sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Development of a prototype anti-pollution filter for volatile anesthetics. (Pubmed Central) -  Dec 18, 2020   
    Adsorption tests showed that the prototype filter fully adsorbed isoflurane in 100 ± 2.3 min, sevoflurane in 95 ± 3.4 min, and desflurane in 95 ± 4.3 min. The new version of our prototype filter adsorbed most of the volatile anesthetics agents during an ex-vivo simulated conventional cardiopulmonary bypass test.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Impact of Sevoflurane Versus Propofol Anesthesia on Post-Operative Cognitive Dysfunction in Elderly Cancer Patients: A Double-Blinded Randomized Controlled Trial. (Pubmed Central) -  Dec 18, 2020   
    During the first 2 days post-operation, the QoR-40 global score was significantly lower in Group S compared to Group P [POD 1: P=0.004; POD 2: P=0.001]. There were no significant differences in in-hospital post-operative complications, post-operative length of hospital stay, all-cause mortality at 30 days, and 3 months post-operation, or post-operative quality of life at 3 months between patients in Group S and Group P. CONCLUSIONS Sevoflurane-based anesthesia did not increase the incidence of POCD compared to propofol-based anesthesia at 7 days or 3 months post-operation or impact short-term post-operative prognosis.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Influence of Halogenated Hydroxyl-Alkanes Inhalation Anesthetic on the Determination of Ethanol Content in Blood (Pubmed Central) -  Dec 17, 2020   
    Results The retention time of sevoflurane and enflurane was similar to that of ethanol and tert butanol respectively when using the J&W DB-ALC1/DB-ALC2 gas chromatographic column, and interfered with the detection of ethanol content in blood; only J&W DB-ALC1 gas chromatographic column can separate the sevoflurane and ethanol components, so as to eliminate their influence on the detection of ethanol content in blood...Conclusion Halogenated hydroxy-alkanes interfere with determination of ethanol content in blood by headspace gas chromatography. The interference can be discriminated effectively by choosing the suitable chromatographic column and double column confirmatory detection.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Anesthesia and Anesthetic-Related Complications of 8 Elegant-Crested Tinamous (Eudromia elegans) Undergoing Experimental Surgery. (Pubmed Central) -  Dec 17, 2020   
    The aim of this study was to describe the anesthetic effects of an injectable anesthetic protocol, based on ketamine, midazolam, and medetomidine, followed by inhalational sevoflurane, in 8 elegant-crested tinamous (Eudromia elegans) undergoing experimental surgery...This report highlights the challenges of tinamou anesthesia. Cardiac complications are common in this species, and close monitoring of intraoperative cardiovascular variables is recommended for prompt recognition and treatment.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Comparison of electroencephalogram between propofol- and thiopental-induced anesthesia for awareness risk in pregnant women. (Pubmed Central) -  Dec 17, 2020   
    EEG data were extracted from the bispectral index (BIS) monitor, and 10-second segments were selected from the following sections: 1) Stage I, BIS below 60 after induction; 2) Stage II, after intubation completion; 3) Stage III, end-tidal sevoflurane above 0 vol%...BIS, spectral entropy, and Renyi permutation entropy were also higher in the thiopental group at Stages II and III (p < 0.05). In conclusion, frontal spectral EEG analysis demonstrated that propofol induction maintained a deeper anesthesia than thiopental in pregnant women.
  • ||||||||||  lithium carbonate / Generic mfg., lithium / Generic mfg.
    Clinical, Journal:  Potentiation of Rocuronium Bromide by Lithium Carbonate: A Case Report. (Pubmed Central) -  Dec 16, 2020   
    General anesthesia was induced with propofol, fentanyl, remifentanil, and sevoflurane...Following administration of sugammadex (200 mg) the TOF ratio increased to 95%...Thus, the effect of the remaining lithium may have been superimposed on the rocuronium neuromuscular blockade. Evaluation with a nerve stimulation device in patients taking lithium is crucial before extubation because of the risk of rocuronium potentiation.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device. (Pubmed Central) -  Dec 16, 2020   
    Because previous experimental and clinical research suggested potential benefits of halogenated volatiles, such as sevoflurane or isoflurane, for lung alveolar epithelial injury and inflammation, two pathophysiologic landmarks of diffuse alveolar damage during ARDS, we designed an animal model to understand the mechanisms of the effects of halogenated agents on lung injury and repair...Although this model induced a marked decrease in arterial oxygenation with altered alveolar-capillary permeability, it is reproducible and is characterized by a rapid onset, good stability over time, and no fatal complications. We have developed a piglet model of acid aspiration that reproduces most of the physiological, biological, and pathological features of clinical ARDS, and it will be helpful to further our understanding of the potential lung-protective effects of halogenated agents delivered through devices used for inhaled ICU sedation.
  • ||||||||||  Ryanodex (dantrolene) / Eagle Pharma
    Journal:  Rhabdomyolysis during Perioperative Period after Cardiac Surgery (Pubmed Central) -  Dec 15, 2020   
    It remained unclear which drug triggered rhabdomyolysis. When MH is suspected, we should consider the use of the clinical grading scale to predict its susceptibility and start dantrolene sodium hydrate infusion.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  50% Effective Concentration of Sevoflurane for Immobility (clinicaltrials.gov) -  Dec 9, 2020   
    P=N/A,  N=20, Recruiting, 
    When MH is suspected, we should consider the use of the clinical grading scale to predict its susceptibility and start dantrolene sodium hydrate infusion. Trial completion date: Apr 2021 --> Mar 2022 | Trial primary completion date: Mar 2021 --> Mar 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open:  Confirmatory Study of HFVI Guided Analgesic Administration in Surgical Subjects (clinicaltrials.gov) -  Dec 7, 2020   
    P=N/A,  N=104, Enrolling by invitation, 
    Furthermore, optimizing the doses of anesthetic drugs based on the individual clinical profile of each patient led to a considerable decrease in drug consumption, as well as to a lower incidence of hemodynamic side-effects. Not yet recruiting --> Enrolling by invitation
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Fluorine-Containing Inhalation Anesthetics: Chemistry, Properties, and Pharmacologies. (Pubmed Central) -  Dec 3, 2020   
    Several regularities were found by experimental studies: 1) the potency and toxicity of the saturated linear chain halogenated ether are enhanced when its molecular weight is increased; 2) the margin of safety decreases and the recovery time is prolonged when the boiling point of the candidate increases; and 3) compounds with an asymmetric carbon terminal exhibit good anesthesia. Nevertheless, the development of new inhalation anesthetics better than desflurane and sevoflurane is still challenging not only because of the poor structure/activity relationship known so far but also the synthetic issues.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, Combination therapy:  Chemocentric Informatics Analysis: Dexamethasone Versus Combination Therapy for COVID-19. (Pubmed Central) -  Dec 1, 2020   
    Other drugs such as sevoflurane and treprostinil interact with the SARS-CoV-2 interactome and deserve further exploration. Moreover, our chemocentric informatics approach provides systems biology evidence that combination therapies for COVID-19 will have higher chances of perturbing the SARS-CoV-2 human interactome, which may negatively impact COVID-19 disease pathways.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Influence of fasting duration on blood volume status of pediatric patients evaluated by ultrasonic technique (Pubmed Central) -  Nov 28, 2020   
    After sedation by inhalation of sevoflurane, the maximum (expiratory) and minimum (inspiratory) diameter of inferior vena cava (IVC(max), IVC(min)) and aorta velocity-time integral (VTI) in apical five-chamber cardiac view were measured with an ultrasound machine...However, the duration of fasting was not correlated with IVC(RVI) and ΔVTI after adjusting the age and weight (IVC(RVI): β=0.177, 0.160; ΔVTI: β=0.037, 0.054; all P>0.05). Age and weight, but not preoperative fasting duration, are correlated with respiratory variabilities of inferior vena cava diameter and aortic VTI in pediatric patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane may not be a complete sigh of relief in COVID-19. (Pubmed Central) -  Nov 26, 2020   
    We hypothesize that low frontal alpha power and increased propensity for burst suppression together characterize a "vulnerable brain" phenotype under anesthesia that could be mechanistically linked to brain metabolism, cognition, and brain aging. No abstract available
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines. (Pubmed Central) -  Nov 22, 2020   
    Sevoflurane augmented or hampered cell proliferation and Matrigel invasion depending on the cancer cell line examined. Loss of sevoflurane-induced apoptosis occurring in cancer cell lines is likely to be correlated with their enhanced proliferation after sevoflurane exposure.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain. (Pubmed Central) -  Nov 21, 2020   
    Disturbing NKCC1/KCC2 balance may underlie circuit hyperexcitability and contribute to neurodevelopmental impairments we have observed in previous studies of neonatal anesthesia exposure. Human infants previously exposed to anesthesia may require higher concentrations of anesthetic drugs, potentially compounding their susceptibility for neurodevelopmental sequalae.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Exposure Results in Sex-Specific Transgenerational Upregulation of Target IEGs in the Subiculum. (Pubmed Central) -  Nov 21, 2020   
    We further investigated correlation between altered arc promoter methylation and observed upregulation of Arc mRNA and observed that sevoflurane reduced methylation in the 5-upstream promoter region of females exposed to sevoflurane. Transgenerational hypomethylation and modifications to IEGs crucial to synaptic plasticity, observed following neonatal sevoflurane exposure could contribute to morphological and cognitive deficits known to occur with neonatal sevoflurane exposure.