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13 Diseases |  |
542 Trials |
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542 Trials |  |
5582 News |  |
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- | sevoflurane / Generic mfg.
Biomarker, Clinical, Journal: Lidocaine effects on neutrophil extracellular trapping and angiogenesis biomarkers in postoperative breast cancer patients with different anesthesia methods: a prospective, randomized trial. (Pubmed Central) - Apr 28, 2024
This supports the hypothesis that intravenous lidocaine during cancer surgery aimed at achieving a cure may potentially decrease the likelihood of recurrence. Further interpretation and discussion of clinical implications are warranted, emphasizing the significance of these findings in the context of cancer surgery and recurrence prevention.
- | ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Journal: Comparison of Hemodynamic Parameters Based on the Administration of Remimazolam or Sevoflurane in Patients under General Anesthesia in the Beach Chair Position: A Single-Blinded Randomized Controlled Trial. (Pubmed Central) - Apr 27, 2024
There were no significant differences in the postoperative complications or hospital LOS between the two groups. Remimazolam should be considered as an anesthetic agent to prevent hypotension when switching to BCP, and hypotension may occur frequently in patients with high baseline BP.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Preclinical, Journal: The Effects of Volatile Anesthetics on Renal Sympathetic and Phrenic Nerve Activity during Acute Intermittent Hypoxia in Rats. (Pubmed Central) - Apr 27, 2024
Volatile anesthetics, isoflurane and sevoflurane, blunted the RSNA response to AIH in comparison to urethane anesthesia. Additionally, the PNA response to acute intermittent hypoxia was preserved, indicating that the respiratory system might be more robust than the sympathetic system response during exposure to acute intermittent hypoxia.
- || sevoflurane / Generic mfg.
Retrospective data, Review, Journal: Comparison of postoperative pain in children after maintenance anaesthesia with propofol or sevoflurane: a systematic review and meta-analysis. (Pubmed Central) - Apr 27, 2024
Children maintained on inhalational sevoflurane had higher odds of postoperative pain compared with those maintained on propofol. The results also suggest that sevoflurane is associated with higher odds of needing postoperative rescue analgesia compared with propofol.
- | sevoflurane / Generic mfg.
Journal: Delayed awakening after sevoflurane anesthesia for MRI brain in a child with undiagnosed mitochondrial disorder. (Pubmed Central) - Apr 26, 2024
The results also suggest that sevoflurane is associated with higher odds of needing postoperative rescue analgesia compared with propofol. No abstract available
- | sevoflurane / Generic mfg.
Journal: Comparison of automated and manual control methods in minimal flow anesthesia. (Pubmed Central) - Apr 25, 2024
No abstract available The ACA mode was more advantageous than the MCA mode, reaching target AA concentrations faster and requiring fewer adjustments to achieve a constant depth of anesthesia.
- | ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
New trial, Surgery: Effect of Combined Administration of Sevoflurane and Remimazolam on Emergence (clinicaltrials.gov) - Apr 25, 2024
P=N/A, N=24, Not yet recruiting, Sponsor: Pusan National University Yangsan Hospital
- | morphine sulphate / Generic mfg., sevoflurane / Generic mfg.
Journal: Advances in pediatric anesthesia services over the past 10?years in French-speaking sub-Saharan Africa. (Pubmed Central) - Apr 24, 2024
However, major efforts must be continued. Standards adapted to the local context should be formulated.
- | remifentanil / Generic mfg., sevoflurane / Generic mfg.
Journal, Surgery: Impact of various anesthetic regimens on motor-evoked potentials in infants undergoing spinal surgery: A case series. (Pubmed Central) - Apr 23, 2024
Adding low-dose inhalation anesthetic to propofol-based TIVA suppresses MEP amplitudes in infants. The optimal anesthetic regimen for infants requires further investigation.
- | sevoflurane / Generic mfg., dantrolene / Generic mfg.
Journal, Surgery: Diagnosis and rescue of malignant hyperthermia induced by anesthesia during radical surgery in a cervical cancer patient using the National Remote Emergency System: A case report. (Pubmed Central) - Apr 23, 2024
The optimal anesthetic regimen for infants requires further investigation. The experience can provide a basis use of MH-NRES and improve the ability of anesthesiologists to deal with intraoperative MH as well as increase the survival probability of patients.
- | sevoflurane / Generic mfg.
New P4 trial, Surgery: PENIS: Effect of Propofol vs. Sevoflurane on Erections During Narcosis In Transurethral Surgery (clinicaltrials.gov) - Apr 22, 2024
P4, N=200, Recruiting, Sponsor: Etienne Xavier Keller
- | sevoflurane / Generic mfg.
Enrollment open, Surgery: PSIOS: Differences in Speed of Recovery From Anesthesia for Intraoral Surgery (clinicaltrials.gov) - Apr 22, 2024
P=N/A, N=42, Recruiting, Sponsor: Clinical Hospital Centre Zagreb
The experience can provide a basis use of MH-NRES and improve the ability of anesthesiologists to deal with intraoperative MH as well as increase the survival probability of patients. Not yet recruiting --> Recruiting
- | sevoflurane / Generic mfg.
Preclinical, Journal: Activity of the sodium leak channel maintains the excitability of paraventricular thalamus glutamatergic neurons to resist anesthetic effects of sevoflurane in mice. (Pubmed Central) - Apr 16, 2024
Not yet recruiting --> Recruiting Activity of sodium leak channel maintains the excitability of paraventricular thalamus glutamatergic neurons to resist the anesthetic effects of sevoflurane in mice.
- | sevoflurane / Generic mfg.
Journal: Discovering the Intriguing Properties of Extrasynaptic ?-Aminobutyric Acid Type A Receptors. (Pubmed Central) - Apr 16, 2024
This tonic current is highly sensitive to most general anesthetics, including sevoflurane and propofol, and likely contributes to the memory-blocking properties of these drugs...?5GABAARs are highly sensitive to GABA, desensitize slowly, and are thus well suited for detecting low, persistent, ambient concentrations of GABA in the extracellular space. Interest in ?5GABAARs has surged since the PNAS report, driven by their pivotal roles in cognitive processes and their potential as therapeutic targets for treating various neurologic disorders.
- | sevoflurane / Generic mfg.
Preclinical, Journal, PARP Biomarker: Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. (Pubmed Central) - Apr 16, 2024
SYR exerts neuroprotective effects on sevoflurane-induced cognitive dysfunction by modulating glial activity, apoptotic signaling, and Tau phosphorylation through the SIRT1 pathway. These findings could inform clinical strategies to safeguard cognitive function in patients undergoing anesthesia.
- | sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Choice of anesthesia technique is associated with earlier hospital discharge and reduced costs after transcatheter transfemoral aortic valve implantation. (Pubmed Central) - Apr 15, 2024
The median hospital length of stay was 5 [interquartile range (IQR): 3, 10] and 7 (IQR: 4, 12) days, P=0.01, and after adjustment for inflation, the total hospital case costs were $48,984 (IQR: $44,802, $61,438) Canadian (CAD) vs. $55,333 (IQR: $46,832, $68,702) CAD, P=0.01, in the conscious sedation and general anesthesia groups, respectively. Advancements in TAVI technologies, conscious sedation and a collaborative, multidisciplinary team approach reduces overall length of hospital stay and procedure costs.
- ||| sevoflurane / Generic mfg.
Journal, Adverse events: Efficacy of Sevoflurane and Propofol Anesthesia on Perioperative Adverse Cardiovascular Events and Hemodynamics in Elderly Patients With Diabetes. (Pubmed Central) - Apr 15, 2024
Advancements in TAVI technologies, conscious sedation and a collaborative, multidisciplinary team approach reduces overall length of hospital stay and procedure costs. Compared with propofol IV general anesthesia, sevoflurane inhalation anesthesia can improve perioperative hemodynamics stability and reduce the incidence of PACE in elderly patients with diabetes undergoing noncardiac surgery.
- | sevoflurane / Generic mfg.
Journal: Influencing Factors of Delirium during Recovery in Urological Postoperative Patients Undergoing Sevoflurane Anaesthesia. (Pubmed Central) - Apr 11, 2024
Compared with propofol IV general anesthesia, sevoflurane inhalation anesthesia can improve perioperative hemodynamics stability and reduce the incidence of PACE in elderly patients with diabetes undergoing noncardiac surgery. Age, history of diabetes, operation time, ASA classification and sevoflurane inhalation concentration are the influencing factors.
- | ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Retrospective data, Journal: Exploring the Utility of remimazolam in cesarean sections under general anesthesia: A preliminary retrospective analysis and Implications for future study. (Pubmed Central) - Apr 10, 2024
These results cannot exclude all adverse effects of remimazolam during cesarean delivery. Further randomized controlled trials must be conducted to obtain high-quality evidence.
- | sevoflurane / Generic mfg.
Journal: Analysis Comparing the Recovery of Airway Reflexes and Cognitive Ability After Sevoflurane with Desflurane Anesthesia. (Pubmed Central) - Apr 10, 2024
For all the other time intervals of T1, T3, and T4, there was evidence of the significant variance.(P = 0.003; 0.0013; <0.001, respectively). Desflurane causes patients to recover more quickly than sevoflurane does after laparoscopic cholecystectomy under controlled circumstances.
- | sevoflurane / Generic mfg.
Biomarker, Journal, Surgery: Comparison of combined intravenous and inhalation anesthesia and total intravenous anesthesia in laparoscopic surgery and the identification of predictive factors influencing the delayed recovery of neurocognitive function. (Pubmed Central) - Apr 9, 2024
In addition to this, the duration from the sevoflurane tank being closed to the extubation period demonstrated a significant reduction in the CIVIA group compared to the TIVA group (p?<?0.05)...The CIVIA technique outperforms the TIVA method in terms of overall assessment in the setting of laparoscopic surgery. It's also important to remember that an increased blood IL-6 level during laparoscopy may operate as a separate risk factor for a delay in the restoration of neurocognitive function.
- | Zolinza (vorinostat) / Merck (MSD)
Journal, Surgery: Suberoylanilide hydroxamic acid attenuates cognitive impairment in offspring caused by maternal surgery during mid-pregnancy. (Pubmed Central) - Apr 2, 2024
SAHA alleviated the cognitive dysfunction and rescued the changes in the protein levels of p-CREB, BDNF and p-TrkB induced by maternal propofol exposure alone or maternal propofol exposure plus surgery. Therefore, SAHA could be a potential and promising agent for treating the learning and memory deficits in offspring caused by maternal nonobstetric surgery under propofol anesthesia.
- | sevoflurane / Generic mfg.
Journal, Gene Expression Profile: Similarity and dissimilarity in alterations of the gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane. (Pubmed Central) - Apr 1, 2024
Our bioinformatics analyses revealed that sevoflurane and, to a greater extent, desflurane significantly activated genes related to xenobiotic metabolism. Our analyses also revealed that both anesthetic agents, especially sevoflurane, downregulated many genes related to immune response.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Damage-associated molecular patterns as a mechanism of sevoflurane-induced neuroinflammation in neonatal rodents. (Pubmed Central) - Apr 1, 2024
In conclusion, 6 h of sevoflurane exposure induces neuroinflammation through the DAMPs pathway, HMGB-1, and galectin-3. Co-administration of ibuprofen reduced sevoflurane-induced neuroinflammation.
- | sevoflurane / Generic mfg.
Journal: Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity. (Pubmed Central) - Apr 1, 2024
Our findings demonstrated that C1q-mediated microglial synaptic elimination by enhancing desialylation contributed to sevoflurane-induced developmental neurotoxicity. Inhibition of C1q or sialidase may be a potential therapeutic strategy for this neurotoxicity.
- | ciprofol injectable emulsion (HSK3486) / Haisco
Preclinical, Journal: A Common Neuronal Ensemble in the Lateral Habenula Regulates Ciprofol Anesthesia in Mice. (Pubmed Central) - Mar 28, 2024
Chemogenetic activation of ciprofol-activated neurons in the LHb delays the emergence of anesthesia and induces a deep hypnotic state during the emergence phase. Taken together, our findings suggest that LHb ciprofol-activated neurons modulate the state of consciousness and could potentially be targeted to manipulate consciousness during ciprofol anesthesia.
- | dexmedetomidine / Generic mfg.
Journal: Impact of a Dexmedetomidine Intravenous Infusion in Septic Dogs: Preliminary Study. (Pubmed Central) - Mar 28, 2024
Mortality was statistically lower in the DEX group (1/10) vs. the NaCl group (5/6). Results of this study suggest that a 1 mcg/kg/h CRI of dexmedetomidine decreases the demand for intraoperative vasopressors and may improve survival in septic dogs.
- | sevoflurane / Generic mfg.
Journal: Influence of Sevoflurane on the Neurological Pupil Index in Surgical and Critically Ill Patients: A Pilot Study. (Pubmed Central) - Mar 28, 2024
Results of this study suggest that a 1 mcg/kg/h CRI of dexmedetomidine decreases the demand for intraoperative vasopressors and may improve survival in septic dogs. The administration of inhaled sevoflurane was associated with a significant reduction in the NPi values of the ICU patients with a concomitant brain injury.
- | sevoflurane / Generic mfg.
Journal: Early sevoflurane sedation in severe COVID-19-related lung injury patients. A pilot randomized controlled trial. (Pubmed Central) - Mar 27, 2024
P3
Unexpectedly low blood levels of IL-6 might indicate a moderate injury with therefore limited improvement options of sevoflurane. Acute renal issues suggest caution in using sevoflurane for sedation in COVID-19.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Preclinical, Journal: Xenobiotics Triggering Acute Intermittent Porphyria and Their Effect on Mouse Brain Respiratory Complexes. (Pubmed Central) - Mar 27, 2024
The damage to the respiratory chain by ALA could be reflecting the pathophysiological condition of patients with AIP. Better understanding the broad effect of porphyrinogenic drugs and the mechanisms acting on the onset of AIP is vital in translational medicine.
- || sevoflurane / Generic mfg.
Clinical, Video, Surgery: The Use of Preoperative Video Distraction on Emergence Delirium in Preschool Children Undergoing Strabismus Surgery Under Anesthesia with Sevoflurane: A Randomized Controlled Trial. (Pubmed Central) - Mar 27, 2024
Better understanding the broad effect of porphyrinogenic drugs and the mechanisms acting on the onset of AIP is vital in translational medicine. The simple modified Yale Perioperative Anxiety Scale scores at separation from parents and the onset of inhalation induction in Group V were significantly lower than those in Group C (36.4
- | sevoflurane / Generic mfg.
Preclinical, Journal: Post-treatment with maropitant reduces oxidative stress, endoplasmic reticulum stress and neuroinflammation on peripheral nerve injury in rats. (Pubmed Central) - Mar 24, 2024
The simple modified Yale Perioperative Anxiety Scale scores at separation from parents and the onset of inhalation induction in Group V were significantly lower than those in Group C (36.4 These findings demonstrate that the determined dose, administered daily for seven days, had an antinociceptive effect, as well as anti-inflammatory and antioxidant activity.
- | sevoflurane / Generic mfg.
Journal: Echinatin mitigates sevoflurane-induced neurotoxicity through regulation of ferroptosis and iron homeostasis. (Pubmed Central) - Mar 22, 2024
Through the regulation of ferroptosis, iron homeostasis, and inflammation, Echinatin demonstrates significant neuroprotection both in vitro and in vivo. These findings illuminate the potential for Echinatin to enhance the safety of surgical procedures involving sevoflurane anesthesia, minimizing the risk of cognitive deficits and neurotoxicity.
- | sevoflurane / Generic mfg.
Trial completion: Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation. (clinicaltrials.gov) - Mar 21, 2024
P=N/A, N=134, Completed, Sponsor: Medical University of South Carolina
These findings illuminate the potential for Echinatin to enhance the safety of surgical procedures involving sevoflurane anesthesia, minimizing the risk of cognitive deficits and neurotoxicity. Active, not recruiting --> Completed
- | ketorolac / Generic mfg.
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Effect of Ketorolac on Post Adenotonsillectomy Pain (clinicaltrials.gov) - Mar 21, 2024
P4, N=63, Completed, Sponsor: Emory University
Active, not recruiting --> Completed Recruiting --> Completed | N=120 --> 63 | Trial completion date: Sep 2024 --> Aug 2023 | Trial primary completion date: Sep 2024 --> Aug 2023
- | sevoflurane / Generic mfg.
New trial: Cerebral and Peripheral Near Infrared Spectroscopy Monitoring in Low and High Flow Anaesthesia in Pediatric (clinicaltrials.gov) - Mar 21, 2024
P=N/A, N=56, Recruiting, Sponsor: Ankara City Hospital Bilkent
- | sevoflurane / Generic mfg.
Enrollment open, Enrollment change, Trial completion date, Trial primary completion date: General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia (clinicaltrials.gov) - Mar 21, 2024
P=N/A, N=366, Recruiting, Sponsor: Peking University First Hospital
Recruiting --> Completed | N=120 --> 63 | Trial completion date: Sep 2024 --> Aug 2023 | Trial primary completion date: Sep 2024 --> Aug 2023 Not yet recruiting --> Recruiting | N=90 --> 366 | Trial completion date: Aug 2024 --> Aug 2026 | Trial primary completion date: Mar 2024 --> Mar 2026
- | sevoflurane / Generic mfg.
Preclinical, Journal: Anesthetic Sevoflurane Induces Enlargement of Dendritic Spine Heads in Mouse Neurons via Tau-Dependent Mechanisms. (Pubmed Central) - Mar 20, 2024
Not yet recruiting --> Recruiting | N=90 --> 366 | Trial completion date: Aug 2024 --> Aug 2026 | Trial primary completion date: Mar 2024 --> Mar 2026 These data suggest that sevoflurane induces a tau phosphorylation-dependent demtrimental effect on dendritic spine via decreasing EAAT3 expression and increasing extracellular glutamate levels, leading to neuronal dysfunction.
- | Journal: Postoperative pain and pain management following selective dorsal rhizotomy. (Pubmed Central) - Mar 20, 2024
Adverse events, while common, are typically mild and managed with medication or therapy. This information can be used as a baseline to improve postoperative care and to support families' understanding of SDR before surgery.
- | sevoflurane / Generic mfg.
Journal, Surgery: Postoperative outcomes after total sevoflurane inhalation sedation using a disposable delivery system (Sedaconda-ACD) in cardiac surgery. (Pubmed Central) - Mar 20, 2024
Total inhaled anesthesia with sevoflurane was not associated with a lower incidence of myocardial injury assessed by the postoperative troponin peak level. However, in our cohort, the use of inotropic drugs was lower.
- | sevoflurane / Generic mfg.
Journal: Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia. (Pubmed Central) - Mar 19, 2024
However, in our cohort, the use of inotropic drugs was lower. This study demonstrates that PrLPyr neurons and their projections to the VTA are involved in facilitating emergence from sevoflurane anesthesia, with the PrLPyr -VTA pathway exerting its effects through the activation of NMDA receptors within the VTA.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Journal: Effect of Sevoflurane, Isoflurane, and Desflurane on the Random Blood Glucose Levels in Non-diabetic Patients Undergoing General Anesthesia: A Randomized, Single-Blind Study. (Pubmed Central) - Mar 18, 2024
The rise was significantly higher in desflurane-based anesthesia than in isoflurane. This study was, however, conducted in non-diabetic patients; hence, results might not be extrapolated to diabetic patients.
- sevoflurane / Generic mfg.
Sevoflurane therapy using anaesthetic conserving device in life-threatening refractory bronchospasm in adults () - Mar 18, 2024 - Abstract #ISICEM2024ISICEM_1024;
They all required invasive mechanical ventilation with high dose inhaled beta -2 agonist, anti -muscarinic agent, paralytic agent, corticosteroid, and ketamine infusion. Sevoflurane via ACD can be safely used in ICU and can improve pCO2, pH, iPEEP and clinical condition of mechanically ventilated adults, who failed standard treatment for refractory bronchospasm.
- | sevoflurane / Generic mfg.
Preclinical, Journal: mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice. (Pubmed Central) - Mar 18, 2024
Blocking the mtDNA release via the mPTP-VDAC channel inhibitor attenuated sevoflurane-induced mtDNA cytosolic escape and reduced cGAS-STING pathway activation in microglia, finally inhibiting the NLRP3 inflammasome activation. Therefore, regulating neuroinflammation by targeting the cGAS-STING pathway may provide a novel therapeutic target for POCD.
- | sevoflurane / Generic mfg.
Journal: Effect of propofol and sevoflurane on postoperative fatigue after laparoscopic hysterectomy. (Pubmed Central) - Mar 18, 2024
POFS after scheduled laparoscopic hysterectomy was unaffected by anesthesia with propofol vs. sevoflurane. The incidence of POFS was highest on the first postoperative day, at 27.7%, and declined progressively over the postoperative 30
- sevoflurane / Generic mfg.
NEUROENDOCRINE EFFECTS OF TRAUMATIC BRAIN INJURY AND SUBSEQUENT EXPOSURE TO THE GENERAL ANESTHETIC SEVOFLURANE IN YOUNG ADULT MALE RATS AND THEIR FUTURE UNEXPOSED OFFSPRING () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_714;
The incidence of POFS was highest on the first postoperative day, at 27.7%, and declined progressively over the postoperative 30 The findings of this study demonstrate that the effects of surgery, TBI, and subsequent exposure to SEVO in young adult male rats interact to induce intergenerational neuroendocrine abnormalities.
- | ketamine / Generic mfg., sevoflurane / Generic mfg.
Journal: Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain. (Pubmed Central) - Mar 15, 2024
No such effects were observed upon stimulating the ventral lateral thalamus, demonstrating specificity. Overall, we identify consistent distributed signatures of consciousness that are orchestrated by specific thalamic nuclei.
- || sevoflurane / Generic mfg.
Review, Journal: Comparing Perioperative Outcomes of Total Intravenous Anesthesia (TIVA) With Volatile Anesthesia in Patients With Obesity: A Systematic Review. (Pubmed Central) - Mar 15, 2024
Findings showed that TIVA (using propofol) might reduce PONV, but there were no significant differences in other outcomes compared to volatile anesthesia (with desflurane as the most common agent). The review highlights the need for more research, especially comparing sevoflurane with TIVA, to establish clear clinical guidelines for anesthesia in obese patients.
- sevoflurane / Generic mfg.
MAINTENANCE SEVOFLURANE SIGNIFICANTLY IMPAIRS THE ESOPHAGEAL CONTRACTILE RESPONSE (Hall A, Poster Hall - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_7093;
The review highlights the need for more research, especially comparing sevoflurane with TIVA, to establish clear clinical guidelines for anesthesia in obese patients. Induction sevoflurane impairs the normal esophageal contractile response in a minority of children, while maintenance sevoflurane impairs the normal contractile response in a majority of children.
- || remifentanil / Generic mfg., sevoflurane / Generic mfg.
PK/PD data, Journal: Pharmacokinetics of propofol in severely obese surgical patients. (Pubmed Central) - Mar 14, 2024
We have developed a new PK model of propofol that is suitable for all adult weight classes. Specifically, it is based on data from an unprecedented number of individuals with very high BMI.