sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity. (Pubmed Central) -  Nov 21, 2020   
    Asymptomatic flies that carry ND23 mutations are sensitized to hyperoxic isoflurane toxicity by age and genetic background. : Editor's Perspective WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Mitochondrial proteins are targets of general anestheticsThe extent to which pathogenic mutations in mitochondrial proteins increase the risk of adverse reactions from anesthetics has not been previously explored WHAT THIS ARTICLE TELLS US THAT IS NEW: Isoflurane but not sevoflurane exposure increased mortality in Drosophila carrying homozygous mutations in mitochondrial complex I, and hyperoxia increased mortality associated with isoflurane administrationIn heterozygous flies, carrying mutations in mitochondrial complex I, age, and hyperoxia rendered flies susceptible to mortality after exposure to isofluraneThese observations raise the possibility that heterozygous carriers of mitochondrial mutations may be more susceptible to perioperative complications after isoflurane exposure.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Volatile Anesthetics Activate a Leak Sodium Conductance in Retrotrapezoid Nucleus Neurons to Maintain Breathing during Anesthesia in Mice. (Pubmed Central) -  Nov 21, 2020   
    Sodium leak channel expression in the retrotrapezoid nucleus is required for the ventilatory response to carbon dioxide during anesthesia by isoflurane and sevoflurane, thus identifying sodium leak channel as a requisite determinant of respiratory output during anesthesia of volatile anesthetics. : WHAT WE ALREADY KNOW ABOUT THIS TOPIC: The voltage-independent sodium leak channel is expressed in chemosensitive retrotrapezoid nucleus neurons of the rostral medulla and is required for physiologic respiratory activityWhether sodium leak channel in retrotrapezoid nucleus neurons contributes to the effects of volatile anesthetics on breathing under general anesthesia has not been previously investigated WHAT THIS ARTICLE TELLS US THAT IS NEW: Isoflurane increased neuronal activity of chemosensitive retrotrapezoid nucleus neurons in brain slices of neonatal miceGenetic ablation of the voltage-independent sodium leak channel from retrotrapezoid nucleus neurons decreased respiratory rate and ventilatory response to carbon dioxide upon isoflurane and sevoflurane but not after propofol exposureThese observations suggest that the voltage-independent sodium leak channel in retrotrapezoid nucleus neurons of the medulla is a target of volatile anesthetics to activate respiratory activity.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial completion date, Trial primary completion date:  Sevoflurane Human Biomonitoring in Operating Room Personnel (clinicaltrials.gov) -  Nov 18, 2020   
    P=N/A,  N=56, Recruiting, 
    The guidance of controlled hypotension with rSO(2) monitoring can reduce the blood loss and infusion volume during spinal surgery in elderly patients with hypertension, reduce postoperative related complications and enhance recovery after surgery. N=20 --> 56 | Trial completion date: Dec 2019 --> Feb 2021 | Trial primary completion date: Nov 2019 --> Feb 2021
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Observational data, Journal:  Prediction of Postoperative Pain and Opioid Consumption Using Intraoperative Surgical Pleth Index After Surgical Incision: An Observational Study. (Pubmed Central) -  Nov 18, 2020   
    This prospective observational study was performed in 50 patients undergoing laparotomy under sevoflurane-based general anesthesia...Group H used higher fentanyl via patient control analgesia during postoperative 24 h (573 (253) µg vs 817 (305) µg, p=0.008)...Our finding suggests that the SPI response to nociceptive stimuli during surgery is closely related to the degree of patient postoperative pain and opioid requirements. This information may be used to provide proper intraoperative analgesia and individual postoperative pain management.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Inhaled Anesthetics and Myocardial Strain (clinicaltrials.gov) -  Nov 17, 2020   
    P1,  N=25, Recruiting, 
    Both drugs caused considerable QT interval prolongation into the proarrhythmogenic range, with methadone causing greater prolongation. Trial completion date: Aug 2020 --> Dec 2021 | Trial primary completion date: Aug 2020 --> Dec 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, IO biomarker:  Sevoflurane increases intracellular calcium to induce mitochondrial injury and neuroapoptosis. (Pubmed Central) -  Nov 12, 2020   
    By using calcium channel blocker Nimodipine, the increase of intracellular Ca was attenuated, and the death rate of neurons, the ROS and opening of mPTP, decreased ATP production, the expressions of cytochrome c, cleaved caspase-9, cleaved caspase-3 and the ratio of Bax/Bcl-2 were alleviated. Our study suggested that Sevoflurane could increase intracellular Ca to induce mitochondrial injury and mitochondria-mediated neuroapoptosis in neurons.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Affects Memory Through Impairing Insulin-Like Growth Factor Receptor Signaling. (Pubmed Central) -  Nov 7, 2020   
    Moreover, transfection with antisense of miR-223-3p significantly attenuated SEVO exposure-induced neuron cell apoptosis. Taken together, these data suggest that SEVO-induced miR-223-3p upregulation suppresses IGF1R to impair IGF signaling, which subsequently leads to learning and memory impairments.
  • ||||||||||  remifentanil / Generic mfg.
    Journal:  Regulatory effects of propofol on high-dose remifentanil-induced hyperalgesia. (Pubmed Central) -  Nov 7, 2020   
    The incidence rates of bradycardia and postoperative chill in PH and SH groups were significantly higher than those of SL group (P<0.05). Anesthesia by infusion of high-dose remifentanil plus sevoflurane caused postoperative hyperalgesia which was relieved through intravenous anesthesia with propofol.
  • ||||||||||  sevoflurane / Generic mfg.
    New P4 trial, Surgery:  Propofol Versus Sevoflurane During FESS (clinicaltrials.gov) -  Nov 6, 2020   
    P4,  N=60, Recruiting, 
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  LUMBES: Lumbar Erector Spinae Plane Block for Back Surgery (clinicaltrials.gov) -  Nov 5, 2020   
    P3,  N=80, Recruiting, 
    The decrease in IL-6 level reflects anti-inflammatory effect and probable neuroprotective potential of propofol and sevoflurane. Trial completion date: Feb 2020 --> Dec 2021 | Trial primary completion date: Feb 2020 --> Dec 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion:  Renal Function During Pediatric Anesthesia (clinicaltrials.gov) -  Nov 4, 2020   
    P1,  N=24, Completed, 
    Trial completion date: Feb 2020 --> Dec 2021 | Trial primary completion date: Feb 2020 --> Dec 2021 Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Pain reduction of topical sevoflurane vs intravenous opioids in pressure ulcers. (Pubmed Central) -  Nov 4, 2020   
    The main aim was to determine the effectiveness of topical sevoflurane in reducing the pain of PUs and reducing the ulcer area. Study findings are reported and discussed herein and suggest that sevoflurane is a viable and promising treatment option for PUs.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Online monitoring of end-tidal propofol in balanced anesthesia by anisole assisted positive photoionization ion mobility spectrometer. (Pubmed Central) -  Nov 2, 2020   
    In previous work, exhaled propofol was detected using acetone assisted negative photoionization ion mobility spectrometer, however, the existence of high concentration sevoflurane interfered the response of propofol...The relative standard deviation (RSD) ranging from 0.64%-0.91% showed good repeatability and the quantitative range was 0.2-40 ppbv with a response time of 4 s. Finally, the performance of the proposed method was demonstrated by monitoring end-tidal propofol of balanced anesthetized patients during gastric cancer surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial initiation date, Trial primary completion date:  MEMSEV: Evaluation of the Sevoflurane Consumption During General Anesthesia When Using the MemsorbTM Membrane (clinicaltrials.gov) -  Oct 29, 2020   
    P=N/A,  N=50, Not yet recruiting, 
    Our results suggest sevoflurane-induced protection against intestinal I/R injury is partly mediated by inhibiting intestinal inflammatory reaction via activation of PPARγ/NF-κB pathway. Initiation date: Sep 2020 --> Dec 2020 | Trial primary completion date: Dec 2020 --> Mar 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Frequency dependent functional brain reorganization in anesthesia is specific to drug concentration. (Pubmed Central) -  Oct 26, 2020   
    Using fMRI, it has been shown that increasing doses of sevoflurane is associated with progressive breakdown in brain functional connectivity, while EEG studies have shown that higher activity in the delta band is associated with unconsciousness...Interestingly, high and low-frequency bands behaved in an opposite manner as a function of condition. We also found significant band*condition interactive effects in clustering coefficient, efficiency and strength both on local and global scales.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Succinylcholine-Induced Rhabdomyolysis in Adults: Case Report and Review of the Literature. (Pubmed Central) -  Oct 25, 2020   
    Conclusion Rhabdomyolysis was observed in a woman following the administration of SCh and sevoflurane for diagnostic procedures lasting 30 minutes. While avoidance is possible in adults with histories of NMDs, a high index of suspicion for occurrence of rhabdomyolysis is needed whenever combining SCh with HA in all adults.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice. (Pubmed Central) -  Oct 24, 2020   
    Furthermore, resveratrol improved the cognitive performance in the Morris water maze test of the adult mice with exposure to sevoflurane in the neonatal stage, without changing motor function in the open field test. Taken together, our findings suggested that SIRT1 deficiency regulated BDNF signaling via regulation of the epigenetic activity of MeCP2 and CREB, and resveratrol might be a promising agent for mitigating sevoflurane-induced neurotoxicity in developing mice.
  • ||||||||||  sevoflurane / Generic mfg.
    Retrospective data, Review, Journal:  Evaluating the anti-inflammatory and analgesic properties of maropitant: A systematic review and meta-analysis. (Pubmed Central) -  Oct 24, 2020   
    However, treatment with maropitant had no effect on pain (SMD 0.06, 95% CI -0.37, 0.48; P = 0.80), or leukocyte cell infiltration in different inflammatory conditions (SMD -0.60, 95% CI -1.31, 0.11; P = 0.10). Based on all eligible studies for this review, it can be deduced that maropitant significantly reduced the minimum alveolar concentrations for isoflurane and sevoflurane for many different surgical procedures but it had no clearly proven effect on inflammation and pain.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Optimization of treatment of acute poisoning with severe psychodisleptics (Pubmed Central) -  Oct 23, 2020   
    Based on all eligible studies for this review, it can be deduced that maropitant significantly reduced the minimum alveolar concentrations for isoflurane and sevoflurane for many different surgical procedures but it had no clearly proven effect on inflammation and pain. Augmentation of conventional therapy with cytoflavin in combination with inhaled sedation with sevoflurane, affecting various links in the pathogenesis of acute severe poisoning with psychodisleptics, made it possible to cope in a shorter time.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  FESSPRD: PRD-guided Analgesia During FESS for Intraoperative Blood Loss (clinicaltrials.gov) -  Oct 22, 2020   
    P=N/A,  N=120, Not yet recruiting, 
    Augmentation of conventional therapy with cytoflavin in combination with inhaled sedation with sevoflurane, affecting various links in the pathogenesis of acute severe poisoning with psychodisleptics, made it possible to cope in a shorter time. Trial completion date: Jan 2021 --> Jan 2023 | Trial primary completion date: Jan 2021 --> Jan 2023
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, IO Biomarker:  Sevoflurane inhibits the progression of PTC by downregulating miR-155. (Pubmed Central) -  Oct 22, 2020   
    In summary, our findings revealed that lncRNA Gm15621 ameliorated the sevoflurane-induced neurotoxicity and the important role of Gm15621/miR-133a/Sox4 axis in cognitive disorder. Sevoflurane inhibited migration and invasion, while enhanced cell apoptosis by downregulating miR-155 in PTC cells, suggesting important clinical implications for anesthetic agents to prevent the metastasis in PTC.