sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Ectothermy and cardiac shunts profoundly slow the equilibration of inhaled anaesthetics in a multi-compartment model. (Pubmed Central) -  Jan 14, 2021   
    The impact of these findings is also influenced by the solubility coefficient of the anaesthetic, such that at net right-to-left shunt fractions of over 0.8, sevoflurane loses the advantage of faster equilibration, in comparison with isoflurane. We explore clinical strategies to regulate anaesthetic uptake in ectotherms by managing convectional flow especially by supportive ventilation and reduction of the right-to-left shunt.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Clinical, Journal:  Anesthetic Management of a Patient With Restless Legs Syndrome: A Case Report. (Pubmed Central) -  Jan 14, 2021   
    The patient underwent general anesthesia for a bilateral sagittal split ramus osteotomy using a combined inhalational and intravenous anesthetic technique with sevoflurane, propofol, remifentanil, and dexmedetomidine...After increasing the dexmedetomidine infusion from 0.2 to 0.4 μg/kg/h, almost all symptoms improved, and she slept for 3 hours...The patient was formally diagnosed with RLS by a neurologist after discharge. In this case, an infusion of dexmedetomidine was helpful in successfully managing a suspected exacerbation of RLS.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Airway Complications After LMA in Children (clinicaltrials.gov) -  Jan 14, 2021   
    P=N/A,  N=140, Recruiting, 
    This study provides experimental evidence for a potential effective, yet simple, method to prevent anesthesia-induced neurotoxicity in children, especially in infants. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  Trial completion date, Trial primary completion date:  Effect of Type of General Anesthesia Maintenance on Exhaled Nitric Oxide and Eosinophil Blood Count (clinicaltrials.gov) -  Jan 13, 2021   
    P=N/A,  N=60, Recruiting, 
    This study highlights the diversity of clinical standards in pediatric cardiac anesthesia for congenital cardiac surgery in Germany. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats. (Pubmed Central) -  Jan 13, 2021   
    TCCs were activated by potentiated GABAergic depolarization with a sub-anesthetic dose of sevoflurane (1%). These data suggest that (1) TCCs in the brain contribute to the generation of PAHBs and the concomitant electroencephalographic changes; (2) the stronger inhibitory effect of sevoflurane contributes to the lack of PAHBs in older rats; and (3) the contribution of TCCs to PAHBs is not mediated by a direct effect of sevoflurane on TCCs.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Comparison of Biochemical Recurrence After Robot-assisted Laparoscopic Radical Prostatectomy with Volatile and Total Intravenous Anesthesia. (Pubmed Central) -  Jan 13, 2021   
    The following predictive factors of prostate cancer recurrence were determined by Cox regression: colloid input [hazard ratio (HR)=1.002, 95% confidence interval (CI): 1.000-1.003; P = 0.011], initial prostate-specific antigen level (HR=1.025, 95% CI: 1.007-1.044; P = 0.006), and pathological tumor stage 3b (HR=4.217, 95% CI:1.207-14.735; P = 0.024), but not the anesthetic agent. Our findings demonstrate that both TIVA with propofol/remifentanil and VA with sevoflurane or desflurane/remifentanil have comparable effects on oncologic outcomes in patients undergoing RALP.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Audit of Anesthetic Equipment in Veterinary Clinics in Spain and Portugal. (Pubmed Central) -  Jan 8, 2021   
    A total of 27.1% of the isoflurane vaporizers and 35.9% of the sevoflurane vaporizers were incorrect. Machine learning techniques showed that the most important variables in the classification of the anesthetic machines as conforming or non-conforming were mostly the scavenger system and the canister, followed some way behind by the APL valve, source of oxygen, reservoir bag, vaporizer, and connections.
  • ||||||||||  sevoflurane / Generic mfg.
    PK/PD data, Journal:  Pharmacokinetics of midazolam in sevoflurane-anesthetized cats. (Pubmed Central) -  Jan 7, 2021   
    There was a high interindividual variability in the plasma 1-hydroxymidazolam concentrations, and this metabolite had a low clearance and persisted in the plasma for longer than the parent drug. Midazolam administration did not result in clinically significant changes in physiologic variables.
  • ||||||||||  Silverzine Tulle (Silver Sulfadiazine) / MinaPharm
    Clinical, Journal:  Conservative multimodal management of osteosynthesis material in surgical wounds with polymicrobial superinfection, including methicillin-resistant Staphylococcus aureus. Clinical case. (Pubmed Central) -  Jan 6, 2021   
    We present the successful conservative management of osteosynthesis material implanted due to ankle fracture in an elderly patient who suffered superinfection by the aforementioned microorganism, in which the antimicrobial treatment consisted of the combination of antibiotic-guided systemic antibiotics (after a first ineffective empirical cycle), together with topical irrigations of sevoflurane, applications of silver sulfadiazine cream, and subsequently coverage of the skin defect with negative pressure therapy. We highlight the novel role of sevoflurane as an analgesic and as a topical antimicrobial agent (in addition to silver sulfadiazine) in the favourable evolution of the wound, especially in the period in which the empirical antibiotic therapy was ineffective and negative pressure therapy had not yet been applied.
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Journal:  Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: A randomized trial. (Pubmed Central) -  Jan 5, 2021   
    SPC confers neuroprotection in focal cerebral ischemia mouse models by upregulating the expression of MT-1 and MT-2 by activating NO and peroxide and increasing MTF-1 expression in the nucleus. LEEP under LA is equally well tolerated and offers patient-reported as well as procedure-related benefits over GA, supporting the preferred practice in some institutions and refuting the preferred practice in others.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Trial completion, Enrollment change, Surgery:  The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep (clinicaltrials.gov) -  Jan 5, 2021   
    P=N/A,  N=74, Completed, 
    The mechanism may be related to increasing the content of key enzymes and ATP of glycolysis in the early stage of hypoxia. Not yet recruiting --> Completed | N=160 --> 74
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Airway Management of Retrosternal Goiters in 22 Cases in a Tertiary Referral Center. (Pubmed Central) -  Dec 31, 2020   
    Thirteen patients received a muscle relaxant intravenously, and two patients were induced with sevoflurane...The incidence of difficult intubation and postoperative tracheomalacia is likely too rare. Furthermore, perioperative bleeding and postoperative airway complication seem frequent.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date:  Tolerance to Sevoflurane in Children Undergoing Repeated Drug Exposure (clinicaltrials.gov) -  Dec 28, 2020   
    P=N/A,  N=16, Recruiting, 
    We attribute this to NOL-driven rather than BP- and HR-driven fentanyl dosing during anaesthesia. Trial primary completion date: Dec 2020 --> Mar 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Sevoflurane induces neuronal activation and behavioral hyperactivity in young mice. (Pubmed Central) -  Dec 23, 2020   
    These results demonstrate an unexpected sevoflurane-induced increase in neuronal activation and behavioral hyperactivity in young mice. These findings suggest the potential mechanisms underlying the sevoflurane-induced agitation and will promote future studies to further determine whether anesthetics can induce behavioral hyperactivity via increasing neuronal activation.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia. (Pubmed Central) -  Dec 22, 2020   
    A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane...These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Clinical, Journal:  Oxidative stress, DNA damage, inflammation and gene expression in occupationally exposed university hospital anaesthesia providers. (Pubmed Central) -  Dec 21, 2020   
    Thus, under the conditions of the study, the findings suggest that occupational exposure to WAGs is not associated with oxidative stress or inflammation when evaluated in serum/plasma, with DNA damage evaluated in lymphocytes and leucocytes or with molecular modulation assessed in peripheral blood cells in university anaesthesia providers. However, it is prudent to reduce WAGs exposure and to increase biomonitoring of all occupationally exposed professionals.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity. (Pubmed Central) -  Dec 19, 2020   
    Enhanced sestrin-2 and phosphorylated AMPK expression were noticed following NGR1 pretreatment. This study revealed the neuroprotective effects of NGR1 through effective suppression of apoptosis and ROS via regulation of apoptotic proteins and activation of Nrf2/HO-1 and sestrin 2/AMPK signaling cascades.