sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Acute airway obstruction in a patient with forestier disease. Case report. (Pubmed Central) -  May 29, 2020   
    The case is reported of an eighty-five-year-old patient who had an acute airway obstruction associated with Forestier disease. A fibre-optic-assisted intubation was accomplished under sevoflurane inhaled anaesthesia, maintaining spontaneous ventilation, with subsequent tracheostomy performed by ENT surgeons.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Genome-Wide Screen of the Hippocampus in Aged Rats Identifies Mitochondria, Metabolism and Aging Processes Implicated in Sevoflurane Anesthesia. (Pubmed Central) -  May 28, 2020   
    The potential signaling pathways were further constructed including mitochondrion and oxidative stress-related Hifs-Prkcd-Akt-Nfe2l2-Sod1 signaling, multiple metabolism signaling (Scd2, Scap-Hmgcs2, Aldh18a1-Glul and Igf1r), as well as aging and neurodegeneration related signaling (Spidr-Ercc4-Cdkn1a-Pmaip1 and Map1lc3b). These results provide potential therapeutic gene targets for brain function modulation and memory formation process after inhaled anesthesia in the elderly, which could be valuable for preventing postoperative brain disorders and diseases, such as perioperative neurocognitive disorders (PND), from the genetic level in the future.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. (Pubmed Central) -  May 27, 2020   
    Sevoflurane attenuated FRET efficiency, indicating that sevoflurane hindered the interaction between Fas DD and FADD. The predicted sevoflurane binding site is known to play a significant role in Fas DD-FADD interaction, supporting our in vitro and in vivo apoptosis results.-Koutsogiannaki, S., Hou, L., Babazada, H., Okuno, T., Blazon-Brown, N., Soriano, S. G., Yokomizo, T., Yuki, K. The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Effects of sevoflurane on reproductive function of male rats and its main mechanism of action. (Pubmed Central) -  May 27, 2020   
    In addition, chronic exposure to sevoflurane down-regulated transcription of gonadotropin-releasing hormone (GnRH) and kisspeptin (Kiss)-1 as well as its receptor GPR54 in hypothalamus, attenuated GnRH receptor and LH-β mRNA levels, but increased FSH-β mRNA in pituitary gland, and enhanced mRNA of LH receptor and FSH receptor, but decreased INH-α and INH-βA mRNA levels in testes.Discussion and Sevoflurane induces disorders of spermatogenesis and causes testicular injury. The underlying mechanism may be related to the imbalance of sex hormones in the hypothalamic-pituitary-gonadal axis.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  The Effect of Intraoperative Music Listening on Sevoflurane Consumption and Recovery Parameters (clinicaltrials.gov) -  May 26, 2020   
    P=N/A,  N=60, Recruiting, 
    The underlying mechanism may be related to the imbalance of sex hormones in the hypothalamic-pituitary-gonadal axis. Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2019 --> Dec 2020
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    Preclinical, Journal:  Anesthesia and Preconditioning Induced Changes in Mouse Brain [F] FDG Uptake and Kinetics. (Pubmed Central) -  May 23, 2020   
    Choice of anesthesia and pre-conditioning affect not only [F] FDG uptake but also kinetics and regional distribution in the mouse brain. Both anesthesia and pre-conditioning should be carefully considered in the interpretation of [F] FDG studies due to its great influence on the uptake and distribution of the tracer along the brain regions.
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  Recent advances in the neuroprotective effects of medical gases. (Pubmed Central) -  May 23, 2020   
    Medical gases include common gases, such as oxygen, hydrogen and carbon dioxide; hydrogen sulphide and nitric oxide that have been considered toxic; volatile anesthetic gases, such as isoflurane and sevoflurane; and inert gases like helium, argon, and xenon...This delay could be attributed to the contradictory paradigms and the conflicting results that have been obtained from experimental models, as well as the presence of inconsistent reports regarding their safety. In this review, we summarize the potential mechanisms underlying the neuroprotective effects of medical gases and discuss possible candidates that could improve the outcomes of brain injury.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Surgery:  Impact of Different Modes of Ventilation With Laryngeal Mask Airway on Pediatric Cataract Surgery (clinicaltrials.gov) -  May 20, 2020   
    P=N/A,  N=150, Recruiting, 
    We hypothesize that low frontal alpha power and increased propensity for burst suppression together characterize a "vulnerable brain" phenotype under anesthesia that could be mechanistically linked to brain metabolism, cognition, and brain aging. Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Delta oscillations phase limit neural activity during sevoflurane anesthesia. (Pubmed Central) -  May 19, 2020   
    Taken together, our results suggest that subanesthetic and general anesthetic sevoflurane brain states emerge from impaired information processing instantiated by a delta-higher frequency phase-amplitude coupling syntax. These results provide fundamental new insights into the neural circuit mechanisms of sevoflurane anesthesia and suggest that anesthetic states may be produced by extracranial perturbations that cause delta-higher frequency phase-amplitude interactions.
  • ||||||||||  fentanyl citrate / Generic mfg., remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Journal:  Anesthetic Management of a Patient With Fanconi Anemia. (Pubmed Central) -  May 19, 2020   
    The patient received 20 units of platelet transfusion over 3 days prior to anesthesia. Dental surgery and multiple dental extractions were successfully completed under general anesthesia with sevoflurane, fentanyl, and remifentanil, and chemotherapy started 3 days postoperatively.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date, Surgery:  The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep (clinicaltrials.gov) -  May 18, 2020   
    P=N/A,  N=160, Not yet recruiting, 
    Dental surgery and multiple dental extractions were successfully completed under general anesthesia with sevoflurane, fentanyl, and remifentanil, and chemotherapy started 3 days postoperatively. Trial completion date: May 2020 --> Dec 2020 | Initiation date: Oct 2019 --> May 2020 | Trial primary completion date: Jan 2020 --> Dec 2020
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Pediatric Emergence Delirium: A Case Study. (Pubmed Central) -  May 18, 2020   
    The case is a 4-year-old male who had myringotomy tube placement while anesthetized with sevoflurane...Various interventions, both pharmacologic and nonpharmacologic are considered. The impact of anesthesia on pediatric brain development is discussed and finally some possible solutions are hypothesized.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane-induced inflammation development: involvement of cholinergic anti-inflammatory pathway. (Pubmed Central) -  May 13, 2020   
    Similarly, this sevoflurane-induced change of tumor necrosis factor-α level in rats was antagonized by PNU-282987 but amplified by methyllycaconitine. In conclusion, our data show that the development of inflammation in sevoflurane-induced cognitive decline is associated with the downregulation of alpha 7 nicotinic acetylcholine receptor cholinergic anti-inflammatory pathway in aged rats.
  • ||||||||||  sevoflurane / Generic mfg., AZD1480 / AstraZeneca
    Preclinical, Journal:  Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models. (Pubmed Central) -  May 13, 2020   
    Interruption of IL-6/JAK/STAT3 pathway by a JAK inhibitor AZD1480 reverses the pro-metastatic effect of sevoflurane and the associated increase of both activated STAT3 and infiltrated CD11b+ cells in 4T1 model. Our study provides the preclinical evidence informing the distinct effects of anesthetics on metastasis of breast cancers through change of cytokines and the tumor microenvironment.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open:  SESAR: SEvoflurane for Sedation in ARds (clinicaltrials.gov) -  May 12, 2020   
    P3,  N=700, Recruiting, 
    Our study provides the preclinical evidence informing the distinct effects of anesthetics on metastasis of breast cancers through change of cytokines and the tumor microenvironment. Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg., Avastin (bevacizumab) / Roche
    Journal:  Sevoflurane for Short Painful Procedures in the Neonatal Intensive Care Unit. (Pubmed Central) -  May 11, 2020   
     Sevoflurane is relatively easy to use and provides an optimal control of pain-related symptoms. Its prescription should be individualized and more long-term follow-up data are needed.
  • ||||||||||  Trial suspension:  Paravertebral Nerve Blocks in Neonates (clinicaltrials.gov) -  May 11, 2020   
    P4,  N=30, Suspended, 
    Isocapnic hyperventilation only had a small effect on emergence times after anesthesia, suggesting that isocapnic hyperventilation may have limited clinical benefits with modern potent inhaled anesthetics. Recruiting --> Suspended
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  VAPOR-2: Volatile Anesthetic Protection Of Renal Transplants 2 (clinicaltrials.gov) -  May 8, 2020   
    P4,  N=488, Recruiting, 
    This study demonstrates the clinical advantage and the simple technique of oral transmucosal DEX premedication for emergence agitation in preschool children undergoing tonsillectomy under sevoflurane anesthesia compared with saline placebo. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2020 --> Dec 2022
  • ||||||||||  Enrollment closed, Trial completion date, Trial primary completion date, Surgery:  The PATHFINDER Study: A Feasibility Trial (clinicaltrials.gov) -  May 6, 2020   
    P1,  N=22, Active, not recruiting, 
    The hemodynamic parameters did not show a significant difference between the groups except for a surge in mean arterial pressure at 30 minutes in group S. Conclusion  Low-dose dexmedetomidine as an adjuvant to sevoflurane- and fentanyl-based anesthesia could provide stable hemodynamics and lesser anesthetics and opioid consumption, without adversely affecting the recovery profile in patients undergoing supratentorial neurosurgical procedures. Recruiting --> Active, not recruiting | Trial completion date: Sep 2020 --> Dec 2020 | Trial primary completion date: May 2020 --> Sep 2020
  • ||||||||||  sevoflurane / Generic mfg.
    EFFECT OF ANESTHETICS DURING ENDOFLIP IMPACTS DIAGNOSIS OF ESOPHAGEAL MOTILITY DISORDERS () -  May 4, 2020 - Abstract #DDW2020DDW_6089;    
    Measurements of IBP and DI at 30 mL and 60 mL BV were obtained while the patient was sedated with propofol infusion alone and then half dose propofol combined with half minimal alveolar concentration (1/2 MAC) of sevoflurane...A significant portion of spastic disease showed no contractility on FLIP topography with ½ MAC. These findings suggest anesthetics could mask esophageal spasms and impact diagnosis.
  • ||||||||||  sevoflurane / Generic mfg., Bridion (sugammadex) / Merck (MSD)
    Journal:  Anesthetic Considerations of Intraoperative Neuromonitoring in Thyroidectomy. (Pubmed Central) -  Apr 30, 2020   
    These findings suggest anesthetics could mask esophageal spasms and impact diagnosis. The present findings suggest that anesthesiologists should use video laryngoscopy to correct tube dislocation and that a rocuronium dose of 0.6 mg/kg, without sugammadex, is adequate for IONM.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Comparison of tracheal intubation with controlled ventilation and laryngeal mask airway with spontaneous ventilation for thoracoscopic bullectomy. (Pubmed Central) -  Apr 30, 2020   
    The PaCO2 value was significantly higher in the intraoperative stage in the study group than in the control group (mean, 57.0 mm Hg vs 42.0 mm Hg, P = .015). In the study group, no cough reflex was found, and the level of collapse of the operative lung was excellent in 31 cases and good in 3 cases.Our study demonstrated that thoracoscopic bullectomy for treatment of PSP can be safely and feasibly performed in highly selected patients under ILMA with spontaneous breathing sevoflurane anesthesia combined with TPB.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Sevoflurane and Percutaneous Coronary Intervention by Stent (clinicaltrials.gov) -  Apr 28, 2020   
    P4,  N=701, Terminated, 
    Further investigations are necessary to determine the safe dosage of volatile anesthetics specifically for this clinical scenario so that anesthesiologists can use this combination method more accurately and precisely. N=1254 --> 701 | Trial completion date: Feb 2019 --> Apr 2020 | Active, not recruiting --> Terminated | Trial primary completion date: Sep 2017 --> Apr 2020; interim analysis suggests futility