sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    [VIRTUAL] RELATIONSHIP OF RISK-GUIDED PRACTICES AND OUTCOMES OF UPFRONT BIOPSIES OF ANTERIOR MEDIASTINAL MASSES IN CHILDREN. (Foyer) -  Aug 26, 2020 - Abstract #SIOP2020SIOP_858;    
    Procedural adverse events occurred in patients who had supine and lateral positioning and definitive airway devices, and was significantly associated with use of morphine and sevoflurane (P50% reduction in tracheal anteroposterior diameter did not encounter increased incidence of procedural adverse events. Our findings suggest that increased awareness of procedural risk factors and implementation of appropriate risk-avoidance practices may effectively obviate the procedural mortality historically associated with high-risk AMM biopsies.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Represses Proliferation and Migration of Glioma Cells by Regulating the ANRIL/let-7b-5p Axis. (Pubmed Central) -  Aug 22, 2020   
    In this study, adding a single injection of intravenous propofol and ketorolac to the end of a brief sevoflurane anesthetic for bilateral myringotomy with tube insertion was associated with a lower incidence of emergence agitation without significantly increasing the time to discharge from the hospital. Sevoflurane hindered proliferation and migration through JAK2/STAT3 pathway mediated by ANRIL and let-7b-5p in glioma cells, indicating a new reference for the application of anesthetics like sevoflurane in glioma.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Enrollment change:  Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension (clinicaltrials.gov) -  Aug 19, 2020   
    P4,  N=95, Completed, 
    Sevoflurane hindered proliferation and migration through JAK2/STAT3 pathway mediated by ANRIL and let-7b-5p in glioma cells, indicating a new reference for the application of anesthetics like sevoflurane in glioma. Recruiting --> Completed | N=60 --> 95
  • ||||||||||  Sufenta (sufentanil) / Akorn
    Trial completion, Surgery:  Remifentanil Anesthesia and Postoperative BIS in Cardiac Surgery (clinicaltrials.gov) -  Aug 19, 2020   
    P=N/A,  N=38, Completed, 
    Recruiting --> Completed | N=60 --> 95 Not yet recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Observational data, Retrospective data, Journal:  Sevoflurane with opioid or dexmedetomidine infusions in dogs undergoing intracranial surgery: a retrospective observational study. (Pubmed Central) -  Aug 18, 2020   
    Post-operative hypertension and agitation were the most common complications (11 and 12 out of 21 animals, respectively). These results suggest that the infusion of dexmedetomidine provides similar intra-operative conditions and post-operative course to a short acting opioid infusion during sevoflurane anesthesia in dogs undergoing elective rostrotentorial or transfrontal intracranial surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  DESEVAR: Desflurane vs. Sevoflurane in Endovascular Aortic Repair (clinicaltrials.gov) -  Aug 18, 2020   
    P4,  N=80, Recruiting, 
    The results of this study show that 1 µg/kg DEX is a beneficial adjuvant to ropivacaine for single-injection SAPB in VATS patients while stable hemodynamics were maintained. Trial completion date: Mar 2020 --> Dec 2020 | Trial primary completion date: Mar 2020 --> Dec 2020
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  Effects of Volatile and Intravenous Anesthetics on Pupillary Function (clinicaltrials.gov) -  Aug 17, 2020   
    P=N/A,  N=22, Recruiting, 
    Trial completion date: Mar 2020 --> Dec 2020 | Trial primary completion date: Mar 2020 --> Dec 2020 Not yet recruiting --> Recruiting | Trial completion date: Oct 2020 --> Feb 2021 | Trial primary completion date: Sep 2020 --> Feb 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Acute liver failure after sevoflurane anesthesia in a pediatric patient. (Pubmed Central) -  Aug 15, 2020   
    The clinical evolution was favorable and after 7 days, laboratory values were completely normalized. All the possible causes of acute liver failure were evaluated and the differential diagnosis is exposed.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  LncRNA Rik-203 Contributes to Sevoflurane Induced Neurotoxicity? (Pubmed Central) -  Aug 15, 2020   
    Overexpression of BDNF restored the neural differentiation repressed by miR-466l-3p and Rik-203 knockdown. Our study suggested that sevoflurane related LncRNARik-203 facilitates neural differentiation by inhibiting miR-466l-3p's ability to reduce BDNF levels.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  New Method of Destroying Waste Anesthetic Gases Using Gas-Phase Photochemistry. (Pubmed Central) -  Aug 12, 2020   
    This is likely also true for other halogenated inhalational anesthetics such as isoflurane. Due to differing chemistry of nitrous oxide, modifications of this prototype photochemical reactor system are necessary to improve its removal efficiency for this gas.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  End-tidal to Arterial Gradients and Alveolar Deadspace for Anesthetic Agents. (Pubmed Central) -  Aug 11, 2020   
    Unlike the three-compartment model, multicompartment VA/Q scatter models explain this from physiologically realistic gas uptake distributions, but suggest a residual factor other than solubility, potentially diffusion limitation, contributes to deadspace. : WHAT WE ALREADY KNOW ABOUT THIS TOPIC: General anesthesia increases the inhomogeneity (scatter) of the distribution of ventilation-perfusion ratios in the lung, widening alveolar to arterial partial pressure gradients for respired gasesThis inhomogeneity is reflected in increased alveolar deadspace fraction in the traditional three-compartment model of ventilation-perfusion scatterThe alveolar to arterial partial pressure difference for isoflurane is inconsistent with that measured simultaneously using end-tidal and arterial carbon dioxide partial pressures WHAT THIS ARTICLE TELLS US THAT IS NEW: Alveolar deadspace fraction calculated for volatile anesthetic agents is much larger than that calculated simultaneously for carbon dioxide, and its magnitude increases as blood solubility decreasesPhysiologically realistic multicompartment modeling of ventilation-perfusion scatter explains the relative differences between inhalational agents in alveolar to arterial partial pressure gradients and alveolar deadspace.
  • ||||||||||  sevoflurane / Generic mfg., decitabine / Generic mfg.
    Journal:  A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane. (Pubmed Central) -  Aug 10, 2020   
    : WHAT WE ALREADY KNOW ABOUT THIS TOPIC: General anesthesia increases the inhomogeneity (scatter) of the distribution of ventilation-perfusion ratios in the lung, widening alveolar to arterial partial pressure gradients for respired gasesThis inhomogeneity is reflected in increased alveolar deadspace fraction in the traditional three-compartment model of ventilation-perfusion scatterThe alveolar to arterial partial pressure difference for isoflurane is inconsistent with that measured simultaneously using end-tidal and arterial carbon dioxide partial pressures WHAT THIS ARTICLE TELLS US THAT IS NEW: Alveolar deadspace fraction calculated for volatile anesthetic agents is much larger than that calculated simultaneously for carbon dioxide, and its magnitude increases as blood solubility decreasesPhysiologically realistic multicompartment modeling of ventilation-perfusion scatter explains the relative differences between inhalational agents in alveolar to arterial partial pressure gradients and alveolar deadspace. These results suggest that similar decitabine-sensitive mechanisms regulating expression of multiple genes are involved in the mediation of neurobehavioral abnormalities in sires neonatally exposed to sevoflurane and in their future unexposed male offspring.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Anesthesia and Postoperative Outcome in Colorectal Cancer Patients (clinicaltrials.gov) -  Aug 8, 2020   
    P1,  N=450, Recruiting, 
    These results suggest that similar decitabine-sensitive mechanisms regulating expression of multiple genes are involved in the mediation of neurobehavioral abnormalities in sires neonatally exposed to sevoflurane and in their future unexposed male offspring. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2019 --> Dec 2020
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date, Surgery:  Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery (clinicaltrials.gov) -  Aug 8, 2020   
    P=N/A,  N=40, Active, not recruiting, 
    Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2019 --> Dec 2020 Recruiting --> Active, not recruiting | Trial completion date: Dec 2019 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Dec 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date, Surgery:  FESSSPI: SPI-guided Analgesia During FESS for Intraoperative Blood Loss (clinicaltrials.gov) -  Aug 8, 2020   
    P=N/A,  N=120, Recruiting, 
    Recruiting --> Active, not recruiting | Trial completion date: Dec 2019 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Dec 2021 Not yet recruiting --> Recruiting | Trial completion date: Jan 2021 --> Jul 2021 | Trial primary completion date: Jan 2021 --> Jul 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date:  SEVONATE: Nitrous Oxide Added at the End of Sevoflurane Anesthesia and Recovery (clinicaltrials.gov) -  Aug 8, 2020   
    P=N/A,  N=100, Recruiting, 
    Not yet recruiting --> Recruiting | Trial completion date: Jan 2021 --> Jul 2021 | Trial primary completion date: Jan 2021 --> Jul 2021 Trial primary completion date: Feb 2020 --> Feb 2021
  • ||||||||||  ketorolac / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Ketorolac on Post Adenotonsillectomy Pain (clinicaltrials.gov) -  Aug 8, 2020   
    P4,  N=120, Recruiting, 
    Trial primary completion date: Feb 2020 --> Feb 2021 Trial completion date: Aug 2020 --> Aug 2021 | Trial primary completion date: Aug 2020 --> Aug 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Acquisition of sensorimotor fMRI under general anaesthesia: Assessment of feasibility, the BOLD response and clinical utility. (Pubmed Central) -  Aug 7, 2020   
    Within a 1.5 T MRI operating room immediately prior to neurosurgery, a passive finger flexion sensorimotor paradigm was performed on each hand with the patients awake, and then immediately after the induction and maintenance of combined sevoflurane and propofol general anaesthesia...These results demonstrate the feasibility of the technique and its potential value if applied intra-operatively. Additionally these methods may enable fMRI investigations in patients unable to perform or lie still for awake paradigms, such as young children, claustrophobic patients and those with movement disorders.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane, a sigh of relief in COVID-19? (Pubmed Central) -  Aug 7, 2020   
    In conclusion, 15 mg/kg BW of IV paracetamol did not significantly reduce sevoflurane MAC in healthy dogs. No abstract available
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  The Use of Bispectral Index Monitoring Does Not Change Intraoperative Exposure to Volatile Anesthetics in Children. (Pubmed Central) -  Aug 6, 2020   
    The duration of time in the recovery room, the time to meet discharge criteria, the Pediatric Agitation Emergence Delirium (PAED) scores and the Face, Legs, Activity, Cry, Consolability (FLACC) scores were not statistically different between the groups. The application and utilization of intraoperative BIS monitoring does not alter the sevoflurane administration nor the discharge readiness nor the recovery profile in healthy ambulatory children.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Sevoflurane EC50 for intravenous cannulation attempt and movement in children. (Pubmed Central) -  Aug 2, 2020   
    The application and utilization of intraoperative BIS monitoring does not alter the sevoflurane administration nor the discharge readiness nor the recovery profile in healthy ambulatory children. Intravenous cannulation can be accomplished without movements at end tidal sevoflurane of 1.3% in children aged 1-3 years in 50% of children.
  • ||||||||||  sevoflurane / Generic mfg.
    [VIRTUAL] Selective impairment of molecular interaction between ADP and ATP synthase by anesthetics () -  Aug 2, 2020 - Abstract #AAIC2020AAIC_339;    
    Further studies will be performed to examine the infiltration of monocytes into the brain and cognitive dysfunction induced by laparotomy. These findings suggest that isoflurane has more binding sites with ATP synthase than sevoflurane or desflurane, which impairs the molecular interaction of ADP and ATP synthase, leading to the selective mitochondrial dysfunction and neurotoxicity observed following the administration of isoflurane but not sevoflurane or desflurane.