sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Chloroform is a potent activator of cardiac and neuronal Kir3 channels. (Pubmed Central) -  Feb 4, 2021   
    Chloroform has been used over decades in anesthesia before it was replaced by other volatile anesthetics like halothane or sevoflurane...This effect was selective and only observed in currents from Kir3 subunits but not in currents from Kir2 subunits. Augmentation of atrial Kir3.1/3.4 currents leads to an effective drop of the heart rate and a reduction in contraction force in isolated mouse atria.
  • ||||||||||  Trial completion date, Trial primary completion date, Epigenetic controller:  EPOPED: Epigenetics in PostOperative Pediatric Emergence Delirium (clinicaltrials.gov) -  Feb 3, 2021   
    P=N/A,  N=322, Recruiting, 
    Augmentation of atrial Kir3.1/3.4 currents leads to an effective drop of the heart rate and a reduction in contraction force in isolated mouse atria. Trial completion date: Jan 2020 --> Dec 2021 | Trial primary completion date: Nov 2019 --> Jun 2021
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  The Value of a Post-induction Fentanyl Test in Identifying Severe Obstructive Sleep Apnea Syndrome. (Pubmed Central) -  Feb 3, 2021   
    Trial completion date: Jan 2020 --> Dec 2021 | Trial primary completion date: Nov 2019 --> Jun 2021 Our study showed that a post-induction fentanyl test had good predictive value in identifying severe obstructive sleep apnea syndrome and early postoperative adverse respiratory events, and could provide a reference for postoperative analgesia in children undergoing adenotonsillectomy.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Clinical Study of Behavior Problems in Children After Different Anesthesia Methods (clinicaltrials.gov) -  Feb 2, 2021   
    P4,  N=500, Recruiting, 
    Our study showed that a post-induction fentanyl test had good predictive value in identifying severe obstructive sleep apnea syndrome and early postoperative adverse respiratory events, and could provide a reference for postoperative analgesia in children undergoing adenotonsillectomy. Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
  • ||||||||||  Chirocaine (levobupivacaine) / Purdue, AbbVie
    Enrollment change, Trial termination:  Anesthesia And Post-operative Mortality After Proximal Femur Fractures (clinicaltrials.gov) -  Feb 1, 2021   
    P=N/A,  N=57, Terminated, 
    Such data indicated that Peg13 mitigated the sevoflurane-related neurotoxicity by sponging miR-128-3p to preserve Sox13 expression in NSCs. N=260 --> 57 | Not yet recruiting --> Terminated; Organizational changes made recruitment no longer possible
  • ||||||||||  Xeomin (incobotulinumtoxinA) / Merz Pharma
    [VIRTUAL] Treatment of persistent nystagmus in children using incobotulinumtoxinA () -  Jan 29, 2021 - Abstract #TOXINS2021TOXINS_136;    
    An improvement in visual function was also noted due to eye accommodation. Treatment of nystagmus using incoBTA injections into the extraocular muscles can be offered as an effective, safe, and minimally invasive approach.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Which Anesthesia Regimen Is Best to Reduce Pulmonary Complications After Head and Neck Surgery? (Pubmed Central) -  Jan 29, 2021   
    IncoBTA can be offered as an effective, safe, minimally invasive method of treating strabismus in children with hyperopia. Compared with intravenous anesthesia, the administration of sevoflurane reduces the incidence of minor PPCs (grades I and II) in moderate- and high-risk patients who have undergone tracheotomy after head and neck cancer surgery with radial forearm or fibular flap reconstruction.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Frontal electroencephalogram activity during emergence from general anaesthesia in children with and without emergence delirium. (Pubmed Central) -  Jan 29, 2021   
    P=N/A
    Compared with intravenous anesthesia, the administration of sevoflurane reduces the incidence of minor PPCs (grades I and II) in moderate- and high-risk patients who have undergone tracheotomy after head and neck cancer surgery with radial forearm or fibular flap reconstruction. Paediatric patients developing ED have increased low-frequency (delta) frontal EEG activity with reduced high-frequency (alpha and beta) activity during emergence from general anaesthesia.
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    Preclinical, Journal:  Effects of sevoflurane anaesthesia on radioligand binding to monoamine oxidase-B in vivo. (Pubmed Central) -  Jan 29, 2021   
    Sevoflurane anaesthesia inhibited radioligand binding to MAO-B in the primate brain. The observation of lower MAO-B binding at clinically relevant concentrations of sevoflurane warrants further exploration of the potential role of MAO-B related mechanisms in regulation of systemic blood pressure during anaesthesia.
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date, Surgery:  The PATHFINDER Study: A Feasibility Trial (clinicaltrials.gov) -  Jan 27, 2021   
    P1,  N=22, Completed, 
    In conclusion, normobaric hyperoxia preconditioning may be a promising strategy against sevoflurane-induced cognitive impairment by inhibiting the hippocampal neuron apoptosis. Active, not recruiting --> Completed | Trial completion date: Mar 2021 --> Jul 2020 | Trial primary completion date: Dec 2020 --> Feb 2020
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion:  CARING: CARbon Impact of aNesthesic Gas (clinicaltrials.gov) -  Jan 27, 2021   
    P=N/A,  N=58, Completed, 
    Active, not recruiting --> Completed | Trial completion date: Mar 2021 --> Jul 2020 | Trial primary completion date: Dec 2020 --> Feb 2020 Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal, Circulating Tumor Cells:  Anesthesia and Circulating Tumor Cells in Primary Breast Cancer Patients. (Pubmed Central) -  Jan 26, 2021   
    P4
    The miR-139-5p/ARF6 axis might be a promising target for the treatment of BC. In this randomized controlled trial investigating the effect of anesthesia on an independent prognostic factor for breast cancer, there was no difference between sevoflurane and propofol with respect to circulating tumor cell counts over time.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Observational data, Journal:  End-tidal to Arterial Gradients and Alveolar Deadspace for Anesthetic Agents. (Pubmed Central) -  Jan 26, 2021   
    Alveolar deadspace for anesthetic agents is much larger than for carbon dioxide and related to blood solubility. Unlike the three-compartment model, multicompartment scatter models explain this from physiologically realistic gas uptake distributions, but suggest a residual factor other than solubility, potentially diffusion limitation, contributes to deadspace.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Effects of Passive Head-and-Neck Movements on the Performance of i-gel Supraglottic Airway Device in Anesthetized Patients - A Randomized Crossover Trial. (Pubmed Central) -  Jan 26, 2021   
    After steady state of general anesthesia was achieved and maintenance with sevoflurane in NO and O was reached, the passive head-and-neck movements were done...Flexion movement did not cause significant changes in the exhaled minute ventilation, rise in ETCO, and audible leak of airway gases as compared to the neutral position. Ventilatory performance of the i-gel® deteriorates upon extension, right or left lateral flexion, and right or left rotation of the head and neck in spontaneously breathing patients under general anesthesia on pressure support ventilation with PEEP.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Surgery:  PHAR: Evaluate the Muscle Protection Effect of Sevoflurane Sedation in Vascular Surgery (clinicaltrials.gov) -  Jan 25, 2021   
    P4,  N=164, Completed, 
    It is feasible to conduct surface surgeries in the most vulnerable population such as neonates and infants under regional anesthesia without intubation and airway instrumentation. Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal, HEOR, Real-World Evidence:  "A real-world evidence" in reduction of volatile anesthetics by BIS-guided anesthesia. (Pubmed Central) -  Jan 23, 2021   
    A total of 6,713 cases were enrolled, where 1,324 cases receiving sevoflurane underwent BIS-guided anesthesia and 378 received desflurane; further, 3,819 receiving sevoflurane underwent standard anesthesia practice and 1,192 cases received desflurane...A significant reduction was found in the hourly consumption of volatile anesthetics in patients under BIS-guided anesthesia compared to standard anesthesia practice in different age groups or different anesthesia time. We concluded that BIS-guided anesthesia could reduce consumption of volatile anesthetics in real-world settings as well.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Evaluation of the perioperative effects of dexmedetomidine on tympanoplasty operations. (Pubmed Central) -  Jan 23, 2021   
    Regional anaesthesia by either preoperative paravertebral block or thoracoscopic intercostal nerve block with ipsilateral vagal block provided an anaesthetic sparing effect, guided by lower Ef sevo concentration, with comparable bi-spectral index in patients undergoing uniportal thoracoscopic surgery. The use of dexmedetomidine during tympanoplasty operations may provide better hemodynamic control and surgical view, may provide faster recovery and may reduce remifentanil consumption.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Effects of Sevoflurane on Lewis Lung Carcinoma Cell Proliferation In Vivo and In Vitro. (Pubmed Central) -  Jan 21, 2021   
    Sevoflurane (2 vol%) exposure could promote proliferation of LLC cells in vitro environment, but may not affect proliferation of LLC cells in vivo environment. These results suggest that in vitro studies on the effects of anesthetics on cancer may differ from those of in vivo or clinical studies.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Trial completion, Surgery:  Impact of Anesthesia Maintenance Methods on Long-term Survival (clinicaltrials.gov) -  Jan 20, 2021   
    P4,  N=1200, Completed, 
    These findings may provide insight into potential new mechanisms of APC-induced cardioprotection against IR injury. Active, not recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Sevoflurane in COVID-19 ARDS (SevCov) (clinicaltrials.gov) -  Jan 18, 2021   
    P3,  N=64, Recruiting, 
    Active, not recruiting --> Completed Trial completion date: Mar 2021 --> Mar 2022 | Trial primary completion date: Mar 2021 --> Mar 2022