sevoflurane / Generic mfg. 
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  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  MULTIMODAL LOW-OPIOID ANESTHESIA - A NEW APPROACH TO THE ISSUE OF ADEQUATE INTRAOPERATIVE ANALGESIA. (Pubmed Central) -  Sep 3, 2019   
    The average dose of fentanyl, which was used for the entire period of anesthesiology support was 1,09±0.03 μg/kg/h (358,3±27,1 μg for the duration of surgery). As a result of the carried-out researches it was established, that multimodal low-opioid anesthesia, provides an adequate analgesic effect, and allows to refuse from intraoperative application of high doses of narcotic analgesics in the performance of highly traumatic operations, which is confirmed by the lack of hemodynamic and endocrine-metabolic shifts in its use.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  Intravenous Propofol Allows Fast Intubation in Neonates and Young Infants Undergoing Major Surgery. (Pubmed Central) -  Sep 3, 2019   
    ...Patients that received intravenous propofol bolus to induce anesthesia were compared to patients who received inhaled sevoflurane...No significant complications were recorded in either group. Propofol is a safe and effective anesthetic in neonates and infants permitting rapid induction of anesthesia and rapid intubation, without negative impact on the quality of intubation and haemodynamic compromise.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Clinical, Journal:  FEATURES OF CEREBRAL BLOOD FLOW DYNAMICS IN PATIENTS WITH ARTERIAL HYPERTENSION DURING CARDIAC SURGERY (Pubmed Central) -  Sep 1, 2019   
    ...Patients were operated under sevoflurane-based endotracheal anesthesia...Determination of the level of MAP does not allow to fully and properly evaluate the cerebral blood flow. In view of this, we recommend intraoperative monitoring of cerebral blood flow to prevent the development of CD for all patients with AH.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Inhibition of Monoamine Oxidase A in pulmonary artery banding-induced right heart failure (7B) -  Aug 26, 2019 - Abstract #ERS2019ERS_5258;    
    During echo and PV loops rats where anesthetized with sevoflurane (mix in 1.5L/min O2, 7% for induction, 3.5% for maintainance)...CONCLUSION Despite normalization of MAO-A activity in PTB rats, no functional improvements or changes in cardiac size were observed. Histological analyses will further elucidate these findings.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  Response to letter to the editor. (Pubmed Central) -  Aug 20, 2019   
    PIO may have the potential to prevent anesthetic SEV‑induced cognitive decline in surgical patients with obstructive sleep apnea. No abstract available
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Clinical, Journal:  Selection of optimal method of general anesthesia for intubation of nasolacrimal duct in young children (Pubmed Central) -  Aug 17, 2019   
    Comparative analysis of safety and efficacy of mask anesthesia with Sevoflurane and Halothane for nasolacrimal duct intubation in children in the supine position showed Sevoflurane to be more preferable. The advantages of Sevoflurane anesthesia for nasolacrimal duct intubation in children in the supine position are higher anesthesia induction speed, absence of respiratory tract irritation, cardiodepressive effects or suppression of laryngeal reflexes, and minimum time between the end of anesthesia and awakening.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Preclinical, Journal:  Involvement of leukotriene pathway in the development of sevoflurane-induced pica in rats. (Pubmed Central) -  Aug 17, 2019   
    Furthermore, we observed that sevoflurane significantly increased urinary leukotriene excretion and 5-lipoxygenase mRNA expression in the spleen, but not hypothalamus. These results suggest that the production of leukotriene may lead to the development of sevoflurane-induced pica in rats, and that inhibition of the leukotriene pathway could be potentially useful for the treatment of PONV.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  Hypnotic potency differs between desflurane and sevoflurane. (Pubmed Central) -  Aug 16, 2019   
    Our data showed Sevoflurane inhibits the migration and invasion of colorectal cancer cells by regulating microRNA-34a/ADAM10 axis. No abstract available
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Comparison of the Effects of TIVA vs VIMA on Content of GSK-3beta in Leucocytes in On-pump Patients (clinicaltrials.gov) -  Aug 15, 2019   
    P4,  N=10, Terminated, 
    No abstract available N=21 --> 10 | Trial completion date: Mar 2017 --> Dec 2018 | Not yet recruiting --> Terminated | Trial primary completion date: Dec 2016 --> Dec 2018
  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date:  MACBIS50 in Patients Undergoing CAG During Normothermic CPB Phase. (clinicaltrials.gov) -  Aug 14, 2019   
    P=N/A,  N=30, Recruiting, 
    N=45 --> 0 | Not yet recruiting --> Withdrawn Trial primary completion date: Jul 2019 --> Oct 2019
  • ||||||||||  fentanyl citrate / generics
    Journal:  Fentanyl vs fentanyl-dexmedetomidine in lumbar foraminotomy surgery. (Pubmed Central) -  Aug 14, 2019   
    On the other hand, requirement of morphine, and postoperative symptoms and episodes of nausea and vomiting were significantly greater in the Fen group than in the Fen-Dex group (p<0.05). The present study suggests the addition of dexmedetomidine during lumbar foraminotomy surgery at different levels would be beneficial to reduce morphine consumption and any adverse drug reaction.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  Dopamine D2-receptor Antagonist Droperidol Deepens Sevoflurane Anesthesia. (Pubmed Central) -  Aug 8, 2019   
    However, the influence of propofol on cognitive function is relatively smaller, which presents a better application value. Droperidol augments both α and δ-θ bicoherences while shifting the α-bicoherence peaks to lower frequencies, and enhances the effect of sevoflurane anesthesia on the electroencephalogram via γ-aminobutyric acid-mediated oscillatory network regulation.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Journal:  Modern Anesthetic Ethers Demonstrate Quantum Interactions with Entangled Photons. (Pubmed Central) -  Aug 7, 2019   
    ...In this work, we studied the linear and non-linear optical properties of the halogenated ethers sevoflurane (SEVO) and isoflurane (ISO), using UV-Vis spectroscopy, time dependent-density functional theory (TD-DFT) calculations, classical two-photon spectroscopy, and entangled two-photon spectroscopy...By contrast, nonhalogenated diethyl ether does not interact with entangled photons. This is the first experimental evidence that halogenated anesthetics can directly undergo quantum interaction mechanisms, offering a new approach to understanding their physicochemical properties.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Clinical, Journal:  Intraoperative feasibility of bulbocavernosus reflex monitoring during untethering surgery in infants and children. (Pubmed Central) -  Aug 7, 2019   
    ...Anesthesia was maintained by propofol or sevoflurane/opioid without neuromuscular blockade...Therefore, the sensitivity and specificity of BCR monitoring used to predict postoperative urinary and bowel dysfunction were 100 and 70.6%, respectively. BCR monitoring during untethering surgery in infants and children under general anesthesia was found to be a feasible method to prevent postoperative urinary and bowel dysfunction.
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg., tramadol / Fortress
    Clinical, Journal:  Effects of Ultrasound-Guided Thoracic Paravertebral Block on Postoperative Pain in Children Undergoing Percutaneous Nephrolithotomy. (Pubmed Central) -  Aug 6, 2019   
    Patient demographics, haemodynamic parameters, peripheral oxygen saturation and sevoflurane concentration were recorded...Pain scores were significantly lower in Group PVB compared with Group P (p=0.001). There were no analgesic requirements in Group PVB; however, all patients needed a supplemental analgesic in Group P. Parental satisfaction was higher in Group PVB than in Group P. This study demonstrated that ultrasound-guided PVB provides more effective postoperative analgesia with no side effects compared to intravenous paracetamol in children undergoing PNL.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    Trial completion, Trial completion date, Trial primary completion date:  Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children (clinicaltrials.gov) -  Aug 6, 2019   
    P=N/A,  N=154, Completed, 
    There were no analgesic requirements in Group PVB; however, all patients needed a supplemental analgesic in Group P. Parental satisfaction was higher in Group PVB than in Group P. This study demonstrated that ultrasound-guided PVB provides more effective postoperative analgesia with no side effects compared to intravenous paracetamol in children undergoing PNL. Recruiting --> Completed | Trial completion date: Feb 2019 --> May 2019 | Trial primary completion date: Feb 2019 --> May 2019
  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Preclinical, Journal:  IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway. (Pubmed Central) -  Aug 3, 2019   
    In comparison with sevoflurane-based inhalational anesthesia, propofol/remifentanil -based total intravenous anesthesia can effectively inhibit the release of VEGF-C induced by breast surgery, but didn't seem to be beneficial in the short-term recurrence rate of breast cancer. Anti-IL-17A may alleviate neuroinflammation and oxidative stress via inhibiting NF-κB pathway, thereby attenuating post-operative cognitive dysfunction (POCD) in aged rats anaesthetized with sevoflurane.