sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Greening the Operating Room (GOR): High-impact initiatives Urologists' can facilitate to jumpstart a program (302B) -  Mar 12, 2024 - Abstract #AUA2024AUA_918;    
    Anesthetic gases : Reducing Nitrous oxide, desflurane, sevoflurane, and isoflurane use, and increasing the use of monitored sedation or regional anesthesia, when possible, helps reduce anesthetic gas use. We present easily implemented high-impact GOR initiatives aligned with industry best practices that any Urologist can initiate to kickstart a GOR program in their own organization and reduce the environmental/climate impacts of healthcare in their community.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane exerts antidepressant-like effects via the BDNF-TrkB pathway. (Pubmed Central) -  Mar 11, 2024   
    Intriguingly, this antidepressant-like effect was abrogated following the downregulation of TrkB expression through the microinjection of siRNA into the lateral ventricle. In conclusion, this study provides evidence supporting the notion that sevoflurane exerts its antidepressant-like effect via the BDNF-TrkB signaling pathway.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Astrocytic phagocytosis in the medial prefrontal cortex jeopardises postoperative memory consolidation in mice. (Pubmed Central) -  Mar 8, 2024   
    The clinical setting of perioperation was mimicked via partial hepatectomy under sevoflurane anaesthesia together with preoperative restraint stress (Hep-Sev-stress) in mice...Limiting astrocyte activation in the mPFC alleviated memory consolidation impairment induced by Hep-Sev-stress. Postoperative memory consolidation was impaired due to astrocytic phagocytosis-induced connectivity injury from the dorsal hippocampus to the medial prefrontal cortex.
  • ||||||||||  dexmedetomidine / Generic mfg.
    Journal, Surgery:  The feasibility of dexmedetomidine-led anesthesia maintenance strategy during major abdominal surgery. (Pubmed Central) -  Mar 6, 2024   
    However, further research is required to assess the long-term impact of such education and the variability in practice patterns across different institutions. Commonly used anesthetics, such as sevoflurane and propofol, have been reported to affect postoperative cognitive function...The anesthesia maintenance was achieved with dexmedetomidine, remifentanil and rocuronium...Perioperative bradycardia and hypertension could be rapidly corrected with atropine and nitroglycerin...dexmedetomidine-led strategy could maintain stable depth of anesthesia throughout surgery, and the ED50 of dexmedetomidine infusion rates was 2.298
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Review, Journal:  Research Progress of Hippocampal Dopamine System Changes in Perioperative Neurocognitive Disorders. (Pubmed Central) -  Mar 4, 2024   
    For clinical application, it is recommended that physicians exercise caution when selecting and managing anesthetic drugs by adopting comprehensive cognitive assessment methods to reduce post-anesthesia cognitive risk. Overall, this review provides a better understanding of the relationship between the hippocampal DA system and perioperative neurocognitive function and provides valuable guidance for prevention and treatment strategies for PND.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Retrospective data, Review, Journal:  Incidence of emergence agitation in children undergoing sevoflurane anesthesia compared to isoflurane anesthesia: An (Pubmed Central) -  Mar 4, 2024   
    The risk of emergence agitation in children after maintenance anesthesia with sevoflurane is significantly greater than with isoflurane; we did not find evidence of prolonged emergence or postanesthetic length of stay. When possible, isoflurane should be considered for maintenance anesthesia over sevoflurane in patients at high risk of emergence agitation.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Preclinical, Journal:  Mouse and Rat Anesthesia and Analgesia. (Pubmed Central) -  Mar 1, 2024   
    Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Injectable anesthesia for mouse and rat Basic Protocol 2: Inhalant anesthesia using isoflurane for mouse and rat Basic Protocol 3: Analgesia for mice and rats.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion:  NACOS: Namsos Anaesthesia Children Outcome Study (clinicaltrials.gov) -  Feb 29, 2024   
    P=N/A,  N=761, Completed, 
    Basic Protocol 1: Injectable anesthesia for mouse and rat Basic Protocol 2: Inhalant anesthesia using isoflurane for mouse and rat Basic Protocol 3: Analgesia for mice and rats. Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg., clonidine / Generic mfg.
    New trial:  Regional Anesthesia EMG Study (clinicaltrials.gov) -  Feb 29, 2024   
    P=N/A,  N=124, Recruiting, 
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Sevoflurane Alters Serum Metabolites in Elders and Aging Mice and Increases Inflammation in Hippocampus. (Pubmed Central) -  Feb 28, 2024   
    Notably, isatin levels significantly decreased after anesthesia, a factor known to stimulate proliferation and proinflammatory gene expression in microglia-the pivotal cell type in inflammatory responses. Sevoflurane-induced alterations in serum metabolites in both elderly patients and aging mice, subsequently contributing to increased inflammation in the hippocampus.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  MiR-181a-5p knockdown ameliorates sevoflurane anesthesia-induced neuron injury via regulation of the DDX3X/Wnt/?-catenin signaling axis. (Pubmed Central) -  Feb 26, 2024   
    Rescue experiments revealed that DDX3X knockdown or overexpression of Wnt antagonist Dickkopf-1 (DKK1) reversed the suppressive effects of miR-181a-5p inhibitor on cell apoptosis, inflammatory response, and oxidative stress in sevoflurane-treated neuronal cells. MiR-181a-5p ameliorated sevoflurane-triggered neuron injury by regulating the DDX3X/Wnt/?-catenin axis, suggesting the potential of miR-181a-5p as a novel and promising therapeutic target for the treatment of sevoflurane-evoked neurotoxicity.
  • ||||||||||  Life-Threatening Pulmonary Manifestation of Plasminogen-Deficiency Type I in a 16-Month-Old Boy: A Case Report (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_6554;    
    He eventually required ketamine, sevoflurane administration, and invasive mechanical ventilation...Chest physiotherapy and inhaled N-acetylcysteine were promptly initiated, allowing for the discontinuation of ECMO therapy within 24 hours... Through this case report, we aim to raise awareness of this rare disease which can present with severe respiratory failure due to mucus plugging masquerading as status asthmaticus with a potentially fatal outcome.
  • ||||||||||  sevoflurane / Generic mfg.
    Evaluation of Waste Anesthetic Gas Exposure at a Veterinary Hospital (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_3823;    
    Additionally, commonly performed tasks, such as improper timing of endotracheal cuff inflation, could result in regular exposure to WAG, particularly if adequate exposure controls are lacking, and the health consequences of such exposures remain unclear. We recommended reinforcing training of workplace exposures and safe work practices.
  • ||||||||||  sevoflurane / Generic mfg.
    A Rare Case of Sevoflurane-associated Diffuse Alveolar Hemorrhage (San Diego Convention Center, Area J (Hall H, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_1899;    
    During the GA, he received propofol, rocuronium, hydromorphone, ketorolac and sevoflurane...He received three doses of intravenous tranexamic acid, fresh frozen plasma, and ceftriaxone...Sevoflurane-associated DAH should be considered in patients with acute pulmonary hemorrhage following GA, while other etiologies are excluded. Despite a lack of recurrence and cross-reactivity data, we recommend life-long avoidance of sevoflurane and other halogenated anesthetics.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Nitrous oxide splurge in a tertiary health care center and its environmental impact: No more laughing stock. (Pubmed Central) -  Feb 16, 2024   
    As a greenhouse gas that has been present in the atmosphere for more than 100 years and damages the ozone layer, nitrous oxide is three times worse than sevoflurane...This indicates that the environmental impact of nitrous oxide (in terms of CO2 equivalents) from our hospital in 2018, 2019, 2020, and 2021 was 13,016.64, 13,287.82, 10,289.94, and 10,841.24 tons, respectively. This huge amount of nitrous oxide splurge is no longer a matter of laughter, and serious efforts should be made at every central and peripheral health center level to reduce it.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Comparison of three scoring criteria to assess recovery from general anesthesia in the postanesthesia care unit in the indian population. (Pubmed Central) -  Feb 15, 2024   
    Induction of anesthesia was done with intravenous (IV) propofol and maintained with sevoflurane inhalation with oxygen and nitrous oxide...While using modified Aldrete score, majority of patients had a shorter stay in PACU and faster time to shift out as compared to fast-track criteria and traditional time-based criteria. Modified Aldrete score when compared to fast-track scoring and time-based criteria shows early recovery and reduces the length of stay in PACU.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  A Case Report of Anesthesia-induced Diffuse Alveolar Hemorrhage Presenting to the Emergency Department. (Pubmed Central) -  Feb 14, 2024   
    The inhaled anesthetic sevoflurane is an uncommon etiology of diffuse alveolar hemorrhage (DAH)...We highlight the etiology of post-anesthesia DAH and the acute management of this rare diagnosis in the ED. With outpatient surgical centers becoming an increasingly popular option for lower risk procedures, emergency physicians would benefit from understanding this presentation and its pathophysiology.
  • ||||||||||  sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Trial completion:  GENERAL vs. REGIONAL ANESTHESIA ON SLEEP QUALITY FOR HIP ARTROPLASTY PATIENTS (clinicaltrials.gov) -  Feb 9, 2024   
    P=N/A,  N=66, Completed, 
    We, therefore, reviewed the current knowledge on mechanisms of iron dyshomeostasis and ferroptosis and aimed to promote a better understanding of their roles in sevoflurane- and isoflurane-induced neurotoxicity. Active, not recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  A Prospective Study of the Effects of General Anesthesia on Intraocular Pressure in Healthy Children. (Pubmed Central) -  Feb 5, 2024   
    Participants underwent a standardized general anesthetic protocol using a mask induction with sevoflurane and propofol maintenance...Intraocular pressure measurements taken 1 minute after induction with 3 minutes after airway placement are most predictive of preinduction IOP, though predictive value is relatively low. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
    Clinical, Surgery:  Comparison of Remimazolam versus Sevoflurane on the Postoperative Quality of Recovery in Cervical Spine Surgery: A Prospective Randomized Controlled Double-Blind Trial. (Pubmed Central) -  Feb 2, 2024   
    Instead, patients in group R showed significantly better sub-scores in psychological and postoperative nausea and vomiting (PONV) items on POD1, as well as a lower degree of PONV, than those in group S. Among the five dimensions of the QoR-15, a significant group-time interaction effect was observed for psychological support. Group R showed significantly less changeability in blood pressure and heart rate with a lower dose of intraoperatively administered vasopressor than group S. Considering QoR-15, including PONV reduction, and intraoperative hemodynamic stability, remimazolam can be used as the novel and safe anesthetic agent for maintaining general anesthesia instead of sevoflurane in patients undergoing ACDF.
  • ||||||||||  Journal:  Higher Brain Uptake of Gentamicin and Ceftazidime under Isoflurane Anesthesia Compared to Ketamine/Xylazine. (Pubmed Central) -  Jan 26, 2024   
    In conclusion, the present study extends our previous findings with permeability markers and suggests that inhalational anesthetic isoflurane increases the BBB permeability of hydrophilic small-molecule endobiotics or xenobiotics when compared to the injection of ketamine/xylazine. This may be of clinical relevance in the case of potential neurotoxic substances.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    A RUDE AWAKENING: A CASE OF SUGAMMADEX CAUSING TRANSIENT CARDIOMYOPATHY MIMICKING STEMI (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_3316;    
    The patient had been given propofol, rocuronium and sevoflurane. In patients who receive muscle relaxant reversal following anticholinergic therapy, clinicians should pay close attention to the potential risk of coronary vasospasm or stress induced cardiomyopathy.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment closed, Trial primary completion date:  Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation. (clinicaltrials.gov) -  Jan 25, 2024   
    P=N/A,  N=134, Active, not recruiting, 
    In patients who receive muscle relaxant reversal following anticholinergic therapy, clinicians should pay close attention to the potential risk of coronary vasospasm or stress induced cardiomyopathy. Recruiting --> Active, not recruiting | Trial primary completion date: Oct 2023 --> Jun 2023