a consequence of transoperative hypothermia.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Preclinical, Journal:  Effects of repeated exposure to different concentrations of sevoflurane on the neonatal mouse hippocampus (Pubmed Central) -  Aug 3, 2019   
    This report evidences the need for thermal control of patients undergoing anesthesia, as well as the manifestation of livedo reticularis as a consequence of transoperative hypothermia. Repeated exposure to sevoflurane, regardless of the concentration, reduced the volume of the neonatal mouse hippocampus, as well as the number of neurons and dendrite length.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Preclinical, Journal:  Intranasal Administration of Insulin Reduces Chronic Behavioral Abnormality and Neuronal Apoptosis Induced by General Anesthesia in Neonatal Mice. (Pubmed Central) -  Jul 31, 2019   
    ...Almost all general anesthetics-including sevoflurane, which is commonly used for children-are potentially neurotoxic to the developing brain...Importantly, insulin administered through intranasal delivery prior to anesthesia was found to prevent the anesthesia-induced long-term behavioral abnormalities, reduction of PSD95, and activation of neuronal apoptosis. These findings suggest that intranasal insulin administration could be an effective approach to prevent the increased risk of neurotoxicity and chronic damage caused by anesthesia in the developing brain.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  SPRV: Interaction of Sevoflurane Propofol and Remifentanil in Anesthesia for Laparoscopic Surgery (clinicaltrials.gov) -  Jul 30, 2019   
    P4,  N=120, Recruiting, 
    These findings suggest that intranasal insulin administration could be an effective approach to prevent the increased risk of neurotoxicity and chronic damage caused by anesthesia in the developing brain. Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2019 --> Dec 2020
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  A Trial of Two Anesthetic Regimes for Minimally Invasive Mitral Valve Repair. (Pubmed Central) -  Jul 28, 2019   
    Propofol and sevoflurane anesthesia were associated with similar degrees of myocardial injury, indicating comparable cardioprotection. Myocardial injury was related directly to the duration of cardioplegic arrest.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  Anesthetics Influence Mortality in a Drosophila Model of Blunt Trauma With Traumatic Brain Injury. (Pubmed Central) -  Jul 26, 2019   
    Therefore, collateral effects of general anesthetics should be considered in the interpretation of results obtained in vertebrate trauma models. Invertebrate model organisms can serve as a productive platform to interrogate anesthetic targets that mediate collateral effects and to inform trauma research in higher organisms about the potential impact of anesthetics on outcomes.
  • ||||||||||  sevoflurane / generics
    Journal:  Sevoflurane prevents miR-181a-induced cerebral ischemia/reperfusion injury. (Pubmed Central) -  Jul 23, 2019   
    This study demonstrates that SAP induces miR-370 and exerts cardioprotective effects on myocardial IRI, where upregulation of miR-370 alleviates myocardial IRI via inhibiting the PLIN5-dependent PPAR signaling pathway. Sevo preconditioning protected against CIRI in vitro and in vivo possibly by inhibiting miR-181a and facilitating XIAP.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Enrollment change:  Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI (clinicaltrials.gov) -  Jul 23, 2019   
    P4,  N=6, Terminated, 
    Sevo preconditioning protected against CIRI in vitro and in vivo possibly by inhibiting miR-181a and facilitating XIAP. N=16 --> 6
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  An insight into clustering of halogenated anesthetics molecules in metal-organic frameworks: Evidence of adsorbate self-association in micropores. (Pubmed Central) -  Jul 21, 2019   
    In order to better understand the adsorption of volatile halogenated anesthetics on metal organic frameworks (MOFs), sevoflurane vapor adsorption experiments were performed on commercial MOF-177 at different temperatures...Consequently, they show a "kink" at a specific pressure that increases with increasing equilibrium temperature. Successful modeling of such data by means of the Talu-Meunier equation confirmed clustering of adsorbate molecules inside adsorbent micropores, similarly to water vapor adsorption on activated carbon, which may play an important role when designing a system using MOFs as the potential adsorbents for capturing anesthetics.
  • ||||||||||  metformin / generics
    Journal:  Cellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness. (Pubmed Central) -  Jul 19, 2019   
    Various compounds that accelerate emergence from anesthesia, thus mitigating problematic effects associated with delayed emergence such as delirium, also activate AMPK (e.g. nicotine, caffeine, forskolin, carbachol)...We propose the novel hypothesis that cellular stress-induced AMPK activation links wakefulness, arousal, and consciousness with paradoxical excitation and accelerated emergence from anesthesia. Because AMPK activators including metformin and nicotine promote proliferation and differentiation of neural stem cells located in the subventricular zone and the dentate gyrus, AMPK activation may also enhance brain repair and promote potential recovery from disorders of consciousness (i.e. minimally conscious state, vegetative state, coma).
  • ||||||||||  sevoflurane / generics
    Preclinical, Journal:  Effects of sevoflurane on female reproductive functions in Wistar rats. (Pubmed Central) -  Jul 19, 2019   
    Because AMPK activators including metformin and nicotine promote proliferation and differentiation of neural stem cells located in the subventricular zone and the dentate gyrus, AMPK activation may also enhance brain repair and promote potential recovery from disorders of consciousness (i.e. minimally conscious state, vegetative state, coma). Chronic exposure to sevoflurane negatively affected the histological structure of the ovary and hormonal regulation.
  • ||||||||||  Sufenta (sufentanil) / Akorn
    Trial completion, Surgery:  Regional Anesthesia Versus General Anesthesia (clinicaltrials.gov) -  Jul 15, 2019   
    P=N/A,  N=28, Completed, 
    Group A patients had stable hemodynamic parameters, reduced intraoperative blood loss, less anesthetic requirement, and could be extubated earlier as compared with group B patients. Recruiting --> Completed
  • ||||||||||  sevoflurane / generics
    Journal:  A comparison between McGrath MAC videolaryngoscopy and Macintosh laryngoscopy in children. (Pubmed Central) -  Jul 11, 2019   
    However, desflurane did not demonstrate any increase in adverse events, which may support its routine use in this patient population. McGrath VL provides better laryngeal views and lower IDS but similar intubation times and success rates compared with the Macintosh laryngoscope in children with normal airway.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open, Trial initiation date, Surgery:  LUMBES: Lumbar Erector Spinae Plane Block for Back Surgery (clinicaltrials.gov) -  Jul 11, 2019   
    P3,  N=80, Recruiting, 
    McGrath VL provides better laryngeal views and lower IDS but similar intubation times and success rates compared with the Macintosh laryngoscope in children with normal airway. Not yet recruiting --> Recruiting | Initiation date: Mar 2019 --> Jul 2019
  • ||||||||||  New P1 trial, Surgery:  The PATHFINDER Study: A Feasibility Trial (clinicaltrials.gov) -  Jul 10, 2019   
    P1,  N=22, Not yet recruiting, 
  • ||||||||||  sevoflurane / generics
    Preclinical, Journal:  Toxicity mechanism of sevoflurane in neural stem cells of rats through DNA methylation. (Pubmed Central) -  Jul 10, 2019   
    Methylation mostly occurred in the autosome, and the content of methylation in the high-concentration group was higher than those in the moderate-concentration, low-concentration and control groups (P<0.05). In conclusion, the concentration of sevoflurane can affect the degree of methylation in neural stem cells of rats and produce certain cytotoxicity.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date, Surgery:  APLICS: Anesthetics to Prevent Lung Injury in Cardiac Surgery (clinicaltrials.gov) -  Jul 9, 2019   
    P1/2,  N=51, Active, not recruiting, 
    Induction with propofol/ketamine would be preferable to thiopental/guaifenesin in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery. Trial primary completion date: May 2019 --> Sep 2019